1. The association between aging-related monocyte transcriptional networks and comorbidity burden: the Multi-Ethnic Study of Atherosclerosis (MESA)
- Author
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Ding, Jingzhong, Lohman, Kurt, Molina, Anthony, Delbono, Osvaldo, Bertoni, Alain, Shea, Steven, Post, Wendy, Guo, Xiuqing, Barr, R Graham, Manichaikul, Ani W, Pankow, James S, Rotter, Jerome I, Hoeschele, Ina, Kritchevsky, Stephen B, and Liu, Yongmei
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Clinical Sciences ,Genetics ,Cardiovascular ,Clinical Research ,Aging ,Atherosclerosis ,Minority Health ,Women's Health ,Health Disparities ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Humans ,Female ,Male ,Monocytes ,Gene Regulatory Networks ,Receptors ,IgG ,Comorbidity ,Monocyte ,Transcriptomic ,Clinical sciences - Abstract
Translating our knowledge of the biological aging from animal models to humans may give rise to novel approaches of targeting multiple aging-related diseases simultaneously and increasing health span. Here, for the first time, we use transcriptomic signatures of monocytes to identify biological aging pathways underlying multiple aging-related diseases in humans. The ordinal logistic regression was used to cross-sectionally investigate transcriptomics of the comorbidity index in 1264 community-based Multi-Ethnic Study of Atherosclerosis (MESA) adults, 47% Caucasian, 32% Hispanic, 21% African American, and 51% female, aged 55-94 years. The comorbidity index was defined as the number of prevalent aging-related diseases including cardiovascular disease, type-2 diabetes, hypertension, cancer, dementia, chronic kidney disease, chronic obstructive pulmonary disease, and hip fracture. We identified 708 gene transcripts associated with the comorbidity index (FDR
- Published
- 2023