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1. Ancestral recipes: a mixed-methods analysis of MyPlate-based recipe dissemination for Latinos in rural communities.

Author

Cheney, Ann, McCarthy, William, Pozar, María, Reaves, Christina, Ortiz, Gabriela, Lopez, Diana, Saldivar, Perla, and Gelberg, Lillian

Subjects
Chronic disease, Community-based interventions, Diabetes, Latinx / indigenous Latin Americans, Low-income patients, MyPlate, Nutrition education, Purépecha community, Humans, Female, Adult, Middle Aged, Male, Rural Population, Diabetes Mellitus, Type 2, Hispanic or Latino, Food, Mental Processes
Abstract

BACKGROUND: The Latinx population experiences some of the highest rates of chronic disease, including obesity and type II diabetes. Such conditions may be especially burdensome in rural Latinx communities that often face barriers to accessing disease prevention resources and public health programs. METHODS: Diverse stakeholders (i.e., patients, community members, system of healthcare clinics, community food bank) tailored an existing cookbook, based on the U.S. Department of Agriculture MyPlate healthy eating and dietary guidelines, for local ingredients, health literacy, and language for rural Latinx and Indigenous Latin Americans. The cookbook recipes were disseminated widely via virtual cooking demonstrations, food distribution events, and social media. Pre- and posttest surveys were used to assess changes in diabetes knowledge measured by the 24-item American Diabetes Association Diabetic Knowledge Questionnaire and confidence in dietary behavior change over time measured by 4 questions of the 17-item Mediterranean Diet Index. A mixed effects, repeated measures analysis was conducted with gender ID, age range and educational attainment included as covariates and assessment interval as the predictor (pretest vs posttest) and change in confidence about adhering to four specific components of the Mediterranean diet. Focus groups elicited information on participants motivation and ability to use the recipes and eat healthy foods following the virtual cooking demonstration participation. RESULTS: A total of 20 virtual cooking demonstrations were conducted and 60 participants completed a pretest survey and 54 a posttest survey, a subsample (n = 19) participated in one of three focus groups. Most participants were female, identified as Latinx/Hispanic, were between the ages of 40-49, and spoke Spanish. 17% identified as Indigenous Latin American specifically as Purépecha, an indigenous group from Michoacán, Mexico. Survey and focus group findings indicated at posttest an increase in diabetes knowledge among participants with no prior diagnosis of chronic health conditions and more confidence in limiting sugary beverages and refined wheat pasta/white rice among indigenous participants. Focus group discussions explicated the quantitative findings. CONCLUSION: This study brought together patients and key stakeholders committed to addressing the social determinants of health and it mobilized the community to develop culturally vetted health education materials. The findings indicate the need for increased access to evidence-based nutrition education and to culturally appropriate food products that can be easily incorporated into daily food preparation.

Published
2023

2. CRISPR–Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells

Author

Lin-Shiao, Enrique, Pfeifer, Wolfgang G, Shy, Brian R, Saffari Doost, Mohammad, Chen, Evelyn, Vykunta, Vivasvan S, Hamilton, Jennifer R, Stahl, Elizabeth C, Lopez, Diana M, Sandoval Espinoza, Cindy R, Deyanov, Alexander E, Lew, Rachel J, Poirer, Michael G, Marson, Alexander, Castro, Carlos E, and Doudna, Jennifer A

Subjects
Biological Sciences, Biotechnology, Genetics, Nanotechnology, Bioengineering, Human Genome, Gene Therapy, Underpinning research, 1.1 Normal biological development and functioning, Generic health relevance, Active Transport, Cell Nucleus, CRISPR-Cas Systems, DNA, Gene Editing, Gene Transfer Techniques, Genome, Humans, Nanostructures, Environmental Sciences, Information and Computing Sciences, Developmental Biology, Biological sciences, Chemical sciences, Environmental sciences
Abstract

