Author: "Maylis Douine" / Topic: humans - Searchworks@Jio Institute Digital Library Search Results

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1. Novel Chronic Anaplasmosis in Splenectomized Patient, Amazon Rainforest

Author: Olivier Duron, Rachid Koual, Lise Musset, Marie Buysse, Yann Lambert, Benoît Jaulhac, Denis Blanchet, Kinan Drak Alsibai, Yassamine Lazrek, Loïc Epelboin, Pierre Deshuillers, Céline Michaud, Maylis Douine, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Laboratoire de Parasitologie [Cayenne, Guyane française], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Virulence bactérienne précoce : fonctions cellulaires et contrôle de l'infection aiguë et subaiguë, Université de Strasbourg (UNISTRA), Biologie moléculaire et immunologie parasitaires et fongiques (BIPAR), École nationale vétérinaire - Alfort (ENVA)-Laboratoire de santé animale, sites de Maisons-Alfort et de Normandie, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), The research was supported by funding from Investissements d’Avenir grants managed by the Agence Nationale de la Recherche (ANR, France, Laboratoire d’Excellence CEBA, ref. ANR-10-LABX-25-01)., and ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010)
Subjects: Microbiology (medical), Anaplasmosis, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Anaplasma, Rainforest, Infectious Diseases, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Epidemiology, Animals, Humans, Rickettsia Infections, Brazil
Abstract: International audience; We report a case of unusual human anaplasmosis in the Amazon rainforest of French Guiana. Molecular typing demonstrated that the pathogen is a novel Anaplasma species, distinct to all known species, and more genetically related to recently described Anaplasma spp. causing infections in rainforest wild fauna of Brazil.
Published: 2022

2. Combatting malaria disease among gold miners: a qualitative research within the Malakit project

Author: André-Anne Parent, Muriel Suzanne Galindo, Miguel Bergeron-Longpré, Yann Lambert, and Maylis Douine
Subjects: Health (social science), Public Health, Environmental and Occupational Health, Humans, Gold, Miners, Mining, Qualitative Research, Malaria
Abstract: Malaria is endemic in French Guiana, in particular, where illegal gold mining activities take place. Gold miners travel from Brazil to remote camps in the Guiana forest to carry out mining activities, exposing themselves to the presumed contamination area. This article presents the results of a qualitative case study of the Malakit project, an intervention where health facilitators offer appropriate training and distribution of self-diagnosis and self-treatment kits to manage an episode of malaria at resting sites on the French Guiana borders. The objectives were: (i) Determine the contextual elements influencing the use of Malakit; (ii) Understand the way gold miners perceive Malakit; (iii) Identify the elements that are favorable and unfavorable to the use of Malakit; (iv4) Identify what can be improved in the project. The data were collected using three methods: on-site observation, semi-structured individual interviews (n = 26), and group interviews (n = 2). The results indicate that Malakit responds to the need for treatment and facilitates access to care. Gold miners say they trust the facilitators and receive accurate explanations, the kit is easy to use and carry, and explanations given are sufficient. Nonetheless, the results lead us to believe that contextual elements influence exposure to numerous risk factors and that malaria among gold miners working illegally in French Guiana is a question of social inequalities in health. Thus, malaria intervention practices such as Malakit cannot be carried out without considering the complexity generated by social inequalities in health.
Published: 2022

3. Implementation of a novel malaria management strategy based on self-testing and self-treatment in remote areas in the Amazon (Malakit): confronting a-priori assumptions with reality

Author: José Hermenegildo Gomes, Antoine Adenis, Martha Cecilia Suárez-Mutis, Alice Sanna, Muriel Galindo, Jane Bordalo Miller, Stephen Vreden, Laure Garancher, Mathieu Nacher, Hedley Cairo, Yann Lambert, Cassio Peterka, Louise Mutricy, Helene Hiwat, Maylis Douine, Malbec, Odile, Centre d'Investigation Clinique Antilles Guyane [Cayenne, Guyane française], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], The Ink Link Association [Paris], DPAC-Fronteira [Oiapoque, Brazil], Ministry of Health [Brasília, Brazil], Ministry of Health [Paramaribo, Suriname], Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] (TBIP), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Instituto Oswaldo Cruz / Oswaldo Cruz Institute [Rio de Janeiro] (IOC), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Foundation for the Advancement of Scientific Research in Suriname [Paramaribo] (SWOS), and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)
Subjects: Motivation, Self-treatment, Computer science, Amazon rainforest, [SDV]Life Sciences [q-bio], Implementation outcomes, Public Health, Environmental and Occupational Health, Miners, medicine.disease, Process evaluation, Mining population, Malaria, [SDV] Life Sciences [q-bio], Border malaria, Management strategy, Self-Testing, Risk analysis (engineering), Remote health, medicine, A priori and a posteriori, Humans, Gold
Abstract: Background A novel strategy to combat malaria was tested using a methodology adapted to a complex setting in the Amazon region and a hard-to-reach, mobile community. The intervention strategy tested was the distribution, after training, of malaria self-management kits to gold miners who cross the Surinamese and Brazilian borders with French Guiana to work illegally in the remote mining sites in the forest of this French overseas entity. Main text This article aims at presenting all process and implementation outcomes following the Conceptual Framework of Implementation Fidelity i.e. adherence, including content and exposure, and moderators, comprising participant responsiveness, quality of delivery, facilitation strategies, and context. The information sources are the post-intervention survey, data collected longitudinally during the intervention, a qualitative study, data collected during an outreach mission to a remote gold mining site, supervisory visit reports, in-depth feedback from the project implementers, and videos self-recorded by facilitators based on opened ended questions. As expected, being part of or close to the study community was an essential condition to enable deliverers, referred to as “facilitators”, to overcome the usual wariness of this gold mining population. Overall, the content of the intervention was in line with what was planned. With an estimated one third of the population reached, exposure was satisfactory considering the challenging context, but improvable by increasing ad hoc off-site distribution according to needs. Participant responsiveness was the main strength of the intervention, but could be enhanced by reducing the duration of the process to get a kit, which could be disincentive in some places. Regarding the quality of delivery, the main issue was the excess of information provided to participants rather than a lack of information, but this was corrected over time. The expected decrease in malaria incidence became a source of reduced interest in the kit. Expanding the scope of facilitators’ responsibilities could be a suitable response. Better articulation with existing malaria management services is recommended to ensure sustainability. Conclusions These findings supplement the evaluation outcomes for assessing the relevance of the strategy and provide useful information to perpetuate and transfer it in comparable contexts. Trial registration ClinicalTrials.gov. NCT03695770. 10/02/2018 “Retrospectively registered”.
Published: 2022

4. Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana

Author: Maylis Douine, Timothée Bonifay, Yann Lambert, Louise Mutricy, Muriel Suzanne Galindo, Audrey Godin, Pascale Bourhy, Mathieu Picardeau, Mona Saout, Magalie Demar, Alice Sanna, Emilie Mosnier, Romain Blaizot, Pierre Couppié, Mathieu Nacher, Antoine Adenis, Martha Suarez-Mutis, Stephen Vreden, Loïc Epelboin, and Roxane Schaub
Subjects: Adult, Leptospirose, EStudo corte transversal, Population working on illegal mining, Mining, Mineração de ouro, Gold mining, Seroepidemiologic Studies, Zoonoses, Yellow Fever, Leishmaniose, Animals, Humans, Leptospirosis, Leishmaniasis, Cross-sectional study, Q fever, Ecosystem, Imunização da febre amarela, Vaccination, Public Health, Environmental and Occupational Health, Yellow fever immunization, Q febre, População que trabalha na mineração ilegal, French Guiana, Guiana Francesa, Infectious Diseases, Cross-Sectional Studies, Gold, Q Fever
Abstract: Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana / TBIP, Université de la Guyane, Cayenne, French Guiana / Centre de Ressources Biologiques Amazonie, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. National Reference Center for Leptospirosis, Biology of Spirochetes unit, Institut Pasteur, Paris, France. National Reference Center for Leptospirosis, Biology of Spirochetes unit, Institut Pasteur, Paris, France. TBIP, Universite´ de la Guyane, Cayenne, French Guiana. TBIP, Universite´ de la Guyane, Cayenne, French Guiana / University Laboratory of Mycology-Parasitology, Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana. Delocalized Health Centers, Centre Hospitalier de Cayenne, Cayenne, French Guiana. TBIP, Universite´ de la Guyane, Cayenne, French Guiana / Department of Dermatology, Centre Hospitalier de Cayenne, Cayenne, French Guiana. TBIP, Université de la Guyane, Cayenne, French Guiana / Department of Dermatology, Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana / TBIP, Université de la Guyane, Cayenne, French Guiana / Centre de Ressources Biologiques Amazonie, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana / TBIP, Université de la Guyane, Cayenne, French Guiana / Centre de Ressources Biologiques Amazonie, Cayenne, French Guiana. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. Foundation for Scientific Research Suriname, Paramaribo, Suriname. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana / TBIP, Université de la Guyane, Cayenne, French Guiana / Infectious and Tropical Diseases Unit, Centre Hospitalier de Cayenne, Cayenne, French Guiana. Centre d’Investigation Clinique Antilles-Guyane (Inserm 1424), Centre Hospitalier de Cayenne, Cayenne, French Guiana / TBIP, Université de la Guyane, Cayenne, French Guiana. Background Most emerging pathogens are zoonoses and have a wildlife origin. Anthropization and disruption of ecosystems favor the crossing of inter-species barriers. We hypothesize that the marginalized population of undocumented goldminers in the Amazon is at risk of acquiring zoonoses. Method A multicentric cross-sectional study included consenting gold-mining adult workers in 2019. A clinical examination recorded dermatological signs of leishmaniosis and past history of yellow fever vaccination. Biological tests were performed for yellow fever, Q fever and leptospirosis serologies. Additional blood samples from a previous study in 2015 were also tested Results In 2019, 380 individuals were included in the study, along with 407 samples from the 2015 biological collection. The seroprevalence of leptospirosis was 31.0% [95%CI = 26.4–35.5] in 2015 and 28.1% [23.5–32.7] in 2019. The seroprevalence of Q fever was 2.9% [1.2–4.6]. The majority of participants reported being vaccinated against yellow fever (93.6%) and 97.9% had seroneutralizing antibodies. The prevalence of suspected active mucocutaneous leishmaniasis was 2.4% [0.8–3.9]. for leptospirosis.
Published: 2022

5. Impact of Malakit intervention on perceptions, knowledge, attitudes, and practices related to malaria among workers in clandestine gold mines in French Guiana: results of multicentric cross-sectional surveys over time

Author: Cécile Longchamps, Muriel Suzanne Galindo, Yann Lambert, Alice Sanna, Louise Mutricy, Laure Garancher, Antoine Adenis, Mathieu Nacher, Martha Suarez-Mutis, Hedley Cairo, Helen Hiwat, Stephen Vreden, and Maylis Douine
Subjects: Health Knowledge, Attitudes, Practice, Infectious Diseases, Cross-Sectional Studies, parasitic diseases, Humans, Parasitology, Gold, French Guiana, Malaria
Abstract: Background Clandestine gold miners remain key hosts for malaria in French Guiana (FG) and contribute to imported malaria cases in Suriname and Brazil. The Malakit intervention, implemented in FG borders with Suriname and Brazil, provided gold miners with training on malaria and kits for self-diagnosis and self-treatment. Having shown a likely impact on malaria transmission, Suriname has now implemented it in routine care for cross-border moving populations. However, a decrease in malaria transmission is frequently associated with a decrease in risk perception, knowledge, and good practices regarding malaria. This study aims to describe the evolution of the perceptions, knowledge, attitudes, and practices (KAP) related to malaria among clandestine gold miners between 2015 and 2019, and to estimate the impact of Malakit on the FG/Suriname border. Methods The primary outcome was the overall KAP score over time and among participants and not participants in the Malakit intervention. A propensity score matching analysis and an inverse probability of treatment weighing analysis were used to estimate the Average Treatment effect on the Treated and the Average Treatment Effect of Malakit, respectively. Results Perception and knowledge scores were significantly lower in 2019 compared to 2015 (− 0.27 and − 0.23 points, respectively, p Conclusion A decrease in perception and knowledge about malaria but an improvement of attitudes and practices as the incidence of malaria decreased are observed. The Malakit intervention seems to have a significant positive impact on the overall KAP related to malaria. The integration of this strategy into malaria control programmes could help to improve the KAP, even in areas where malaria is nearly eliminated, through optimal training and health empowerment. Trial registration ClinicalTrials.gov registration number: NCT03695770.
Published: 2022

6. COVID-19 epidemic in remote areas of the French Amazon, March 2020 to May 2021: Another reality

Author: Loïc Epelboin, Tiphanie Succo, Céline Michaud, Margot Oberlis, Bastien Bidaud, Pauline Naudion, Lise Dudognon, Clara Fernandes, Charlène Cochet, Cécile Caspar, Estelle Jacoud, Sébastien Teissier, Maylis Douine, Dominique Rousset, Claude Flamand, Félix Djossou, Mathieu Nacher, Cyril Rousseau, Nicolas Vignier, Mélanie Gaillet, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Santé publique France Guyane, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Croix rouge française, Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and FEDER European funding for the « AMAZCOV’N FEVER» project: FEADER /2020/AAP-FLASH COVID-19 /N°18 - GY0028034.
Subjects: Microbiology (medical), Adolescent, COVID-19 vaccines, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, parasitic diseases, MESH: French Guiana, Humans, MESH: COVID-19, Epidemics, MESH: Epidemics, MESH: Adolescent, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, MESH: Humans, SARS-CoV-2, COVID-19, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, French Guiana, Europe, Infectious Diseases, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Health promotion, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Parasitology, MESH: Europe, MESH: Brazil, Brazil
Abstract: International audience; Background:French Guiana (FG) is an ultra-peripheral European region in the Amazon, and the COVID-19 epidemic has had very different kinetics from both its giant neighbors, Brazil or mainland France.Methods:This study summarized the epidemics of COVID-19 in FG.Results:The tropical climate, multiethnicity, and remoteness of the population forced healthcare providers to accordingly adapt the management of the epidemic. Incidence and mortality have been lower than that in Europe and Latin America due to a combination of prevalence of the youth in the population and highly developed healthcare system.Conclusions:Currently, vaccine hesitancy hinders the rapid expansion of vaccine coverage.
Published: 2022

