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1. Seroprevalence of anti‐SARS‐CoV‐2 IgG antibodies in children with household exposure to adults with COVID‐19: Preliminary findings

Author

Buonsenso, Danilo, Valentini, Piero, De Rose, Cristina, Pata, Davide, Sinatti, Dario, Speziale, Domenico, Ricci, R., Carfi, A., Landi, Francesco, Ferrari, V., De Maio, Flavio, Palucci, Ivana, Sanguinetti, Maurizio, Sali, Michela, Landi, F., Gremese, E., Bernabei, R., Fantoni, M., Gasbarrini, A., Settanni, C. R., Benvenuto, F., Bramato, G., Ciciarello, F., Lo Monaco, M. R., Martone, A. M., Marzetti, Emanuele, Napolitano, C., Pagano, F., Rocchi, S., Rota, E., Salerno, A., Tosato, M., Tritto, M., Calvani, Riccardo, Catalano, L., Picca, A., Savera, G., Cauda, R., Tamburrini, E., Borghetti, A., Di Gianbenedetto, S., Murri, R., Cingolani, A., Ventura, G., Taddei, E., Moschese, D., Ciccullo, A., Stella, L., Addolorato, G., Franceschi, F., Mingrone, G., Zocco, Maria Assunta, Sanguinetti, M., Cattani Franchi, Paola, Marchetti, S., Posteraro, Brunella, Sali, M., Bizzarro, A., Lauria, A., Rizzo, S., Savastano, Maria Cristina, Gambini, G., Cozzupoli, G. M., Culiersi, C., Passali, G. C., Paludetti, G., Galli, J., Crudo, F., Di Cintio, G., Longobardi, Y., Tricarico, L., Santantonio, M., Buonsenso, D., Valentini, P., Pata, D., Sinatti, D., De Rose, C., Richeldi, Luca, Lombardi, F., Calabrese, A., Sani, G., Janiri, D., Giuseppin, G., Molinaro, M., Modica, M., Natale, Luigi, Larici, A. R., Marano, R., Paglionico, A., Petricca, L., Gigante, L., Natalello, G., Fedele, A. L., Lizzio, M. M., Tolusso, B., Alivernini, S., Santoliquido, A., Santoro, L., Nesci, A., and Popolla, V.

Subjects
Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Antibodies, Viral, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Immunoglobulin G, SARS‐CoV‐2, 03 medical and health sciences, 0302 clinical medicine, children, COVID‐19, Seroepidemiologic Studies, 030225 pediatrics, Internal medicine, medicine, Seroprevalence, Humans, Pediatrics, Perinatology, and Child Health, Child, Index case, biology, seroprevalence, business.industry, SARS-CoV-2, Public health, Infant, Newborn, COVID-19, Infant, Environmental Exposure, Middle Aged, household, 030228 respiratory system, Child, Preschool, Pediatrics, Perinatology and Child Health, biology.protein, Commentary, Antibody, business, Pediatric population
Abstract

Weather and the susceptibility of children to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection is still a debated question and currently a hot topic, particularly in view of important decisions regarding opening schools. Therefore, we performed this prospective analysis of anti‐SARS‐CoV‐2 immunoglobulin G (IgG) antibodies in children with known household exposure to SARS‐CoV‐2 and compared their IgG status with the other adults exposed to the index case in the same household. A total of 30 families with a documented COVID‐19 index case were included. A total of 44 out of 80 household contacts (55%) of index patients had anti SARS‐CoV‐2 IgG antibodies. In particular, 16/27 (59,3%) adult partners had IgG antibodies compared with 28/53 (52,3%) of pediatric contacts (p > .05). Among the pediatric population, children ≥5 years of age had a similar probability of having SARS‐CoV‐2 IgG antibodies (21/39, 53.8%) compared to those less than 5 years old (7/14, 50%) (p > .05). Adult partners and children also had a similar probability of having SARS‐CoV‐2 IgG antibodies. Interestingly, 10/28 (35.7%) of children and 5/27 (18.5%) of adults with SARS‐CoV‐2 IgG antibodies were previously diagnosed as COVID‐19 cases. Our study shows evidence of a high rate of IgG antibodies in children exposed to SARS‐CoV‐2. This report has public health implications, highlighting the need to establish appropriate guidelines for school openings and other social activities related to childhood.

Published
2021
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2. Italian registry of cardiac magnetic resonance

Author

Francone, M, Di Cesare, E, Cademartiri, F, Pontone, G, Lovato, L, Matta, G, Secchi, F, Maffei, E, Pradella, S, Carbone, I, Marano, R, Bacigalupo, L, Chiodi, E, Donato, R, Sbarbati, S, Di, Renzi, Cmr Italian Registry Group, Ligabue, G, Mancini, A, Palmierir, F, Restaino, G, Puppini, G, Centonze, M, Toscano, W, Tessa, C, Faletti, R, Conti, M, Scardapane, A, Galea, S, Liguori, C, Pagliacci, M, Lumia, D, Nullm, Nulldi Girolamo, Romagnoli, A, Guarise, A, Cirillo, S, Gagliardi, B, Borghi, C, Quarenghi, M, Contin, F, Scaranello, F, Tartaro, A, Marinucci, C, Monti, L., DE COBELLI, FRANCESCO, Francone, M, Di Cesare, E, Cademartiri, F, Pontone, G, Lovato, L, Matta, G, Secchi, F, Maffei, E, Pradella, S, Carbone, I, Marano, R, Bacigalupo, L, Chiodi, E, Donato, R, Sbarbati, S, DE COBELLI, Francesco, Di, Renzi, Cmr Italian Registry, Group, Ligabue, G, Mancini, A, Palmierir, F, Restaino, G, Puppini, G, Centonze, M, Toscano, W, Tessa, C, Faletti, R, Conti, M, Scardapane, A, Galea, S, Liguori, C, Pagliacci, M, Lumia, D, Nullm, Nulldi Girolamo, Romagnoli, A, Guarise, A, Cirillo, S, Gagliardi, B, Borghi, C, Quarenghi, M, Contin, F, Scaranello, F, Tartaro, A, Marinucci, C, and Monti, L.

