7 results on '"Lou, R."'
Number of results to display per page
Search Results
2. Genome-wide association study identifies eight loci associated with blood pressure
- Author
-
Peter Holmans, Udo Seedorf, Beverley M. Shields, Peter McGruffin, Arne Pfeufer, Steve Eyre, Nathalie J. Prescott, Michael Boehnke, Valentina Moskovina, Abiodun Onipinla, Leena Peltonen, Nadira Yuldasheva, Peter M. Nilsson, Valeria Romanazzi, Vincent Mooser, Göran Berglund, Alistair S. Hall, Dominic P. Kwiatkowski, Barry Widmer, Benjamin F. Voight, Stefania Bandinelli, Mark M. Iles, Sven Bergmann, Thomas Meitinger, James P. Boorman, Simonetta Guarrera, Nazneen Rahman, Murielle Bochud, Graham A. Hitman, Emma Keniry, Nelson B. Freimer, Richard Dobson, Francis S. Collins, Gerjan Navis, Jennifer L. Pointon, Richard N. Bergman, Ruth J. F. Loos, Roberto Lorbeer, Carolina A. Braga Marcano, Christian Gieger, Florian Ernst, Xin Yuan, Catherine Potter, Hazel E. Drummond, Allan H. Young, George Kirov, John F. Peden, Helen Stevens, David Clayton, Mattijs E. Numans, Katherine Gordon-Smith, Anne Farmer, Alastair Forbes, M. Khalid Mohiuddin, John A. Todd, Christopher G. Mathew, David A. Collier, Mark I. McCarthy, Francesca Bredin, Clive M. Onnie, Dan Davidson, Markus Perola, Pamela Whittaker, Yvonne T. van der Schouw, Rathi Ravindrarajan, I. C.A. Spencer, Teresa Ferreira, Nilesh J. Samani, Serge Hercberg, Gonçalo R. Abecasis, Christopher J. Groves, Nicholas John Craddock, Angela Döring, Edward G. Lakatta, Muminatou Jallow, Wendy L. McArdle, David Bentley, Susana Eyheramendy, Uwe Völker, Christopher Newton-Cheh, Jaspal S. Kooner, Hugh Watkins, Gavin Lucas, H. T. Leung, Marjo Ritta Jarvelin, Johanna Kuusisto, Wiek H. van Gilst, Wendy Thomson, Lou R. Cardon, Harold Snieder, Marju Orho-Melander, Patricia B. Munroe, Toshiko Tanaka, Jeffrey C. Barrett, Azhar Maqbool, Henry Völzke, John M. C. Connell, Elaine R. Nimmo, John R. B. Perry, Michael R. Stratton, Ralph McGinnis, Pekka Jousilahti, Michiel L. Bots, Ian Jones, Elizabeth Meech, Matthew A. Brown, Johannie Gungadoo, Jian'an Luan, Jilur Ghori, Richard J. Dixon, N. Charlotte Onland-Moret, Fulvio Ricceri, Anthony J. Balmforth, Catherine E. Todhunter, Inês Barroso, Sheila Bingham, Timo T. Valle, Fredrik O. Vannberg, Diana Zelenika, Stephen Sawcer, Anneli Pouta, David M. Evans, Cuno S. P. M. Uiterwaal, Pilar Galan, Georg Homuth, Hannah Donovan, David J. Conway, Paul Elliott, Alessandra Allione, Paul E. de Jong, Miles Parkes, Amy Chaney, John C. Chambers, Toby Johnson, Isaac Subirana, Vesela Gateva, Cathryn M. Lewis, Christopher J. O'Donnell, Hana Lango, David Schlessinger, Mark J. Caulfield, Thorsten Reffelmann, Jamie Barbour, Karen L. Mohlke, Sarah E. Hunt, Thilo Winzer, Frances M K Williams, Christopher Mathew, I. Wallace, Anuj Goel, Jaakko Tuomilehto, Louise V. Wain, Gabriel Crawford, Samantha L. Hider, Detelinea Grozeva, Elaine K. Green, Paul D. Gilbert, Peter S. Braund, Jaume Marrugat, Rainer Rettig, Pim van der Harst, Yik Ying Teo, Andrew P. Morris, Guiseppe Matullo, Serena Sanna, Cristen J. Willer, Suzannah Bumpstead, Niall C. Taylor, Jacques S. Beckmann, Pierre Meneton, Elin Org, Luigi Ferrucci, Doug Easton, Sheila Seal, Joanne M. Heward, Anne U. Jackson, Eleftheria Zeggini, Rachel M. Freathy, Maris Laan, Paul Wordsworth, Sarah Nutland, Kerstin Koch, Sian Ceasar, Anders Hamsten, Judith M. Hussey, Tariq Ahmad, Derek P. Jewell, Paul Scheet, Charlie W. Lees, C Farrar, Christopher Prowse, Markku Laakso, David St Clair, Kate Downes, Diederick E. Grobbee, Paul Burton, Simon C. Potter, Ian N. Bruce, Tim D. Spector, Anne Barton, H.