Search

Your search keyword '"Laura, Mastrangelo"' showing total 13 results
Start Over Author "Laura, Mastrangelo" Topic humans
13 results on '"Laura, Mastrangelo"'

1. Feasibility and outcome of spleen and vessel preserving total pancreatectomy (SVPTP) in pancreatic malignancies — a retrospective cohort study

Author

Christian, Beltzer, Elio, Jovine, Konstantin-Viktor, Hesch, Derna, Stifini, Laura, Mastrangelo, Marco, Huth, Alfred, Königsrainer, and Silvio, Nadalin

Subjects
Pancreatic Neoplasms, Pancreatic Fistula, Pancreatectomy, Postoperative Complications, Treatment Outcome, Humans, Feasibility Studies, Laparoscopy, Surgery, Adenocarcinoma, Spleen, Retrospective Studies
Abstract

Introduction Total pancreatectomy (TP) is most commonly performed to avoid postoperative pancreatic fistula (POPF) in patients with high-risk pancreas or to achieve tumor-free resection margins. As part of TP, a simultaneous splenectomy is usually performed primarily for the reason of oncologic radicality. However, the benefit of a simultaneous splenectomy remains unclear. Likewise, the technical feasibility as well as the safety of spleen and vessel preserving total pancreatectomy in pancreatic malignancies has hardly been evaluated. Thus, the aims of the study were to evaluate the feasibility as well as the results of spleen and vessel preserving total pancreatectomy (SVPTP). Material and methods Patient characteristics, technical feasibility, perioperative data, morbidity, and mortality as well as histopathological results after SVPTP, mainly for pancreatic malignancies, from patient cohorts of two European high-volume-centers for pancreatic surgery were retrospectively analyzed. Mortality was set as the primary outcome and morbidity (complications according to Clavien-Dindo) as the secondary outcome. Results A SVPTP was performed in 92 patients, predominantly with pancreatic adenocarcinoma (78.3%). In all cases, the splenic vessels could be preserved. In 59 patients, the decision to total pancreatectomy was made intraoperatively. Among these, the most common reason for total pancreatectomy was risk of POPF (78%). The 30-day mortality was 2.2%. Major complications (≥ IIIb according to Clavien-Dindo) occurred in 18.5% within 30 postoperative days. There were no complications directly related to the spleen and vascular preservation procedure. A tumor-negative resection margin was achieved in 71.8%. Conclusion We could demonstrate the technical feasibility and safety of SVPTP even in patients mainly with pancreatic malignancies. In addition to potential immunologic and oncologic advantages, we believe a major benefit of this procedure is preservation of gastric venous outflow. We consider SVPTP to be indicated in patients at high risk for POPF, in patients with multilocular IPMN, and in cases for extended intrapancreatic cancers.

Published
2022
Full Text
View/download PDF

2. coMpliAnce with evideNce-based cliniCal guidelines in the managemenT of acute biliaRy pancreAtitis): The MANCTRA-1 international audit