Subjects
Adult, Male, medicine.medical_specialty, Referral, Heart disease, Adolescent, Heart Diseases, Clinical indications, Cardiomyopathy, Infarction, Magnetic Resonance Imaging, Cine, safety profile, cardiac magnetic resonance, CMR-registry, Coronary artery disease, Young Adult, medicine, Prevalence, Humans, Radiology, Nuclear Medicine and imaging, Registries, Young adult, Practice Patterns, Physicians', Child, acquisition protocols, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Aged, Aged, 80 and over, business.industry, Infant, General Medicine, Middle Aged, medicine.disease, patient's management, clinical indications, cmr-registry, Italy, Radiological weapon, Child, Preschool, Utilization Review, Female, Radiology, Cardiac magnetic resonance, business, cardiomyopathy, coronary artery disease
Abstract

Objectives Forty sites were involved in this multicenter and multivendor registry, which sought to evaluate indications, spectrum of protocols, impact on clinical decision making and safety profile of cardiac magnetic resonance (CMR). Materials and methods Data were prospectively collected on a 6-month period and included 3376 patients (47.2 ± 19 years; range 1–92 years). Recruited centers were asked to complete a preliminary general report followed by a single form/patient. Referral physicians were not required to exhibit any specific certificate of competency in CMR imaging. Results Exams were performed with 1.5 T scanners in 96% of cases followed by 3 T (3%) and 1 T (1%) magnets and contrast was administered in 84% of cases. The majority of cases were performed for the workup of inflammatory heart disease/cardiomyopathies representing overall 55.7% of exams followed by the assessment of myocardial viability and acute infarction (respectively 6.9% and 5.9% of patients). In 49% of cases the final diagnosis provided was considered relevant and with impact on patient's clinical/therapeutic management. Safety evaluation revealed 30 (0.88%) clinical events, most of which due to patient's preexisting conditions. Radiological reporting was recorded in 73% of exams. Conclusions CMR is performed in a large number of centers in Italy with relevant impact on clinical decision making and high safety profile.

Published
2013

3. Indicazioni cliniche per l'utilizzo della cardio RM. A cura del Gruppo di lavoro della Sezione di Cardio-Radiologia della SIRM

Author

Di Cesare, E., Cademartiri, F., Carbone, I., Carriero, A., Centonze, M., De Cobelli, F., De Rosa, R., Di Renzi, P., Esposito, A., Faletti, R., Fattori, R., Francone, M., Giovagnoni, A., La Grutta, L., Ligabue, G., Lovato, L., Marano, R., Midiri, M., Romagnoli, A., Russo, V., Sardanelli, F., Natale, L., Bogaert, J., De Roos, A, Di Cesare, E., Cademartiri, F., Carbone, I., Carriero, A., Centonze, M., De Cobelli, F., De Rosa, R., Di Renzi, P., Esposito, A., Faletti, R., Fattori, R., Francone, M., Giovagnoni, A., La Grutta, L., Ligabue, G., Lovato, L., Marano, R., Midiri, M., Romagnoli, A., Russo, V., Sardanelli, F., Natale, L., Bogaert, J., and De Roos, A

Subjects
Radiology, Nuclear Medicine and Imaging, Heart, Magnetic resonance, Cardiovascular Diseases, Contrast Media, Humans, Italy, Magnetic Resonance Imaging, Cardiovascular Disease, Nuclear Medicine and Imaging, Radiology, Human
Abstract

Cardiac magnetic resonance (CMR) is considered an useful method in the evaluation of many cardiac disorders. Based on our experience and available literature, we wrote a document as a guiding tool in the clinical use of CMR. Synthetically we describe different cardiac disorders and express for each one a classification, I to IV, depending on the significance of diagnostic information expected. © 2012 Springer-Verlag Italia.

Published
2013

4. Clinical indications for cardiac computed tomography. From the Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radiology (SIRM)

Author

di Cesare, E, Carbone, I, Carriero, A, Centonze, M, De Cobelli, F, De Rosa, R, Di Renzi, P, Esposito, A, Faletti, Riccardo, Fattori, R, Francone, M, Giovagnoni, A, La Grutta, L, Ligabue, G, Lovato, L, Marano, R, Midiri, M, Natale, L, Romagnoli, A, Russo, V, Sardanelli, F, Cademartiri, F, Working Group of the Cardiac Radiology Section of the Italian Society of Medical Radiology, Di Cesare, E, Carbone, I, Carriero, A, Centonze, M, DE COBELLI, Francesco, De Rosa, R, Di Renzi, P, Esposito, Antonio, Faletti, R, Fattori, R, Francone, M, Giovagnoni, A, La Grutta, L, Ligabue, G, Lovato, L, Marano, R, Midiri, M, Natale, L, Romagnoli, A, Russo, V, Sardanelli, F, Cademartiri, F., De Cobelli, F, Esposito, A, and Cademartiri, F

Subjects
medicine.medical_specialty, Consensus, linee guida, genetic structures, Cardiac computed tomography, Clinical indications, cardiac CT, Guidelines, Radiation Dosage, Computed tomography coronary angiography, cct, CCT, CTCA, Cardiovascular Diseases, Humans, Italy, Tomography, X-Ray Computed, medicine, ctca, Radiology, Nuclear Medicine and imaging, Medical physics, guidelines, Tomography, Neuroradiology, medicine.diagnostic_test, business.industry, Radiation dose, Interventional radiology, General Medicine, indicazioni cliniche, computed tomography coronary angiography, consensus, clinical indications, Angiografia coronarica a tomografia computerizzata, consenso, eye diseases, Angiografia coronarica a tomografia computerizzata, linee guida, consenso, indicazioni cliniche, computed tomography coronary angiography, guidelines, consensus, clinical indications, X-Ray Computed, Clinical indication, sense organs, Radiology, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, business
Abstract

"\"La tomografia computerizzata del cuore (CCT) è diventata uno strumento efficace in differenti contesti clinici. Lo sviluppo della tecnologia ha portato ad una progressiva espansione delle indicazioni con una concomitante riduzione della dose di radiazioni necessaria per l’esecuzione dell’indagine. Ancora oggi sono pochi i documenti delle maggiori società scientifiche internazionali che si esprimono sulle effettive modalità di utilizzo e sulle indicazioni cliniche della CCT; in particolare mancano delle linee guida complete. Questo documento rispecchia la visione del gruppo di lavoro della Sezione di Cardio-Radiologia della Società Italiana di Radiologia Medica in merito alle indicazioni correnti della CCT.\"" "\"Cardiac computed tomography (CCT) has grown as a useful means in different clinical contexts. Technological development has progressively extended the indications for CCT while reducing the required radiation dose. Even today there is little documentation from the main international scientific societies describing the proper use and clinical indications of CCT; in particular, there are no complete guidelines. This document reflects the position of the Working Group of the Cardiac Radiology Section of the Italian Society of Radiology concerning the indications for CCT.\""