-Erich Wichmann, Matthew J. Simmonds, David Hadley, Cecilia M. Lindgren, Gérard Waeber, Nigel W. Rayner, Melanie J. Newport, Manjinder S. Sandhu, Audrey Duncanson, Guangju Zhai, Simon Heath, Susan M. Ring, Alessandra Di Gregorio, Richard Williamson, Nicholas J. Wareham, Zhan Su, Olle Melander, John R. Thompson, Alexander Teumer, Sheila A. Fisher, Lachlan J. M. Coin, Leif Groop, Giovanni Tognoni, Amanda Elkin, Alan J. Silman, Jack Satsangi, Jane Worthington, Martin Farrall, John Webster, Niall Cardin, Neil Walker, Anna F. Dominiczak, Jeremy D. Sanderson, Damjan Vukcevic, Bryan Howie, Silvia Polidoro, Stephen G. Ball, Mark Tremelling, Stephen Newhouse, Stephen M. Schwartz, Lori L. Bonnycastle, Chris Wallace, Kijoung Song, Mario A. Morken, I. Nicol Ferrier, Beverley Barke, Paolo Vineis, Manuela Uda, Deborah P M Symmons, Emily J. Lyons, Mingzhan Xue, Timothy M. Frayling, Stephen C.L. Cough, David Withers, Adrian V. S. Hill, Suzanne Stevens, Jennifer Jolley, Marcus Dörr, Kirk A. Rockett, David B. Dunger, Mark Walker, Jayne A. Franklyn, Lisa Jones, David S. Siscovick, Ann-Christine Syvänen, Laura J. Scott, Morris J. Brown, Barbera Cant, Michael Inouye, Feng Zhang, Carlotta Sacerdote, Katherine S. Elliott, Jonathan Marchini, Peter Donnely, Michael John Owen, An Goris, Marcus Prembey, Andrew T. Hattersley, Gerome Breen, Marian L. Hamshere, Thomas Illig, Samer S. Najjar, Nicole Soranzo, Kay-Tee Khaw, Graham R. Walters, Willem H. Ouwehand, David P. Strachan, Martin D. Tobin, Alastair Compston, John C. Mansfield, David Altshuler, Salvatore Panico, Sekar Kathiresan, Dawn M. Waterworth, Michael N. Weedon, D. Timothy Bishop, Claire Bryan, Alexandra S. Knight, Kate L. Lee, Paul F. O'Reilly, Massimo Mangino, Michael Conlon O'Donovan, Jing Hua Zhao, Konstantinos A. Papadakis, Jennifer H. Barrett, Joanne Pereira-Gale, N J Timpson, Stephan B. Felix, Panos Deloukas, Nicholas A. Watkins, Anna-Liisa Hartikainen, Peter Vollenweider, Richard Jones, Anne Hinks, Fraser Cummings, Noha Lim, Linda A. Bradbury, Rhian G. William, Nita G. Forouhi, Roberto Eluosa, Ingeleif B. Hallgrimsdottir, Giorgio Sirugo, Robert Luben, Veikko Salomaa, Robert Clarke, Sally John, Ursula Everson, Emma King, Ivan Nikolov, Heather M. Stringham, Antony P. Attwood, Angelo Scuteri, Wellcome Trust Case Control Consortium, Burton, PR., Clayton, DG., Cardon, LR., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, DP., McCarthy, MI., Ouwehand, WH., Samani, NJ., Todd, JA., Donnelly, P., Barrett, JC., Davison, D., Easton, D., Evans, D., Leung, HT., Marchini, JL., Morris, AP., Spencer, IC., Tobin, MD., Attwood, AP., Boorman, JP., Cant, B., Everson, U., Hussey, JM., Jolley, JD., Knight, AS., Koch, K., Meech, E., Nutland, S., Prowse, CV., Stevens, HE., Taylor, NC., Walters, GR., Walker, NM., Watkins, NA., Winzer, T., Jones, RW., McArdle, WL., Ring, SM., Strachan, DP., Pembrey, M., Breen, G., St