Author

Mauro Podda, Daniela Pacella, Gianluca Pellino, Federico Coccolini, Alessio Giordano, Salomone Di Saverio, Francesco Pata, Benedetto Ielpo, Francesco Virdis, Dimitrios Damaskos, Belinda De Simone, Ferdinando Agresta, Massimo Sartelli, Ari Leppaniemi, Cristiana Riboni, Vanni Agnoletti, Damian Mole, Yoram Kluger, Fausto Catena, Adolfo Pisanu, Chiara Gerardi, Salomone di Saverio, Dimitris Damaskos, Stavros Gourgiotis, Gaetano Poillucci, Kumar Jayant, Luca Ferrario, Mikel Prieto Calvo, Michael Wilson, Fiammetta Soggiu, Alaa Hamdan, Carlos Augusto Gomes, Gustavo Fraga, Argyrios Ioannidis, Zaza Demetrashvili, Saaz Sahani, Lovenish Bains, Almu'atasim Khamees, Hazim Ababneh, Osama Aljaiuossi, Samuel Pimentel, Ikhwan Sani Mohamad, Ahmad Ramzi Yusoff, Narcis Octavian Zarnescu, Valentin Calu, Andrey Litvin, Dusan Lesko, Ahmed Elmehrath, Mohamedraed Elshami, Martin de Santibañes, Justin Gundara, Kamel Alawadhi, Rashid Lui, Alexander Julianov, Sergio Ralon, Ibrahim-Umar Garzali, Gustavo M. Machain, Darwin Artidoro Quispe-Cruz, Abigail Cheska C. Orantia, Maciej Walędziak, Tiago Correia de Sá, Syed Muhammad Ali, Bojan Kovacevic, Colin Noel, Haidar M. Abdalah, Ali Kchaou, Arda Isik, Luca Ansaloni, Walter Biffl, Mario Guerrieri, Alberto Sartori, Manuel Abradelo, Giuseppe Nigri, Nicola Di Lorenzo, Andrea Mingoli, Massimo Chiarugi, Juliana Di Menno Stavron, Oscar Mazza, José Ignacio Valenzuela, Diana Alejandra Pantoja Pachajoa, Fernando Andrés Alvarez, Julian Ezequiel Liaño, Joan Tefay, Abdulrahman Alshaikh, Layla Hasan, Felipe Couto Gomes, Gustavo P. Fraga, Thiago R.A. Calderan, Elcio S. Hirano, Dragomir Dardanov, Azize Saroglu, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, Shannon Melissa Chan, Hon-Ting Lok, Diego Salcedo, Diana Robayo, María Alejandra Triviño, Jan Manak, Jorann de Araujo, Ananya Sethi, Ahmed Awad, Merihan Elbadawy, Ahmed Farid, Asmaa Hanafy, Ahmed Nafea, null Sherief-Ghozy, Alzhraa Salah – Abbas, Wafaa Abdelsalam, Sameh Emile, Ahmed Elfallal, Hossam Elfeki, Hosam Elghadban, Ashraf Shoma, Mohamed Shetiwy, Mohamed Elbahnasawy, Salem- Mohamed, Emad Fawzi Hamed, Usama Ahmed Khalil, Elie Chouillard, Andrew Gumbs, Andréa Police, Andrea Mabilia, Kakhi Khutsishvili, Anano Tvaladze, Orestis Ioannidis, Elissavet Anestiadou, Lydia Loutzidou, Konstantinis Konstantinidis, Sofia Konstantinidou, Dimitrios Manatakis, Vasileios Acheimastos, Nikolaos Tasis, Nikolaos Michalopoulos, Panagiotis Kokoropoulos, Maria Papadoliopoulou, Maria Sotiropoulou, Stylianos Kapiris, Panagiotis Metaxas, Ioannis Tsouknidas, Despoina Kefili, George Petrakis, Konstantinos Dakis, Eirini Alexandridou, Eirini Synekidou, Kostas Dakis, Aristeidis Papadopoulos, Christos Chouliaras, Odysseas Mouzakis, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Tania Triantafyllou, Dimitrios Theodorou, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Paraskevi Tourountzi, Efstratia Baili, Alexandros Charalabopoulos, Theodore Liakakos, Dimitrios Schizas, Alexandros Kozadinos, Athanasios Syllaios, Nikolaos Machairas, Stylianos Kykalos, Paraskevas Stamopoulos, Spiros Delis, Christos Farazi-Chongouki, Evangelos Kalaitzakis, Miltiadis Giannarakis, Konstantinos Lasithiotakis, Giorgia Petra, Amit Gupta, Noushif Medappil, Vijayanand Muthukrishnan, Jubin Kamar, Pawan Lal, Rajendra Agarwal, Matteo Magnoli, Paolo Aonzo, Alberto Serventi, Antonio Giuliani, Pierpaolo Di Lascio, Margherita Pinto, Carlo Bergamini, Andrea Bottari, Laura Fortuna, Jacopo Martellucci, Atea Cicako, Claudio Miglietta, Mario Morino, Daniele Delogu, Andrea Picchetto, Marco Assenza, Giancarlo D'Ambrosio, Giulio Argenio, Mariano Fortunato Armellino, Giovanna Ioia, Savino Occhionorelli, Dario Andreotti, Lacavalla Domenico, Davide Luppi, Massimiliano Casadei, Luca Di Donato, Farshad Manoochehri, Tiziana Rita Lucia Marchese, William Sergi, Roberto Manca, Raimondo Murgia, Enrico Piras, Lorenzo Conti, Simone Gianazza, Andrea Rizzi, Edoardo Segalini, Marco Monti, Elena Iiritano, Nicolò Maria Mariani, Enrico De Nicola, Giovanna Scifo, Giusto Pignata, Jacopo Andreuccetti, Francesco Fleres, Guglielmo Clarizia, Alessandro Spolini, Alan Biloslavo, Paola Germani, Manuela Mastronardi, Selene Bogoni, Silvia Palmisano, Nicolo’ De Manzini, Marco Vito Marino, Gennaro Martines, Giuseppe Trigiante, Elpiniki Lagouvardou, Gabriele Anania, Cristina Bombardini, Dario Oppici, Tiziana Pilia, Valentina Murzi, Emanuela Gessa, Umberto Bracale, Maria Michela Di Nuzzo, Roberto Peltrini, Francesco Salvetti, Jacopo Viganò, Gabriele Sganga, Valentina Bianchi, Pietro Fransvea, Tommaso Fontana, Giuliano Sarro, Vincenza Paola Dinuzzi, Luca Scaravilli, Mario Virgilio Papa, Elio Jovine, Giulia Ciabatti, Laura Mastrangelo, Matteo Rottoli, Claudio Ricci, Iris Shari Russo, Alberto Aiolfi, Davide Bona, Francesca Lombardo, Pasquale Cianci, Roberto Bini, Osvaldo Chiara, Stefano Cioffi, Stefano Cantafio, Guido Coretti, Edelweiss Licitra, Grazia Savino, Sergio Grimaldi, Raffaele Porfidia, Elisabetta Moggia, Mauro Garino, Chiara Marafante, Antonio Pesce, Nicolò Fabbri, Carlo Vittorio Feo, Ester Marra, Marina Troian, Davide Drigo, Carlo Nagliati, Muratore Andrea, Riccardo Danna, Alessandra Murgese, Michele Crespi, Claudio Guerci, Alice Frontali, Luca Ferrari, Francesco Favi, Erika Picariello, Alessia Rampini, Fabrizio D'Acapito, Giorgio Ercolani, Leonardo Solaini, Francesco Palmieri, Matteo Calì, Francesco Ferrara, Irnerio Angelo Muttillo, Edoardo Maria Muttillo, Biagio Picardi, Raffaele Galleano, Ali Badran, Omar Ghazouani, Maurizio Cervellera, Gaetano Campanella, Gennaro Papa, Annamaria Di Bella, Gennaro Perrone, Gabriele Luciano Petracca, Concetta Prioriello, Mario Giuffrida, Federico Cozzani, Matteo Rossini, Marco Inama, Giovanni Butturini, Gianluigi Moretto, Luca Morelli, Giulio Di Candio, Simone Guadagni, Enrico Cicuttin, Camilla Cremonini, Dario Tartaglia, Valerio Genovese, Nicola Cillara, Alessandro Cannavera, Antonello Deserra, Arcangelo Picciariello, Vincenzo Papagni, Leonardo Vincenti, Giulia Bagaglini, Giuseppe Sica, Pierfrancesco Lapolla, Gioia Brachini, Dario Bono, Antonella Nicotera, Marcello Zago, Fabrizio Sammartano, Laura Benuzzi, Marco Stella, Stefano Rossi, Alessandra Cerioli, Caterina Puccioni, Stefano Olmi, Carolina Rubicondo, Matteo Uccelli, Andrea Balla, Anna Guida, Pasquale Lepiane, Diego Sasia, Giorgio Giraudo, Sara Salomone, Elena Belloni, Alessandra Cossa, Francesco Lancellotti, Roberto Caronna, Piero Chirletti, Paolina Saullo, Raffaele Troiano, Felice Mucilli, Mirko Barone, Massimo Ippoliti, Michele Grande, Bruno Sensi, Leandro Siragusa, Monica Ortenzi, Andrea Santini, Isidoro Di Carlo, Massimiliano Veroux, Rossella Gioco, Gastone Veroux, Giuseppe Currò, Michele Ammendola, Iman Komaei, Giuseppe Navarra, Valeria Tonini, Lodovico Sartarelli, Samuele Vaccari, Marco Ceresoli, Stefano Perrone, Linda Roccamatisi, Paolo Millo, Riccardo Brachet Contul, Elisa Ponte, Matteo Zuin, Giuseppe Portale, Alice Sabrina Tonello, Geri Fratini, Matteo Bianchini, Bruno Perotti, Emanuele Doria, Elia Giuseppe Lunghi, Diego Visconti, Khayry Al-Shami, Sajeda Awadi, Mohammad Musallam Khalil Buwaitel, Mo'taz Fawzat Naief Naffa', Ahmad Samhouri, Hatem Sawalha, Mohd Firdaus Che Ani, Ida Nadiah Ahmed Fathil, Jih Huei, Andee Dzulkarnaen Zakaria, Mohammad Zawawi Ya'acob, Jose-Luis Beristain-Hernandez, Alejandro Garcia-Meza, Rafael Sepulveda-Rdriguez, Edgard Efren Lozada Hernández, Camilo Levi Acuña Pinzón, Jefferson Nieves Condoy, Francisco C. Becerra García, Mohammad Sadik, null Jalpa, Bushra kadir, Jalpa Devi, Nandlal Seerani, null Zainab, Mohammad Sohail- Asghar, Ameer Afzal, Ali Akbar, Helmut Segovia Lohse, Herald Segovia Lohse, Zamiara Solange Leon Cabrera, Gaby Susana Yamamoto Seto, José Ríos Chiuyari, Jorge Ordemar, Martha Rodríguez, Abigail Cheska C. Orantia-Carlos, Margie Antionette Quitoy, Andrzej Kwiatkowski, Maciej Mawlichanów, Mónica Rocha, Carlos Soares, Alexandru Rares Stoian, Andreea Diana Draghici, Valentin Titus Grigorean, Raluca Bievel Radulescu, Radu Virgil Costea, Eugenia Claudia Zarnescu, Mikhail Kurtenkov, George Gendrikson, Volovich Alla-Angelina, Tsurbanova Arina, Ayrat Kaldarov, Mahir Gachabayov, Abakar Abdullaev, Milica Milentijevic, Milovan Karamarkovic, Arpád Panyko, Jozef Radonak, Marek Soltes, Laura Álvarez Morán, Haydée Calvo García, Pilar Suárez Vega, Sergio Estevez, Fabio Ausania, Jordi Farguell, Carolina González-Abós, Santiago Sánchez-Cabús, Belén Martín, Víctor Molina, Luis Oms, Lucas Ilzarbe, Eva Pont Feijóo, Elena Sofia Perra, Noel Rojas-Bonet, Rafael Penalba-Palmí, Susana Pérez-Bru, Jaume Tur-Martínez, Andrea Álvarez-Torrado, Marta Domingo-Gonzalez, Javier Tejedor-Tejada, Marcello Di Martino, Yaiza García del Alamo, Fernando Mendoza-Moreno, Francisca García-Moreno-Nisa, Belén Matías-García, Manuel Durán, Rafael Calleja-Lozano, José Manuel Perez de Villar, Luis Sánchez-Guillén, Iban Caravaca, Daniel Triguero-Cánovas, Antonio Carlos Maya Aparicio, Blas Durán Meléndez, Andrea Masiá Palacios, Aitor Landaluce-olavarria, Mario De Francisco, Begoña Estraviz-Mateos, Felipe Alconchel, Tatiana Nicolás-López, Pablo