Published
2011

5. Frontal assessment battery scores and non-motor symptoms in parkinsonian disorders

Author

Marconi, R., Grasso, L., Antonini, A., De Gaspari, D., Barone, P., Santangelo, G., Colosimo, C., Meco, G., Avarello, T. P., Bottacchi, E., Cannas, A., Ceravolo, M. G., Ceravolo, R., Cicarelli, G., Gaglio, R. M., Giglia, L., Iemolo, F., Manfredi, M., Nicoletti, A., Pederzoli, M., Petrone, A., Pisani, A., Pontieri, F. E., Quatrale, R., Ramat, S., Scala, R., Volpe, G., Zappulla, S., Bentivoglio, R., Stocchi, F., Trianni, G., Del Dotto, P., Morgante, F., Morgante, L., Fabbrini, G., Benincasa, D., Sensi, M., Braga, M., Capecci, M., Caravona, N., D'Asta, G., De Falco, F. A., Pezzoli, G., Di Giovanni, M., Floris, G., Gallerini, S., Gurgone, G., Frosini, D., Meoni, S., Savica, R., Moschella, V., Pepe, F., Petretta, V., Randisi, M. G., Romeno, M., Picillo, M., Sorbello, V., Tiple, D., Guidubaldi, A., Muoio, R., Toni, V., Logi, C., Bartalini, S., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Pradotto, L., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Bartolomei, L., L'Erario, R., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Corbetta, T., Sgarbi, S., Rapisarda, A., Rizzoli, S., Zanoli, L., Manfredi, A., Marconi, R, Antonini, A, Barone, P, Colosimo, C, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, De Gaspari, D, Grasso, L, Morgante, F, Santangelo, Gabriella, Fabbrini, G, Morgante, L, and PRIAMO study, Group

Subjects
Questionnaires, Lung Diseases, Male, Aged, Aged, 80 and over, Attention Deficit Disorder with Hyperactivity, Cardiovascular Diseases, Cognition Disorders, Fatigue, Female, Frontal Lobe, Gastrointestinal Diseases, Humans, Kidney Diseases, Logistic Models, Longitudinal Studies, Middle Aged, Parkinsonian Disorders, Predictive Value of Tests, Skin Diseases, Sleep Wake Disorders, Surveys and Questionnaires, Neuropsychological Tests, 2708, Neurology (clinical), Psychiatry and Mental Health, Neurology, Disease, Logistic regression, Parkinson and cognitive impairment, 80 and over, Verbal fluency test, Neuroradiology, Sleep Disorders, General Medicine, non-motor symptoms, Psychiatry and Mental health, Settore MED/26 - NEUROLOGIA, Frontal lobe, Predictive value of tests, Psychology, medicine.medical_specialty, Dermatology, behavioral disciplines and activities, Internal medicine, medicine, Psychiatry, Surrogate endpoint, Frontal functions, Non-motor symptoms, frontal functions, parkinson and cognitive impairment
Abstract

Using data from the PRIAMO study, we investigated non-motor symptoms (NMS) versus frontal lobe dysfunction in patients with idiopathic Parkinson disease (PD); 808 patients with PD and 118 with atypical parkinsonisms (AP) were consecutively enrolled at 55 Centers in Italy. Twelve categories of NMS were investigated. Cognitive impairment was defined as a Mini-Mental Status Evaluation score ≤ 23.8 and frontal lobe dysfunction as a Frontal Assessment Battery (FAB) score ≤ 3.48. Multivariable logistic regression was used to identify predictor of frontal lobe dysfunction in 524 PD patients, and a generalized linear model was used for each of the six FAB items. Not only the total FAB scores but also the single FAB items were lower in AP versus PD (p ≤ 0.005). Age (OR = 1.05), cognitive impairment (OR = 9.54), lack of cardiovascular symptoms (OR = 3.25), attention or memory problems (OR = 0.59) and treatment with L: -DOPA (OR = 5.58) were predictors of frontal lobe dysfunction. MMSE was negatively associated with all FAB items (β ≤ -0.16) and age with all FAB items but prehension behavior (β ≤ -0.01). Previous use of L: -DOPA was negatively associated with verbal fluency (β = -0.32) possibly acting as surrogate marker of disease duration. Cognitive impairment is a predictor of frontal lobe dysfunction. Among NMS, lack of attention or memory problems were negatively associated with frontal impairment. Further studies are nonetheless needed to better identify the predictors of frontal impairment in PD patients.

Published
2012

6. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study

Author

Colosimo, C, Morgante, L, Antonini, A, Barone, P, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, Priamo, Sg, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, D'Asta, G, De Falco, Fa, De Gaspari, D, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Grasso, L, Gurgone, G, Kiferle, L, Meoni, S, Morgante, F, Savica, R, Moschella, V, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Santangelo, G, Ianniciell, M, Sorbello, V, Fabbrini, G, Berardelli, A, Guidubaldi, A, Muoio, R, Toni, V, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Colosimo C., Morgante L., Antonini A., Barone P., Avarello T.P., Bpttacchi E., Cannas A., Ceravolo M.G., Ceravolo R., Cicarelli G., Gaglio R.M., Giglia L., Iemolo F., Manfredi M., Meco G., Nicoletti A., Pederzoli M., Petrone A., Pisani A., Pontieri FE., Quatrale r., Ramat S., Scala R., Volpe G., Zappulla S., Bentivoglio A.R., Stocchi F., Trianni G., Del Dotto P., Simoni L., Marconi R., PRIAMO STUDY GROUP [.., Martinelli P., ], Colosimo, C, Morgante, L, Antonini, A, Barone, Paolo, Avarello, Tp, Bottacchi, E, Cannas, A, Ceravolo, Mg, Ceravolo, R, Cicarelli, G, Gaglio, Rm, Giglia, L, Iemolo, F, Manfredi, M, Meco, G, Nicoletti, A, Pederzoli, M, Petrone, A, Pisani, A, Pontieri, Fe, Quatrale, R, Ramat, S, Scala, R, Volpe, G, Zappulla, S, Bentivoglio, Ar, Stocchi, F, Trianni, G, Del Dotto, P, Simoni, L, Marconi, R, and PRIAMO STUDY, G. R. O. U. P.