Clair, D., Caesar, S., Gordon-Smith, K., Jones, L., Fraser, C., Green, EK., Grozeva, D., Hamshere, ML., Holmans, PA., Jones, IR., Kirov, G., Moskvina, V., Nikolov, I., O'Donovan, MC., Owen, MJ., Collier, DA., Elkin, A., Farmer, A., Williamson, R., McGuffin, P., Young, AH., Ferrier, IN., Ball, SG., Balmforth, AJ., Barrett, JH., Bishop, DT., Iles, MM., Maqbool, A., Yuldasheva, N., Hall, AS., Braund, PS., Dixon, RJ., Mangino, M., Stevens, S., Thompson, JR., Bredin, F., Tremelling, M., Parkes, M., Drummond, H., Lees, CW., Nimmo, ER., Satsangi, J., Fisher, SA., Forbes, A., Lewis, CM., Onnie, CM., Prescott, NJ., Sanderson, J., Mathew, CG., Barbour, J., Mohiuddin, MK., Todhunter, CE., Mansfield, JC., Ahmad, T., Cummings, FR., Jewell, DP., Webster, J., Brown, MJ., Lathrop, GM., Connell, J., Dominiczak, A., Braga Marcano, CA., Burke, B., Dobson, R., Gungadoo, J., Lee, KL., Munroe, PB., Newhouse, SJ., Onipinla, A., Wallace, I., Xue, M., Caulfield, M., Farrall, M., Barton, A., Bruce, IN., Donovan, H., Eyre, S., Gilbert, PD., Hider, SL., Hinks, AM., John, SL., Potter, C., Silman, AJ., Symmons, DP., Thomson, W., Worthington, J., Dunger, DB., Widmer, B., Frayling, TM., Freathy, RM., Lango, H., Perry, JR., Shields, BM., Weedon, MN., Hattersley, AT., Hitman, GA., Walker, M., Elliott, KS., Groves, CJ., Lindgren, CM., Rayner, NW., Timpson, NJ., Zeggini, E., Newport, M., Sirugo, G., Lyons, E., Vannberg, F., Hill, AV., Bradbury, LA., Farrar, C., Pointon, JJ., Wordsworth, P., Brown, MA., Franklyn, JA., Heward, JM., Simmonds, MJ., Gough, SC., Seal, S., Stratton, MR., Rahman, N., Ban, M., Goris, A., Sawcer, SJ., Compston, A., Conway, D., Jallow, M., Rockett, KA., Bryan, C., Bumpstead, SJ., Chaney, A., Downes, K., Ghori, J., Gwilliam, R., Hunt, SE., Inouye, M., Keniry, A., King, E., McGinnis, R., Potter, S., Ravindrarajah, R., Whittaker, P., Withers, D., Cardin, NJ., Ferreira, T., Pereira-Gale, J., Hallgrimsdóttir, IB., Howie, BN., Su, Z., Teo, YY., Vukcevic, D., Bentley, D., Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), and Medical Research Council (MRC)
- Subjects
Hemodynamics ,Genome-wide association study ,Blood Pressure ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Diastole ,11 Medical and Health Sciences ,POPULATION ,Genetics ,Genetics & Heredity ,RISK ,0303 health sciences ,education.field_of_study ,Econometric and Statistical Methods: General ,CELL-DIFFERENTIATION ,biology ,Intracellular Signaling Peptides and Proteins ,Chromosome Mapping ,Steroid 17-alpha-Hydroxylase ,COMMON VARIANTS ,3. Good health ,DNA-Binding Proteins ,Europe ,Cardiovascular Diseases ,PUBLIC-HEALTH ,BARTTERS-SYNDROME ,Blood Pressure/genetics ,Cardiovascular Diseases/genetics ,Cardiovascular Diseases/physiopathology ,Cytochrome P-450 CYP1A2/genetics ,DNA-Binding Proteins/genetics ,Diastole/genetics ,European Continental Ancestry Group/genetics ,Fibroblast Growth Factor 5/genetics ,Genetic Variation ,Genome-Wide Association Study ,Humans ,India ,Methylenetetrahydrofolate Reductase (NADPH2)/genetics ,Open Reading Frames/genetics ,Phospholipase C delta/genetics ,Polymorphism, Single Nucleotide ,Proteins/genetics ,Steroid 17-alpha-Hydroxylase/genetics ,Systole/genetics ,Wellcome Trust Case Control Consortium ,Life Sciences & Biomedicine ,hypertension ,Fibroblast Growth Factor 5 ,Systole ,Population ,European Continental Ancestry Group ,METHYLENETETRAHYDROFOLATE REDUCTASE GENE ,Single-nucleotide polymorphism ,LOW-RENIN HYPERTENSION ,White People ,Article ,03 medical and health sciences ,Open Reading Frames ,Fibroblast growth factor-5 ,Cytochrome P-450 CYP1A2 ,Geneeskunde(GENK) ,education ,Methylenetetrahydrofolate Reductase (NADPH2) ,Adaptor Proteins, Signal Transducing ,030304 developmental biology ,Genetic association ,genome-wide association ,Science & Technology ,MUTATIONS ,Proteins ,06 Biological Sciences ,POLYMORPHISM ,Blood pressure ,Methylenetetrahydrofolate reductase ,biology.protein ,biology.gene ,Phospholipase C delta ,Developmental Biology - Abstract
Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N ≤ 71,225 European ancestry, N ≤ 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N = 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2 (P = 1 × 10(-23)), FGF5 (P = 1 × 10(-21)), SH2B3 (P = 3 × 10(-18)), MTHFR (P = 2 × 10(-13)), c10orf107 (P = 1 × 10(-9)), ZNF652 (P = 5 × 10(-9)) and PLCD3 (P = 1 × 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.
- Published
- 2009
3. [Group counselling for the second trimester ultrasound: can group counselling be an alternative for individual counselling?]
- Author
-
Hinke, de Lau, Martine, Depmann, Yvo J M, Laeven, Philip H, Stoutenbeek, Lou R, Pistorius, Erik, van Beek, and Nico W E, Schuitemaker
- Subjects
Adult ,Counseling ,Health Knowledge, Attitudes, Practice ,Decision Making ,Age Factors ,Choice Behavior ,Ultrasonography, Prenatal ,Cohort Studies ,Parity ,Patient Satisfaction ,Pregnancy ,Risk Factors ,Pregnancy Trimester, Second ,Surveys and Questionnaires ,Humans ,Female ,Pregnant Women ,Prospective Studies - Abstract
To compare group counselling to individual counselling with respect to the second trimester ultrasound.A prospective cohort study at two hospitals.At one hospital, 100 pregnant women were counselled on the risks and benefits of the second trimester ultrasound in groups of up to 15 patients. Shortly before the ultrasound they were asked to fill out a questionnaire. Results were compared to 100 women who were counselled individually at another hospital. The primary outcome was the level of informed choice whether or not to undergo the ultrasound, defined as sufficient knowledge and a value-consistent decision. The secondary outcome measures were level of understanding of the second trimester ultrasound and the degree of satisfaction with the counselling.The resulting level of informed choice was 87.0% after group counselling compared to 79.4% after individual counselling (p = 0.47). The mean knowledge score was 8.8 for the women who attended group counselling; women who were individually counselled had a mean score of 7.4 (p0.001). Satisfaction with counselling was 7.0 for group counselling and 6.2 for individual counselling (p0.001).Although there was no statistically significant difference in the level of informed choice, group counselling was associated with higher post-counselling knowledge and satisfaction scores. Group counselling should therefore be considered as an alternative counselling method.