Ramírez, Virginia Duran Muñoz-Cruzado, Felipe Pareja Ciuró, Eduardo Perea del Pozo, Sergio Olivares Pizarro, Vicente Herrera Cabrera, Jose Muros Bayo, Hytham K.S. Hamid, Raffaello Roesel, Alessandra Cristaudi, Kinan Abbas, Iyad Ali, Ahmed Tlili, Hüseyin Bayhan, Mehmet Akif Türkoğlu, Mustafa Yener Uzunoglu, Ibrahim Fethi Azamat, Nail Omarov, Derya Salim Uymaz, Fatih Altintoprak, Emrah Akin, Necattin First, Koray Das, Nazmi Ozer, Ahmet Seker, Yasin Kara, Mehmet Abdussamet Bozkurt, Ali Kocataş, Semra Demirli Atici, Murat Akalin, Bulent Calik, Elif Colak, Yuksel Altinel, Serhat Meric, Yunus Emre Aktimur, Victoria Hudson, Jean-Luc Duval, Mansoor Khan, Ahmed Saad, Mandeep Kaur, Alison Bradley, Katherine Fox, Ivan Tomasi, Daniel Beasley, Alekhya Kotta Prasanti, Pinky Kotecha, Husam Ebied, Michaela Paul, Hemant Sheth, Ioannis Gerogiannis, Mohannad Gaber, Zara Sheikh, Shatadru Seth, Maria Kunitsyna, Cosimo Alex Leo, Vittoria Bellato, Noman - Zafar, Amr Elserafy, Giles Bond-smith, Giovanni Tebala, Pawan Mathur, Izza Abid, Nnaemeka Chidumije, Pardip Sandhar, Syed Osama Zohaib Ullah, Tamara Lezama, Muhammad Hassan Anwaar, Conor Magee, Salma Ahmed, Brooke Davies, Jeyakumar Apollos, Kieran McCormack, Hasham Choudhary, Triantafyllos Doulias, Tamsin Morrison, Anna Palepa, Fernando Bonilla Cal, Lianet Sánchez, Fabiana Domínguez, Ibrahim Al-Raimi, Haneen Alshargabi, Abdullah Meead, Podda, Mauro, Pacella, Daniela, Pellino, Gianluca, Coccolini, Federico, Giordano, Alessio, Di Saverio, Salomone, Pata, Francesco, Ielpo, Benedetto, Virdis, Francesco, Damaskos, Dimitrio, De Simone, Belinda, Agresta, Ferdinando, Sartelli, Massimo, Leppaniemi, Ari, Riboni, Cristiana, Agnoletti, Vanni, Mole, Damian, Kluger, Yoram, Catena, Fausto, Pisanu, Adolfo, de Manzini, Nicolo', Palmisano, Silvia, Podda, M, Pacella, D, Pellino, G, Coccolini, F, Giordano, A, Di Saverio, S, Pata, F, Ielpo, B, Virdis, F, Damaskos, D, De Simone, B, Agresta, F, Sartelli, M, Leppaniemi, A, Riboni, C, Agnoletti, V, Mole, D, Kluger, Y, Catena, F, Pisanu, A, Gerardi, C, Gourgiotis, S, Poillucci, G, Jayant, K, Ferrario, L, Calvo, M, Wilson, M, Soggiu, F, Hamdan, A, Gomes, C, Fraga, G, Ioannidis, A, Demetrashvili, Z, Sahani, S, Bains, L, Khamees, A, Ababneh, H, Aljaiuossi, O, Pimentel, S, Mohamad, I, Yusoff, A, Zarnescu, N, Calu, V, Litvin, A, Lesko, D, Elmehrath, A, Elshami, M, de Santibanes, M, Gundara, J, Alawadhi, K, Lui, R, Julianov, A, Ralon, S, Garzali, I, Machain, G, Quispe-Cruz, D, Orantia, A, Waledziak, M, Correia de Sa, T, Ali, S, Kovacevic, B, Noel, C, Abdalah, H, Kchaou, A, Isik, A, Ansaloni, L, Biffl, W, Guerrieri, M, Sartori, A, Abradelo, M, Nigri, G, Di Lorenzo, N, Mingoli, A, Chiarugi, M, Di Menno Stavron, J, Mazza, O, Valenzuela, J, Pantoja Pachajoa, D, Alvarez, F, Liano, J, Tefay, J, Alshaikh, A, Hasan, L, Augusto Gomes, C, Gomes, F, Calderan, T, Hirano, E, Dardanov, D, Saroglu, A, Atanasov, B, Belev, N, Kovachev, N, Chan, S, Lok, H, Salcedo, D, Robayo, D, Trivino, M, Manak, J, de Araujo, J, Sethi, A, Awad, A, Elbadawy, M, Farid, A, Hanafy, A, Nafea, A, Sherief-Ghozy, Salah - Abbas, A, Abdelsalam, W, Emile, S, Elfallal, A, Elfeki, H, Elghadban, H, Shoma, A, Shetiwy, M, Elbahnasawy, M, Mohamed, S, Hamed, E, Khalil, U, Chouillard, E, Gumbs, A, Police, A, Mabilia, A, Khutsishvili, K, Tvaladze, A, Ioannidis, O, Anestiadou, E, Loutzidou, L, Konstantinidis, K, Konstantinidou, S, Manatakis, D, Acheimastos, V, Tasis, N, Michalopoulos, N, Kokoropoulos, P, Papadoliopoulou, M, Sotiropoulou, M, Kapiris, S, Metaxas, P, Tsouknidas, I, Kefili, D, Petrakis, G, Dakis, K, Alexandridou, E, Synekidou, E, Papadopoulos, A, Chouliaras, C, Mouzakis, O, Mulita, F, Maroulis, I, Vailas, M, Triantafyllou, T, Theodorou, D, Lostoridis, E, Nagorni, E, Tourountzi, P, Baili, E, Charalabopoulos, A, Liakakos, T, Schizas, D, Kozadinos, A, Syllaios, A, Machairas, N, Kykalos, S, Stamopoulos, P, Delis, S, Farazi-Chongouki, C, Kalaitzakis, E, Giannarakis, M, Lasithiotakis, K, Petra, G, Gupta, A, Medappil, N, Muthukrishnan, V, Kamar, J, Lal, P, Agarwal, R, Magnoli, M, Aonzo, P, Serventi, A, Giuliani, A, Di Lascio, P, Pinto, M, Bergamini, C, Bottari, A, Fortuna, L, Martellucci, J, Cicako, A, Miglietta, C, Morino, M, Delogu, D, Picchetto, A, Assenza, M, D'Ambrosio, G, Argenio, G, Armellino, M, Ioia, G, Occhionorelli, S, Andreotti, D, Domenico, L, Luppi, D, Casadei, M, Di Donato, L, Manoochehri, F, Lucia Marchese, T, Sergi, W, Manca, R, Murgia, R, Piras, E, Conti, L, Gianazza, S, Rizzi, A, Segalini, E, Monti, M, Iiritano, E, Mariani, N, De Nicola, E, Scifo, G, Pignata, G, Andreuccetti, J, Fleres, F, Clarizia, G, Spolini, A, Biloslavo, A, Germani, P, Mastronardi, M, Bogoni, S, Palmisano, S, De Manzini, N, Marino, M, Martines, G, Trigiante, G, Lagouvardou, E, Anania, G, Bombardini, C, Oppici, D, Pilia, T, Murzi, V, Gessa, E, Bracale, U, Di Nuzzo, M, Peltrini, R, Salvetti, F, Vigano, J, Sganga, G, Bianchi, V, Fransvea, P, Fontana, T, Sarro, G, Dinuzzi, V, Scaravilli, L, Papa, M, Jovine, E, Ciabatti, G, Mastrangelo, L, Rottoli, M, Ricci, C, Russo, I, Aiolfi, A, Bona, D, Lombardo, F, Cianci, P, Bini, R, Chiara, O, Cioffi, S, Cantafio, S, Coretti, G, Licitra, E, Savino, G, Grimaldi, S, Porfidia, R, Moggia, E, Garino, M, Marafante, C, Pesce, A, Fabbri, N, Feo, C, Marra, E, Troian, M, Drigo, D, Nagliati, C, Andrea, M, Danna, R, Murgese, A, Crespi, M, Guerci, C, Frontali, A, Ferrari, L, Favi, F, Picariello, E, Rampini, A, D'Acapito, F, Ercolani, G, Solaini, L, Palmieri, F, Cali, M, Ferrara, F, Muttillo, I, Muttillo, E, Picardi, B, Galleano, R, Badran, A, Ghazouani, O, Cervellera, M, Campanella, G, Papa, G, Di Bella, A, Perrone, G, Petracca, G, Prioriello, C, Giuffrida, M, Cozzani, F, Rossini, M, Inama, M, Butturini, G, Moretto, G, Morelli, L, Di Candio, G, Guadagni, S, Cicuttin, E, Cremonini, C, Tartaglia, D, Genovese, V, Cillara, N, Cannavera, A, Deserra, A, Picciariello, A, Papagni, V, Vincenti, L, Bagaglini, G, Sica, G, Lapolla, P, Brachini, G, Bono, D, Nicotera, A, Zago, M, Sammartano, F, Benuzzi, L, Stella, M, Rossi, S, Cerioli, A, Puccioni, C, Olmi, S, Rubicondo, C, Uccelli, M, Balla, A, Guida, A, Lepiane, P, Sasia, D, Giraudo, G, Salomone, S, Belloni, E, Cossa, A, Lancellotti, F, Caronna, R, Chirletti, P, Saullo, P, Troiano, R, Mucilli, F, Barone, M, Ippoliti, M, Grande, M, Sensi, B, Siragusa, L, Ortenzi, M, Santini, A, Di Carlo, I, Veroux, M, Gioco, R, Veroux, G, Curro, G, Ammendola, M, Komaei, I, Navarra, G, Tonini, V, Sartarelli, L, Vaccari, S, Ceresoli, M, Perrone, S, Roccamatisi, L, Millo, P, Contul, R, Ponte, E, Zuin, M, Portale, G, Tonello, A, Fratini, G, Bianchini, M, Perotti, B, Doria, E, Lunghi, E, Visconti, D, Al-Shami, K, Awadi, S, Khalil Buwaitel, M, Naief Naffa', M, Samhouri, A, Sawalha, H, Ramzi Yusoff, A, Che Ani, M, Ahmed Fathil, I, Huei, J, Zakaria, A, Ya'Acob, M, Beristain-Hernandez, J, Garcia-Meza, A, Sepulveda-Rdriguez, R, Lozada Hernandez, E, Acuna Pinzon, C, Condoy, J, Becerra Garcia, F, Sadik, M, Jalpa, Kadir, B, Devi, J, Seerani, N, Zainab, Asghar, M, Afzal, A, Akbar, A, Lohse, H, Artidoro Quispe-Cruz, D, Leon Cabrera, Z, Yamamoto Seto, G, Chiuyari, J, Ordemar, J, Rodriguez, M, Orantia-Carlos, A, Quitoy, M, Kwiatkowski, A, Mawlichanow, M, Rocha, M, Soares, C, Muhammad Ali, S, Stoian, A, Diana Draghici, A, Draghici, A, Grigorean, V, Radulescu, R, Costea, R, Zarnescu, E, Kurtenkov, M, Gendrikson, G, Alla-Angelina, V, Arina, T, Kaldarov, A, Gachabayov, M, Abdullaev, A, Milentijevic, M, Karamarkovic, M, Panyko, A, Radonak, J, Soltes, M, Alvarez Moran, L, Garcia, H, Vega, P, Estevez, S, Ausania, F, Farguell, J, Gonzalez-Abos, C, Sanchez-Cabus, S, Martin, B, Molina, V, Oms, L, Ilzarbe, L, Feijoo, E, Perra, E, Rojas-Bonet, N, Penalba-Palmi, R, Perez-Bru, S, Tur-Martinez, J, Alvarez-Torrado, A, Domingo-Gonzalez, M, Tejedor-Tejada, J, Di Martino, M, Garcia del Alamo, Y, Mendoza-Moreno, F, Garcia-Moreno-Nisa, F, Matias-Garcia, B, Duran, M, Calleja-Lozano, R, Perez de Villar, J, Sanchez-Guillen, L, Caravaca, I, Triguero-Canovas, D, Maya Aparicio, A, Melendez, B, Palacios, A, Landaluce-olavarria, A, De Francisco, M, Estraviz-Mateos, B, Alconchel, F, Nicolas-Lopez, T, Ramirez, P, Munoz-Cruzado, V, Ciuro, F, Perea del Pozo, E, Pizarro, S, Cabrera, V, Bayo, J, Hamid, H, Roesel, R, Cristaudi, A, Abbas, K, Ali, I, Tlili, A, Bayhan, H, Turkoglu, M, Uzunoglu, M, Azamat, I, Omarov, N, Uymaz, D, Altintoprak, F, Akin, E, First, N, Das, K, Ozer, N, Seker, A, Kara, Y, Bozkurt, M, Kocatas, A, Atici, S, Akalin, M, Calik, B, Colak, E, Altinel, Y, Meric, S, Aktimur, Y, Hudson, V, Duval, J, Khan, M, Saad, A, Kaur, M, Bradley, A, Fox, K, Tomasi, I, Beasley, D, Prasanti, A, Kotecha, P, Ebied, H, Paul, M, Sheth, H, Gerogiannis, I, Gaber, M, Sheikh, Z, Seth, S, Kunitsyna, M, Leo, C, Bellato, V, Zafar, N, Elserafy, A, Bond-smith, G, Tebala, G, Mathur, P, Abid, I, Chidumije, N, Sandhar, P, Zohaib Ullah, S, Lezama, T, Anwaar, M, Magee, C, Ahmed, S, Davies, B, Apollos, J, Mccormack, K, Choudhary, H, Doulias, T, Morrison, T, Palepa, A, Cal, F, Sanchez, L, Dominguez, F, Al-Raimi, I, Alshargabi, H, and Meead, A