Subjects
Male, Secondary, Neurology, secondary parkinsonism, parkinson and cognitive impairment, Neurological disorder, PRIAMO STUDY, Orthostatic vital signs, Prevalence, Corticobasal degeneration, Supranuclear Palsy, Longitudinal Studies, Parkinsonism, Cognitive disorder, Parkinson Disease, Neurodegenerative Diseases, Middle Aged, non-motor symptoms, atypical parkinsonism, Italy, Atypical parkinsonism, Non-motor symptoms, Parkinson and cognitive impairment, Secondary parkinsonism, epidemiology, Settore MED/26 - Neurologia, Female, Supranuclear Palsy, Progressive, Lewy Body Disease, medicine.medical_specialty, Humans, Aged, Parkinson Disease, Secondary, Cross-Sectional Studies, Multiple System Atrophy, Parkinsonian Disorders, Atypical parkinsonism, Non-motor symptoms, Parkinson and cognitive impairment, Secondary parkinsonism, Neurology (clinical), Aged, Cross-Sectional Studies, Female, Humans, Italy, epidemiology, Lewy Body Disease, epidemiology, Longitudinal Studies, Male, Middle Aged, Multiple System Atrophy, epidemiology, Neurodegenerative Diseases, epidemiology, Parkinson Disease, epidemiology, Parkinsonian Disorders, epidemiology, Prevalence, Supranuclear Palsy, Progressive, Progressive supranuclear palsy, Internal medicine, mental disorders, medicine, Dementia with Lewy bodies, business.industry, medicine.disease, nervous system diseases, Physical therapy, business, PARKINSONISM
Abstract

The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.

Published
2009

7. Anhedonia and cognitive impairment in Parkinson's disease: Italian validation of the Snaith-Hamilton Pleasure Scale and its application in the clinical routine practice during the PRIAMO study

Author

Santangelo, G, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, Priamo, Sg, Colosimo, C, Benincasa, D, Biguzzi, S, Braga, M, Capecci, M, Caravona, N, De Falco, Fa, Pezzoli, G, Di Giovanni, M, Floris, G, Gallerini, S, Gurgone, G, Kiferle, L, Meoni, S, Moschella, V, Morgante, F, Pepe, F, Petretta, V, Randisi, Mg, Romeno, M, Ianniciello, M, Sciortino, G, Guzzardi, Po, Sorbello, V, Fabbrini, G, Guidubaldi, A, Muoio, R, Toni, V, Ferrari, Po, Logi, C, Ciacci, G, Ulivelli, M, Perini, M, Lanfranchi, S, Griffini, S, Troianiello, B, Baratti, M, Amidei, S, Consoli, D, Iellamo, M, Cuomo, T, Scaglioni, A, Medici, D, Abbruzzese, Giovanni, Di Brigida, G, Cocco, Ga, Agnetti, V, Cossu, G, Deriu, M, Abrignani, M, Modica, C, Albani, G, Milan, E, Martinelli, P, Scaglione, C, Mucchiut, M, Zanini, S, Pennisi, F, Soliveri, P, Albanese, A, Bartolomei, L, L'Erario, R, Capus, L, Ferigo, L, Marano, R, Nastasi, V, Luciano, R, Maiello, L, Simone, P, Fogli, D, Lopiano, L, Pesare, M, Molinette, As, Nordera, G, Pilleri, E, Scaravilli, T, Giaccaglini, E, Alesi, C, Corbetta, T, Dumitriu, A, Ingelheim, B, Sgarbi, S, Rapisarda, A, Rizzoli, S, Zanoli, L, Manfredi, A., Santangelo, Gabriella, Morgante, L, Savica, R, Marconi, R, Grasso, L, Antonini, A, De Gaspari, D, Ottaviani, D, Tiple, D, Simoni, L, Barone, P, PRIAMO Study, Group, Santangelo, G, Barone, Paolo, and PRIAMO Study, G. r. o. u. p.

Subjects
Male, medicine.medical_specialty, Parkinson's disease, media_common.quotation_subject, Multilingualism, Pilot Projects, Test validity, Affect (psychology), behavioral disciplines and activities, Aged, Aged, 80 and over, Cognition Disorders, diagnosis/epidemiology/psychology, Depressive Disorder, Major, diagnosis/epidemiology/psychology, Female, Humans, Italy, epidemiology, Male, Middle Aged, Multilingualism, Parkinson Disease, diagnosis/epidemiology/psychology, Pilot Projects, Psychiatric Status Rating Scales, standards, Reproducibility of Results, Pleasure, medicine, 80 and over, Humans, Psychiatry, Depression (differential diagnoses), media_common, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, Depressive Disorder, Major, Depressive Disorder, Parkinsonism, Anhedonia, Reproducibility of Results, Parkinson Disease, Middle Aged, medicine.disease, Test (assessment), Neurology, Italy, standards, Female, epidemiology, Neurology (clinical), Geriatrics and Gerontology, medicine.symptom, Psychology, Cognition Disorders, diagnosis/epidemiology/psychology, Clinical psychology
Abstract

To assess the psychometric properties of the Italian version of the Snaith-Hamilton Pleasure Scale (SHAPS) and to study the relationship between anhedonia, depression and cognitive impairment in patients with Parkinson's disease (PD).The SHAPS (14 items) was translated into Italian and pre-tested in a pilot study. Two items evaluating physical anhedonia related to sexual issues were added. The Italian version of SHAPS was validated in 274 consecutive PD patients, divided into patients with major depression according to DSM-IV criteria (dPD) and patients without depression (nPD), and in healthy subjects. To test the feasibility of the instrument and to determine whether clinical data affect anhedonia, we also administered SHAPS to 1307 patients with different types of parkinsonism.The Italian SHAPS proved to be easy to understand as regards the question and answer modes. Intraclass coefficient for test-retest reliability was 0.65 for the total score. KR index was 0.61. ANOVA of the SHAPS total score revealed that scores were higher in dPD patients than in healthy controls and nPD (p0.05). In the 1307 patients with various types of parkinsonism, the SHAPS data showed that anhedonia was related to age, type of parkinsonism, apathy, depression and cognitive impairment. Anhedonia was correlated with frontal dysfunctions in supranuclear palsy and PD patients (r=-0.682 and -0.264 respectively, p0.05).The Italian version of the SHAPS is a reliable tool with which to assess anhedonia in patients with PD and other forms of parkinsonism.