7. Kelch13 mutations in Plasmodium falciparum and risk of spreading in Amazon basin countries

Author: Paola Marchesini, Maria-Paz Ade, Maylis Douine, Marcus V. G. Lacerda, Angel Manuel Alvarez, Luana Mathieu, Magda Magris, Yassamine Lazrek, Magalie Demar, Gisely Cardoso de Melo, Lise Musset, Prabhjot Singh, Wuelton Marcelo Monteiro, Horace Cox, Jean S F Alexandre, Laboratoire de Parasitologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Ecole Doctorale 587 : Diversités, santé et développement en Amazonie (ED 587), Université de Guyane (UG), Réseau International des Instituts Pasteur (RIIP), Pan American Health Organization [Washington] (PAHO), Fundação de Medicina Tropical Doutor Heitor Vieira Dourado (FMT-HVD), Universidade do Estado do Amazonas (UEA), Servicio Autónomo Centro Amazónico de Investigación y Control de Enfermedades Tropicales 'Simón Bolívar' (SACAICET), Ministry of Public Health [Georgetown, Guyana], Ministry of Health [Brasília, Brazil], Pan American Health Organization [Georgetown, Guyana] (PAHO), Pan American Health Organization - Organización Panamericana de la Salud [Caracas, Venezuela] (PAHO - OPS), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Instituto Leônidas e Maria Deane - Fiocruz Amazônia [Manaus, Brésil] (ILMD), Fundação Oswaldo Cruz (FIOCRUZ), This work was supported by Global Malaria Program (World Health Organization), Communicable Diseases and Environmental Determinants of Health Department (Pan American Health Organization), Guyamazon 3 Program, French Ministry for Research, European Commission Grant (Regional Fund for Development, Synergie GY0012082), Santé Publique France as National Reference Centre for Malaria and Investissement d’Avenir grant managed by Agence Nationale de la Recherche [CEBA (ref. ANR-10-LABX-25–01)]. L.C.M. received funding support from the Centre National d’Etudes Spatiales (CNES). The Manaus team was funded by Fundação de Amparo à Pesquisa do Estado do Amazonas-FAPEAM (PAPAC 005/2019, Posgrad and Pró-Estado). W.M.M. and M.V.G.L. are research fellows from CNPq., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Musset, Lise, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), and Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ)
Subjects: Veterinary medicine, Drug Resistance, Protozoan Proteins, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genotype, Pharmacology (medical), Malaria, Falciparum, Original Research, Sanger sequencing, 0303 health sciences, education.field_of_study, Human migration, 3. Good health, AcademicSubjects/MED00290, Infectious Diseases, symbols, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Brazil, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Amazon basin, Microbiology (medical), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Plasmodium falciparum, 030231 tropical medicine, Population, Biology, Kelch Repeat, Antimalarials, 03 medical and health sciences, symbols.namesake, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], parasitic diseases, Humans, AcademicSubjects/MED00740, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, education, 030304 developmental biology, Pharmacology, business.industry, Artemisinin resistance, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, biology.organism_classification, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Mutation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, AcademicSubjects/MED00230, business
Abstract: Background The first potential focus for artemisinin resistance in South America was recently confirmed with the presence of the C580Y mutation in the Plasmodium falciparum kelch 13 gene (pfk13) in Guyana. Objectives This study aimed to strengthen pfk13 monitoring in the Amazon basin countries, to compile the available data and to evaluate the risk of spreading of mutations. Methods Sanger sequencing was done on 862 samples collected between 1998 and 2019, and a global map of pfk13 genotypes available for this region was constructed. Then, the risk of spreading of mutations based on P. falciparum case importation between 2015 and 2018 within countries of the Amazon basin was evaluated. Results No additional pfk13 C580Y foci were identified. Few mutations (0.5%, 95% CI = 0.3%–0.8%) in the propeller domain were observed in the general parasite population of this region despite a high proportion of K189T mutations (49.1%, 95% CI = 46.2%–52.0%) in the non-propeller domain. Case information revealed two patterns of intense human migration: Venezuela, Guyana and the Roraima State in Brazil; and French Guiana, Suriname and the Amapá State in Brazil. Conclusions There are few pfk13 mutant foci, but a high risk of dispersion in the Amazon basin, mainly from the Guiana Shield, proportionate to mining activities. Therefore, access to prompt diagnosis and treatment, and continuous molecular monitoring is essential in these geographical areas.
Published: 2021

8. When local phytotherapies meet biomedicine. Cross-sectional study of knowledge and intercultural practices against malaria in Eastern French Guiana

Author: Mélanie Gaillet, Marc-Alexandre Tareau, Loïc Epelboin, Claire Cropet, Paul Brousse, Céline Michaud, F. Djossou, Maylis Douine, Emilie Mosnier, P. Travers, Lise Musset, B. Philogene, Damien Davy, Yassamine Lazrek, Guillaume Odonne, Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Parasitologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], DAAC - NGO [Saint Georges de l’Oyapock], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] (TBIP), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Guyane (UG), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was funded by: European Funds for Regional Development (Synergie: n°GY0012082), the Regional Agency for Health of French Guiana, Cayenne Hospital, the French Ministry for Research and Santé Publique France through the Institut Pasteur de la Guyane. It was also supported by 'Investissement d’Avenir' grants managed by the Agence Nationale de la Recherche (Labex DRIIHM/IRDHEI: ANR-11-LABX-0010 and Labex CEBA: ANR-10-LABX-25-01)., ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Service des maladies infectieuses, Hopital Andree Rosemond, Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Réseau International des Instituts Pasteur (RIIP), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG), Musset, Lise, Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux - - DRIIHM / IRDHEI2011 - ANR-11-LABX-0010 - LABX - VALID, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens [LEEISA], Centre National de Référence du Paludisme [Cayenne, Guyane française] [CNR - laboratoire associé], Centre d'Investigation Clinique Antilles-Guyane [CIC - Antilles Guyane], Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale [SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD], Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), and Observatoire Hommes Milieux (OHM) Oyapock-Labex DRIIHM ANR-11-LABX-0010
Subjects: Male, Health Knowledge, Attitudes, Practice, Cross-sectional study, Ethnic group, Medical pluralism, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SHS]Humanities and Social Sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Drug Discovery, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, education.field_of_study, Rapid diagnostic test, Amazon rainforest, 3. Good health, French Guiana, Geography, 030220 oncology & carcinogenesis, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], Female, Knowledge attitudes and practices, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Adult, medicine.medical_specialty, Fever, Integrated community survey, Population, 03 medical and health sciences, Antimalarials, Young Adult, Medicinal plants, Amazonia, Environmental health, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], parasitic diseases, medicine, Humans, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, education, Traditional phytotherapies, Biomedicine, 030304 developmental biology, Pharmacology, Plants, Medicinal, business.industry, Public health, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SHS.ANTHRO-SE]Humanities and Social Sciences/Social Anthropology and ethnology, medicine.disease, Malaria, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, OHM Oyapock, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, medicinal plants, traditional phytotherapies, integrated community survey, medical pluralism, knowledge attitudes and practices, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Medicine, Traditional, business, Phytotherapy
Abstract: International audience; Ethnopharmacological relevance: In French Guiana, traditional phytotherapies are an important part of self-healthcare, however, a precise understanding of the interactions between local phytotherapies and biomedicine is lacking. Malaria is still endemic in the transition area between French Guiana and Brazil, and practices of self-treatment, although difficult to detect, have possible consequences on the outcome of public health policies.Aim of the study: The objectives of this research were 1) to document occurences of co-medication (interactions between biomedicine and local phytotherapies) against malaria around Saint-Georges de l’Oyapock (SGO), 2) to quantify and to qualify plant uses against malaria, 3) and to discuss potential effects of such co-medications, in order to improve synergy between community efforts and public health programs in SGO particularly, and in Amazonia more broadly.Materials and methods: This cross-sectional study was conducted in 2017 in SGO. Inhabitants of any age and nationality were interviewed using a questionnaire (122 questions) about their knowledge and habits regarding malaria, and their use of plants to prevent and treat it. They were invited to show their potential responses on a poster illustrating the most common antimalarial plants used in the area. In order to correlate plant uses and malaria epidemiology, all participants subsequently received a medical examination, and malaria detection was performed by Rapid Diagnostic Test (RDT) and Polymerase Chain Reaction (PCR).Results: A total of 1566 inhabitants were included in the study. Forty-six percent of them declared that they had been infected by malaria at least once, and this rate increased with age. Every person who reported that they had had malaria also indicated that they had taken antimalarial drugs (at least for the last episode), and self-medication against malaria with pharmaceuticals was reported in 142 cases. A total of 550 plant users was recorded (35.1% of the interviewed population). Among them 95.5% associated pharmaceuticals to plants. All plants reported to treat malaria were shared by every cultural group around SGO, but three plants were primarily used by the Palikur: Cymbopogon citratus, Citrus aurantifolia and Siparuna guianensis. Two plants stand out among those used by Creoles: Eryngium foetidum and Quassia amara, although the latter is used by all groups and is by far the most cited plant by every cultural group. Cultivated species accounts for 91.3% of the use reports, while wild taxa account for only 18.4%.Conclusions: This study showed that residents of SGO in French Guiana are relying on both traditional phytotherapies and pharmaceutical drugs to treat malaria. This medical pluralism is to be understood as a form of pragmatism: people are collecting or cultivating plants for medicinal purposes, which is probably more congruent with their respective cultures and highlights the wish for a certain independence of the care process. A better consideration of these practices is thus necessary to improve public health response to malaria.
Published: 2021

9. Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

Author: Anne Lavergne, Marine Ginouves, Florian Binetruy, Claude Flamand, Mathieu Nacher, Emmanuel Roux, Roxane Schaub, Sébastien Gourbière, Benoit de Thoisy, Pierre Couppié, Arthur Kocher, Lise Musset, Philippe Quénel, Sourakhata Tirera, Luisiane Carvalho, Jérôme Murienne, Sébastien Briolant, Magalie Demar, Yanouk Epelboin, Ghislaine Prévot, Olivier Duron, Isabelle Dusfour, Benjamin Roche, Maylis Douine, Stéphane Pelleau, Luana Mathieu, Agathe Chavy, Loïc Epelboin, Alain Franc, Paul Le Turnier, Pauline Thill, Jean-François Guégan, Emeline Houël, Dominique Rousset, Stanislas Talaga, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Réseau International des Instituts Pasteur (RIIP), Centre de Recherche en Ecologie et Evolution de la Santé (CREES), Institut de Recherche pour le Développement (IRD)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Laboratoire de Parasitologie [Cayenne, Guyane française], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre de Recherches Ecologiques et Evolutives sur le Cancer (MIVEGEC-CREEC), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), Santé publique France Guyane, Santé publique France - French National Public Health Agency [Saint-Maurice, France], Université de Guyane (UG), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Département de Santé Globale - Department Global Health, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Laboratoire Génome et développement des plantes (LGDP), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française], Unité d'Epidémiologie [Cayenne, Guyane française], Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), from patterns to models in computational biodiversity and biotechnology (PLEIADE), Laboratoire Bordelais de Recherche en Informatique (LaBRI), Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-École Nationale Supérieure d'Électronique, Informatique et Radiocommunications de Bordeaux (ENSEIRB)-Centre National de la Recherche Scientifique (CNRS)-Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Biodiversité, Gènes & Communautés (BioGeCo), Université de Bordeaux (UB)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Biome Tropical et Immuno-Pathophysiologie = Tropical Biome and ImmunoPhysiopathology [Lille] (TBIP), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG), Ecologie des forêts de Guyane (UMR ECOFOG), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-AgroParisTech-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre hospitalier universitaire de Nantes (CHU Nantes), Malaria : parasites et hôtes - Malaria : parasites and hosts, Institut Pasteur [Paris] (IP), UMR 228 Espace-Dev, Espace pour le développement, Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), LMI Sentinela [Rio de Janeiro], Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Service Universitaire des Maladies Infectieuses et du Voyageur [Tourcoing], Centre Hospitalier Tourcoing, Centre Hospitalier Gustave Dron [Tourcoing], Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work has benefited from three 'Investissement d’Avenir' grants managed by Agence Nationale de la Recherche (CEBA: ANR-10-LABX-25-01, TULIP: ANR-10-LABX-0041, DRIIHM: ANR-11-LABX-0010). The two lead coauthors received European funding through the European Regional Development Fund Operational Program FEDER RESERVOIRS Project (BdT) and a US NSF-NIH (NSF#1911457) Ecology of infectious diseases award (J-FG). J-FG is also supported by IRD, INRAE, and Université of Montpellier. OD thanks l’Office français de la biodiversité, le Groupe d'Étude et de Protection des Oiseaux en Guyane (GEPOG), la Direction de l'Alimentation, de l'Agriculture et de la Forêt de Guyane (DAAF). AL acknowledges European funding through the European Regional Development Fund Operational Program FEDER RESERVOIRS, CAROLLIA, EFAG and VIRUSES projects. LM is supported by European funding through the European Regional Development Fund Operational Program FEDER ELIMALAR project and Santé publique France as the National Reference Center for Malaria. PQ thanks Publique France/Cire Guyane, CNR sur les arboviroses, CNR du paludisme. EH and ID acknowledge European funding through the European Regional Development Fund Operational Program FEDER CONTROLE Projet, the French Guiana Regional Council and the Air Liquide Foundation. SB is supported by the French Army (Grant LR607e). ER is grateful for European funding through the European Regional Development Fund Operational Program FEDER OSE-Guyamapa project, the French Embassy in Brazil, the Guyamazon program ('GAPAM-Sentinela' project), CNES, and the Bill and Melinda Gates Foundation., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), Génétique et évolution des maladies infectieuses (GEMI), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Génétique et évolution des maladies infectieuses (GEMI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz (FIOCRUZ), Dusfour, Isabelle, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, Towards a Unified theory of biotic Interactions: the roLe of environmental - - TULIP2010 - ANR-10-LABX-0041 - LABX - VALID, Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux - - DRIIHM / IRDHEI2011 - ANR-11-LABX-0010 - LABX - VALID, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur [Paris], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Guyane (UG), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)
Subjects: 0301 basic medicine, Microbiology (medical), Emerging and reemerging infectious diseases, Ecology (disciplines), media_common.quotation_subject, [SDV]Life Sciences [q-bio], [SDE.MCG]Environmental Sciences/Global Changes, 030106 microbiology, Immigration, Interdisciplinary Research, Wildlife, Vector Borne Diseases, Animals, Wild, Anthropogenic pressures, Biology, Microbiology, 03 medical and health sciences, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Zoonoses, Genetics, Prevalence, Animals, Humans, Human Activities, Molecular Biology, Epidemiologic transition, Global change, Ecology, Evolution, Behavior and Systematics, Ecosystem, media_common, Demography, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Resistance (ecology), Ecology, Incidence, Outbreak, 15. Life on land, French Guiana, [SDV] Life Sciences [q-bio], Epidemiological transition, [SDE.MCG] Environmental Sciences/Global Changes, 030104 developmental biology, Infectious Diseases, Promiscuity, Vector (epidemiology), [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Abstract: International audience; French Guiana is a European ultraperipheric region located on the northern Atlantic coast of South America. It constitutes an important forested region for biological conservation in the Neotropics. Although very sparsely populated, with its inhabitants mainly concentrated on the Atlantic coastal strip and along the two main rivers, it is marked by the presence and development of old and new epidemic disease outbreaks, both research and health priorities. In this review paper, we synthetize 15 years of multidisciplinary and integrative research at the interface between wildlife, ecosystem modification, human activities and sociodemographic development, and human health. This study reveals a complex epidemiological landscape marked by important transitional changes, facilitated by increased interconnections between wildlife, land-use change and human occupation and activity, human and trade transportation, demography with substantial immigration, and identified vector and parasite pharmacological resistance. Among other French Guianese characteristics, we demonstrate herein the existence of more complex multi-host disease life cycles than previously described for several disease systems in Central and South America, which clearly indicates that today the greater promiscuity between wildlife and humans due to demographic and economic pressures may offer novel settings for microbes and their hosts to circulate and spread. French Guiana is a microcosm that crystallizes all the current global environmental, demographic and socioeconomic change conditions, which may favor the development of ancient and future infectious diseases.
Published: 2021