Subjects
Acute pancreatitis, Biliary pancreatitis, Global surgery, Guidelines compliance, International audit, Hepatology, Endocrinology, Diabetes and Metabolism, Gastroenterology, Settore MED/18, Hospitalization, Enteral Nutrition, Pancreatitis, Acute Disease, Humans, Biliary pancreatiti, Cholecystectomy, Acute pancreatiti, Human
Abstract

Background/objectives: Reports about the implementation of recommendations from acute pancreatitis guidelines are scant. This study aimed to evaluate, on a patient-data basis, the contemporary practice patterns of management of biliary acute pancreatitis and to compare these practices with the recommendations by the most updated guidelines. Methods: All consecutive patients admitted to any of the 150 participating general surgery (GS), hepatopancreatobiliary surgery (HPB), internal medicine (IM) and gastroenterology (GA) departments with a diagnosis of biliary acute pancreatitis between 01/01/2019 and 31/12/2020 were included in the study. Categorical data were reported as percentages representing the proportion of all study patients or different and well-defined cohorts for each variable. Continuous data were expressed as mean and standard deviation. Differences between the compliance obtained in the four different subgroups were compared using the Mann-Whitney U, Student's t, ANOVA or Kruskal-Wallis tests for continuous data, and the Chi-square test or the Fisher's exact test for categorical data. Results: Complete data were available for 5275 patients. The most commonly discordant gaps between daily clinical practice and recommendations included the optimal timing for the index CT scan (6.1%, χ2 6.71, P = 0.081), use of prophylactic antibiotics (44.2%, χ2 221.05, P < 0.00001), early enteral feeding (33.2%, χ2 11.51, P = 0.009), and the implementation of early cholecystectomy strategies (29%, χ2 354.64, P < 0.00001), with wide variability based on the admitting speciality. Conclusions: The results of this study showed an overall poor compliance with evidence-based guidelines in the management of ABP, with wide variability based on the admitting speciality. Study protocol registered in ClinicalTrials.Gov (ID Number NCT04747990).