Published
2009

8. Diagnostic accuracy of 16-row multislice CT angiography in the evaluation of coronary segments

Author

Filippo Cademartiri, Runza G, Marano R, Luccichenti G, Gualerzi M, Brambilla L, Galia M, Gp, Krestin, Coruzzi P, Midiri M, Belgrano M, Cademartiri, F., Runza, G., Marano, R., Luccichenti, G., Gualerzi, M., Brambilla, L., Galia, M., Krestin, G., Coruzzi, P., Midiri, M., and Belgrano, MANUEL GIANVALERIO

Subjects
Male, Coronary Stenosis, Contrast Media, Middle Aged, Coronary Angiography, Sensitivity and Specificity, Electrocardiography, Contrast Media *Coronary Angiography Coronary Stenosis/*radiography Electrocardiography Female Humans Male Middle Aged Predictive Value of Tests Sensitivity and Specificity *Tomography, Spiral Computed, Predictive Value of Tests, Humans, Female, Tomography, Spiral Computed
Abstract

PURPOSE: To evaluate the diagnostic accuracy of 16-row multislice spiral computed tomography coronary angiography (16-MSCT-CA) for the non-invasive assessment of significant coronary artery stenosis. MATERIALS AND METHODS: We enrolled 40 patients (36 male, aged 59+/-11 yrs) with suspected obstructive coronary artery disease and a heart rate 2 mm in diameter were evaluated by two independent observers for the presence of significant coronary artery stenosis (= or >50%). Consensus reading was compared to quantitative coronary angiography. RESULTS: The average heart rate was 55+/-6 bpm. Of the 428 segments of = or >2.0 mm diameter 92 were significantly diseased. Without exclusion of any branches (428), the sensitivity, specificity, positive, and negative predictive values to identify = or >50% obstructed segments were 95.7% (88/92), 95.8% (322/336), 86.3% (88/102), and 98.8% (322/326), respectively. No occluded left main, left anterior descending, circumflex or right coronary artery segments remained undetected. CONCLUSIONS: 16-MSCT-CA in a selected low-heart-rate patient population provides high diagnostic accuracy in the evaluation of significant coronary artery stenosis.

9. Cognitive impairment in Parkinson's disease

Author

Girotti, F., Marano, R., Licia Grazzi, Scigliano, G., and Caraceni, T.

Subjects
Intelligence Tests, Movement Disorders, Humans, Dementia, Parkinson Disease, Cognition Disorders, Psychomotor Performance
Abstract

Neuropsychologic studies on Parkinson's disease have shown an impairment of specific cognitive functions and a greater evidence of dementia. Cognitive alterations are related to the gravity of some peculiar motor symptoms of the disease and show a major role of motor disturbances in intellectual disorders. The concept of bradyphrenia and subcortical dementia still seems to be suitable to define the cognitive disorders of Parkinson's disease.

10. Recommendations in pre-procedural imaging assessment for TAVI intervention: SIC-SIRM position paper part 2 (CT and MR angiography, standard medical reporting, future perspectives)

Author

Riccardo Marano, Gianluca Pontone, Eustachio Agricola, Brunilda Alushi, Antonio Bartorelli, Matteo Cameli, Nazario Carrabba, Antonio Esposito, Riccardo Faletti, Marco Francone, Nicola Galea, Paolo Golino, Marco Guglielmo, Anna Palmisano, Sonia Petronio, Maria Petullà, Silvia Pradella, Flavio Ribichini, Francesco Romeo, Vincenzo Russo, Salvatore Scandura, Nicolò Schicchi, Carmen Spaccarotella, Fabrizio Tomai, Ciro Indolfi, Maurizio Centonze, Marano, R., Pontone, G., Agricola, E., Alushi, B., Bartorelli, A., Cameli, M., Carrabba, N., Esposito, A., Faletti, R., Francone, M., Galea, N., Golino, P., Guglielmo, M., Palmisano, A., Petronio, S., Petulla, M., Pradella, S., Ribichini, F., Romeo, F., Russo, V., Scandura, S., Schicchi, N., Spaccarotella, C., Tomai, F., Indolfi, C., and Centonze, M.

Subjects
Aortic valve stenosi, Angiography, Cardiology, General Medicine, Aortic valve stenosis, Computed tomography, Echocardiography, Imaging, Magnetic resonance, TAVI, Transcatheter Aortic Valve Replacement, Aortic Valve, Humans, Radiology, Nuclear Medicine and imaging, Tomography, X-Ray Computed
Abstract

Non-invasive cardiovascular imaging owns a pivotal role in the preoperative assessment of patient candidates for transcatheter aortic valve implantation (TAVI), providing a wide range of crucial information to select the patients who will benefit the most and have the procedure done safely. This document has been developed by a joined group of experts of the Italian Society of Cardiology and the Italian Society of Medical and Interventional Radiology and aims to produce an updated consensus statement about the pre-procedural imaging assessment in candidate patients for TAVI intervention. The writing committee consisted of members and experts of both societies who worked jointly to develop a more integrated approach in the field of cardiac and vascular radiology. Part 2 of the document will cover CT and MR angiography, standard medical reporting, and future perspectives.

Published
2022
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11. The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson’s disease