10. Sexual and addictive risk behaviors and sexually transmitted infections in illegal gold miners in French Guiana: A multicenter observational study

Author: Louise Mutricy-Hureau, Amandine Pisoni, Martha Suarez-Mutis, Amanda Figueira da Silva, Yann Lambert, Pauline Mespoulhe, Audrey Godin, Marie-Claire Parriault, Astrid Van Melle, Emilie Mosnier, Mélanie Gaillet, Céline Michaud, Roxane Schaub, Muriel Galindo, Antoine Adenis, Mathieu Nacher, Stephen Vreden, Edouard Tuaillon, Maylis Douine, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Pathogénèse et contrôle des infections chroniques (PCCI), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service des maladies infectieuses et tropicales [Cayenne, Guyane Française], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Centres Délocalisés de Prévention et de Soins (CDPS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), and Foundation for the Advancement of Scientific Research in Suriname [Paramaribo] (SWOS)
Subjects: Male, Mineiros de ouro ilegais, [SDV]Life Sciences [q-bio], Sexually Transmitted Diseases, HIV Infections, Infecção sexualmente transmissível, Risk-Taking, MESH: Cross-Sectional Studies, Sexual and addictive risk behaviors, Cocaine, MESH: Cocaine, MESH: French Guiana, Illegal gold miners, Multicenter observational study, Humans, Syphilis, Sexually transmitted infection, MESH: Humans, Multidisciplinary, MESH: HIV Infections, MESH: Male, French Guiana, Guiana Francesa, Estudo observacional multicêntrico, Cross-Sectional Studies, MESH: Risk-Taking, MESH: Syphilis, MESH: Gold, Female, Gold, MESH: Female, MESH: Sexually Transmitted Diseases, Comportamentos sexuais e de risco de dependência
Abstract: Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. UMR 1058 INSERM/EFS/University of Montpellier, Pathogenesis and Control of Chronic Infection, Montpellier University Hospital, Department of Bacteriology-Virology, Montpellier, France. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. CRB Amazonie (Biological Resource Center), Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. Department of Infectious and Tropical Diseases, Cayenne Hospital, Cayenne, French Guiana, France / Aix-Marseille University, INSERM, IRD, SESSTIM—Economic and Social Sciences, Health Systems, and Medical Informatics, F-13005, Marseille, France. Centres Délocalisés de Prévention et de Soins (CDPS), Cayenne Hospital, Cayenne, French Guiana, France. Centres Délocalisés de Prévention et de Soins (CDPS), Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France / TBIP, University of French Guiana, University of Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019-UMR9017-CIIL Center for Infection and Immunity of Lille, Lille, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France / TBIP, University of French Guiana, University of Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019-UMR9017-CIIL Center for Infection and Immunity of Lille, Lille, France. Foundation for the Advancement of Scientific Research in Suriname (SWOS), Paramaribo, Suriname. UMR 1058 INSERM/EFS/University of Montpellier, Pathogenesis and Control of Chronic Infection, Montpellier University Hospital, Department of Bacteriology-Virology, Montpellier, France. Center for Clinical Investigation Antilles-Guyane, Inserm 1424, Cayenne Hospital, Cayenne, French Guiana, France / TBIP, University of French Guiana, University of Lille, CNRS, Inserm, Institut Pasteur de Lille, U1019-UMR9017-CIIL Center for Infection and Immunity of Lille, Lille, France. Objectives Common representations of the world of gold mining–especially illegal–are usually negative: the activity conjures up images of drug trafficking, human exploitation, the sex trade, environmental destruction, and infectious diseases, in particular sexually transmitted infections (STIs). The aim of the present article is to describe the levels of risk behaviors such as transactional sex, multiple sexual partners, and the frequency of condom use, addictive substance consumption, and the prevalence of STIs among the population of illegal gold miners in French Guiana (FG), a French overseas entity in Amazonia, in order to guide potential interventions. Methods An observational multicenter cross-sectional study was carried out from October to December 2019 along the two borders of FG with Suriname and Brazil at rest sites used by the miners. Results Among the 499 participants, transactional sex was very prevalent, declared by 33.5% of men and 8.4% of women. Condoms were more frequently used for transactional sex than with a non-commercial partner (93.4% versus 42.1%). More women were tested for HIV than men (91.1% versus 55.2%). Excessive alcohol consumption (57.3%%) and tobacco use (41.2%) were very frequent, but cocaine or crack consumption was low (1.2%), which refuted our initial assumption. Consumers of alcohol had more sexual partners and reported condom use more frequently. Prevalence of HIV, HCV, HBV, and syphilis was respectively 0.5% (95% CI: 0.1–2.1), 2.1% (95% CI: 0.7–3.6), 1.6% (95% CI: 0.3–2.8), and 12.4% (95% CI: 9.0–15.7), which was higher than in the local population, especially for syphilis. Conclusion This study documents for the first time the risk behaviors of gold miners in FG. Although the level of condom use was high, the prevalence of STIs combined with the high rate of transactional sex should encourage an increase in prevention and screening, in particular through rapid tests, given the mobility of the population concerned.
Published: 2022

11. The Epidemiology of COVID 19 in the Amazon and the Guianas: Similarities, Differences, and International Comparisons

Author: Mathieu Nacher, Cyril Rousseau, Tiphanie Succo, Audrey Andrieu, Mélanie Gaillet, Céline Michaud, Véronique Servas, Maylis Douine, Roxane Schaub, Antoine Adenis, Magalie Demar, Philippe Abboud, Loïc Epelboin, and Félix Djossou
Subjects: medicine.medical_specialty, Internationality, Amazonian, Context (language use), Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, parasitic diseases, Case fatality rate, Epidemiology, medicine, Humans, 030212 general & internal medicine, Epidemics, Amazon, Socioeconomic status, Original Research, 030304 developmental biology, 0303 health sciences, SARS-CoV-2, Amazon rainforest, lcsh:Public aspects of medicine, Mortality rate, International comparisons, Public Health, Environmental and Occupational Health, COVID-19, lcsh:RA1-1270, mortality, testing, French Guiana, Europe, Geography, North America, Guiana shield, epidemiology, Public Health, COVID 19, Brazil, vulnerable populations, Demography
Abstract: Background: The COVID 19 epidemic submerged many health systems in the Amazon. The objective of the present study was to focus on the epidemic curves of the COVID 19 epidemic in different centers, and to look at testing and mortality data.Methods: Publicly available datasets were used. The log10 of the daily cumulated number of cases starting from the day the territory reached 100 cumulated cases was plotted to compare the magnitude, shape and slope of the different curves. The maximum daily testing efforts were plotted for each territory in relation to the maximum daily number of diagnoses. The case fatality rate was computed by dividing the number of COVID 19 deaths by the number of confirmed cases.Results: In the Amazonian regions in general the speed of growth was generally lower than in Europe or the USA, or Southern Brazil. Whereas, countries like South Korea or New Zealand “broke” the curve relatively rapidly the log linear trajectory seemed much longer with signs of a decline in growth rate as of early July 2020. After a very slow start, French Guiana had the lowest slope when compared to other Amazonian territories with significant epidemics. The Amazonian states of Roraima, Amazonas, Parà, and Amapà had among the highest number of cases and deaths per million inhabitants in the world. French Guiana had significantly fewer deaths relative to its number of confirmed cases than other Amazonian territories. French Guiana had a late epidemic surge with intense testing scale-up often exceeding 4,000 persons tested daily per million inhabitants. Brazil was an outlier with low daily testing levels in relation to the number of daily diagnoses.Conclusions: There were marked heterogeneities mortality rates suggesting that socioeconomic, political factors, and perhaps ethnic vulnerability led to striking outcome differences in this Amazonian context.
Published: 2021

12. Setting-up a cross-border action-research project to control malaria in remote areas of the Amazon: describing the birth and milestones of a complex international project (Malakit)

Author: Muriel Galindo, Mathieu Nacher, Helene Hiwat, Jane Bordalo Miller, Yann Lambert, Martha Cecilia Suárez-Mutis, Hélène Hilderal, Stephen Vreden, Hedley Cairo, Laure Garancher, Cassio Peterka, José Hermenegildo Gomes, Louise Mutricy, Alice Sanna, and Maylis Douine
Subjects: Adult, Male, medicine.medical_specialty, Malaria control, International Cooperation, 030231 tropical medicine, Population, Control (management), RC955-962, Context (language use), Infectious and parasitic diseases, RC109-216, Mining population, Mobile migrants, 03 medical and health sciences, Border malaria, 0302 clinical medicine, Complex intervention, Arctic medicine. Tropical medicine, Health care, medicine, Malaria, Vivax, Humans, 030212 general & internal medicine, Action research, Malaria, Falciparum, education, education.field_of_study, Suriname, business.industry, Public health, Methodology, Neglected population, Public relations, Middle Aged, medicine.disease, French Guiana, Intervention (law), Infectious Diseases, Action-research, Communicable Disease Control, Implementation science, Parasitology, Female, Business, Health Services Research, Malaria, Brazil
Abstract: Background In French Guiana, gold miners working illegally represents a major reservoir of malaria. This mobile population, mainly of Brazilian descent, enters the French Guianese forest from neighbouring countries, Suriname and Brazil. A complex and innovative intervention was piloted as a cooperation with the three involved countries involved to control malaria in this specific population. The principle was that health workers called “facilitators” provide the participants with a self-diagnosis and self-treatment kit along with adequate training and material to rapidly manage an episode of malaria symptoms on their own, when they find themselves isolated from health care services. Methods This paper describes the design, development, content of the intervention and players’ organization of this multi-country project, the opportunities and constraints encountered, and the lessons learnt at this stage. Results The choice not to implement the usual “Test and Treat” approach within the community is mainly driven by regulatory reasons. The content of medical messages tends to balance the tension between thoroughness, accuracy and efficacy. The wide range of tools developed through a participatory approach was intended to cope with the challenges of the literacy level of the target population. Despite the difficulties encountered due to language, regulation differences and distance between partners, cooperation was fruitful, due to the complementary of stakeholders, their involvement at all important stages and regular face-to-face meetings. Discussion and conclusion This experience shows the feasibility of an ambitious project of action-research in a border malaria context, involving several countries and with a mobile and undocumented population. It reveals some factors of success which may be transferable in analogous settings.
Published: 2020