- Published
- 2013
4. The fetal profile line: a proposal for a sonographic reference line to classify forehead and mandible anomalies in the second and third trimester
- Author
-
Elisabeth A P, de Jong-Pleij, Lucia S M, Ribbert, Lou R, Pistorius, Ellen, Tromp, and Caterina M, Bilardo
- Subjects
Male ,Cross-Sectional Studies ,Pregnancy ,Pregnancy Trimester, Second ,Pregnancy Trimester, Third ,Humans ,Female ,Longitudinal Studies ,Reference Standards ,Ultrasonography, Prenatal ,Maxillofacial Abnormalities - Abstract
To test the fetal profile (FP) line, defined as the line that passes through the anterior border of the mandible and the nasion, as a reference line for forehead and mandible anomalies.Volumes of 248 normal and 24 pathological fetuses (16-36 and 19-37 weeks' gestation, respectively) were analysed retrospectively. When the FP line passes anteriorly, across or posteriorly to the frontal bone, this was defined as 'negative', 'zero' or 'positive', respectively. When the FP line was positive the distance (F distance) between the FP line and the frontal bone was measured.No cases with a negative FP line were found in the normal fetuses. Before 27 weeks' gestation the FP line was always 'zero' except in one case. After 27 weeks' gestation the FP line was 'positive' in up to 25% (F distance (mean, range): 2.8, 2.1-3.6 mm). The FP line correctly identified 13 cases with retrognathia, 5 cases with frontal bossing and 3 cases with a sloping forehead.Although large prospective studies are needed, the FP line may be a useful tool to detect second trimester profile anomalies such as retrognathia, sloping forehead and frontal bossing with the possibility of quantifying the latter.
- Published
- 2012
5. Functions of an Adult Sickle Cell Group: Education, Task Orientation, and Support
- Author
-
Lou R. Beltran and Dennis J. Butler
- Subjects
Adult ,Health Knowledge, Attitudes, Practice ,medicine.medical_specialty ,Health (social science) ,medicine.medical_treatment ,Pain ,Anemia, Sickle Cell ,Disease ,Support group ,Social support ,Patient Education as Topic ,Adaptation, Psychological ,Health care ,medicine ,Humans ,Psychiatry ,Physician-Patient Relations ,business.industry ,Mental Disorders ,Social Support ,Group education ,Middle Aged ,medicine.disease ,Sickle cell anemia ,Anxiety ,medicine.symptom ,business ,Psychosocial - Abstract
Although psychosocial concerns of patients with sickle cell disease have been described, these descriptions are based primarily on experience with adolescents and children. In addition, there is an absence of reports on sickle cell groups specifically designed for adult patients. This article reports on the development of an adult sickle cell support group and provides a description of the psychosocial factors most prevalent in patients' lives. Major adjustment difficulties for group members included increasing anxiety about death, the disruption of their social support network, disability, dependence on pain medication, and conflicts with health care providers. This community-based support group enhanced participants' knowledge about sickle cell disease, improved the physician-patient relationship, and helped resolve psychosocial adjustment problems.