Published
2022

4. Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study

Author

Péter Jenő Hegyi, Áron Vincze, Alexandra Demcsák, László Gajdán, Andrey Litvin, Andra Iulia Suceveanu, Eva Pijoan Comas, Riccardo Casadei, George I Papachristou, Vincenzo Cennamo, Yu-Ting Chang, Péter Hegyi, Ionut Negoi, Carlo Ingaldi, Vitor Nunes, Adriano Quiroga Castiñeira, Lihui Deng, Orestis Ioannidis, Ernő Bóna, Milene Raquel Ramos Moreira e Sá, Juan Armando Rodriguez-Oballe, Andrea Jardi Cuadrado, József Hamvas, Judit Bajor, Alexander Schneider, Tiago Cúrdia Gonçalves, Haluk Tarik Kani, Alexandra Soós, Serge Chooklin, Marcus Hollenbach, Claudio Ricci, Marta Freitas, Isabel Miguel Salas, Michael Hirth, Cristina Tocia, Dóra Illés, Daniel de la Iglesia Garcia, Amir Gougol, Patrícia Sarlós, Marco Marino, Emőke Miklós, Qing Xia, Valentina Negoita, Mihailo Bezmarevic, Radislav Nakov, Erika Darvasi, Deniz Güney Duman, Péter Kanizsai, Laura Mastrangelo, Vasile Sandru, Andrea Párniczky, Hubert Zatorski, Andrea Szentesi, Mária Papp, Mario Pelaez-Luna, Marcel Tantau, Yliya Rabotyagova, Ferenc Izbéki, Natalia V Shirinskaya, Cristian Gheorghe, Ewa Małecka-Panas, Giedrius Barauskas, Engin Altintaş, Wei Huang, Ali Kchaou, Povilas Ignatavicius, Cezar Ciubotaru, Stefania Bunduc, Jorge Paulino Pereira, Dong Wu, Sabite Kacar, Alina Tantau, António Pedro Gomes, Svetlana Turcan, Bálint Erőss, Sorin T. Barbu, Adriana Gherbon, Georgi Minkov, Júlio Constantino, Márk Félix Juhász, Jimin Han, Serhii Chuklin, Klementina Ocskay, Mila Kovacheva-Slavova, Eugen Tcaciuc, Elio Jovine, Lilla Barbara Kincses, Ines Capunge, Gabriel Constantinescu, Bogdan Mateescu, Eugen Dumitru, Ming-Chu Chang, Andrea Soriano Rios, Márta Varga, László Czakó, Volkan Gökbulut, Alexandra Mikó, Szilárd Váncsa, Ahmed Tlili, Demcsak, Alexandra, Soos, Alexandra, Kincses, Lilla, Capunge, Ines, Minkov, Georgi, Kovacheva-Slavova, Mila, Nakov, Radislav, Wu, Dong, Huang, Wei, Xia, Qing, Deng, Lihui, Hollenbach, Marcus, Schneider, Alexander, Hirth, Michael, Ioannidis, Orestis, Vincze, Aron, Bajor, Judit, Sarlos, Patricia, Czako, Laszlo, Illes, Dora, Izbeki, Ferenc, Gajdan, Laszlo, Papp, Maria, Hamvas, Jozsef, Varga, Marta, Kanizsai, Peter, Bona, Erno, Miko, Alexandra, Vancsa, Szilard, Juhasz, Mark Felix, Ocskay, Klementina, Darvasi, Erika, Miklos, Emoke, Eross, Balint, Szentesi, Andrea, Parniczky, Andrea, Casadei, Riccardo, Ricci, Claudio, Ingaldi, Carlo, Mastrangelo, Laura, Jovine, Elio, Cennamo, Vincenzo, Marino, Marco V., Barauskas, Giedrius, Ignatavicius, Povilas, Pelaez-Luna, Mario, Rios, Andrea Soriano, Turcan, Svetlana, Tcaciuc, Eugen, Malecka-Panas, Ewa, Zatorski, Hubert, Nunes, Vitor, Gomes, Antonio, Goncalves, Tiago Curdia, Freitas, Marta, Constantino, Julio, Sa, Milene, Pereira, Jorge, Mateescu, Bogdan, Constantinescu, Gabriel, Sandru, Vasile, Negoi, Ionut, Ciubotaru, Cezar, Negoita, Valentina, Bunduc, Stefania, Gheorghe, Cristian, Barbu, Sorin, Tantau, Alina, Tantau, Marcel, Dumitru, Eugen, Suceveanu, Andra Iulia, Tocia, Cristina, Gherbon, Adriana, Litvin, Andrey, Shirinskaya, Natalia, Rabotyagova, Yliya, Bezmarevic, Mihailo, Hegyi, Peter Jeno, Han, Jimin, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Comas, Eva Pijoan, de la Iglesia Garcia, Daniel, Cuadrado, Andrea Jardi, Castineira, Adriano Quiroga, Chang, Yu-Ting, Chang, Ming-Chu, Kchaou, Ali, Tlili, Ahmed, Kacar, Sabite, Gokbulut, Volkan, Duman, Deniz, Kani, Haluk Tarik, Altintas, Engin, Chooklin, Serge, Chuklin, Serhii, Gougol, Amir, Papachristou, George, Hegyi, Peter, Demcsak A., Soos A., Kincses L., Capunge I., Minkov G., Kovacheva-Slavova M., Nakov R., Wu D., Huang W., Xia Q., Deng L., Hollenbach M., Schneider A., Hirth M., Ioannidis O., Vincze A., Bajor J., Sarlos P., Czako L., Illes D., Izbeki F., Gajdan L., Papp M., Hamvas J., Varga M., Kanizsai P., Bona E., Miko A., Vancsa S., Juhasz M.F., Ocskay K., Darvasi E., Miklos E., Eross B., Szentesi A., Parniczky A., Casadei R., Ricci C., Ingaldi C., Mastrangelo L., Jovine E., Cennamo V., Marino M.V., Barauskas G., Ignatavicius P., Pelaez-Luna M., Rios A.S., Turcan S., Tcaciuc E., Malecka-Panas E., Zatorski H., Nunes V., Gomes A., Goncalves T.C., Freitas M., Constantino J., Sa M., Pereira J., Mateescu B., Constantinescu G., Sandru V., Negoi I., Ciubotaru C., Negoita V., Bunduc S., Gheorghe C., Barbu S., Tantau A., Tantau M., Dumitru E., Suceveanu A.I., Tocia C., Gherbon A., Litvin A., Shirinskaya N., Rabotyagova Y., Bezmarevic M., Hegyi P.J., Han J., Rodriguez-Oballe J.A., Salas I.M., Comas E.P., Garcia D.D.L.I., Cuadrado A.J., Castineira A.Q., Chang Y.-T., Chang M.-C., Kchaou A., Tlili A., Kacar S., Gokbulut V., Duman D., Kani H.T., Altintas E., Chooklin S., Chuklin S., Gougol A., Papachristou G., and Hegyi P.

Subjects
Male, Endocrinology, Diabetes and Metabolism, Gastroenterology, Cohort Studies, Feces, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Acid suppressing drug, Acute pancreatitis, Gastrointestinal bleeding, Gastrointestinal infection, Proton pump inhibitor, Enterocolitis, Pseudomembranous, Aged, 80 and over, RISK, ASSOCIATION, Middle Aged, Clostridium difficile, CANCER, 3. Good health, Hospitalization, Treatment Outcome, 030220 oncology & carcinogenesis, Acute Disease, Female, 030211 gastroenterology & hepatology, Gastrointestinal Hemorrhage, Cohort study, Adult, medicine.medical_specialty, GI bleeding, medicine.drug_class, Proton-pump inhibitor, Infections, PROTON-PUMP INHIBITORS, 03 medical and health sciences, Internal medicine, mental disorders, medicine, MANAGEMENT, Humans, DRUGS, Acute pancreatiti, Aged, Retrospective Studies, Hepatology, Clostridioides difficile, business.industry, Proton Pump Inhibitors, medicine.disease, Pancreatitis, Acid suppression, business
Abstract

Background: Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, large cohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluate the association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal (GI) bleeding and GI infection in patients with AP. Methods: We initiated an international survey and performed retrospective data analysis on AP patients hospitalized between January 2013 and December 2018. Results: Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We found that 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to 57.6% of patients at discharge. ASD administration was associated with more severe AP and higher mortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity, mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positive results. Clostridium difficile was the cause of GI infection in 60.5% of cases. Among the patients with GI infections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infection was associated with more severe pancreatitis and higher mortality. Conclusions: Although ASD therapy is widely used, it is unlikely to have beneficial effects either on the outcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be substantially decreased in the therapeutic management of AP. (C) 2020 IAP and EPC. Published by Elsevier B.V.