13. Simultaneous dengue and COVID-19 epidemics: Difficult days ahead?

Author: Stanley Carroll, Audrey Valdes, Maylis Douine, Mélanie Gaillet, Mathieu Nacher, Dominique Rousset, Cyril Rousseau, Nathalie Passard, Chedli Mahdaoui, Félix Djossou, Magalie Demar, Claude Flamand, Loïc Epelboin, Gabriel Carles, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Guyane (UG), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité d'Epidémiologie [Cayenne, Guyane française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de Référence pour les Arbovirus - Laboratoire de Virologie [Cayenne, Guyane française] (CNR - laboratoire associé), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Réseau de médecins sentinelles, Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], The authors received no specific funding for this work., Flamand, Claude, and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)
Subjects: RNA viruses, Viral Diseases, MESH: Coronavirus Infections, Epidemiology, [SDV]Life Sciences [q-bio], RC955-962, [MATH] Mathematics [math], MESH: Dengue, MESH: Hospitalization, Pathology and Laboratory Medicine, Social Distancing, Geographical locations, Dengue fever, Dengue Fever, Dengue, 0302 clinical medicine, Medical Conditions, Arctic medicine. Tropical medicine, Medicine and Health Sciences, 030212 general & internal medicine, [MATH]Mathematics [math], ComputingMilieux_MISCELLANEOUS, Coinfection, [SDV] Life Sciences [q-bio], [STAT]Statistics [stat], Viewpoints, Hospitalization, Infectious Diseases, Medical Microbiology, Viral Pathogens, Viruses, MESH: Betacoronavirus, Public aspects of medicine, RA1-1270, Pathogens, Coronavirus Infections, Brazil, Neglected Tropical Diseases, 2019-20 coronavirus outbreak, MESH: Pandemics, Coronavirus disease 2019 (COVID-19), Infectious Disease Control, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), 030231 tropical medicine, Physical Distancing, Pneumonia, Viral, Microbiology, Diagnosis, Differential, 03 medical and health sciences, Betacoronavirus, MESH: Diagnosis, Differential, Diagnostic Medicine, medicine, Humans, Microbial Pathogens, Pandemics, MESH: Humans, Biology and life sciences, Flaviviruses, business.industry, SARS-CoV-2, Public Health, Environmental and Occupational Health, Organisms, COVID-19, Covid 19, Dengue Virus, South America, medicine.disease, Tropical Diseases, [STAT] Statistics [stat], MESH: Coinfection, MESH: Pneumonia, Viral, Co-Infections, Medical Risk Factors, MESH: Social Distance, People and places, business, Co infection
Abstract: International audience
Published: 2020

14. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil

Author: Emmanuel Roux, Yanouk Epelboin, Isabelle Dusfour, Guillaume Lacour, Félix Djossou, Mathieu Nacher, Maylis Douine, Lise Musset, Magalie Demar, Amandine Guidez, Damien Davy, Vanessa Ardillon, Margarete do Socorro Mendonça Gomes, Johana Restrepo, Alice Sanna, Emilie Mosnier, Raphael de Freitas Saldanha, Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Altopictus [Biarritz], Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro] (ICICT), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Superintendência de Vigilância em Saúde do Amapá (SVS-AP), Health Regional Agency [Cayenne], Collectivité Territoriale de Guyane (CTG), Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Laboratoire Hospitalo-Universitaire de Parasitologie et Mycologie [Cayenne, Guyane Française], Université de Guyane (UG), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Cellule interrégionale d'épidémiologie Antilles-Guyane [CIRE], Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), LMI Sentinela [Rio de Janeiro], Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz (FIOCRUZ), Vectopôle Amazonien Emile Abonnenc [Cayenne, Guyane française], Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Laboratoire de Parasitologie [Cayenne, Guyane française], Centre Collaborateur OMS pour la surveillance de la résistance aux antipaludiques [Cayenne, Guyane française] (CCOMS), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), Institut de Recherche pour le Développement (IRD)-Universidade de Brasilia [Brasília] (UnB)-Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), Universidade de Brasilia [Brasília] (UnB), Agence Régionale de la Santé [Cayenne, Guyane française] (ARS), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe]-CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Guyane (UG)-Université des Antilles (UA)-Université de Montpellier (UM), OHM Oyapock, ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), Roux, Emmanuel, and Aix Marseille Université (AMU)
Subjects: Male, [SDV]Life Sciences [q-bio], [SHS.GEO] Humanities and Social Sciences/Geography, Plasmodium vivax, Attack rate, Distribution (economics), [SHS]Humanities and Social Sciences, Disease Outbreaks, 0302 clinical medicine, [STAT.AP] Statistics [stat]/Applications [stat.AP], Residence Characteristics, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Anopheles darlingi, 030212 general & internal medicine, Socioeconomics, [STAT.AP]Statistics [stat]/Applications [stat.AP], biology, Amazon rainforest, Incidence, Transnational, [SHS.GEO]Humanities and Social Sciences/Geography, 3. Good health, French Guiana, Indigenous south Americans, Infectious Diseases, Geography, Female, Seasons, Brazil, Research Article, medicine.medical_specialty, Adolescent, 030231 tropical medicine, Outbreak investigation, Mosquito Vectors, Indigenous, lcsh:Infectious and parasitic diseases, Young Adult, 03 medical and health sciences, Spatio-Temporal Analysis, Amazonia, Anopheles, parasitic diseases, Malaria, Vivax, medicine, Animals, Humans, lcsh:RC109-216, business.industry, Outbreak, biology.organism_classification, medicine.disease, Malaria, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Tropical medicine, OHM Oyapock, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: BackgroundIn 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due toPlasmodium vivax(Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017.MethodsTwo investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were estimated using French and Brazilian surveillance systems.ResultsOn the French Guianese side of the border in Saint-Georges de l’Oyapock, the attack rate was 5.5% (n = 4000), reaching 51.4% (n = 175) in one Indigenous neighborhood. Entomological findings suggest a peak ofAnopheles darlingidensity in August and September. Two femaleAn. darlingi(n = 1104, 0.18%) were found to bePv-positive during this peak. During the same period, aggregated data from passive surveillance conducted by Brazilian and French Guianese border health centers identified 1566 cases ofPvinfection. Temporal distribution during the 2007–2018 period displayed seasonal patterns with a peak in November 2017. Four clusters were identified among epidemic profiles of cross-border area localities. All localities of the first two clusters were Brazilian. The localization of the first cluster suggests an onset of the outbreak in an Indigenous reservation, subsequently expanding to French Indigenous neighborhoods and non-Native communities.ConclusionsThe current findings demonstrate a potential increase in malaria cases in an area with otherwise declining numbers. This is a transborder region where human mobility and remote populations challenge malaria control programs. This investigation illustrates the importance of international border surveillance and collaboration for malaria control, particularly in Indigenous villages and mobile populations.
Published: 2020

15. Prevalence of Plasmodium spp. in the Amazonian border context (French Guiana-Brazil) : associated factors and spatial distribution

Author: Lise Musset, Emilie Mosnier, Emmanuel Roux, Olivier Moriceau, Maylis Douine, Stéphane Pelleau, Mélanie Gaillet, Luana Mathieu, Magalie Demar, Céline Michaud, Claire Cropet, Mathieu Nacher, Félix Djossou, Yassamine Lazrek, Guillaume Odonne, Pôle des Centres Délocalisés de Prévention et de Soins [CH Andrée Rosemon, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), UMR 228 Espace-Dev, Espace pour le développement, Université de Guyane (UG)-Université des Antilles (UA)-Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM), Institute of Scientific and Technological Communication and Information in Health / Instituto de Comunicação e Informação Científica e Tecnológica em Saúde [Rio de Janeiro] (ICICT), Fundação Oswaldo Cruz (FIOCRUZ), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Institut Pasteur de la Guyane, Laboratoire Hospitalier et Universitaire Parasitologie Mycologie, Laboratoire Ecologie, Evolution, Interactions des Systèmes amazoniens (LEEISA), Centre National de la Recherche Scientifique (CNRS)-Université de Guyane (UG)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), This study was funded by European Funds for Regional Development, N° Synergie: GY0012082, the Regional Agency for Health of French Guiana, Cayenne Hospital, the French Ministry for Research and Sante Publique France through the Institut Pasteur de la Guyane., We are grateful to the study participants in STG, French Guiana, the NGO, DAAC, provided culturally adapted mediators, offering crucial support throughout this study, and Franck De Laval, Gaelle Walter, Bastien Bidaud, Loıc Epelboin, Alessia Melzani, and Mylene Cebe also contributed to data collection., Roux, Emmanuel, Institut de Recherche pour le Développement (IRD)-Université de Perpignan Via Domitia (UPVD)-Avignon Université (AU)-Université de La Réunion (UR)-Université de Montpellier (UM)-Université de Guyane (UG)-Université des Antilles (UA), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Guyane (UG)-Centre National de la Recherche Scientifique (CNRS), Fundação Oswaldo Cruz / Oswaldo Cruz Foundation (FIOCRUZ), and Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé)
Subjects: Adult, Male, Multivariate analysis, Adolescent, 030231 tropical medicine, Plasmodium vivax, Plasmodium falciparum, Context (language use), Plasmodium, 03 medical and health sciences, Young Adult, 0302 clinical medicine, [STAT.AP] Statistics [stat]/Applications [stat.AP], [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Virology, parasitic diseases, medicine, Malaria, Vivax, Humans, Malaria, Falciparum, Child, Rapid diagnostic test, [STAT.AP]Statistics [stat]/Applications [stat.AP], biology, Infant, Articles, medicine.disease, biology.organism_classification, 3. Good health, French Guiana, Infectious Diseases, Carriage, Geography, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Child, Preschool, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Parasitology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, Malaria, Brazil, Demography
Abstract: International audience; To implement future malaria elimination strategies in French Guiana, a characterization of the infectious reservoir is recommended. A cross-sectional survey was conducted between October and December 2017 in the French Guianese municipality of St Georges de l'Oyapock, located along the Brazilian border. The prevalence of Plasmodium spp. was determined using a rapid diagnostic test (RDT) and a polymerase chain reaction (PCR). Demographic, house locations, medical history, and biological data were analyzed. Factors associated with Plasmodium spp. carriage were analyzed using logistic regression, and the carriage localization was investigated through spatial cluster analysis. Of the 1,501 samples analyzed with PCR, positive results totaled 90 and 10 for Plasmodium vivax and Plasmodium falciparum, respectively. The general PCR prevalence was 6.6% [5.3-7.9], among which 74% were asymptomatic. Only 13/1,549 were positive by RDT. In multivariate analysis, participants older than 15 years, living in a remote neighborhood, with a prior history of malaria, anemia, and thrombocytopenia were associated with an increased odds of Plasmodium spp. carriage. High-risk clusters of P. vivax carriage were detected in the most remote neighborhoods on the village outskirts and two small foci in the village center. We also detected a hot spot for both P. vivax and P. falciparum symptomatic carriers in the northwestern part of the village. The present study confirms a wide-scale presence of asymptomatic P. falciparum and P. vivax carriers in this area. Although they were more often located in remote areas, their geographic distribution was spatially heterogeneous and complex.
Published: 2020

16. Investigation of a possible malaria epidemic in an illegal gold mine in French Guiana: an original approach in the remote Amazonian forest

Author: Franck de Laval, Alice Sanna, Helene Hiwat, François Michel Le Tourneau, Didier Belleoud, Sébastien Briolant, Hervé Bogreau, Mathieu Nacher, Maylis Douine, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Health Regional Agency [Cayenne], National Malaria Programme [Suriname]], Ministry of Health [Paramaribo, Suriname], Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), French Armed Forces medical health service [Cayenne], Interdisciplinary and Global Environmental Studies (iGLOBES), University of Arizona-Centre National de la Recherche Scientifique (CNRS), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées (IRBA), French National Centre for Malaria [Marseille] (CNR Paludisme), Regional Health Agency of French Guiana, COMBE, Isabelle, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), Université de Guyane (UG), Interdisciplinary and Global Environmental Studes (iGLOBES), Centre d'épidémiologie et de santé publique des armées (CESPA), and Service de Santé des Armées
Subjects: Male, Pilot Projects, [SHS]Humanities and Social Sciences, 0302 clinical medicine, Communicable Diseases, Imported, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, Socioeconomics, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, education.field_of_study, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Amazon rainforest, Middle Aged, French Guiana, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Infectious Diseases, Geography, Population Surveillance, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, [SDV.MP.PAR] Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Adult, medicine.medical_specialty, Gold mining, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, Population, Context (language use), Miners, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Amazonia, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, parasitic diseases, medicine, Humans, lcsh:RC109-216, [SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/Parasitology, Epidemics, education, Investigation, business.industry, Research, Public health, Outbreak, medicine.disease, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Malaria, Guiana Shield, Tropical medicine, Parasitology, Gold, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background: In April 2017, Suriname's Ministry of Health alerted French Guiana's Regional Health Agency (RHA) about an increase of imported malaria cases among people coming from an illegal gold mining site called Sophie, in French Guiana, a French overseas territory located in the Amazonian forest. Methods: Due to safety issues and the remoteness of Sophie, the RHA requested the collaboration of the French Armed Forces for the epidemiological investigation. A medical unit, and six soldiers to ensure the security of the mission , were transported by helicopter. Results: During the investigation, two malaria episodes were diagnosed among 46 persons. Twenty-six of them were from Sophie, where PCR-Plasmodium prevalence was estimated at 60% (15/26). This result was concordant with previous studies revealing high malaria endemicity in the gold miner population. The increase of imported cases in Suriname may have resulted from decreased access to under-the-counter anti-malarials and increased migration of gold miners to Suriname following a decline of the profitability of gold mining in a context of increased repression against illegal mining by the French army. Conclusion: This investigation of a suspicious malaria epidemic confirms the importance of malaria among illegal gold miners. Their mobility along the Guiana Shield and their health-seeking behaviour are likely to spread malaria in populations for which significant efforts are undertaken to fight against this disease. Fighting malaria in this population remains more relevant than ever. A pilot study (Malakit project) is currently in progress to evaluate the efficacy of kits for self-diagnosis and self-treatment.
Published: 2019