DNA nanostructures are a promising tool to deliver molecular payloads to cells. DNA origami structures, where long single-stranded DNA is folded into a compact nanostructure, present an attractive approach to package genes; however, effective delivery of genetic material into cell nuclei has remained a critical challenge. Here, we describe the use of DNA nanostructures encoding an intact human gene and a fluorescent protein encoding gene as compact templates for gene integration by CRISPR-mediated homology-directed repair (HDR). Our design includes CRISPR-Cas9 ribonucleoprotein binding sites on DNA nanostructures to increase shuttling into the nucleus. We demonstrate efficient shuttling and genomic integration of DNA nanostructures using transfection and electroporation. These nanostructured templates display lower toxicity and higher insertion efficiency compared to unstructured double-stranded DNA templates in human primary cells. Furthermore, our study validates virus-like particles as an efficient method of DNA nanostructure delivery, opening the possibility of delivering nanostructures in vivo to specific cell types. Together, these results provide new approaches to gene delivery with DNA nanostructures and establish their use as HDR templates, exploiting both their design features and their ability to encode genetic information. This work also opens a door to translate other DNA nanodevice functions, such as biosensing, into cell nuclei.

Published
2022

3. A posteriori dietary patterns better explain variations of the gut microbiome than individual markers in the American Gut Project

Author

Cotillard, Aurélie, Cartier-Meheust, Agnès, Litwin, Nicole S, Chaumont, Soline, Saccareau, Mathilde, Lejzerowicz, Franck, Tap, Julien, Koutnikova, Hana, Lopez, Diana Gutierrez, McDonald, Daniel, Song, Se Jin, Knight, Rob, Derrien, Muriel, and Veiga, Patrick

Subjects
Complementary and Integrative Health, Nutrition, Prevention, Oral and gastrointestinal, Adult, Diet, Diet Surveys, Diet, Healthy, Feces, Female, Gastrointestinal Microbiome, Humans, Male, Nutritional Physiological Phenomena, RNA, Ribosomal, 16S, United States, dietary patterns, gut microbiome, alpha diversity, beta diversity, American Gut Project, cohort study, food frequency questionnaire, Healthy Eating Index, 16S rRNA gene sequencing, Engineering, Medical and Health Sciences, Nutrition & Dietetics
Abstract

BackgroundIndividual diet components and specific dietary regimens have been shown to impact the gut microbiome.ObjectivesHere, we explored the contribution of long-term diet by searching for dietary patterns that would best associate with the gut microbiome in a population-based cohort.MethodsUsing a priori and a posteriori approaches, we constructed dietary patterns from an FFQ completed by 1800 adults in the American Gut Project. Dietary patterns were defined as groups of participants or combinations of food variables (factors) driven by criteria ranging from individual nutrients to overall diet. We associated these patterns with 16S ribosomal RNA-based gut microbiome data for a subset of 744 participants.ResultsCompared to individual features (e.g., fiber and protein), or to factors representing a reduced number of dietary features, 5 a posteriori dietary patterns based on food groups were best associated with gut microbiome beta diversity (P ≤ 0.0002). Two patterns followed Prudent-like diets-Plant-Based and Flexitarian-and exhibited the highest Healthy Eating Index 2010 (HEI-2010) scores. Two other patterns presented Western-like diets with a gradient in HEI-2010 scores. A fifth pattern consisted mostly of participants following an Exclusion diet (e.g., low carbohydrate). Notably, gut microbiome alpha diversity was significantly lower in the most Western pattern compared to the Flexitarian pattern (P ≤ 0.009), and the Exclusion diet pattern was associated with low relative abundance of Bifidobacterium (P ≤ 1.2 × 10-7), which was better explained by diet than health status.ConclusionsWe demonstrated that global-diet a posteriori patterns were more associated with gut microbiome variations than individual dietary features among adults in the United States. These results confirm that evaluating diet as a whole is important when studying the gut microbiome. It will also facilitate the design of more personalized dietary strategies in general populations.