Published
2020

5. Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study

Author

Andrea Domanico, Luca Di Tommaso, Leonardo Mirandola, Esterita Accogli, Dorina Qehajaj, Sirio Fiorino, Maurizio Chiriva-Internati, Andrea Tura, Dario de Biase, Fabio Grizzi, Adele Fornelli, Carlo Russo, Elio Jovine, Robert S. Bresalier, Matteo Zanello, Laura Mastrangelo, Michele Masetti, Raffaele Lombardi, Paolo Leandri, Grizzi F., Fiorino S., Qehajaj D., Fornelli A., Russo C., De Biase D., Masetti M., Mastrangelo L., Zanello M., Lombardi R., Domanico A., Accogli E., Tura A., Mirandola L., Chiriva-Internati M., Bresalier R.S., Jovine E., Leandri P., and Di Tommaso L.

Subjects
0301 basic medicine, Male, Pathology, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Carcinogenesis, lcsh:Medicine, Pilot Projects, Matrix (biology), General Biochemistry, Genetics and Molecular Biology, Extracellular matrix, 03 medical and health sciences, chemistry.chemical_compound, Degradation, 0302 clinical medicine, medicine, Humans, Computer Simulation, Diagnosis, Computer-Assisted, Degradation process, Sirius Red, Pancreas, Aged, Spatial complexity, business.industry, Research, Significant difference, lcsh:R, Modeling, General Medicine, Middle Aged, Extracellular Matrix, Pancreatic Neoplasms, 030104 developmental biology, Fractals, chemistry, 030220 oncology & carcinogenesis, Extra-cellular matrix, Pancreatic carcinogenesis, Female, Collagen, business, Fractal, Pancreatic adenocarcinoma
Abstract

Background A hallmark of pancreatic ductal adenocarcinoma is the desmoplastic reaction, but its impact on the tumor behavior remains controversial. Our aim was to introduce a computer -aided method to precisely quantify the amount of pancreatic collagenic extra-cellular matrix, its spatial distribution pattern, and the degradation process. Methods A series of normal, inflammatory and neoplastic pancreatic ductal adenocarcinoma formalin-fixed and paraffin-embedded Sirius red stained sections were automatically digitized and analyzed using a computer-aided method. Results We found a progressive increase of pancreatic collagenic extra-cellular matrix from normal to the inflammatory and pancreatic ductal adenocarcinoma. The two-dimensional fractal dimension showed a significant difference in the collagenic extra-cellular matrix spatial complexity between normal versus inflammatory and pancreatic ductal adenocarcinoma. A significant difference when comparing the number of cycles necessary to degrade the pancreatic collagenic extra-cellular matrix in normal versus inflammatory and pancreatic ductal adenocarcinoma was also found. The difference between inflammatory and pancreatic ductal adenocarcinoma was also significant. Furthermore, the mean velocity of collagenic extra-cellular matrix degradation was found to be faster in inflammatory and pancreatic ductal adenocarcinoma than in normal. Conclusion These findings demonstrate that inflammatory and pancreatic ductal adenocarcinomas are characterized by an increased amount of pancreatic collagenic extra-cellular matrix and by changes in their spatial complexity and degradation. Our study defines new features about the pancreatic collagenic extra-cellular matrix, and represents a basis for further investigations into the clinical behavior of pancreatic ductal adenocarcinoma and the development of therapeutic strategies.

Published
2018

6. Matricellular proteins and survival in patients with pancreatic cancer: A systematic review

Author

Maria Letizia Bacchi-Reggiani, Raffaele Lombardi, Andrea Domanico, Paolo Leandri, Paolo Emilio Orlandi, Francesco Monetti, Fabio Grizzi, Luca Di Tommaso, Vincenzo Cennamo, Michele Imbriani, Giorgia Acquaviva, Salomone Di Saverio, Matteo Zanello, Federica Patrinicola, Arrigo Bondi, Michele Masetti, Elena Siopis, Laura Mastrangelo, Michela Visani, Elio Jovine, Silvia Giovanelli, Andrea Tura, Claudia Benini, Dario de Biase, Esterita Accogli, Stefano Sbrignadello, Chiara Birtolo, Sirio Fiorino, Adele Fornelli, Daniela Grifoni, Carlo Fabbri, Fiorino, Sirio, Bacchi-Reggiani, Maria Letizia, Birtolo, Chiara, Acquaviva, Giorgia, Visani, Michela, Fornelli, Adele, Masetti, Michele, Tura, Andrea, Sbrignadello, Stefano, Grizzi, Fabio, Patrinicola, Federica, Zanello, Matteo, Mastrangelo, Laura, Lombardi, Raffaele, Benini, Claudia, Di Tommaso, Luca, Bondi, Arrigo, Monetti, Francesco, Siopis, Elena, Orlandi, Paolo Emilio, Imbriani, Michele, Fabbri, Carlo, Giovanelli, Silvia, Domanico, Andrea, Accogli, Esterita, Di Saverio, Salomone, Grifoni, Daniela, Cennamo, Vincenzo, Leandri, Paolo, Jovine, Elio, and de Biase, Dario

Subjects
0301 basic medicine, Endocrinology, Diabetes and Metabolism, Matricellular proteins, Review, medicine.disease_cause, Bioinformatics, Matricellular protein, Extracellular matrix, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Cell surface receptor, Pancreatic cancer, Cancer, Pancreas, Pancreatic adenocarcinoma, Diabetes and Metabolism, Hepatology, medicine, Extracellular, Humans, Pancrea, In patient, business.industry, Gastroenterology, medicine.disease, Survival Analysis, Extracellular Matrix, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, 030104 developmental biology, Systematic review, 030220 oncology & carcinogenesis, Carcinogenesis, business, Homeostasis
Abstract

Extracellular matrix (ECM) plays a fundamental role in tissue architecture and homeostasis and modulates cell functions through a complex interaction between cell surface receptors, hormones, several bioeffector molecules, and structural proteins like collagen. These components are secreted into ECM and all together contribute to regulate several cellular activities including differentiation, apoptosis, proliferation, and migration. The so-called "matricellular" proteins (MPs) have recently emerged as important regulators of ECM functions. The aim of our review is to consider all different types of MPs family assessing the potential relationship between MPs and survival in patients with pancreatic ductal adenocarcinoma (PDAC). A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) Statement issued in 2009 was conducted through Ovid interface, and literature review was performed in May 2017. The search text words were identified by means of controlled vocabulary, such as the National Library of Medicine's MESH (Medical Subject Headings) and Keywords. Collected data showed an important role of MPs in carcinogenesis and in PDAC prognosis even though the underlying mechanisms are still largely unknown and data are not univocal. Therefore, a better understanding of MPs role in regulation of ECM homeostasis and remodeling of specific organ niches may suggest potential novel extracellular targets for the development of efficacious therapeutic strategies.

Published
2018

7. Analysis of Prognostic Factors in Metastatic Tumors of the Pancreas

Author

Carlo Fabbri, Federica Martuzzi, Marcellino Burzi, Laura Mastrangelo, Elena Vezzelli, Giovanni Landolfo, Elio Jovine, Michele Masetti, Adele Fornelli, and Nicola Zanini

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, MEDLINE, Kaplan-Meier Estimate, Single Center, Risk Assessment, Pancreatectomy, Endocrinology, Text mining, Risk Factors, Internal medicine, Internal Medicine, Humans, Medicine, Aged, Proportional Hazards Models, Retrospective Studies, Hepatology, business.industry, Proportional hazards model, Patient Selection, Retrospective cohort study, Middle Aged, Pancreatic Neoplasms, Treatment Outcome, medicine.anatomical_structure, Female, business, Risk assessment, Pancreas
Abstract

Pancreatic metastases are rare. The role of surgery is poorly defined, and data on long-term survival are lacking.Data from patients with pancreatic metastases observed in our division from 2003 to 2008 were retrospectively analyzed. In addition, the recent English medical literature was reviewed regarding series of patients with pancreatic secondary tumors.Data from 234 patients including 9 consecutive patients observed in our division were retrieved. Metastasis from renal cell carcinoma accounted for 67.9% of all cases. Factors predictive of worse survival, as determined by multivariate analysis, were symptoms at diagnosis, synchronous tumors, radical-intent surgery not performed, and pathologic diagnosis of the primary tumor. Compared with pancreatic metastases from renal cell cancer, metastases from melanoma (P0.001) and lung cancer (P = 0.002) were associated with worse survival. The differences in survival of patients with renal cell cancer metastases and those with breast cancer, colorectal, or sarcoma metastases did not reach statistical significance.There may be a subset of patients with pancreatic metastases who are able to benefit from surgery with respect to improved long-term survival. Symptoms at diagnosis, presentation with primary tumor, surgical resection, and pathologic diagnosis seem to be important prognostic factors.