17. The singular epidemiology of HPV infection among French Guianese women with normal cytology

Author: Vincent Lacoste, Jean Luc Deshayes, Fatiha Najioullah, Hatem Ben Amor, Paul Brousse, Maylis Douine, Vincent Molinie, Raymond Césaire, Odile Kilié, Nadia Thomas, Valentin Dufit, Gabriel Carles, Remy Pignoux, Dominique Catherine, Antoine Adenis, Claire Grenier, Mathieu Nacher, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Laboratoire de Virologie [Fort-de-France, Martinique], CHU de la Martinique [Fort de France], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Service de Gynecologie Obstétrique [Cayenne], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association de Dépistage Organisé des Cancers de Guyane (AGDOC), Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), The Study was funded by the European Regional Development Fund (FEDER) Presage number 30814., We wish to thank all study participants and the staff from the health centers of French Guiana., Lacoste, Vincent, Centre d'investigation clinique Antilles-Guyane ( CIC - Antilles Guyane ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU de la Martinique-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique], Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Association guyanaise de dépistage organisé des cancers ( AGDOC ), Service de gynécologie-obstétrique [Saint Laurent du Maroni, Guyane Française], Réseau International des Instituts Pasteur ( RIIP ), and Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine ( COREVIH Guyane )
Subjects: MESH: Cervix Uteri/cytology, MESH: Uterine Cervical Neoplasms/pathology, [SDV]Life Sciences [q-bio], MESH: Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms, Cervix Uteri, 0302 clinical medicine, Informed consent, Surveys and Questionnaires, Epidemiology, Prevalence, MESH: DNA, Viral/genetics, Medicine, 030212 general & internal medicine, Papillomaviridae, MESH: Aged, MESH: Papillomavirus Infections/epidemiology, Cervical cancer, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Middle Aged, Obstetrics, lcsh:Public aspects of medicine, HPV infection, virus diseases, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: Uterine Cervical Neoplasms/diagnosis, Middle Aged, female genital diseases and pregnancy complications, 3. Good health, French Guiana, [SDV] Life Sciences [q-bio], MESH: Papillomaviridae/genetics, Women's Health Services, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Papillomaviridae/isolation & purification, MESH: Young Adult, 030220 oncology & carcinogenesis, Female, Normal cytology, Research Article, Papanicolaou Test, Adult, medicine.medical_specialty, Human papillomavirus, MESH: French Guiana/epidemiology, Genotype, MESH: Papillomavirus Infections/prevention & control, MESH: Women's Health Services, MESH: Papanicolaou Test, Young Adult, 03 medical and health sciences, MESH: Cross-Sectional Studies, Humans, MESH: Papillomaviridae/classification, MESH: Surveys and Questionnaires, MESH: Uterine Cervical Neoplasms/prevention & control, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, MESH: Prevalence, MESH: Papillomavirus Infections/pathology, Aged, Gynecology, MESH: Humans, business.industry, Public health, Papillomavirus Infections, Public Health, Environmental and Occupational Health, Cancer, MESH: Adult, lcsh:RA1-1270, medicine.disease, MESH: Papillomavirus Infections/diagnosis, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Concomitant, DNA, Viral, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Biostatistics, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; BACKGROUND:In French Guiana, cervical cancer is the second most frequent cancer in females. The objective of the present study was to describe the prevalence of HPV infections in women with normal cervical cytology living in the remote villages of French Guiana.METHODS:Before the study, the study team communicated in the remote villages on the importance of screening. All women from the target population were offered to participate. They signed informed consent during inclusion and then had a concomitant HPV-test and cervical smear. Only women with normal cytology and a good quality smear were analyzed. The detection of HPV-DNA was performed using the GREINER-BIO-ONE kit.RESULTS:Overall, 27.2% of women with normal cervical cytology had a positive HPV-test. There was a U-shaped evolution of prevalence with women over 50 years having the highest HPV prevalence, followed by the 20 to 29 years group. The most prevalent HPV genotypes were HPV 53(3.52%), 68(3.33%), 52(2.59%), 31(2.22%) and 16 (1.85%). The proportion of HPV 16 among HPV-infected women was 6.8%.CONCLUSIONS:HPV prevalence in cytologically normal women was very high. The most prevalent genotypes were very different from what is usually described in the world, and notably in South America.
Published: 2017

18. High prevalence of hepatitis B and syphilis in illegal gold miners in French Guiana

Author: Antoine Adenis, Amandine Pisoni, H. Jardin, Mathieu Nacher, Emilie Mosnier, S. Vreden, Edouard Tuaillon, Roxane Schaub, L. Hureau-Mutricy, Maylis Douine, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier ), and roussel, pascale
Subjects: 0301 basic medicine, Microbiology (medical), Adult, Male, medicine.medical_specialty, Hepatitis B virus, [SDV]Life Sciences [q-bio], 030106 microbiology, Population, Context (language use), Miners, Vulnerable Populations, law.invention, 03 medical and health sciences, 0302 clinical medicine, Condom, Informed consent, law, Environmental health, medicine, Prevalence, Humans, Serologic Tests, 030212 general & internal medicine, Syphilis, Treponema pallidum, education, education.field_of_study, business.industry, Public health, Undocumented Immigrants, General Medicine, Hepatitis B, medicine.disease, 3. Good health, French Guiana, [SDV] Life Sciences [q-bio], Infectious Diseases, Female, Gold, Viral hepatitis, business
Abstract: International audience; Viral hepatitis and syphilis remain important public health issues because of chronic forms and clinical complications. The omission of hard-to-reach and disadvantaged populations from public health and medical research is one of the current barriers to achieve the WHO target of reducing the burden of viral hepatitis and syphilis by 2030 [ 1 ]. Illegal gold miners in French Guiana, a French overseas territory in South America, are a perfect example of this type of population: they comprise about 10 000 people from Brazil living in a remote mining camp in the rainforest. We have previously shown that gold miners are a vulnerable population, notably with a human immunodeficiency virus (HIV) prevalence of 1.4% (95% CI 0.29–2.56) in a context where prostitution is frequent and condom access is difficult [ 2 ]. This study, nested in the Orpal study conducted in 2015 (NCT02903706) [ 3 ], aimed to estimate the prevalence of hepatitis B (HBV), D (HDV) and C (HCV) viruses, and syphilis in the specific population of illegal gold miners in French Guiana. The data collection method was previously reported [ 3 ]. Subjects provided informed consent. This ancillary study was approved by the Cayenne General Hospital Ethics committee.
Published: 2019

19. High mortality due to snakebites in French Guiana: Time has come to re-evaluate medical management protocols

Author: R. Mutricy, Frédérique Perotti, Véronique Lambert, Mathieu Nacher, Christian Marty, Jean-Philippe Chippaux, Xavier Heckmann, Maylis Douine, Anne Jolivet, David Boels, Sébastien Larréché, Loïc Epelboin, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service d’Accueil des Urgences/SAMU/SMUR [Cayenne, Guyane Fraçaise], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Croix-rouge française [Cayenne, Guyane Fraçaise], Département de Santé Publique [Saint-Laurent-du-Maroni, Guyane Française], Service de gynécologie et d’obstétrique [Saint Laurent du Maroni, Guyanne Française], Pharmacy, Centre Hospitalier de l’Ouest Guyanais, Saint Laurent du Maroni, France, Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni), Centre Antipoison et Toxicovigilance du Grand Ouest (Angers) (CAPTV Angers), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM), Hôpital d'Instruction des Armées Begin, Service de Santé des Armées, Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance [Cotonou, Bénin] (CERPAGE), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), PRES Sorbonne Paris Cité, Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie), Université Paris Descartes - Paris 5 (UPD5), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne, Guyane] (COREVIH), Unité des Maladies Infectieuses et Tropicales (UMIT), Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Centres antipoison et de toxicovigilance (CAPTV Angers), Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et l’Enfance (CERPAGE), University of Abomey Calavi (UAC), Université des Antilles et de la Guyane - UFR des sciences médicales (UAG UFR SM), Université des Antilles et de la Guyane (UAG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Service d'Oto-Rhino-Laryngologie [CH Briançon], Centre Hospitalier des Escartons de Briançon (CH Briançon), Université de Guyane (UG), and Latour, Marie
Subjects: 0301 basic medicine, [SDV]Life Sciences [q-bio], Snake Bites, Toxicology, Pathology and Laboratory Medicine, Geographical locations, 0302 clinical medicine, Medicine and Health Sciences, Medicine, Toxins, Snakebite, ComputingMilieux_MISCELLANEOUS, Mortality rate, lcsh:Public aspects of medicine, High mortality, Eukaryota, Snakes, Squamates, 3. Good health, French Guiana, [SDV] Life Sciences [q-bio], Viewpoints, Infectious Diseases, Research Design, Vertebrates, Brazil, Neglected Tropical Diseases, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Death Rates, Clinical Research Design, 030231 tropical medicine, Toxic Agents, Colombia, Research and Analysis Methods, 03 medical and health sciences, Population Metrics, Environmental health, Animals, Humans, Adverse effect, Population Biology, business.industry, Venoms, Public Health, Environmental and Occupational Health, Organisms, Biology and Life Sciences, Reptiles, lcsh:RA1-1270, South America, Tropical Diseases, Health Care, 030104 developmental biology, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Amniotes, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Adverse Events, People and places, Health Statistics, Morbidity, business
Abstract: International audience; no abstract
Published: 2018

20. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

Author: Yoann Madec, Cécile Herrmann-Storck, Arnaud Fontanet, Bruno Hoen, Caroline Callier, Raymond Césaire, Dominique Rousset, Alice Monthieux, Cédric Laouénan, Manon Boullard, Anna L. Funk, Maylis Douine, S. Stegmann-Planchard, Benoit Tressières, Bruno Schaub, Fatiha Najioullah, Jean-Luc Voluménie, Eustase Janky, André Cabié, Gabriel Carles, Kinda Schepers, Samson Yassinguezo, Sylvie Cassadou, Vanessa Ardillon, Philippe Kadhel, Mathieu Nacher, Catherine Ryan, CHU Pointe-à-Pitre/Abymes [Guadeloupe], Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université des Antilles et de la Guyane (UAG), Maison de la Femme de la Mère et de l'Enfant [CHU de la Martinique] (MFME [Fort de France]), CHU de la Martinique [Fort de France], Epidémiologie des Maladies Emergentes - Emerging Diseases Epidemiology, Pasteur-Cnam Risques infectieux et émergents (PACRI), Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut Pasteur [Paris] (IP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université des Antilles et de la Guyane - UFR des sciences médicales (UAG UFR SM), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Maladies infectieuses et tropicales dans la Caraïbe (MAITC EA 4537), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Université des Antilles (UA), Centre Hospitalier Louis Constant Fleming, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Center for Global Health Research and Education - Centre pour la Recherche et la Formation en Santé Mondiale (CGH), Institut Pasteur [Paris] (IP)-Réseau International des Instituts Pasteur (RIIP), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Supported by the French Ministry of Health (Soutien Exceptionnel à la Recherche et à l’Innovation), by a grant (ANR-10-LABX-62-IBEID) from Laboratoire d’Excellence Integrative Biology of Emerging Infectious Diseases project, by the ZIKAlliance consortium (the European Union’s Horizon 2020 Research and Innovation Program), and by INSERM. This study is part of the ZIKAlliance consortium project., We thank the women who participated in this study, all the physicians, midwives, clinical research assistants, health officers, and epidemiologists who helped conduct this study in each of the French territories in the Americas: Myriam Atine, Lyderic Aubert, Marie Barrau, Kebe Beavogui, Christelle Celeste, Joelle Colat-Peyron, Elvire Couchy, Véronique Davidas, Lucetta Delver, Jacqueline Dubois, Stanie Gaete, Dorothée Harrois, Marie-Laure Lalanne-Mistrih, Mathilde Melin, Marie-France Mirane, Francelise Nadessein, Marie-Josée Pelczar, Véronique Plantier, Céline Rocquet, Magdalena Saint-Marc, Patrick Saint-Martin, Valérie Soter, Ingrid Soubdhan, Jennifer Taillefond, Lambo Velonasy, and Véronique Walter (Guadeloupe), Nicole Ambroisine, Gilda Belrose, Alain Blateau, Patricia Blondel, Isabelle Calmont, Valérie Decatrelle, Michèle Gueneret, Eugénie Jolivet, Isabelle Komla-Soukha, Corinne Plavonil, Marie-andrée Pyram, and Jean-Luc Voluménie (Martinique), Antoine Adenis, Audrey Andrieu, Luisiane Carvalho, Sandy Dabrowski, Céline Delorme, Maryvonne Dueymes, Aniza Fahrasmane, Arthur Felix, Hélène Hilderal, Anne Jolivet, Justine Krajewsky, Véronique Lambert, Thomas Lemaitre, Myriam Livain, Jérémie Pasquier, Marion Petit-Sinturel, Céline Pomar, Léo Pomar, and Stéphanie Rogier (French Guiana), and David Baud (University of Lausanne, Switzerland) and Rebecca Grant (Institut Pasteur de Paris, France) for their critical review of an earlier version of the manuscript., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Jonchère, Laurent, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut Pasteur [Paris]-Conservatoire National des Arts et Métiers [CNAM] (CNAM), CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université des Antilles (UA)-CHU de la Martinique [Fort de France], and Réseau International des Instituts Pasteur (RIIP)-Institut Pasteur [Paris]
Subjects: 0301 basic medicine, Microcephaly, [SDV]Life Sciences [q-bio], Chromosome Disorders, MESH: Amniotic Fluid, Zika virus, Cohort Studies, 0302 clinical medicine, MESH: Pregnancy, Pregnancy, MESH: Martinique, ZikV Infection, Medicine, 030212 general & internal medicine, Pregnancy Complications, Infectious, Prospective cohort study, Guadeloupe, MESH: Cohort Studies, MESH: Chromosome Disorders, MESH: Middle Aged, biology, Zika Virus Infection, Obstetrics, MESH: Infant, Newborn, Pregnancy Outcome, Gestational age, MESH: Congenital Abnormalities, General Medicine, Middle Aged, French Guiana, 3. Good health, [SDV] Life Sciences [q-bio], Fetal Diseases, MESH: Fetal Diseases, MESH: Young Adult, Cohort, Female, Pregnancy Trimesters, Adult, medicine.medical_specialty, Adolescent, MESH: Zika Virus, Article, MESH: Microcephaly, Congenital Abnormalities, Young Adult, 03 medical and health sciences, MESH: Zika Virus Infection, MESH: French Guiana, Humans, MESH: Guadeloupe, Martinique, MESH: Pregnancy Complications, Infectious, Pregnancy outcomes, MESH: Adolescent, Fetus, MESH: Humans, business.industry, Infant, Newborn, MESH: Adult, Zika Virus, Amniotic Fluid, medicine.disease, biology.organism_classification, MESH: Pregnancy Outcome, Confidence interval, 030104 developmental biology, business, MESH: Female, MESH: Pregnancy Trimesters
Abstract: International audience; BACKGROUND:The risk of congenital neurologic defects related to Zika virus (ZIKV) infection has ranged from 6 to 42% in various reports. The aim of this study was to estimate this risk among pregnant women with symptomatic ZIKV infection in French territories in the Americas.METHODS:From March 2016 through November 2016, we enrolled in this prospective cohort study pregnant women with symptomatic ZIKV infection that was confirmed by polymerase-chain-reaction (PCR) assay. The analysis included all data collected up to April 27, 2017, the date of the last delivery in the cohort.RESULTS:Among the 555 fetuses and infants in the 546 pregnancies included in the analysis, 28 (5.0%) were not carried to term or were stillborn, and 527 were born alive. Neurologic and ocular defects possibly associated with ZIKV infection were seen in 39 fetuses and infants (7.0%; 95% confidence interval, 5.0 to 9.5); of these, 10 were not carried to term because of termination of pregnancy for medical reasons, 1 was stillborn, and 28 were live-born. Microcephaly (defined as head circumference more than 2 SD below the mean for sex and gestational age) was detected in 32 fetuses and infants (5.8%), of whom 9 (1.6%) had severe microcephaly (more than 3 SD below the mean). Neurologic and ocular defects were more common when ZIKV infection occurred during the first trimester (24 of 189 fetuses and infants [12.7%]) than when it occurred during the second trimester (9 of 252 [3.6%]) or third trimester (6 of 114 [5.3%]) (P=0.001).CONCLUSIONS:Among pregnant women with symptomatic, PCR-confirmed ZIKV infection, birth defects possibly associated with ZIKV infection were present in 7% of fetuses and infants. Defects occurred more frequently in fetuses and infants whose mothers had been infected early in pregnancy. Longer-term follow-up of infants is required to assess any manifestations not detected at birth. (Funded by the French Ministry of Health and others; ClinicalTrials.gov number, NCT02916732 .).
Published: 2018

21. Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana

Author: Jerome Ponty, Raymond Césaire, Nadia Thomas, Vincent Molinie, Claire Grenier, Valentin Dufit, Maylis Douine, Laure Bianco, Mathieu Nacher, Paul Brousse, Antoine Adenis, Dominique Catherine, Gabriel Carles, Fatiha Najioullah, Odile Kilié, Jean Luc Deshayes, Vincent Lacoste, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique] (EA 4537), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association Guyanaise Dépistage Organisé des Cancers [Cayenne] (A.G.D.O.C), Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française], Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), The present study was funded by the European Regional Development Funds (FEDER) N° Presage 30,814., and Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
Subjects: Rural Population, [SDV]Life Sciences [q-bio], Uterine Cervical Neoplasms, MESH: Genotype, 0302 clinical medicine, MESH: Rural Population, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cytology, Genotype, Medicine, 030212 general & internal medicine, Life history, Papillomaviridae, Anamnesis, MESH: Aged, MESH: Middle Aged, lcsh:Public aspects of medicine, Obstetrics and Gynecology, virus diseases, General Medicine, MESH: Papillomavirus Vaccines, Middle Aged, Abnormal cytology, female genital diseases and pregnancy complications, MESH: Predictive Value of Tests, 3. Good health, French Guiana, Vaccination, MESH: Young Adult, 030220 oncology & carcinogenesis, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, MESH: Papillomavirus Infections/complications, MESH: DNA, Viral/analysis, Research Article, Adult, medicine.medical_specialty, Cytodiagnosis, Reproductive medicine, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Papillomavirus Infections/prevention & control, lcsh:Gynecology and obstetrics, MESH: Papillomaviridae/isolation & purification, MESH: Cytodiagnosis/statistics & numerical data, 03 medical and health sciences, Young Adult, Predictive Value of Tests, Internal medicine, MESH: French Guiana, Humans, Papillomavirus Vaccines, MESH: Papillomaviridae/genetics, Normal cytology, lcsh:RG1-991, Aged, MESH: Uterine Cervical Neoplasms/virology, MESH: Humans, business.industry, Papillomavirus Infections, MESH: Papillomavirus Infections/virology, lcsh:RA1-1270, MESH: Adult, Reproductive Medicine, DNA, Viral, MESH: Uterine Cervical Neoplasms/prevention & control, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: International audience; BACKGROUND: Cervical cancer prevention using cervical cytology is insufficiently sensitive, a significant proportion of HPV-infected women having normal cytology. The objective of the present study was to try to identify factors associated with abnormal cytology in HPV-infected women living in remote areas of French Guiana.METHODS: A study was conducted in women aged 20-65 years having HPV infections confirmed by HPV DNA detection using the GREINER-BIO-ONE kit. In addition to HPV testing, cytology was performed and classified as normal or abnormal. Demographic and life history variables, and infecting genotypes were compared between the normal and abnormal cytology groups.RESULTS: None of the demographic and life history variables were associated with cytology results. HPV genotype 53 was significantly associated with absence of cytological abnormalities whereas HPV 52, 58, 16 and perhaps 33 and 66 were independently associated with a greater risk of cytological abnormalities. When grouping HPV genotypes in different species, only species 9 (HPV 16, 31, 33, 35, 52, 58, 67) was significantly associated with abnormal cytology AOR = 5.1 (95% CI = 2.3-11.2), P
Published: 2018

22. Dépistage du cancer du col de l'utérus en Guyane : taux de couverture du dépistage entre 2006 et 2011

Author: Maylis Douine, Christian Lelarge, Tristan Roue, Nadia Thomas, Mathieu Nacher, Antoine Adenis, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Registre des Cancers de Guyane, Laboratoire d’anatomopathologie - Abbeville, Laboratoire d’anatomopathologie, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Association Guyanaise Dépistage Organisé des Cancers [Cayenne] (A.G.D.O.C), and The present study was funded by the Health Regional Agency of French Guiana.
Subjects: Overseas department, MESH: Mass Screening/statistics & numerical data, MESH: Uterine Cervical Neoplasms/pathology, MESH: Mass Screening/organization & administration, MESH: Uterine Cervical Neoplasms/epidemiology, Uterine Cervical Neoplasms, 0302 clinical medicine, Epidemiology, Mass Screening, MESH: Incidence, Early Detection of Cancer, Cervical cancer, MESH: Middle Aged, 030219 obstetrics & reproductive medicine, Incidence, Incidence (epidemiology), Mortality rate, Age Factors, MESH: Uterine Cervical Neoplasms/diagnosis, Middle Aged, French Guiana, 3. Good health, 030220 oncology & carcinogenesis, Pap-smear, Screening, Female, Papanicolaou Test, Adult, medicine.medical_specialty, MESH: French Guiana/epidemiology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pathology and Forensic Medicine, 03 medical and health sciences, parasitic diseases, medicine, Humans, Neoplasm Invasiveness, MESH: Uterine Cervical Neoplasms/prevention & control, Mass screening, Retrospective Studies, MESH: Age Factors, Gynecology, MESH: Humans, MESH: Early Detection of Cancer*/statistics & numerical data, business.industry, MESH: Adult, MESH: Retrospective Studies, Retrospective cohort study, MESH: Neoplasm Invasiveness, medicine.disease, Metropolitan France, MESH: Papanicolaou Test/statistics & numerical data, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: International audience; In French Guiana, the age-standardized incidence rate of cervical cancer is four times higher than in France and the mortality rate 5.5 times higher. A survival study revealed that stage at diagnosis was the main factor influencing the prognosis, showing that early detection is crucial to increase cervical cancer survival. The present study aimed at evaluating the cervical cancer screening rate between 2006 and 2011 by age and for 3-years period in French Guiana. All pap smears realised in French Guiana were analysed in two laboratories allowing exhaustive review of screening data. The screening rate was estimated at about 54% from 2006 to 2011, with a statistical difference between coastal and rural area (56.3% versus 18.7%).Although the methodological difference did not allow comparisons with mainland France, these results could be used to evaluate the impact of organised cervical cancer screening by the French Guiana Association for Organized Screening of Cancers implemented in French Guiana since 2012.; En Guyane, l’incidence du cancer du col de l’utérus est quatre fois plus élevée qu’en métropole, et la létalité 5,5 fois plus élevée. Dans ce vaste département recouvert à plus de 90 % de forêt amazonienne, les difficultés d’accès aux soins, l’âge précoce au premier rapport et le manque de dépistage sont de possibles facteurs explicatifs. Une première étude a montré que le diagnostic tardif était le principal facteur impactant la survie. Un diagnostic précoce - par frottis cervico-vaginal tous les 3 ans de 25 à 64 ans selon les recommandations nationales - est donc crucial pour améliorer la survie. L’objectif de cette étude est d’évaluer le taux de couverture de dépistage par frottis en Guyane entre 2006 et 2011 ainsi que l’activité de réalisation de frottis et le taux de cancers dépistés. Tous les frottis cervico-vagin aux réalisés en Guyane sont analysés dans seulement deux laboratoires d’anatomie pathologique, ce qui permet une analyse exhaustive des données de dépistage de ce département. La date de naissance, la date de réalisation du frottis, l’adresse de la patiente ou celle du prescripteur (selon les laboratoires) ainsi que la date de réalisation du précédent frottis ont été recueillis. Le taux de couverture de dépistage a été évalué à 54 % entre 2006 et 2011, avec une différence significative entre le littoral et l’intérieur de la Guyane (56,3 % versus 18,7 %). L’activité de réalisation de frottis était de 23,5 à 25,8 frottis pour 100 femmes-année. Le taux de diagnostic de cancer était de 191,8/100 000 femmes année, soit un cancer cervical diagnostiqué pour 521 personnes dépistées. Bien que le taux de couverture de dépistage en Guyane ne semble pas très différent de la métropole, nous ne pouvons réaliser de comparaison statistique du fait de la différence de méthodologie utilisée. Le taux de diagnostic de cancer était de 6 à 12 fois plus élevé qu’en métropole, confirmant l’importance du dépistage par frottis en Guyane. Des efforts de dépistage doivent être réalisés notamment dans l’intérieur de la Guyane, où le taux de dépistage est plus faible. Cet état des lieux du dépistage entre 2006 et 2011 pourra permettre d’évaluer l’impact de la campagne organisée de dépistage du cancer du col mise en place en 2012 par l’Association guyanaise du dépistage organisé des cancers (AGDOC).
Published: 2015

23. Mycobacterium ulcerans infection (Buruli ulcer) in French Guiana, South America, 1969–2013: an epidemiological study

Author: Sylvain Labbé, Dominique Sainte-Marie, Roger Pradinaud, Rodolphe E. Gozlan, Mathieu Nacher, Jean-François Guégan, Maylis Douine, J. Dufour, Pierre Couppié, Yann Reynaud, Christine Chevillon, Alain Berlioz-Arthaud, Marine Combe, Eric Elguero, Camilla Jensen Velvin, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine [Cayenne] (COREVIH), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Institut Pasteur de la Guadeloupe, Réseau International des Instituts Pasteur (RIIP), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Evolution of host-microbe communities (MIVEGEC-EVCO), Processus Écologiques et Évolutifs au sein des Communautés (PEEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institut Pasteur de la Guyane, Service de Dermatologie [Cayenne, Guyanne Française], Centre Hospitalier Andre Rosemon, This work was funded by an 'Investissement d’Avenir' grant managed by Agence Nationale de la Recherche (Centre d’Étude de la Biodiversité Amazonienne, reference ANR-10-LABX-2501)., Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Génétique et évolution des maladies infectieuses (GEMI), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Génétique et évolution des maladies infectieuses (GEMI)
Subjects: Male, Buruli ulcer, Health (social science), Medicine (miscellaneous), MESH: Mycobacterium ulcerans, MESH: Buruli Ulcer/epidemiology, 0302 clinical medicine, MESH: Aged, 80 and over, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Child, Epidemiology, 030212 general & internal medicine, MESH: Incidence, Child, Buruli Ulcer, lcsh:Environmental sciences, lcsh:GE1-350, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, biology, Transmission (medicine), Incidence, Health Policy, Incidence (epidemiology), MESH: Infant, Newborn, Middle Aged, MESH: Infant, French Guiana, 3. Good health, MESH: Young Adult, Child, Preschool, Mycobacterium ulcerans, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Leprosy, Adult, medicine.medical_specialty, Tuberculosis, Adolescent, MESH: French Guiana/epidemiology, 030231 tropical medicine, Bone Infection, Young Adult, 03 medical and health sciences, medicine, Humans, Aged, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, MESH: Adult, medicine.disease, biology.organism_classification, Dermatology, MESH: Male, Surgery, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female
Abstract: Summary Background Mycobacterium ulcerans infection is the third most common mycobacterial disease in the world after tuberculosis and leprosy. To date, transmission pathways from its environmental reservoir to humans are still unknown. In South America, French Guiana has the highest reported number of M ulcerans infections across the continent. This empirical study aimed to characterise the epidemiology of M ulcerans infection in French Guiana between 1969 and 2013. Methods Data were collected prospectively mainly by two dermatologists at Cayenne Hospital's dermatology department between Jan 1, 1969, and Dec 31, 2013, for age, date of diagnosis, sex, residence, location of the lesion, type of lesion, associated symptoms, and diagnostic method (smear, culture, PCR, or histology) for all confirmed and suspected cases of M ulcerans . We obtained population data from censuses. We calculated mean M ulcerans infection incidences, presented as the number of cases per 100 000 person-years. Findings 245 patients with M ulcerans infections were reported at Cayenne Hospital's dermatology department during the study period. M ulcerans infection incidence decreased over time, from 6·07 infections per 100 000 person-years (95% CI 4·46–7·67) in 1969–83 to 4·77 infections per 100 000 person-years (3·75–5·79) in 1984–98 and to 3·49 infections per 100 000 person-years (2·83–4·16) in 1999–2013. The proportion of children with infections also declined with time, from 42 (76%) of 55 patients in 1969–83 to 26 (31%) of 84 in 1984–98 and to 22 (21%) of 106 in 1999–2013. Most cases occurred in coastal areas surrounded by marshy savannah (incidence of 21·08 per 100 000 person-years in Sinnamary and 21·18 per 100 000 person-years in Mana). Lesions mainly affected limbs (lower limbs 161 [66%] patients; upper limbs 60 [24%] patients). We diagnosed no bone infections. Interpretation The decrease of M ulcerans infection incidence and the proportion of children with infections over a 45 year period in this ultra-peripheral French territory might have been mostly driven by improving living conditions, prophylactic recommendations, and access to health care. Funding Agence Nationale de la Recherche.
Published: 2017