- Published
- 1993
6. Canine retraction: A photoelastic study
- Author
-
Lou R. Baeten
- Subjects
Models, Anatomic ,Orthodontics ,Cuspid ,Tooth Movement Techniques ,Periodontal Membrane ,Equipment Design ,Root resorption ,medicine.disease ,Models, Biological ,Canine retraction ,Alveolar crest ,stomatognathic diseases ,Tooth root ,medicine.anatomical_structure ,Orthodontic Appliances ,stomatognathic system ,Human tooth ,medicine ,Humans ,Maxillary central incisor ,Stress, Mechanical ,Psychology ,General Dentistry ,Instant centre of rotation - Abstract
0 rthodontists have always been aware of the need for root control when a tooth is being moved through bone. I-3 However, of the early men, Case seemed to understand best the mechanics of root control, and he devised sophisticated appliances that attempted to shift coronally applied forces apically. He also denounced the many orthodontists who held the belief that a mysterious “developing force” rather than adequate mechanics would move the tooth roots into proper alignment with their crowns.” Physiologic implications of improper root control were drawn by Reitan” to increased root resorption and by Cianelly and Goldman6 to diminished vascular supply to the alveolar crest area. Sleichte? also linked tipping mechanics to increased hyalinization of the periodontal membrane, while Hixon and associates8 believed it to lead to possible blunting of the alveolar crest. In an effort to learn more concerning root control and force-distribution levels in the periodontal membrane during orthodontic force application, much research has been done with tooth-alveolar bone simulations or tooth models. Early investigators considered the tooth in its alveolus as a stick in wet plaster and attempted to draw meaningful conclusions pertaining to the human alveolus.g Later Schwartz,1o followed by Synge,ll set up mathematical models to determine a tooth’s axis of rotation. A mathematical model was also used by Burstone12 in an attempt to determine the center of resistance of a single-rooted tooth with a parabolic shape. This was followed by Jarabak and FizzelW mathematical explanations of tooth movement, about which they stated : “The ability to describe the mechanism of translation mathematically does not guarantee its feasibility.” Physical tooth models became more sophisticated, as seen by Zak’s14 tooth model utilizing photoelasticity for the first time in orthodontic research. Models of many other types were constructed and studied, but they all provided a very poor simulation of an actual human tooth in its alveolus with actual orthodontic appliances acting on it. IB-lR More recently, Davidian,lg with a computer model, found the theoretical center of rotation of a, maxillary central incisor to be be
- Published
- 1975
7. 16O(n, p)16N: a fast neutron detector for rapid tissue inhomogeneity correction
- Author
-
Ronald J. Watts, Lou R. Milavickas, and J.L. Beach
- Subjects
Nuclear reaction ,medicine.medical_treatment ,Biophysics ,Neutron scattering ,Radiation ,Biophysical Phenomena ,Bone and Bones ,Nuclear physics ,Fast Neutrons ,Radiotherapy, High-Energy ,medicine ,Neutron detection ,Humans ,Scattering, Radiation ,Neutron ,Radiometry ,Lung ,Fast neutron therapy ,Physics ,Neutrons ,Nitrogen Radioisotopes ,General Medicine ,Neutron temperature ,Neutron spectroscopy ,Oxygen ,Atomic physics - Abstract
We have devised a transit dose technique for fast neutron therapy treatment planning based on the 16O(n, p)16N reaction in recirculating water, and have determined the effect of simulated bone and lung inhomogeneities in phantom. An effective threshold of 10.2 MeV in the 16O(n, p) reaction is exploited to detect transmitted neutrons without the need detector collimation. This system has been demonstrated with 14 MeV (d, T) neutrons and with cyclotron produced p(42) + Be neutrons. 16N decays to the 6.13 MeV excited states of 16O in 7.14 s, allowing for easy identification by NaI(T1) and for rapid recirculation. The transmission of fast neutrons can thus be related to an effective thickness of soft tissue, providing a rapid and direct measure of the effects of inhomogeneities under actual treatment conditions, with the 10 MeV threshold providing a useful degree of insensitivity to multiply scattered neutrons. Equivalent thickness of compact bone and lung relative to water were found to be 1.4 and 0.34 respectively, closely resembling the effective thicknesses for Cobalt-60 gamma rays.
- Published
- 1981
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.