Published
2010
Full Text
View/download PDF

8. Possible association between hepatitis C virus and malignancies different from hepatocellular carcinoma: A systematic review

Author

Carlo Fabbri, Giorgia Acquaviva, Raffaele Lombardi, Laura Pontoriero, Fabio Grizzi, Andrea Cuppini, Elio Jovine, Luca Di Tommaso, Arrigo Bondi, Sergio Sabbatani, Michele Masetti, Michela Visani, Andrea Tura, Adele Fornelli, Annalisa Pession, Laura Mastrangelo, Matteo Zanello, Sirio Fiorino, Letizia Bacchi-Reggiani, Dario de Biase, Fiorino, Sirio, Bacchi Reggiani, Maria Letizia, De Biase, Dario, Fornelli, Adele, Masetti, Michele, Tura, Andrea, Grizzi, Fabio, Zanello, Matteo, Mastrangelo, Laura, Lombardi, Raffaele, Acquaviva, Giorgia, Di Tommaso, Luca, Bondi, Arrigo, Visani, Michela, Sabbatani, Sergio, Pontoriero, Laura, Fabbri, Carlo, Cuppini, Andrea, Pession, Annalisa, and Jovine, Elio

Subjects
Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Systematic Reviews, Hepatocellular carcinoma, Hepatitis C virus, macromolecular substances, Hepacivirus, medicine.disease_cause, Risk Assessment, Cholangiocarcinoma, Breast cancer, Risk Factors, Internal medicine, Pancreatic cancer, Neoplasms, Medicine, Humans, Thyroid cancer, Cancer, business.industry, Liver Neoplasms, Gastroenterology, virus diseases, General Medicine, Hepatitis C, Extra-hepatic malignancie, medicine.disease, digestive system diseases, Neoplasm, Risk factor, business, Hepatitis C viru, Kidney cancer
Abstract

AIM: To summarize the current knowledge about the potential relationship between hepatitis C virus (HCV) infection and the risk of several extra-liver cancers. METHODS: We performed a systematic review of the literature, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) Statement. We extracted the pertinent articles, published in MEDLINE and the Cochrane Library, using the following search terms: neoplasm/cancer/malignancy/tumor/carcinoma/adeno-carcinoma and non-Hodgkin lymphomas, kidney/renal-, cholangio-, pancreatic-, thyroid-, breast-,oral-, skin-, prostate-, lung-, colon-, stomach-, haematologic. Case series, case-series with control-group, case-control, cohort-studies as well as meta-analyses, written in English were collected. Some of the main characteristics of retrieved trials, which were designed to investigate the prevalence of HCV infection in each type of the above-mentioned human malignancies were summarised. A main table was defined and included a short description in the text for each of these tumours, whether at least five studies about a specific neoplasm, meeting inclusion criteria, were available in literature. According to these criteria, we created the following sections and the corresponding tables and we indicated the number of included or excluded articles, as well as of meta-analyses and reviews: (1) HCV and haematopoietic malignancies; (2) HCV and cholangiocarcinoma; (3) HCV and pancreatic cancer; (4) HCV and breast cancer; (5) HCV and kidney cancer; (6) HCV and skin or oral cancer; and (7) HCV and thyroid cancer. RESULTS: According to available data, a clear correlation between regions of HCV prevalence and risk of extra-liver cancers has emerged only for a very small group of types and histological subtypes of malignancies. In particular, HCV infection has been associated with: (1) a higher incidence of some B-cell Non-Hodgkin-Lymphoma types, in countries, where an elevated prevalence of this pathogen is detectable, accounting to a percentage of about 10%; (2) an increased risk of intra-hepatic cholangiocarcinoma; and (3) a correlation between HCV prevalence and pancreatic cancer (PAC) incidence. CONCLUSION: To date no definitive conclusions may be obtained from the analysis of relationship between HCV and extra-hepatic cancers. Further studies, recruiting an adequate number of patients are required to confirm or deny this association.

Published
2015

9. Liver Damage in Obese Patients

Author

Antonio Del Gaudio, Giovanni-Alberto Del Gaudio, Laura Mastrangelo, Luca Boschi, and Daniela Munari

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Adolescent, Endocrinology, Diabetes and Metabolism, Population, Gastroenterology, Asymptomatic, Liver Function Tests, Internal medicine, medicine, Humans, Prospective Studies, Risk factor, education, Prospective cohort study, education.field_of_study, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, Middle Aged, medicine.disease, Obesity, Morbid, Liver, Liver biopsy, Female, Surgery, Steatosis, medicine.symptom, Liver function tests, business
Abstract

Background: Hepatic steatosis, nonalcoholic steatohepatitis and cryptogenetic cirrhosis are frequent in an obese population. Therefore, it is wise to submit all obese patients with significant alterations in hepatic function tests to transparietal liver biopsy. The aim of this study is to determine the hepatic conditions of morbidly obese patients during bariatric surgery by means of a wedge liver biopsy, to avoid any eventual hepatic damage being ascribed to the surgical procedure. Methods: This prospective study entails 216 consecutive patients, whose work-up included liver function tests, before undergoing vertical gastroplasty and wedge liver biopsy. Histology was assessed for hepatic steatosis, necroinflammatory activity and liver fibrosis/cirrhosis. Results: Abnormal preoperative liver function tests were detected in 65 patients, in 52 unexpectedly. Histologically, significant steatosis was found in 168 patients (77.8%); necroinflammatory activity in 13 (6.0%); liver fibrosis in 46 (21.3%), 5 of whom (2.3%) were found to have an asymptomatic and unknown liver cirrhosis. Conclusion: In morbidly obese patients, the incidence of histological liver damage is very high, despite acceptable liver function tests. In addition to steatosis, however, a "second hit" to induce necrosis and inflammation, favoring the development of significant fibrosis, is not essential. Being obese is an independent risk factor for liver damage and could contribute to liver fibrosis either alone or in association with other insulting factors.The identification of obese patients with septal fibrosis/cirrhosis, at surgery, is of considerable interest in clinical practice, mainly under the aspect of prognosis and liability.

Published
2002
Full Text
View/download PDF

10. MicroRNAs as possible biomarkers for diagnosis and prognosis of hepatitis B- and C-related-hepatocellular-carcinoma

Author

Laura Mastrangelo, Dario de Biase, Sirio Fiorino, Andrea Domanico, Michela Visani, Andrea Tura, Arrigo Bondi, Adele Fornelli, Giorgia Acquaviva, Luca Di Tommaso, Carlo Fabbri, Michele Masetti, Raffaele Lombardi, Paolo Leandri, Sergio Sabbatani, Matteo Zanello, Maria Letizia Bacchi-Reggiani, Elio Jovine, Fabio Grizzi, Annalisa Pession, Fiorino, Sirio, BACCHI REGGIANI, MARIA LETIZIA, Visani, Michela, Acquaviva, Giorgia, Fornelli, Adele, Masetti, Michele, Tura, Andrea, Grizzi, Fabio, Zanello, Matteo, Mastrangelo, Laura, Lombardi, Raffaele, DI TOMMASO, LUCA LUIGI, Bondi, Arrigo, Sabbatani, Sergio, Domanico, Andrea, Fabbri, Carlo, Leandri, Paolo, Pession, Annalisa, Jovine, Elio, and DE BIASE, Dario

