1. Salivary IL-4: A Bleeding Predictor on Probing in Descendants of Severe Periodontitis Patients
- Author
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Mabelle Freitas Monteiro, Hélvis Enri de Sousa Paz, Larissa Bizarre, Gabriela Martin Bonilha, Marcio Zaffalon Casati, and Renato Corrêa Viana Casarin
- Subjects
Aggressive Periodontitis ,Tumor Necrosis Factor-alpha ,Dental Plaque Index ,Interleukin-17 ,Cytokines ,Humans ,General Medicine ,Interleukin-4 ,Periodontal Index ,Child ,Saliva - Abstract
Objective: Periodontitis in younger patients can cause severe periodontal destruction, and cases are usually more numerous in members of the same family due to the sharing of susceptibility factors. Thus, the use of a familial study design could improve our understanding of initial alterations in periodontal tissue. This observational study aimed to evaluate the salivary inflammatory pattern in descendants of periodontitis patients and identify any correlation with the clinical periodontal condition. Study design: Fifteen children of Generalized Aggressive Periodontitis (GAgP) patients and 15 children with periodontally healthy parents were evaluated for their plaque index (PI), gingival index (GI), bleeding on probing (BoP), and probing depth (PD). The concentrations of interferon (IFN)-γ, interleukin (IL)-10, IL-17, IL-1β, IL-4, and tumor necrosis factor (TNF)-α were measured in unstimulated saliva using the Luminex MAGPix platform. Results: Children from the GAgP group presented higher probing depth (PD) and bleeding on probing (BoP) (p
- Published
- 2022