1. Chronic pantothenic acid supplementation does not affect muscle coenzyme A content or cycling performance
- Author
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Lawrence L. Spriet, Louise M. Burke, Roger C. Harris, Gregory Shaw, Elizabeth Broad, Megan L. Ross, Alison K. Patterson, and Jamie Whitfield
- Subjects
Adult ,Male ,medicine.medical_specialty ,Physiology ,Endocrinology, Diabetes and Metabolism ,Coenzyme A ,exercise performance ,Athletic Performance ,coenzyme A ,030204 cardiovascular system & hematology ,Affect (psychology) ,Pantothenic Acid ,Young Adult ,03 medical and health sciences ,chemistry.chemical_compound ,Oxygen Consumption ,0302 clinical medicine ,Acetyl Coenzyme A ,Physiology (medical) ,Internal medicine ,skeletal Muscle ,Exercise performance ,Pantothenic acid ,medicine ,Humans ,Muscle, Skeletal ,Nutrition and Dietetics ,acetyl-CoA ,Acetyl-CoA ,Skeletal muscle ,General Medicine ,Bicycling ,Sports Nutritional Physiological Phenomena ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Dietary Supplements ,Cycling ,030217 neurology & neurosurgery - Abstract
[English] This study determined if supplementation with pantothenic acid (PA) for 16 weeks could increase skeletal muscle coenzyme A (CoASH) content and exercise performance. Trained male cyclists (n = 14) were matched into control or PA (6 g·day1) groups. At 0, 4, 8, and 16 weeks, subjects performed an incremental time to exhaustion cycle with muscle biopsies taken prior to and following exercise. Prolonged PA supplementation did not change skeletal muscle CoASH and acetyl- CoA contents or exercise performance. Novelty: Supplementation with pantothenic acid for 16 weeks had no effect on skeletal muscle CoASH and acetyl-CoA content or exercise performance in trained male cyclists. [French] Cette étude détermine si une supplémentation en acide pantothénique (« PA ») pendant 16 semaines peut augmenter la teneur en coenzyme A (« CoASH ») du muscle squelettique et la performance à l’exercice. Les cyclistes masculins entraînés (n = 14) sont appariés dans des groupes témoins ou PA (6 g·jour−1). Aux semaines 0, 4, 8 et 16, les sujets effectuent un exercice incrémental de pédalage au cours duquel on mesure la durée jusqu’à épuisement ; des biopsies musculaires sont prélevées avant et après l’exercice. Une supplémentation prolongée en PA ne modifie pas les teneurs en CoASH et en acétyl-CoA du muscle squelettique ni la performance à l’exercice. [Traduit par la Rédaction]
- Published
- 2021
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