Published
2022

4. Apremilast for immune checkpoint inhibitor-induced psoriasis: A case series

Author

Espinosa Arranz Enrique, Ander Mayor Ibarguren, Custodio Ana, Peiteado Lopez Diana, and Herranz Pinto Pedro

Subjects
PGA, physician's global assessment, medicine.medical_specialty, pSA, psoriatic arthritis, ICI, immune checkpoint inhibitor, BSA, body surface area, apremilast, Ipilimumab, Pembrolizumab, Dermatology, supportive dermato-oncology, PDE-4 inhibitors, Acitretin, PD-1, programmed cell death protein 1, immune checkpoint inhibitors, Psoriatic arthritis, Antineoplastic Agents, Immunological, Psoriasis, medicine, Maculopapular rash, Humans, Case Series, irAE, immune-related adverse events, PDL-1, programmed death-ligand 1, anti-pd1, nivolumab, business.industry, PASI, psoriasis area severity index, psoriasis, immune-induced psoriasis, medicine.disease, RL1-803, PFS, progression free survival, immune-related adverse events, Apremilast, medicine.symptom, Nivolumab, business, medicine.drug
Abstract

Immune checkpoint inhibitors (ICI) such as anti-programmed cell death protein 1 (PD-1) or anti-programmed death-ligand 1 (PDL-1) antibodies represent a breakthrough in the treatment of advanced neoplasms such as melanoma, lung, or renal cancer. The therapeutic use of these agents is rapidly growing in both active as well as adjuvant settings. Anti-PD-1 agents such as pembrolizumab or nivolumab target PD-1 present on the surface of T cells and other immune cells, enhancing the antitumoral response. Although they offer a better safety profile than anti-CTLA-4 antibodies such as ipilimumab, immune-related adverse events (irAE) still have an important impact on morbidity during treatment. Gastrointestinal and skin irAE are the most frequent adverse events associated with their use and tend to occur early in treatment. Maculopapular rash and lichenoid dermatitis are among the most common skin irAE, affecting approximately 3%-20% of the patients. Most of these reactions are mild and are easily managed with topical corticosteroids, rendering immunotherapy withdrawal unnecessary. Psoriasis might also be exacerbated or present as de novo, both with nivolumab or pembrolizumab, although the exact incidence rate has not been established. This immune-related psoriasis has also been observed during ipilimumab therapy, but its severity has not been defined according to clinical scales such as the psoriasis area severity index (PASI), body surface area (BSA), or physician's global assessment (PGA). Most published series report mild cases with a good outcome after treatment with topical steroids, ultraviolet B phototherapy, or acitretin. Here, we describe 3 patients with moderate to severe psoriasis related to nivolumab treatment, with a favorable response to apremilast and no impairment of antitumoral efficacy.

