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The objective of this study was to reflect on the meanings of the work of Brazilian nursing care in the context of the Covid-19 pandemic. This is a theoretical study anchored in the definition of meanings of work, according to Estelle Morin's perspective. The work developed by nursing professionals became even more evident in pandemic times, with the precarious conditions of health services in Brazil coming to light. During the pandemic, the incorporation of meanings of work became more important, given that the society recognized the relevance of these professionals in dealing with the pandemic, and this allowed the discussion about their social, political, and economic recognition. The impacts of nursing performance during the Covid-19 pandemic are related to the economic issue, social values, autonomy in the exercise of the profession, recognition, and safety, reflecting on the sense of purpose of work. Thus, the work that makes sense for nursing professionals is related to professional appreciation, specifically, to salary recognition, while what makes no sense is what hinders intellectual, cognitive, and financial progress. Thus, conditions were imposed that give directions to ambivalent meanings to work.