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatocellular carcinoma, Prognosi, Molecular Diagnostic Technique, Hepatitis C virus, Predictive Value of Test, Review, medicine.disease_cause, 03 medical and health sciences, Predictive Value of Tests, Internal medicine, microRNA, Biomarkers, Tumor, medicine, Humans, Topic Highlight, Early Detection of Cancer, Hepatitis B virus, business.industry, Liver Neoplasms, Gastroenterology, MicroRNA, Hepatitis B viru, General Medicine, Hepatitis C, Hepatitis B, Prognosis, medicine.disease, digestive system diseases, MicroRNAs, 030104 developmental biology, Systematic review, Molecular Diagnostic Techniques, Liver Neoplasm, Predictive value of tests, Hepatitis C viru, business, Liver disease, Human
Abstract

Aim of the present review is to summarize the current knowledge about the potential relationship between miRNAs and hepatitis B virus (HBV)-hepatitis C virus (HCV) related liver diseases. A systematic computer-based search of published articles, according to the Preferred Reporting Items for Systematic reviews and Meta-Analysis Statement, was performed to identify relevant studies on usefulness of serum/plasma/urine miRNAs, as noninvasive biomarkers for early detection of HBV and HCV-induced hepatocellular carcinoma (HCC) development, as well as for its prognostic evaluation. The used Medical Subject Headings terms and keywords were: “HBV”, “HCV”, “hepatocellular carcinoma”, “microRNAs”, “miRNAs”, “diagnosis”, “prognosis”, “therapy”, “treatment”. Some serum/plasma miRNAs, including miR-21, miR-122, mi-125a/b, miR-199a/b, miR-221, miR-222, miR-223, miR-224 might serve as biomarkers for early diagnosis/prognosis of HCC, but, to date, not definitive results or well-defined panels of miRNAs have been obtained. More well-designed studies, focusing on populations of different geographical areas and involving larger series of patients, should be carried out to improve our knowledge on the potential role of miRNAs for HCC early detection and prognosis.

Published
2016
Full Text
View/download PDF

11. [Laparoscopic colorectal surgery: is the 'learning curve' necessary?]

Author

Elio, Jovine, Fernando, Talarico, Federico, Bolchini, Giovanni, Landolfo, Laura, Mastrangelo, Maria Federica, Lerro, Federica, Martuzzi, Simonetta, Selleri, Andrea, Lazzari, Domenico Rosario, Iusco, and Giuseppe, Gizzi

Subjects
Adult, Aged, 80 and over, Male, Laparotomy, Time Factors, Length of Stay, Middle Aged, Humans, Learning, Female, Laparoscopy, Colorectal Neoplasms, Colorectal Surgery, Colectomy, Aged
Abstract

To present the early experience of the Authors' division in the field of colorectal laparoscopic surgery, in order to evaluate the so-called "learning curve".From February 2003 to May 2004, we have performed 220 surgical procedures for colorectal pathology: 63 were conducted by a laparoscopic approach with 10 patients who, converted to a laparotomic procedure in theatre, were not taken under consideration. The present work is thus based on a population of 53 patients, 27 men and 26 women, at a median age of 64.4 y.o. (range 42-81).We performed 1 total colectomy, 24 right hemicolectomy, 1 resection of the splenic flexure, 12 left hemicolectomy (in 1 case a left hepatic lobectomy was associated), 11 anterior resection of the rectum, 1 Hartmann' sigmoid resection and 3 abdomino-perineal resection. Mean operative time was 200.34 +/- 64.17 min, while the mean hospital stay was 6.44 +/- 2.68 days. Peri-operative mortality was 0%, 30-days mortality was 1/53 patients (9%) while morbidity was 5/53 patients (9.4%): in 2 cases reintervention was necessary.From the evaluation of the results, we found some significant data: first, the conversion rate was similar to those reported by other authors, so also the mortality and morbidity rates.The advantages of the laparoscopic technique, indirectly documented by shorter in-hospital stay. At least for patients submitted to right or left hemicolectomy without complications (5.5 e 5.7 days, respectively), could be seen also after only a 1 year of activity. As far as the "learning curve" is concerned, dividing our activity into 3 times, we verified a progressive shortening of the operative time and, at least for the patients submitted to a right emicolecomy, also of the morbidity rates.

Published
2005

12. Malignant gastrointestinal stromal neoplasm

Author

Federica Martuzzi, Laura Mastrangelo, Federica M. Lerro, Frederico Biolchini, and Elio Jovine

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Gastrointestinal Stromal Tumors, medicine.medical_treatment, Colonoscopy, Antineoplastic Agents, Piperazines, Laparotomy, Medicine, Humans, Gastrointestinal cancer, medicine.diagnostic_test, GiST, business.industry, Stomach, Liver Neoplasms, Sarcoma, medicine.disease, Malignant Gastrointestinal Stromal Tumor, medicine.anatomical_structure, Pyrimidines, Chemotherapy, Adjuvant, Benzamides, Imatinib Mesylate, Abdomen, Surgery, business
Abstract

An otherwise healthy 36-year-old man was admitted to our department because of a mechanical ileus associated with an increased abdominal girth. The abdomen was distended, and a nontender mass was palpable and localized to all abdominal quadrants but especially on the right side. Laboratory values were normal, except for an increased level of lactate dehydrogenase. A computed tomographic (CT) scan was performed, revealing an enormous, nonhomogeneously enhanced neoplasm (30 cm 22 cm 10.5 cm) that reached the pelvis, and displaced the stomach and the small bowel without infiltrating them. The CT scan also revealed the presence of multiple lesions in liver segments V, VI, and VII, compatible with metastases (Fig 1, A). Arteriography showed patency of the digestive arteries, which were displaced to the left without signs of infiltration. Colonoscopy and gastroscopy were negative for mucosal lesions. A transabdominal needle biopsy showed interlacing fasciculi of spindled cells with a high mitotic index, strongly positive for CD117 and CD34 but negative for desmin, vimentin, and protein S100. The diagnosis was malignant gastrointestinal stromal tumor (GIST). At laparotomy an enormous, hypervascularized, cerebroid mass occupied the entire abdominal cavity (Fig 2). The mass appeared to originate from

Published
2005

13. Endogenous TGF-beta activity is modified during cellular aging: effects on metalloproteinase and TIMP-1 expression

Author

Albert J.T. Millis, Guangyuan Zeng, Laura Mastrangelo, and Heather M. Mccue

Subjects
Senescence, Male, Endogeny, Biology, Matrix metalloproteinase, Antibodies, Epithelium, Cell Line, Transforming Growth Factor beta, Skin Physiological Phenomena, TGF beta signaling pathway, Gene expression, medicine, Animals, Humans, Collagenases, Fibroblast, Lung, Cells, Cultured, Cellular Senescence, Glycoproteins, Skin, Infant, Newborn, Tissue Inhibitor of Metalloproteinases, Cell Biology, Molecular biology, Kinetics, medicine.anatomical_structure, Cell culture, Mink, Culture Media, Conditioned, Collagenase, Matrix Metalloproteinase 3, Cell Division, medicine.drug
Abstract

In culture, nontransformed human diploid fibroblasts divide a limited number of times, resulting in a nonproliferating senescent cell culture which exhibits an altered pattern of gene expression. Previously we reported that an early event in the process of replicative senescence was an increase in the synthesis of two connective tissue degrading metalloproteinases, collagenase and stromelysin, and a decrease in the synthesis of the physiological inhibitor of those enzymes, tissue inhibitor of metalloproteinases-1 (TIMP-1). The cytokine TGF-beta1 is known to regulate the expression of each of these three genes and to be synthesized and secreted by cultured human fibroblasts. This suggested the hypothesis that the age-specific modulation of collagenase, stromelysin, and TIMP-1 expression is the result of a change in TGF-beta1 activity during replicative senescence. To test this hypothesis, the responses of early, mid, and late passage (presenescent) fibroblast cell cultures to a TGF-beta neutralizing antibody were evaluated. In early passage cell cultures, exposure to TGF-beta neutralizing antibody resulted in a significant increase in the expression of collagenase and stromelysin and decreased TIMP-1 expression. The antibody did not affect expression of either of those genes by late passage cell cultures, although late passage cultures did respond to added TGF-beta1. Quantification of the levels of active TGF-beta, using a growth inhibition assay, indicates that the level of active TGF-beta1 is decreased during replicative senescence, supporting the conclusion that the modulation of collagenase, stromelysin, and TIMP-1 expression results from diminished TGF-beta activity.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results