Author

L Grasso, Silvia Ramat, Simone Gallerini, Paolo Barone, G. Di Brigida, D. Fogli, Tommaso Scaravilli, M. Braga, Alessandra Nicoletti, M. Romeno, Paolo Martinelli, G. Gurgone, Cesare Colosimo, E. Pilleri, V. Sorbello, S. Amidei, F. Pennisi, Francesco Iemolo, Giorgio Trianni, Vincenzo Toni, E. Milan, Raffaele Palladino, D. Benincasa, Giovanni Pezzoli, M. G. Randisi, Alfredo Petrone, Arianna Guidubaldi, R. Alfano, Tania P. Avarello, A. Scaglioni, Anna Rita Bentivoglio, C. Modica, L. Ferigo, M. Manfredi, Domenico Consoli, Giuseppe Meco, Giampiero Volpe, S. Griffini, Francesca Morgante, R. Scala, G. Nordera, Angelo Antonini, G. Floris, Roberto Erro, R. Muoio, Salvatore Zappulla, Luigi Bartolomei, Edo Bottacchi, Antonio Pisani, V. Petretta, Giovanni Fabbrini, G. Ciacci, L. Maiello, G. Ceravolo, M. Di Giovanni, V. Nastasi, Rocco Quatrale, D. Tiple, Marcello Deriu, S. Lanfranchi, Marianna Capecci, Alberto Albanese, T. Cuomo, Francesco E. Pontieri, Vincenzo Moschella, G. Sciortino, F. A. De Falco, S. Biguzzi, Leonardo Lopiano, Marina Picillo, C. Alesi, D. De Gaspari, Michele Abrignani, Gabriella Santangelo, Fabrizio Stocchi, R. Luciano, M. Baratti, R. M. Giglia, Cesa Scaglione, B. Troianiello, Giovanni Abbruzzese, M. Mucchiut, F. Pepe, S. Zanini, L. Capus, N. Caravona, Giovanni Cossu, V. Agnetti, G. Albani, L. Kiferle, E. Giaccaglini, Roberto Marconi, M. Iellamo, R. Marano, D. Medici, Monica Ulivelli, G. A. Cocco, M. Perini, P. Del Dotto, Rosa M. Gaglio, Rodolfo Savica, C. Logi, G. Ciccarelli, P. Massimo, M. Pesare, Antonino Cannas, Roberto Ceravolo, P. Simone, Letterio Morgante, P. Soliveri, S. Meoni, Picillo, M., Palladino, R., Erro, R., Alfano, R., Colosimo, C., Marconi, R., Antonini, A., Barone, P., Morgante, L., Benincasa, D., Quatrale, R., Biguzzi, S., Braga, M., Ceravolo, G., Capecci, M., Meco, G., Caravona, N., Scala, R., De Falco, F. A., Pezzoli, G., De Gaspari, D., Bottacchi, E., Di Giovanni, M., Cannas, A., Floris, G., Gallerini, S., Grasso, L., Gaglio, R. M., Gurgone, G., Volpe, G., Zappulla, S., Ceravolo, R., Kiferle, L., Ramat, S., Meoni, S., Pisani, A., Moschella, V., Morgante, F., Savica, R., Pepe, F., Ciccarelli, G., Petretta, V., Giglia, R. M., Randisi, M. G., Iemolo, F., Avarello, T. P., Romeno, M., Santangelo, G., Stocchi, F., Sciortino, G., Sorbello, V., Nicoletti, A., Tiple, D., Fabbrini, G., Bentivoglio, A., Pontieri, F. E., Guidubaldi, A., Muoio, R., Toni, V., Del Dotto, P., Logi, C., Ciacci, G., Ulivelli, M., Perini, M., Lanfranchi, S., Griffini, S., Troianiello, B., Baratti, M., Amidei, S., Consoli, D., Iellamo, M., Cuomo, T., Scaglioni, A., Medici, D., Manfredi, M., Abbruzzese, G., Di Brigida, G., Cocco, G. A., Agnetti, V., Cossu, G., Deriu, M., Abrignani, M., Modica, C., Albani, G., Milan, E., Martinelli, P., Scaglione, C., Mucchiut, M., Zanini, S., Pennisi, F., Soliveri, P., Albanese, A., Massimo, P., Bartolomei, L., Capus, L., Ferigo, L., Marano, R., Nastasi, V., Luciano, R., Maiello, L., Simone, P., Fogli, D., Lopiano, L., Pesare, M., Nordera, G., Pilleri, E., Scaravilli, T., Giaccaglini, E., Alesi, C., Petrone, A., and Trianni, G.

Subjects
Male, Neurology, Parkinson's disease, Constipation, Heterogeneity, Parkinson, Phenotype, Prodromal, Sex, PROGRESSION, Disease, 0302 clinical medicine, Apathy, Neuroradiology, Original Communication, Cognition, Parkinson Disease, 030211 gastroenterology & hepatology, Female, medicine.symptom, NONMOTOR SYMPTOMS, Life Sciences & Biomedicine, PRIAMO study group, Human, medicine.medical_specialty, Clinical Neurology, Prodromal Symptoms, Prodromal Symptom, 03 medical and health sciences, Internal medicine, medicine, Humans, Clinical phenotype, Aged, Science & Technology, Neurology & Neurosurgery, business.industry, 1103 Clinical Sciences, Biomarker, medicine.disease, DYSFUNCTION, Biomarkers, Neurology (clinical), Neurosciences & Neurology, business, 1109 Neurosciences, 030217 neurology & neurosurgery
Abstract

Objectives To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

Published
2021

12. Cardiac Magnetic Resonance Characterization of Myocarditis-Like Acute Cardiac Syndrome in COVID-19

Author

Giovanni Peretto, Luigi Natale, Antonio Esposito, Vincenzo Russo, Riccardo Marano, Davide Vignale, Anna Palmisano, Luigi Lovato, Guido Ligabue, Federica Fiocchi, Esposito, A., Palmisano, A., Natale, L., Ligabue, G., Peretto, G., Lovato, L., Vignale, D., Fiocchi, F., Marano, R., and Russo, V.

Subjects
Male, Respiratory complications, medicine.medical_specialty, Systemic disease, Myocarditis, Coronavirus disease 2019 (COVID-19), Left, Magnetic Resonance Imaging, Cine, 030204 cardiovascular system & hematology, medicine.disease_cause, Ventricular Function, Left, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Ventricular Function, Humans, Radiology, Nuclear Medicine and imaging, Respiratory system, Coronavirus, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, COVID-19, Female, Italy, Middle Aged, Prognosis, Syndrome, medicine.diagnostic_test, business.industry, Acute Myocardial Injury, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, N/A, Cine, Radiology Nuclear Medicine and imaging, SARS-CoV2, Cardiology, Takotsubo cardiomyopathy, Cardiac magnetic resonance, business, Cardiology and Cardiovascular Medicine
Abstract

Novel coronavirus infection causes a systemic disease (coronavirus disease-2019 [COVID-19]) with, most frequently, respiratory involvement. In addition to systemic and respiratory complications, COVID-19 can reveal itself as a myocarditis-like syndrome (AMCovS), whose underlying mechanism is largely

Published
2020

13. Clinical indications for the use of cardiac MRI. By the SIRM Study Group on Cardiac Imaging

Author

Riccardo Faletti, Jan Bogaert, Vincenzo Russo, Luigi Lovato, Iacopo Carbone, Alessandro Carriero, R. De Rosa, A. de Roos, Marco Francone, Rossella Fattori, Massimo Midiri, Riccardo Marano, Andrea Romagnoli, P. Di Renzi, Luigi Natale, Maurizio Centonze, Filippo Cademartiri, Francesco Sardanelli, Ludovico La Grutta, F. De Cobelli, Andrea Giovagnoni, Antonio Esposito, E. Di Cesare, Guido Ligabue, Di Cesare, E, Cademartiri, F, Carbone, I, Carriero, A, Centonze, M, De Cobelli, F, De Rosa, R, Di Renzi, P, Esposito, A, Faletti, R, Fattori, R, Francone, M, Giovagnoni, A, La Grutta, L, Ligabue, G, Lovato, L, Marano, R, Midiri, M, Romagnoli, A, Russo, V, Sardanelli, F, Natale, L, Bogaert, J, and De Roos, A

Subjects
Diagnostic information, medicine.medical_specialty, Contrast Media, medicine, Humans, Radiology, Nuclear Medicine and imaging, Heart, Mgnetic resonance, Cardiac disorders, Cardiac imaging, Neuroradiology, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Interventional radiology, General Medicine, Magnetic Resonance Imaging, Italy, Magnetic resonance, Cardiovascular Diseases, cardiovascular system, Radiology, heart, magnetic resonance, Settore MED/36 - Diagnostica Per Immagini E Radioterapia, business, Nuclear medicine, Cardiac magnetic resonance
Abstract

Cardiac magnetic resonance (CMR) is considered an useful method in the evaluation of many cardiac disorders. Based on our experience and available literature, we wrote a document as a guiding tool in the clinical use of CMR. Synthetically we describe different cardiac disorders and express for each one a classification, I to IV, depending on the significance of diagnostic information expected.