Published
2021

5. Outcome of 1890 tracheostomies for critical COVID-19 patients: a national cohort study in Spain

Author

Martin-Villares, Cristina, Perez Molina-Ramirez, Carmen, Bartolome-Benito, Margarita, Bernal-Sprekelsen, Manuel, Perez-Fernandez, Aranzazu, Alcantara-Armenteros, Sara, Monjas-Cánovas, Irene, Sancho-Mestre, Manuela, Alemán-Lopez, Oscar, Deola-Trasserra, M Dolors, Villarraga-Cova, Vanessa, Carreras-Alcaraz, Azor, Montaner-Sala, Esther, Sota-Eguizabal, Esther, Tolosa, Aihnoa, De la Iglesia, Belen, Garcia-Sardon, Rafael, Diez, Laura, Lehrer, Eduardo, Aviles-Jurado, Francisco Xavier, Tudela-Cabello, Kiara, Huguet-Llull, Gabriel, Mesalles-Ruíz, Marta, Jimenez-Montoya, Ramon, Navazo-Eguïa, Ana, Galindo-Torres, Blanca, Fernandez-Pello, Marta, Rodriguez-Prado, Nuria, Salazar, Carmen, Ramos, Francisco, Amor-Dorado, Juan Carlos, Faubel-Serra, Marta, Nuñez-Carrasco, Valery, Agüero-Medina, Adriana, Carlos-Villatoro, Juan, Lopez-Diu, Roser, Gonzalez-Melgan, Selvyn, Uzcanga-Lacabe, María, Cardier-Suárez, Marisela, Úbeda-Fernández, Esther, Alañon-Fernández, Miguel Ángel, Sanchez-Herrero, Carlos, Municio-Martin, Jose Antonio, Pascua-Gomez, Luis, Andrino-Martin, Sergio, Ayala-Mejias, Sandra, Molina-Gil, Bárbara, De Abajo-Larriba, Jorge, Piñeiro-Aguín, Zenaida, Gil-Carcedo, Elisa, Herrero-Agustín, Javier, Freijanes-Otero, Jorge, Cuetos-Azcona, Mario, Garcia-Fernandez, Alfredo, Jimenez-Huerta, Ignacio, Babarro-Fernández, Rosa, Junjgohann-Jofre, Felipe, Martel-Lopez, Antonio, Martin-Sanchez, Maria Dolores, Benitez-del Rosario, Jesus, Luorido, Diana, Granda, Monica, Tejeda, Jose Miguel, Martinez Ruiz-Coello, Antonio, Almodovar-Iniesta, Antonio, Bonnin, Jesus, Chao-Vietes, Jacobo, Hernández-Garcia, Estefanía, Plaza, Guillermo, Villacampa-Auba, Jose Miguel, Campos-Gonzalez, Alfonso, Casqueiro, Jose Carlos, Baguena-Campos, Lucia, Encinas-Vicente, Alberto, Rubio-Yanguas, Raul, Lowy-Benoliel, Alejandro, Poletti-Serafini, Daniel, Pasamontes-Pingarron, Juan Antonio, Aristegui-Ruiz, Miguel, Hernando-Cuñado, Monica, Souviron-Encabo, Rosalia, Martinez-Guirado, Tomas, Fernandez-Fernandez, Mario, Gonzalez-Orus, Ricardo, Molina-Montes, Beatriz, De la Fuente-Hernandez, Raquel, Crovato-Rojas, Jesús, Ruminot, Cristian, Laguado, Daniella, Acosta, Hander, Hernández-Garcia, María José, Zuaza-Gonzalez, Alejandro, Domingo-Carrasco, Carlos, Valor-García, Cristina, Lopez-Martin, Javier, Mogollon-Cano, Tomas, Meler-Claramonte, Carla, Flores-Martín, Juan Carlos, Arzok del Toro, Juanjo, Garcia-Piñero, Alfonso, Muñoz-Fernandez, Noelia, del