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Your search keyword '"K., Pyorala"' showing total 14 results
Start Over Author "K., Pyorala" Topic humans
14 results on '"K., Pyorala"'

1. [Prevention of coronary disease in clinical practice. Guidelines of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hypertension]

Author

K, Pyorala, G, De Backer, I, Graham, P, Poole-wilson, and D, Wood

Subjects
Adult, Male, Alcohol Drinking, Physical Exertion, Smoking, Age Factors, Blood Pressure, Coronary Disease, Middle Aged, Lipids, Diet, Primary Prevention, Cholesterol, Diabetes Mellitus, Type 1, Sex Factors, Diabetes Mellitus, Type 2, Risk Factors, Humans, Female, Obesity, Insulin Resistance, Life Style, Triglycerides, Aged
Published
1996

2. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: population based study

Author

J Kuusisto, K Koivisto, K Kervinen, L Mykkanen, E-L Helkala, M Vanhanen, T Hanninen, K Pyorala, Y A Kesaniemi, P Riekkinen, and M Laasko

Subjects
Apolipoprotein E, Gerontology, Male, medicine.medical_specialty, Apolipoprotein B, Population, Disease, Random Allocation, Degenerative disease, Apolipoproteins E, Gene Frequency, Alzheimer Disease, Internal medicine, medicine, Odds Ratio, Prevalence, Dementia, Humans, Allele, Sex Distribution, education, Alleles, Finland, General Environmental Science, Aged, education.field_of_study, biology, business.industry, General Engineering, General Medicine, medicine.disease, Cross-Sectional Studies, Dementia, Multi-Infarct, Phenotype, Population Surveillance, biology.protein, General Earth and Planetary Sciences, Female, Alzheimer's disease, business, Research Article
Abstract

OBJECTIVE--To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. DESIGN--Cross sectional population based study. SUBJECTS--980 people aged 69 to 78 (349 men, 631 women). SETTING--Population of Kuopio, eastern Finland. MAIN OUTCOME MEASURES--Presence of e4 allele and diagnosis of Alzheimer's disease by detailed neurological and neurophysiological evaluation. RESULTS--46 (4.7%) subjects were classified as having probable or possible Alzheimer's disease. The frequency of the apolipoprotein E e4 allele was 0.359 in patients with Alzheimer's disease and 0.165 subjects without dementia (P < 0.0001). The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E. CONCLUSIONS--Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population.

Published
1994

3. Demonstration of disturbed free fatty acid metabolism of myocardium in patients with non-insulin-dependent diabetes mellitus as measured with iodine-123-heptadecanoic acid

Author

E. Vanninen, K. Pyorala, Mikko P. Laakso, Jyrki T. Kuikka, Pentti Rautio, Matti Uusitupa, Esko Länsimies, and J. Mustonen

Subjects
medicine.medical_specialty, Fatty Acids, Nonesterified, Ventricular Function, Left, Iodine Radioisotopes, chemistry.chemical_compound, Diabetes mellitus, Internal medicine, Iodine-123, medicine, Humans, Radiology, Nuclear Medicine and imaging, chemistry.chemical_classification, Tomography, Emission-Computed, Single-Photon, Ejection fraction, Fatty acid metabolism, business.industry, Myocardium, Fatty Acids, Fatty acid, General Medicine, Metabolism, Venous blood, Middle Aged, medicine.disease, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Heptadecanoic acid, business
Abstract

Myocardial free fatty acid metabolism and left ventricular function were evaluated in 15 middle-aged patients with non-insulin-dependent diabetes mellitus (NIDDM) and in 8 healthy control subjects. The study subjects had no evidence of coronary heart disease on the basis of clinical history, exercise ECG or myocardial perfusion scintigraphy. During peak exercise, iodine-123 hepatadecanoic acid (HDA) was intravenously injected. Myocardial activity distribution of 123I-HDA was measured 10, 30, and 50 min after exercise using single-photon emission tomography (SPET); and then further corrected by free 123I-iodine. Venous blood samples were drawn for detecting the plasma activity of 123I. The net extraction of 123I-HDA into the myocardium was obtained by dividing the corrected tissue 123I concentration by the integral of the plasma time activity curve. The net extraction was 0.40 ± 0.06 min−1 (mean ± SD) patients with NIDDM and 0.38 ± 0.06 min−1 in control subjects (P>0.1), respectively. The faster elimination rate of 123I-HDA was found in patients with NIDDM (0.029±0.008 min−1) than in control subjects (0.022±0.004 min−1; P

Published
1991

9. Solitary tricuspid stenosis

Author

K, PYORALA, L, SAXEN, and P I, HALONEN

Subjects
Heart Valve Diseases, Humans, Disease, Constriction, Pathologic, Tricuspid Valve, Tricuspid Valve Stenosis
Published
1959

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