Published
2012
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14. Italian registry of cardiac computed tomography

Author

Cademartiri, Filippo, Di Cesare, Ernesto, Francone, Marco, Ballerini, Giovanni, Ligabue, Guido, Maffei, Erica, Romagnoli, Andrea, Argiolas, Giovanni Maria, Russo, Vincenzo, Buffa, Vitaliano, Marano, Riccardo, Guzzetta, Maria, Belgrano, Manuel, Carbone, Iacopo, Macarini, Luca, Borghi, Claudia, Di Renzi, Paolo, Barile, Vicenzo, Patriarca, Lucia, Donato, Rocco, Zerboni, Filippo, Tresoldi, Silvia, Tessa, Carlo, Rengo, Marco, Manglaviti, Giuseppina, Danti, Massimiliano, Crusco, Federico, Carotti, Lucia, Zobel, Bruno Beomonte, Bernardini, Antonio, Scardapane, Arnaldo, Banderali, Simone, Acquafresca, Manlio, Carusi, Luca Maria, Negro, Umberto, Priotto, Roberto, De Cobelli, Francesco, Quarenghi, Matteo, Paganoni, Silvia, Secchi, Francesco, Sforza, Nicola, Lumia, Domenico, De Rosa, Roberto, Bissoli, Ernesto, Olivotti, Luca, Barbiero, Giulio, Centonze, Maurizio, Leurini, Rodolfo, Malagò, Roberto, Pinto, Dario, Cademartiri, F., Di Cesare, E., Francone, M., Ballerini, G., Ligabue, G., Maffei, E., Romagnoli, A., Argiolas, G. M., Russo, V., Buffa, V., Marano, R., Guzzetta, M., Belgrano, M., Carbone, I., Macarini, L., Borghi, C., Di Renzi, P., Barile, V., Patriarca, L., Donato, R., Zerboni, F., Tresoldi, S., Tessa, C., Rengo, M., Manglaviti, G., Danti, M., Crusco, F., Carotti, L., Zobel, B. B., Bernardini, A., Scardapane, A., Banderali, S., Acquafresca, M., Carusi, L. M., Negro, U., Priotto, R., De Cobelli, F., Quarenghi, M., Paganoni, S., Secchi, F., Sforza, N., Lumia, D., De Rosa, R., Bissoli, E., Olivotti, L., Barbiero, G., Centonze, M., Leurini, R., Malago, R., Pinto, D., Cademartiri, Filippo, Di Cesare, Ernesto, Francone, Marco, Ballerini, Giovanni, Ligabue, Guido, Maffei, Erica, Romagnoli, Andrea, Argiolas, Giovanni Maria, Russo, Vincenzo, Buffa, Vitaliano, Marano, Riccardo, Guzzetta, Maria, Belgrano, MANUEL GIANVALERIO, Carbone, Iacopo, Macarini, Luca, Borghi, Claudia, Di Renzi, Paolo, Barile, Vicenzo, Patriarca, Lucia, Donato, Rocco, Zerboni, Filippo, Tresoldi, Silvia, Tessa, Carlo, Rengo, Marco, Manglaviti, Giuseppina, Danti, Massimiliano, Crusco, Federico, Carotti, Lucia, Zobel, Bruno Beomonte, Bernardini, Antonio, Scardapane, Arnaldo, Banderali, Simone, Acquafresca, Manlio, Carusi, Luca Maria, Negro, Umberto, Priotto, Roberto, De Cobelli, Francesco, Quarenghi, Matteo, Paganoni, Silvia, Secchi, Francesco, Sforza, Nicola, Lumia, Domenico, DE ROSA, Roberto, Bissoli, Ernesto, Olivotti, Luca, Barbiero, Giulio, Centonze, Maurizio, Leurini, Rodolfo, Malagò, Roberto, Pinto, Dario, and Radiology & Nuclear Medicine

Subjects
Registrie, Male, Radiology, Nuclear Medicine and Imaging, genetic structures, Cardiac computed tomography, Cardiac CT, Coronary artery, Heart diseases, Indications, Registry, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Heart Diseases, Humans, Infant, Italy, Middle Aged, Young Adult, Cardiac Imaging Techniques, Registries, Tomography, X-Ray Computed, Nuclear Medicine and Imaging, 80 and over, Medicine, Young adult, Tomography, Settore MED/36 - DIAGNOSTICA PER IMMAGINI E RADIOTERAPIA, Neuroradiology, medicine.diagnostic_test, Medicine (all), Interventional radiology, General Medicine, X-Ray Computed, Radiology, Human, medicine.medical_specialty, Cardiac anatomy, Heart disease, Acute chest pain, Radiology, Nuclear Medicine and imaging, In patient, Preschool, Cardiac Imaging Technique, business.industry, Indication, cardiac CT, coronary artery, heart diseases, indications, registry, adolescent, adult, aged, child, child preschool, female, humans, infant, male, middle aged, young adult, cardiac imaging techniques, registries, tomography X-Ray computed, radiology, nuclear medicine and imaging, business
Abstract

Cardiac CT (CCT) is an imaging modality that is becoming a standard in clinical cardiology. We evaluated indications, safety, and impact on patient management of routine CCT in a multicenter national registry. MATERIALS AND METHODS: During a period of 6 months, 47 centers in Italy enrolled 3,455 patients. RESULTS: CCT was performed mainly with 64-slice CT scanners (73.02 %). Contrast agents were administrated in 3,185 patients (92.5 %). Mean DLP changes with type of scanner and was lower in >64 row detector scanner. The most frequent indication for CCT was suspected CAD (44.8 %), followed by calcium scoring (9.6 %), post-angioplasty/stenting (8.3 %), post-CABGs (7.5 %), study of cardiac anatomy (4.22 %) and assessment in patients with known CAD (4.1 %) and acute chest pain (1.99 %). Most of the CCTs were performed in outpatient settings (2,549; 74 %) and a minority in inpatient settings (719, 20.8 %). Adverse clinical events (mild-moderate) occurred in 26 examinations (0.75 %). None of them was severe. In 45.3 % of the cases CCT findings impacted patient management. CONCLUSION: CCT is performed with different workloads in participating centers. It is a safe procedure and its results have a strong impact on patient management.