Palacio, Antonio, Mateos-Serrano, Blanca, Garcia-Lopez, Isabel, Rodrigañez-Riesco, Laura, Aragon, Paula, Rivera, Teresa, Eisenberg-Plaza, Gustavo, Fernandez-Robledo, Inmaculada, Prada-Pendolero, Jorge, Alvarez-Alvarez, Ignacio, Puente-Verez, Maria, Quintana-Sanjuas, Ana, Parente-Arias, Pablo, García-Cordoba, Francisco, Garcia-Purriños, Francisco Jose, Morales-Angulo, Carmelo, Rodriguez-Rondon, Simara, Lopez-Lopez, Diana, Fernandez-Liesa, Rafael, Lázaro-Sánchez, Amaya, Alonso-Alonso, I, Rusiecka, Michalina, Ramirez, Rosa Delia, Vila, Javier, Bellmunt-Fontanet, Angela, Montoro-Martinez, Victoria, Piqueras, Francisco, Novoa-Morales, Vania, Simonetti, Gabriela, Guillen-Lozada, Enrique, Velasco, Maria Jesus, Alonso-Castiñeira, Ignacio, Hernandez, Maria, Rovira-Ramos, Carlota, Diaz-Argüello, Juan Jose, Escamilla-Carpintero, Yolanda, Torrico-Roman, Pablo, Calvo-Navarro, Carlos, Viza-Puiggros, Ignacio, Vaduva, Cristina, Higuera-Lucas, Juan, Tato, Jose Ignacio, Rivera-Rodriguez, Teresa, Rodriguez-Contreras, Diego, Caravaca-Garcia, Antonio, Ayala, Alejandra, Morales-Puebla, José Manuel, Ruiz-Escudero, Carlos, Lozano-Reina, E, Maza-Solano, Juan Manuel, Alfaro-Garcia, Jorge, Sanchez, Fatima, Montes-Jovellar, Luordes, Medina, Mar, Barbera, Rafael, Marco-Garrido, Alfonso, Cremades-Navalon, Isabel, García-Callejo, Javier, Bastida, C Garcia, Gutierrez-Fonseca, Raimundo, Muñoz-Herrera, Angel, Calvo, Marta, Rosal-Fraga, Carmen, Iglesias-Moreno, Mari Cruz, Gimeno-Hernández, Jesus, Vázquez-Romero, Cristina A, Alzate-Amaya, Fabian, Palomino, Laura, Alcaraz, Marta, Romeu-Figuerola, Coia, Foglia-Fernandez, Maria, Dios-Loureiro, Cristina, Gonzalez-Guijarro, Isabel, Vera-Llao, Rafael, Sancho-Calvo, Rosa, Ramos-Fernandez, Jesus Jose, Lasso-delaVega, Mar, Martinez-Pascual, Paula, Dominguez-Ovejas, Silvia, Morera-Senra, Eduardo, Alba-Mesquida, Jacoba, Bonilla, Alfonso, Martinez-Subias, Javier, Martinez-Salazar, Jesus M, Martinez-Lapeña, Antonio, Corrales-Millan, Rocio, Ruiz, Rosario, Mata, Nieves, Espinosa, Alfredo, Cianci-Jaimes, Laura Gerarda, Zapater-Latorre, Enrique, Alba-Garcia, Jose Ramon, Oishi-Konari, Miriam Natsuki, Pallares-Marti, Beatriz, Rubio-Fernandez, Andrea, Santos-Pérez, Jaime, Idigora-Planas, Albert, Sanchez-Barrueco, Alvaro, Alcala-Rueda, Ignacio, Jara-Rubio, Ruben, Lozano, Estefanía, Tirado-Zamora, Isabel, Coscaron-Blanco, Enrique, Suarez-Ortega, Soledad, Gil-Grasa, Guillermo, Lavilla-Martin de Valmaseda, Maria Jose, Sebastian, Jose Miguel, Nijim, Hazem, Dominguez-Calvo, Jesus, Gonzalez-Gimeno, Maria Jose, Carvajal-Urueña, Ana, Anel, Luis, and Gonzalo-Orden, Manuel