24. High prevalence of HPV infection in the remote villages of French Guiana: an epidemiological study

Author: Florine Corlin, Vincent Lacoste, Mathieu Nacher, Vincent Molinie, Raymond Césaire, Valentin Dufit, Antoine Adenis, Maylis Douine, Gabriel Carles, Fatiha Najioullah, Gulen Ayhan, Paul Brousse, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, European Regional Development Fund - FEDER presage n°30814 - INCOMING, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Laboratoire de Virologie-Immunologie [Fort de France, Martinique] (EA 4537), Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique], Service d'anatomopathologie [Fort de France, Martinique], CHU Fort de France, Département des Centres Délocalisés de Prévention et de Soins [Cayenne, Guyane Française], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de gynécologie-obstétrique [Saint Laurent du Maroni, Guyane Française], Centre Hospitalier de l'Ouest Guyanais, Laboratoire des Interactions Virus-Hôtes [Cayenne, Guyane Française], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), This project was supported by an European Union Grant (PO FEDER 2007-2013, No. Présage: 30814, Guyane Française., We thank the health professionals of the Centres Délocalisés de Prévention et de Soins and the Protection Maternelle et Infantile., European Project: FEDER presage n°30814, and CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG)
Subjects: Genotyping Techniques, Epidemiology, Prevalence, MESH: Genotype, 0302 clinical medicine, 5. Gender equality, MESH: Papillomavirus Infections/virology, MESH: DNA, Viral/genetics, 030212 general & internal medicine, MESH: Cytological Techniques, Papillomaviridae, Cervical cancer, MESH: Aged, MESH: Papillomavirus Infections/epidemiology, education.field_of_study, MESH: Middle Aged, MESH: Epidemiologic Studies, Incidence (epidemiology), HPV infection, Middle Aged, Original Papers, 3. Good health, French Guiana, Vaccination, MESH: Papillomaviridae/genetics, Infectious Diseases, MESH: Papillomaviridae/isolation & purification, MESH: Young Adult, 030220 oncology & carcinogenesis, Female, MESH: DNA, Viral/analysis, Adult, medicine.medical_specialty, HPV, MESH: Vaginal Smears, MESH: French Guiana/epidemiology, Genotype, Population, Cytological Techniques, 03 medical and health sciences, Young Adult, MESH: Genotyping Techniques, medicine, Humans, MESH: Papillomaviridae/classification, education, MESH: Prevalence, Aged, Gynecology, Vaginal Smears, MESH: Humans, business.industry, Public health, Papillomavirus Infections, MESH: Adult, medicine.disease, Epidemiologic Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, DNA, Viral, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: SUMMARYCervical cancer is the second most frequent cancer in women in French Guiana. Studies have shown that populations living in the remote areas of the interior have early sexual debut and that multiple sexual partnerships are common. The objective of the present study was thus to determine the prevalence of human papillomavirus (HPV) infection in these areas. A study was conducted in women aged 20–65 years with previous sexual activity. Women were included on a voluntary basis after using local media and leaders to inform them of the visit of the team. HPV infection was defined by the detection of HPV DNA using the Greiner Bio-One kit. In addition to HPV testing cytology was performed. The overall age-standardized prevalence rate was 35%. There was a U-shaped evolution of HPV prevalence by age with women aged >50 years at highest risk for HPV, followed by the 20–29 years group. Twenty-seven percent of women with a positive HPV test had normal cytology. Given the high incidence of cervical cancer in French Guiana and the high prevalence of HPV infections the present results re-emphasize the need for screening for cervical cancer in these remote areas. Vaccination against HPV, preferably with a nonavalent vaccine, also seems an important prevention measure. However, in this region where a large portion of the population has no health insurance, this still represents a challenge.
Published: 2017

25. Predictors of complications of snake envenomation in Cayenne, French Guiana, 2007-2015

Author: Maylis Douine, Mathieu Nacher, Gérald Egmann, R. Mutricy, Stéphanie Houcke, Loïc Epelboin, Antoine Adenis, Christian Marty, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Service d’Accueil des Urgences/SAMU/SMUR [Cayenne, Guyane Fraçaise], Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Croix-rouge française [Cayenne, Guyane Fraçaise], Unité de Soins Intensifs [Cayenne, Guyane Française], Unité des Maladies Infectieuses et Tropicales (UMIT), and Funding was provided by Ministère des Affaires Sociales et de la Santé (Grant No. Bourse année recherche 2015/2016).
Subjects: medicine.medical_specialty, Cayenne, Pain medicine, 030231 tropical medicine, Snake Bites, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Anesthesiology, medicine, Humans, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, computer.programming_language, Snake envenomation, business.industry, Anatomy, medicine.disease, Snake bites, French Guiana, 3. Good health, Emergency medicine, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, business, computer
Abstract: International audience
Published: 2017

26. Predictors of antimalarial self-medication in illegal gold miners in French Guiana: a pathway towards artemisinin resistance

Author: Mathieu Nacher, Félix Djossou, Louise Hureau, Maylis Douine, Yassamine Lazrek, Stéphane Pelleau, R Chanlin, Magalie Demar, Lise Musset, Florine Corlin, S. Vreden, Helene Hiwat, Béatrice Volney, D. Blanchet, Centre d'Investigation Clinique Antilles Guyane, Inserm CIC1424, Laboratoires d'excellence - CEnter of the study of Biodiversity in Amazonia - - CEBA2010 - ANR-10-LABX-0025 - LABX - VALID, European Funds for Regional Development (Feder), N° Presage 32078 - OrPal - 32078 - INCOMING, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Malaria Program, Paramaribo, Suriname, Ministry of Health [Mozambique], Foundation for the Advancement of Scientific Research in Suriname [Paramaribo] (SWOS), Unité des Maladies Infectieuses et Tropicale, Centre Hospitalier de Cayenne, Coordination Régionale de la lutte contre le Virus de L'Immunodéficience Humaine (COREVIH Guyane), This study was funded by European Funds for Regional Development (Feder), N° Presage 32078, benefited from funding from Santé Publique France (French Ministry of Health) and was supported by an 'Investissement d'Avenir' grant managed by Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01)., ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010), European Project: 32078,OrPal, and Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé)
Subjects: Male, Cross-sectional study, Psychological intervention, Drug Resistance, Drug resistance, Self Medication, 0302 clinical medicine, Surveys and Questionnaires, Medicine, Mass Screening, Pharmacology (medical), 030212 general & internal medicine, Artemisinin, Malaria, Falciparum, Suriname, Traditional medicine, biology, Middle Aged, Artemisinins, 3. Good health, French Guiana, Infectious Diseases, Criminal Behavior, Female, medicine.drug, Self-medication, Microbiology (medical), Adult, Adolescent, 030231 tropical medicine, Plasmodium falciparum, Miners, 03 medical and health sciences, Antimalarials, Young Adult, Environmental health, parasitic diseases, Humans, Mass screening, Pharmacology, business.industry, biology.organism_classification, medicine.disease, Treatment Adherence and Compliance, Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Gold, business, Malaria
Abstract: International audience; Background:Malaria is endemic in French Guiana (FG), South America. Despite the decrease in cases in the local population, illegal gold miners are very affected by malaria (22.3% of them carried Plasmodium spp.). Self-medication seems to be very common, but its modalities and associated factors have not been studied. The aim of this study was to evaluate parasite susceptibility to drugs and to document behaviours that could contribute to resistance selection in illegal gold miners.Methods:This multicentric cross-sectional study was conducted in resting sites along the FG-Surinamese border. Participating gold miners working in FG completed a questionnaire and provided a blood sample.Results:From January to June 2015, 421 illegal gold miners were included. Most were Brazilian (93.8%) and 70.5% were male. During the most recent malaria attack, 45.5% reported having been tested for malaria and 52.4% self-medicated, mainly with artemisinin derivatives (90%). Being in FG during the last malaria attack was the main factor associated with self-medication (adjusted OR = 22.1). This suggests that access to malaria diagnosis in FG is particularly difficult for Brazilian illegal gold miners. Treatment adherence was better for persons who reported being tested. None of the 32 samples with Plasmodium falciparum presented any mutation on the pfK13 gene, but one isolate showed a resistance profile to artemisinin derivatives in vitro.Conclusions:The risk factors for the selection of resistance are well known and this study showed that they are present in FG with persons who self-medicated with poor adherence. Interventions should be implemented among this specific population to avoid the emergence of artemisinin resistance.
Published: 2017

27. Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir

Author: Helene Hiwat, Frédérique Perotti, Antoine Adenis, Félix Djossou, Mathieu Nacher, Stephen Vreden, Magalie Demar, Florine Corlin, Paul Brousse, Maylis Douine, Stéphane Pelleau, Jérémie Pasquier, Louise Mutricy, Lise Musset, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR - laboratoire associé), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Stem cell and microenvironment laboratory, Weill Cornell Medicine [Qatar], Department Genetic Medicine, Corneil University-Weill Medical College of Cornell University [New York], Unité des Maladies Infectieuses et Tropicales (UMIT), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Direction Interarmées du Service de Santé en Guyane, Département des Centres Délocalisés de Prévention et de Soins, Pharmacy, Centre Hospitalier de l’Ouest Guyanais, Saint Laurent du Maroni, France, Centre Hospitalier de l'Ouest Guyanais Franck Joly (Saint-Laurent-du-Maroni), Medical Mission, Academisch Ziekenhuis, Paramaribo Hospital, Medicine Department, Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), funded by European Funds for Regional Development (Feder), N° Presage 32078 and the Institut Veille Sanitaire (French Ministry of Health), European Project: 32078,OrPal, CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Service d'Immunologie [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de Référence du Paludisme [Cayenne, Guyane française] (CNR), ADENIS, ANTOINE, and European Funds for Regional Development (Feder), N° Presage 32078 - OrPal - 32078 - INCOMING
Subjects: Male, Plasmodium, Cross-sectional study, artemisinin resistance, Polymerase Chain Reaction, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Health care, Prevalence, 030212 general & internal medicine, Immunoassay, Microscopy, Rapid diagnostic test, education.field_of_study, Malaria reservoir, Ecology, Transmission (medicine), Illegal gold mining, Middle Aged, French Guiana, 3. Good health, Infectious Diseases, Geography, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, Adult, medicine.medical_specialty, 030231 tropical medicine, Population, Miners, 03 medical and health sciences, Environmental health, parasitic diseases, medicine, Humans, education, Diagnostic Tests, Routine, business.industry, Research, Public health, medicine.disease, Malaria, Cross-Sectional Studies, Guiana Shield, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Asymptomatic Diseases, Tropical medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Parasitology, Gold, business
Abstract: International audience; BackgroundMalaria is endemic in French Guiana, an overseas territory of France on the Guiana Shield. Since 2005, notified malaria cases are decreasing. However, new data show that malaria affects many Brazilian gold miners working illegally in French Guiana, the majority of whom are not counted in official data. In addition, one major concern is the usual practice of improper self-treatment in this mining population, raising fear of the development of antimalarial resistance. This prospective study, conducted in 2015, aimed to estimate the prevalence of Plasmodium spp. in illegal gold miners working in French Guiana. MethodsThe recruitment of gold miners was carried out in resting sites along the French Guiana-Suriname border, where they go for supplies, medical care or leisure. After recording agreement, three malaria diagnostic methods were performed: rapid diagnostic test, microscopy and PCR,ResultsAmong 421 persons recruited in the study, malaria prevalence, detected by nested-PCR, was 22.3% (CI=[18.3-26.3], n=94/421) of which 84% were asymptomatic. ConclusionThis significant malaria reservoir in a mobile and illegal population with difficult access to a health care system raises the threat of artemisinin resistance and puts the population of the Guiana Shield at risk of new transmission foci while countries of the region aim at malaria elimination. Even though French legislation may hamper dealing with this population, France must face the reality of malaria in illegal gold miners in order to meet its commitment to malaria elimination.
Published: 2016

28. Predictive factors of the survival of women with invasive breast cancer in French Guiana: the burden of health inequalities