Published
2015

15. Italian multicenter, prospective study to evaluate the negative predictive value of 16- and 64-slice MDCT imaging in patients scheduled for coronary angiography (NIMISCAD-Non Invasive Multicenter Italian Study for Coronary Artery Disease)

Author

Marano, Riccardo, Liguori, Carlo, Bonomo, Lorenzo, De Cobelli Francesco, Esposito, Antonio, Del Maschio Alessandro, Becker, Christoph, Herzog, Christopher, Centonze, Maurizio, Coser, Daniela, Morana, Giovanni, Salviato, Elisabetta, Gualdi Gian Franco, Casciani, Emanuele, Ligabue, Guido, Fiocchi, Federica, Pontone, Gianluca, Andreini, Daniele, Catalano, Carlo, Carbone, Iacopo, Chiappino, Dante, Midiri, Massimo, Simonetti, Giovanni, Marchisio, Filippo, Olivetti, Lucio, Fattori, Rossella, Scardapane, Arnaldo, Principi, Massimo, Romano, Luigia, Arcadi, Nicola, Profili, Manuel, Volterrani, Luca, Marano, R, De Cobelli, F, Floriani, I, Becker, C, Herzog, C, Centonze, M, Morana, G, Gualdi, GF, Ligabue, G, Pontone, G, Catalano, C, Chiappino, D, Midiri, M, Simonetti, G, Marchisio, F, Olivetti, L, Fattori, R, Bonomo, L, and Novo, S

Subjects
Coronary angiography, Adult, Diagnostic Imaging, Male, medicine.medical_specialty, Coronary Artery Disease, Coronary Angiography, diagnosis/radiography, Coronary artery disease, methods, 16- and 64-slice MDCT imaging, coronary angiography, Settore MED/36 - Diagnostica per Immagini e Radioterapia, Predictive Value of Tests, Coronary Angiography/*methods Coronary Artery Disease/*diagnosis/*radiography Diagnostic Imaging/methods, 80 and over, Cardiac CT, Medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Prospective Studies, Prospective cohort study, Tomography, Neuroradiology, Aged, Aged, 80 and over, medicine.diagnostic_test, business.industry, Multidetector CT, Non invasive, Reproducibility of Results, Interventional radiology, General Medicine, Adult, Aged, Aged, 80 and over, Coronary Angiography, methods, Coronary Artery Disease, diagnosis/radiography, Diagnostic Imaging, methods, Female, Humans, Italy, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Reproducibility of Results, Tomography, X-Ray Computed, Middle Aged, medicine.disease, Predictive value, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, coronary angiography,CT, Italy, Female, Radiology, coronary angiography, business, Tomography, X-Ray Computed
Abstract

This was a prospective, multicenter study designed to evaluate the utility of MDCT in the diagnosis of coronary artery disease (CAD) in patients scheduled for elective coronary angiography (CA) using different MDCT systems from different manufacturers. Twenty national sites prospectively enrolled 367 patients between July 2004 and June 2006. Computed tomography (CT) was performed using a standardized/optimized scan protocol for each type of MDCT system (> or =16 slices) and compared with quantitative CA performed within 2 weeks of MDCT. A total of 284 patients (81%) were studied by 16-slice MDCT systems, while 66 patients (19%) by 64-slice MDCT scanners. The primary analysis was on-site/off-site evaluation of the negative predictive value (NPV) on a per-patient basis. Secondary analyses included on-site evaluation on a per-artery and per-segment basis. On-site evaluation included 327 patients (CAD prevalence 58%). NPV, positive predictive value (PPV), sensitivity, specificity, and diagnostic accuracy (DA) were 0.91 (95% CI 0.85-0.95), 0.91 (95% CI 0.86-0.95), 0.94 (95% CI 0.89-0.97), 0.88 (95% CI 0.81-0.93), and 0.91 (95% CI 0.88-0.94), respectively. Off-site analysis included 295 patients (CAD prevalence 56%). NPV, PPV, sensitivity, specificity, and DA were 0.73 (95% CI 0.65-0.79), 0.93 (95% CI 0.87-0.97), 0.73 (95% CI 0.65-0.79), 0.93 (95% CI 0.87-0.97), and 0.82 (95% CI 0.77-0.86), respectively. The results of this study demonstrate the utility of MDCT in excluding significant CAD even when conducted by centers with varying degrees of expertise and using different MDCT machines.

Published
2009

16. [Choledocholithiasis: semeiotic and diagnostic accuracy of cholangiography with magnetic resonance]

Author

Simeone A, Carriero A, Armillotta M, Riccardo Marano, De Maio G, Scarabino T, Cammisa M, Rotondo A, Bonomo L, Simeone, A, Carriero, A, Armillotta, M, Marano, R, DE MAIO, G, Scarabino, T, Cammisa, M, Rotondo, Antonio, and Bonomo, L.

Subjects
Cholangiopancreatography, Endoscopic Retrograde, Male, Humans, Reproducibility of Results, Female, Gallstones, Middle Aged, Magnetic Resonance Imaging
Abstract

The authors report their experience in the optimization of the diagnostic accuracy of Magnetic Resonance Cholangiography (MRC) to detect choledochal stones; pre- and post-MIP post-processing images were compared. Thirty patients with dilated biliary ducts (mean age: 55.6 years) were examined with MRC; two of them had stones in the intrahepatic biliary ducts. The gold standard and the inclusion criterion was ERCP. MRC was carried out with a 1.5 T superconductive magnet (Signa) with T2-weighted FAST SE sequences (TR/TE; 10000/256, matrix: 256 x 128, slice thickness: 3 mm, TA: 6 min 28 s). Coronal MR images were blindly studied before and after MIP post-processing; Friedman's test was used for statistical analysis (p.05). ERCP showed 92 cases of choledocholithiasis, with the stones ranging .2 to 3.4 cm; MRC before MIP post-processing had 97.1% diagnostic accuracy, 97.8% sensitivity and 95.8% specificity. These values are significantly different from those obtained after MIP (91.4%, 86.9% and 95.8% respectively). In our experience, pre- and post-MIP post-processing MRC can be considered a reliable and accurate noninvasive technique to detect choledochal stones.

Published
1997

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