Subjects
medicine.medical_specialty, Percutaneous, medicine.medical_treatment, law.invention, Cohort Studies, 03 medical and health sciences, Tracheostomy, Mechanical ventilation, 0302 clinical medicine, law, medicine, Humans, Weaning, Intensive care unit, 030223 otorhinolaryngology, Retrospective Studies, SARS-CoV-2, business.industry, General surgery, COVID-19, General Medicine, Respiration, Artificial, Otorhinolaryngology, Spain, 030220 oncology & carcinogenesis, Cohort, Observational study, Neurosurgery, business, Head and Neck
Abstract

Background The question of an optimal strategy and outcomes in COVID-19 tracheostomy has not been answered yet. The critical focus in our case study is to evaluate the outcomes of tracheostomy on intubated COVID-19 patients. Methods A multicentric prospective observational study of 1890 COVID-19 patients undergoing tracheostomy across 120 hospitals was conducted over 7 weeks in Spain (March 28 to May 15, 2020). Data were collected with an innovative approach: instant messaging via WhatsApp. Outcome measurements: complications, achieved weaning and decannulation and survival. Results We performed 1,461 surgical (81.3%) and 429 percutaneous tracheostomies. Median timing of tracheostomy was 12 days (4–42 days) since orotracheal intubation. A close follow-up of 1616/1890 (85.5%) patients at the cut-off time of 1-month follow-up showed that in 842 (52.1%) patients, weaning was achieved, while 391 (24.2%) were still under mechanical ventilation and 383 (23.7%) patients had died from COVID-19. Decannulation among those in whom weaning was successful (n = 842) was achieved in 683 (81%) patients. Conclusion To the best of our knowledge, this is the largest cohort of COVID-19 patients undergoing tracheostomy. The critical focus is the unprecedented amount of tracheostomies: 1890 in 7 weeks. Weaning could be achieved in over half of the patients with follow-up. Almost one out of four tracheotomized patients died from COVID-19.

