1. The α
- Author
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Leonardo, Sandrini, Patrizia, Amadio, Alessandro, Ieraci, Alessandro, Malara, José P, Werba, Paolo M, Soprano, Alessandra, Balduini, Marta, Zarà, Alice, Bonomi, Fabrizio, Veglia, Gualtiero I, Colombo, Maurizio, Popoli, Francis S, Lee, Elena, Tremoli, and Silvia S, Barbieri
- Subjects
Aged, 80 and over ,Male ,Depression ,Brain-Derived Neurotrophic Factor ,Desipramine ,Thrombosis ,Coronary Artery Disease ,Middle Aged ,Polymorphism, Single Nucleotide ,Mice ,Norepinephrine ,Receptors, Adrenergic, alpha-2 ,Animals ,Humans ,Female ,Blood Coagulation ,Aged - Abstract
Depression is associated with thrombotic risk and arterial events, its proper management is strongly recommended in coronary artery disease (CAD) patients. We have previously shown that the Brain-Derived Neurotrophic Factor (BDNF)Val66Met polymorphism, related to depression, is associated with arterial thrombosis in mice, and with an increased risk of acute myocardial infarction in humans. Herein, expanding the previous findings on BDNFVal66Met polymorphism, we show that desipramine, a norepinephrine reuptake-inhibitor, rescues behavioral impairments, reduces the arterial thrombosis risk, abolishes pathological coagulation and platelet hyper-reactivity, normalizes leukocyte, platelet, and bone marrow megakaryocyte number and restores physiological norepinephrine levels in homozygous knock-in BDNF Val66Met (BDNF
- Published
- 2021