Author: Sophie Belliardo, Maylis Douine, Tristan Roue, Sylvain Labbé, Mathieu Nacher, Juliette Plenet, Registre des Cancers de Guyane, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), The present study was funded by the Health Regional Agency of French Guiana., The authors thank Professor J.P. Droz for a critical reading of the manuscript., Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and ADENIS, ANTOINE
Subjects: Cancer Research, Pediatrics, Survival, Immigration, Health Services Accessibility, MESH: Healthcare Disparities/statistics & numerical data, 0302 clinical medicine, Breast cancer, MESH: Aged, 80 and over, Risk Factors, MESH: Risk Factors, Medicine, 030212 general & internal medicine, Early Detection of Cancer, MESH: Breast Neoplasms/pathology, media_common, Aged, 80 and over, MESH: Aged, MESH: Middle Aged, Relative survival, Carcinoma, Ductal, Breast, Age Factors, MESH: Neoplasm Staging, Place of birth, Middle Aged, Prognosis, MESH: Emigrants and Immigrants, 3. Good health, French Guiana, Survival Rate, Oncology, MESH: Breast Neoplasms/mortality, 030220 oncology & carcinogenesis, MESH: Survival Analysis, Female, Immigrant, Adult, medicine.medical_specialty, MESH: Socioeconomic Factors, MESH: Early Detection of Cancer/statistics & numerical data, MESH: French Guiana/epidemiology, MESH: Survival Rate, media_common.quotation_subject, Emigrants and Immigrants, Breast Neoplasms, MESH: Carcinoma, Ductal, Breast/mortality, MESH: Prognosis, 03 medical and health sciences, South America Word count : 2278, MESH: Health Services Accessibility, parasitic diseases, Humans, Healthcare Disparities, Survival rate, Survival analysis, Aged, Neoplasm Staging, MESH: Age Factors, MESH: Humans, business.industry, MESH: Adult, medicine.disease, Survival Analysis, MESH: Carcinoma, Ductal, Breast/pathology, Cancer registry, Metropolitan France, Socioeconomic Factors, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Female, Demography
Abstract: International audience; This study aimed to compare the relative survival of patients with invasive breast cancer between women from French Guiana (a French territory in South America) and metropolitan France. No study hadever compared survival of breast cancer on the basis of immigrant status in France. Our study underlined that access to care for migrants is challenging whichwgenerates health inequalities. Background The prognosis of breast cancer in French Guiana is worse than in France with 23 deaths per 100 incident cases against 17 per 100 in metropolitan France. This study aimed to compare relative survival of patients with invasive breast cancer (IBC) between women from French Guiana and metropolitan France and to determine risk factors influencing breast cancer survival in French Guiana.Materials and methods Data were collected from the Cancer registry of French Guiana. We comparedthe relative survival of women with IBC between French Guiana and metropolitan France. We used Cox's proportional hazard regression to evaluate the effect of prognostic factors on cancer-specific mortality in French Guiana. Results We included all 269 cases of IBC in women diagnosed in French Guiana between 2003 and 2009. The overall 5-year relative survival rate of patients with IBC was 79% in French Guiana and 86% in metropolitan France. The place of birth (foreign country versus French territory), the tumor stage at the time of diagnosis, the mode of diagnosis (symptoms versus screening), the presence of hormone receptors in the tumor and the histologic type were the variables associated with survival differences. None of the other study variables were significantly associated with prognosis. Conclusion Access to care for migrants is challenging,which leads to health inequalities. Early detection through prevention programs is crucial to increaseIBC survival notably for foreign-born patients.
Published: 2016

29. Prevalence and predictive factors for renouncing medical care in poor populations of Cayenne, French Guiana

Author: Marie Claire Parriault, Mathieu Nacher, Larissa Valmy, Maylis Douine, Thomas Pavlovsky, Astrid Van Melle, Antoine Adenis, Barbara Gontier, Célia Basurko, Claire Grenier, ADENIS, ANTOINE, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Croix rouge française, Health Regional Agency (ARS), Laboratoire de Mathématiques Informatique et Applications (LAMIA), Université des Antilles (UA), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Centre Hospitalier Andrée Rosemon, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), UNICANCER-Université Lille Nord de France (COMUE), Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), and Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
Subjects: Adult, Male, Health Knowledge, Attitudes, Practice, Renouncement, medicine.medical_specialty, media_common.quotation_subject, Immigration, Population, Emigrants and Immigrants, Logistic regression, Vulnerable Populations, Health informatics, Health administration, Treatment Refusal, 03 medical and health sciences, 0302 clinical medicine, Nursing, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], Poverty Areas, Health care, medicine, Humans, Social inequality, 030212 general & internal medicine, Healthcare Disparities, education, ComputingMilieux_MISCELLANEOUS, Tree analysis, media_common, Physician-Patient Relations, education.field_of_study, business.industry, Health Policy, Public health, Nursing research, Refusal to Treat, French Guiana, 3. Good health, Poor populations, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Epidemiologic Methods, business, Research Article, Demography
Abstract: International audience; Background: Access to health care is a global public problem. In French Guiana, there exists social inequalities which are specially marked amongst immigrants who make up a third of the population. Health care inequalities are prevalent. The objective of this study was to determine factors associated with why health care amongst the poor population of Cayenne was renounced.Study design The study was cross sectional. It focused on knowledge, attitudes, practices and beliefs of the population living in poor neighborhoods of the Cayenne area. Methods: Populations coming at the Red Cross mobile screening unit in poor urban areas of Cayenne were surveyed from July 2013 to June 2014. Structured questionnaires consisted of 93 questions. Written informed consent was requested at the beginning of the questionnaire. The predictors for renouncing medical care were determined using logistic regression models and tree analysis. Results: Twenty percent of persons had renounced care. Logistic regression showed that renouncement of health care was negatively associated with having no regular physician Adjusted Odds Ratio (AOR)=0.43 (95%CI=0.24-0.79) and positively associated with being embarrassed to ask certain questions AOR=6.81 (95%CI=3.98-11.65) and having been previously refused health care by a doctor AOR=3.08 (95%CI=1.43-6.65) . Tree analysis also showed that three of these variables were linked to renouncement, with feeling shy to ask certain questions as the first branching.Conclusion: Although most people felt it was easy to see a doctor, one in five had renounced health care. The variables identified by the models suggest vulnerable persons generally had previous negative encounters with the health system and felt unwanted or non eligible for healthcare. Health care mediation and welcoming staff may be simple solutions to the above problems which were underscored in our observations.
Published: 2015

30. Cerebral injuries associated with Zika virus in utero exposure in children without birth defects in French Guiana

Author: Anne Favre, Maylis Douine, Olivier Flechelles, Antoine Defo, Narcisse Elenga, Mathieu Nacher, Edouard Hallet, Arthur Felix, Rémi Kom-Tchameni, and Jean-Marc Rosenthal
Subjects: Adult, Male, Microcephaly, Pediatrics, medicine.medical_specialty, neurological disorders, Risk Assessment, Ultrasonography, Prenatal, Zika virus, 03 medical and health sciences, Child Development, 0302 clinical medicine, Pregnancy, medicine, Humans, Clinical Case Report, 030212 general & internal medicine, Pregnancy Complications, Infectious, 030505 public health, biology, Cesarean Section, Zika Virus Infection, business.industry, Metabolic disorder, Infant, Newborn, Infant, General Medicine, biology.organism_classification, Pathogenicity, medicine.disease, Magnetic Resonance Imaging, French Guiana, birth defects, In utero, Brain Injuries, Prenatal Exposure Delayed Effects, Female, Abnormality, Differential diagnosis, 0305 other medical science, business, Research Article, Follow-Up Studies
Abstract: Rationale: A major epidemic of Zika virus (ZIKV) infection occurred in French Guiana and West Indies. French national epidemiological surveillance estimated that 1650 pregnant women contracted the ZIKV during epidemic period from January 2016 to October 2016 in French Guiana. Patient concerns: ZIKV infection during pregnancy is a cause of microcephaly and birth defects. Diagnoses: In this report, we describe 2 children with proven in utero ZIKV exposure. Their mothers were both symptomatic and ZIKV infection occurred early in pregnancy. Ultrasonography monitoring in utero did not show any abnormality for both patient. They were born at full-term, healthy, without any birth defects and no sign of congenital ZIKV infection. Interventions: ZIKV was neither found on placenta fragments nor children blood and urine at birth. Their neurodevelopment outcomes in early-life fitted the expectations. As recommended in national guidelines, we performed cerebral MRIs at 2 months old, showing severe brain abnormalities, especially of white matter areas. After a large screening, we did not find any differential diagnosis for their brain lesions. Outcomes: We concluded it was due to their in utero ZIKV exposure. Lessons: In this report, pathogenicity of ZIKV may involve mother's immunological response or metabolic disorder during the infection.
Published: 2017

31. Survival of patients with invasive cervical cancer in French Guiana, 2003-2008

Author: Antoine Adenis, Mathieu Nacher, Angela Fior, Nadia Thomas, Tristan Roue, Maylis Douine, Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Registre des Cancers de Guyane, Service d'Anatomie et Cytologie Pathologiques, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Association Guyanaise Dépistage Organisé des Cancers [Cayenne] (A.G.D.O.C), Ecosystemes Amazoniens et Pathologie Tropicale (EPat), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Guyane (UG), Health Regional Agency of French Guiana, Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and ADENIS, ANTOINE
Subjects: Oncology, Adult, Pediatrics, medicine.medical_specialty, Invasive cervical cancer, Survival, Uterine Cervical Neoplasms, Adenocarcinoma, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, 030212 general & internal medicine, Fre nch Guiana, Early Detection of Cancer, ComputingMilieux_MISCELLANEOUS, Aged, Neoplasm Staging, Cervical cancer, Aged, 80 and over, Proportional hazards model, business.industry, Obstetrics and Gynecology, General Medicine, Middle Aged, medicine.disease, 3. Good health, French Guiana, Survival Rate, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, 030220 oncology & carcinogenesis, Cox model, Carcinoma, Squamous Cell, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: International audience
Published: 2014

32. [Representations and illness narratives in migrants HIV-patients originating from West Africa]

Author: Maylis, Douine, Olivier, Bouchaud, Marie-Rose, Moro, Thierry, Baubet, and Olivier, Taïeb
Subjects: Adult, Male, Unsafe Sex, Health Behavior, Social Stigma, Emigrants and Immigrants, Causality, Africa, Western, HIV Seropositivity, Interview, Psychological, Humans, Female, France, Acculturation, Confidentiality, Prejudice, Illness Behavior
Abstract: Migrants, especially from West African countries, are highly affected by HIV in France but their representations of the illness have not been much studied. The aim of this study is to explore their representations of HIV infection through their explanatory models and etiologic theories.Nine interviews of patients living with HIV from West African countries and migrants in France have been carried out with the Mac Gill Illness Narrative Interview, an interview schedule to elicit meanings and modes of reasoning related to illness experience. The illness narratives have then been analyzed through a method from medical anthropology.According to this study, AIDS remains a shameful illness, related to immoral behaviors such as unfaithfulness, intercourses with prostitutes or a high number of partners. Causality of illness is often related to the migration story. Stigmatization of people living with HIV is prevailing in the personal experience of the illness, which leads to underestimate oneself, to stop making plans for the future and brings social loneliness because of the secret around this illness.Like any illness, diagnosis of HIV infection involves questions: "Why me? Why now?" requiring an interpretation to recreate coherence in patients' lives. For medicals, caring about illnesses representations of the patients helps therapeutic relationship. Complementary surveys lead by a multidisciplinary team and an interpreter at different times could improve understandings of global representations of illness and their evolution.
Published: 2010

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32 results on '"Maylis Douine"'

1. Novel Chronic Anaplasmosis in Splenectomized Patient, Amazon Rainforest

2. Combatting malaria disease among gold miners: a qualitative research within the Malakit project

3. Implementation of a novel malaria management strategy based on self-testing and self-treatment in remote areas in the Amazon (Malakit): confronting a-priori assumptions with reality

4. Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana

5. Impact of Malakit intervention on perceptions, knowledge, attitudes, and practices related to malaria among workers in clandestine gold mines in French Guiana: results of multicentric cross-sectional surveys over time

6. COVID-19 epidemic in remote areas of the French Amazon, March 2020 to May 2021: Another reality

7. Kelch13 mutations in Plasmodium falciparum and risk of spreading in Amazon basin countries

8. When local phytotherapies meet biomedicine. Cross-sectional study of knowledge and intercultural practices against malaria in Eastern French Guiana

9. Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

10. Sexual and addictive risk behaviors and sexually transmitted infections in illegal gold miners in French Guiana: A multicenter observational study

11. The Epidemiology of COVID 19 in the Amazon and the Guianas: Similarities, Differences, and International Comparisons

12. Setting-up a cross-border action-research project to control malaria in remote areas of the Amazon: describing the birth and milestones of a complex international project (Malakit)

13. Simultaneous dengue and COVID-19 epidemics: Difficult days ahead?

14. Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil

15. Prevalence of Plasmodium spp. in the Amazonian border context (French Guiana-Brazil) : associated factors and spatial distribution

16. Investigation of a possible malaria epidemic in an illegal gold mine in French Guiana: an original approach in the remote Amazonian forest

17. The singular epidemiology of HPV infection among French Guianese women with normal cytology

18. High prevalence of hepatitis B and syphilis in illegal gold miners in French Guiana

19. High mortality due to snakebites in French Guiana: Time has come to re-evaluate medical management protocols

20. Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas

21. Predictors of abnormal cytology among HPV-infected women in remote territories of French Guiana

22. Dépistage du cancer du col de l'utérus en Guyane : taux de couverture du dépistage entre 2006 et 2011

23. Mycobacterium ulcerans infection (Buruli ulcer) in French Guiana, South America, 1969–2013: an epidemiological study

24. High prevalence of HPV infection in the remote villages of French Guiana: an epidemiological study

25. Predictors of complications of snake envenomation in Cayenne, French Guiana, 2007-2015

26. Predictors of antimalarial self-medication in illegal gold miners in French Guiana: a pathway towards artemisinin resistance

27. Prevalence of Plasmodium spp. in illegal gold miners in French Guiana in 2015: a hidden but critical malaria reservoir

28. Predictive factors of the survival of women with invasive breast cancer in French Guiana: the burden of health inequalities

29. Prevalence and predictive factors for renouncing medical care in poor populations of Cayenne, French Guiana

30. Cerebral injuries associated with Zika virus in utero exposure in children without birth defects in French Guiana

31. Survival of patients with invasive cervical cancer in French Guiana, 2003-2008

32. [Representations and illness narratives in migrants HIV-patients originating from West Africa]

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