Published
2020

6. Risk of contagion of SARS-CoV-2 among otorhinolaryngologists in Spain during the 'Two waves'

Author

Martin-Villares, Cristina, Bernal-Sprekelsen, Manuel, Molina-Ramirez, Carmen Perez, Bartolome-Benito, Margarita, Aristegui-Ruiz, M., Agüero-Medina, Adriana, Tolosa, Aihnoa, Maturana, Aitor Zabala-Lopezde, Idigora-Planas, Albert, Codina-Aroca, Alberto, Encinas-Vicente, Alberto, Sanchez-Tudela, Alberto, Ayala, Alejandra, Lowy-Benoliel, Alejandro, Zuaza-Gonzalez, Alejandro, Bonilla-Perez, Alfonso, Campos-Gonzalez, Alfonso, Garcia-Piñero, Alfonso, Marco-Garrido, Alfonso, Garcia-Fernandez, Alfredo, Trinidad, Almudena, Sanchez-Barrueco, Alvaro, Lázaro-Sánchez, Amaya, Piñeiro, Z, Navazo-Eguïa, Ana, Quintana-Sanjuas, Ana, Rubio-Fernandez, Andrea, Moreno-Juara, Angel, Muñoz-Herrera, Angel, Bellmunt-Fontanet, Angela, Almodovar-Iniesta, Antonio, Caravaca-Garcia, Antonio, del Palacio, Antonio, Martel-Lopez, Antonio, Martinez-Lapeña, Antonio, MartinezRuiz-Coello, Antonio, Perez-Fernandez, Aranzazu, Carreras-Alcaraz, Azor, Molina-Gil, Bárbara, Molina-Montes, Beatriz, Pallares-Marti, Beatriz, De la Iglesia, Belen, Galindo-Torres, Blanca, Mateos-Serrano, Blanca, Garcia-Bastida, C., Meler-Claramonte, Carla, Calvo-Navarro, Carlos, Domingo-Carrasco, Carlos, Escobar-Sanchez, Carlos, Sanchez-Herrero, Carlos, Rovira-Ramos, Carlota, Morales-Angulo, Carmelo, Rosal-Fraga, Carmen, Salazar, Carmen, Orus, Cesar, Romeu-Figuerola, Coia, Ruminot, Cristian, Vázquez-Romero, Cristina A., Dios-Loureiro, Cristina, Valor-García, Cristina, Poletti-Serafini, Daniel, Laguado, Daniella, Lopez-Lopez, Diana, Luorido, Diana, Rodriguez-Contreras, Diego, Morera-Serna, Eduardo, Gil-Carcedo, Elisa, Coscaron-Blanco, Enrique, Guillén-Lozada, Enrique, Zapater-Latorre, Enrique, Hernández-Garcia, Estefanía, Lozano, Estefanía, Montane-Sala, Esther, Sota-Eguizabal, Esther, Úbeda-Fernández, Esther, Alzate-Amaya, Fabian, Sanchez-Fernandez, Fatima, Junjgohann-Jofre, Felipe, García-Cordoba, Francisco, Garcia-Purriños, Francisco Jose, Ramos, Francisco, Huguet-Llull, Gabriel, Simonetti, Gabriela, Gil-Grasa, Guillermo, Plaza, Guillermo, Eisenberg-Plaza, Gustavo, Acosta, Hander, Alonso-Alonso, I., Alcala-Rueda, Ignacio, Alvarez-Alvarez, Ignacio, Jimenez-Huerta, Ignacio, Viza-Puiggros, Ignacio, Clemente, Ignacio, Fernandez-Robledo, Inmaculada, Monjas-Cánovas, Irene, Castillo-Lopez, Irma Yolanda, Cremades-Navalon, Isabel, Garcia-Lopez, Isabel, Gonzalez-Guijarro, Isabel, Tirado-Zamora, Isabel, Alba-Mesquida, Jacoba, Chao-Vietes, Jacobo, Santos-Pérez, Jaime, García, Javier, Herrero-Agustín, Javier, Lopez-Martin, Javier, Martinez-Subias, Javier, Vila, Javier, Rosario, Jesus Benitez-del, Crovato-Rojas, Jesús, Gimeno-Hernández, Jesus, Dominguez-Calvo, Jesus Ignacio, Ramos-Fernandez, Jesus Jose, Martinez-Salazar, Jesus M., Alfaro-Garcia, Jorge, De Abajo-Larriba, Jorge, Freijanes-Otero, Jorge, Prada-Pendolero, Jorge, Municio-Martin, Jose Antonio, Casqueiro, Jose Carlos, Tato, Jose Ignacio, Sebastian, Jose Miguel, Tejeda, Jose Miguel, Villacampa-Auba, Jose Miguel, Morales, JManuel, Alba-Garcia, Jose Ramon, Dalmau, Josep, Pasamontes-Pingarron, Juan Antonio, Amor-Dorado, Juan Carlos, Flores-Martín, Juan Carlos, Carlos-Villatoro, Juan, Higuera-Lucas, Juan, Toro, Juan Jose Artazkoz-del, Diaz-Argüello, Juan Jose, Tudela-Cabello, Kiara, Rubio-Yanguas, L., Cianci-Jaimes, Laura Gerarda, Palomino, Laura, Rodrigañez-Riesco, Laura, Montes-Jovellar, Lourdes, Baguena-Campos, Lucia, Pascua-Gomez, Luis, Deola-Trasserra, MDolors, Cueva-Díaz, Jenifer, Sancho-Mestre, Manuela, Lasso-delaVega, Mar, Medina, Mar, Iglesias-Moreno, Mari Cruz, Martin-Sanchez, Maria Dolores, Foglia-Fernandez, María, Velasco, Maria Jesus, Jesús-Dominguez, Maria, Hernández-Garcia, María José, de Valmaseda, Maria Jose Lavilla-Martin, Gonzalez-Gimeno, Maria José, Puente-Verez, Maria, Uzcanga-Lacabe, María, Cuetos-Azcona, Mario, Fernandez-Fernandez, Mario, Vazquez, Mariano Andres, Cardier-Suárez, Marisela, Alcaraz, Marta, Calvo, Marta, Estévez, M., Faubel-Serra, Marta, Fernandez-Pello, Marta, Mesalles-Ruíz, Marta, Rusiecka, Michalina, Alañon-Fernández, Miguel Ángel, Oishi-Konari, Miriam Natsuki, Granda, Monica, Hernando-Cuñado, Monica, Muñoz-Fernandez, Noelia, Rodriguez-Prado, Nuria, Alemán-Lopez, Oscar, Parente-Arias, Pablo, Torrico-Roman, Pablo, Aragon, Paula, Martinez-Pascual, Paula, Barbera, Rafael, Fernandez-Liesa, Rafael, Garcia-Sardon, Rafael, Gutierrez-Fonseca, Raimundo, Jimenez-Montoya, Ramon, De la Fuente-Hernandez, Raquel, Raquelortiz-Rodrigo, Gonzalez-Orus, Ricardo, Corrales-Millan, Rocio, Ramirez, Rosa Delia, Fernandez, Rosa Babarro, Sancho-Calvo, Rosa, Souviron-Encabo, Rosalia, Almela-Cortes, Rosana, Ruiz-Gomez, Rosario, Lopez-Diu, Roser, Jara-Rubio, Ruben, Alcantara-Armenteros, Sara, Tamboura, Sara, Santos-Santos, Saturnino, Gonzalez-Melgan, Selvyn, Andrino-Martin, Sergio, Dominguez-Ovejas, Silvia, Rodriguez-Rondon, Simara, Suarez-Ortega, Soledad, Rivera, Teresa, Rivera-Rodriguez, Teresa, Martinez-Guirado, Tomas, Mogollon-Cano, Tomas, Nuñez-Carrasco, Valery, Villarraga-Cova, Vanessa, Montoro-Martinez, Victoria, and Escamilla-Carpintero, Yolanda

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Short Communication, Population, Communicable diseases, 03 medical and health sciences, Otolaryngology, 0302 clinical medicine, Otorrinolaringologia, Pandemic, Otolaryngologists, medicine, Mortalitat, Humans, Mortality, 030223 otorhinolaryngology, education, Pandemics, education.field_of_study, business.industry, SARS-CoV-2, COVID-19, General Medicine, Malalties infeccioses, medicine.disease, Pneumonia, Morbiditat, Otorhinolaryngology, Spain, 030220 oncology & carcinogenesis, Emergency medicine, Cohort, Observational study, Morbidity, business
Abstract

Introduction The aim of our study was to obtain data about the contagion rate among Otolaryngologists in Spanish ENT Departments and about the clinical outcomes in positive otolaryngologists. As a secondary objective, we aim to assess the rate of contagion in the first and the second Covid-19 wave in Spain among Otorhinolaryngologists and the regional distribution by ENT-Departments. Methods Study design and population: This is a prospective observational study in a cohort of 975 Otolaryngologists from 87 ENT Departments conducted from March 25 to November 17 in our collaborative group, COVID ORL ESP. COVID‐19 polymerase chain reaction (PCR) was the diagnostic standard. Hospitalization and/or intensive care admission and mortality was recorded as non-identified data. Results Data collected from 975 otolaryngologist from 87 Departments resulted in 157 (16.5%) otolaryngologists testing positive for SARS-CoV-19 by RT-PCR. Important geographic differences in contagion are reported. A total of 136 (86.6%) otolaryngologists were tested positive during the first wave and 21 (13.3%) during the second wave. At the last cut-off point of the study only 30/87 ENT Departments (34.5%) remained COVID19-free and 5 Departments reported more than 50% staff members testing positive. The majority of positive tested otolaryngologists (126/157; 80.2%) had only mild or no symptoms, 17 developed moderate symptoms (10.8%) and 3 had pneumonia not requiring hospitalization (2%). Five colleagues were admitted at hospital, 4 required ICU (2.5%) and 2 colleges died from COVID-19. Conclusions During the first wave of the SARS-CoV-19 pandemic otolaryngologists in Spain have been overall the group suffering the highest rate of contagion, particularly during the first month. Subsequently, the Spanish Ministry of Health should include otorhinolaryngologists as a high-risk group in airborne pandemics.

Published
2021

7. Patients’ Perceptions of Colorectal Cancer Screening Tests and Preparatory Education in Federally Qualified Health Centers1

Author

Gwede, Clement K., Koskan, Alexis M., Quinn, Gwendolyn P., Davis, Stacy N., Ealey, Jamila, Abdulla, Rania, Vadaparampil, Susan T., Elliott, Gloria, Lopez, Diana, Shibata, David, Roetzheim, Richard G., and Meade, Cathy D.

Subjects
Male, Health Knowledge, Attitudes, Practice, Federal Government, Colonoscopy, Community Health Centers, Middle Aged, Article, United States, Patient Education as Topic, Occult Blood, Surveys and Questionnaires, Humans, Patient Compliance, Female, Practice Patterns, Physicians', Colorectal Neoplasms, Early Detection of Cancer, Aged, Follow-Up Studies
Abstract

This study explored federally qualified health center (FQHC) patients' perceptions about colorectal cancer screening (CRCS) tests, including immunochemical fecal occult blood tests (iFOBT), as well as preferences for receiving in-clinic education about CRCS. Eight mixed gender focus groups were conducted with 53 patients. Findings centered on three thematic factors: (1) motivators and impediments to CRCS, (2) test-specific preferences and receptivity to iFOBTs, and (3) preferences for entertaining and engaging plain language materials. Results informed the development of educational priming materials to increase CRCS using iFOBT in FQHCs.

Published
2015

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