1. Prevalence of structural birth defects among infants with Down syndrome, 2013–2017: A US population‐based study
- Author
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Sarah C. Fisher, Tyiesha D Short, Mimi Le, Wendy N. Nembhard, Xiaoyi Shan, Jason L. Salemi, Russell S. Kirby, Hoang H. Nguyen, Dominique Heinke, Jennifer Isenburg, Philip J. Lupo, Erin B. Stallings, Paul A. Romitti, and Eirini Nestoridi
- Subjects
Male ,0301 basic medicine ,Embryology ,Pediatrics ,medicine.medical_specialty ,Down syndrome ,Health, Toxicology and Mutagenesis ,Population ,Chromosomal disorder ,030105 genetics & heredity ,Toxicology ,Article ,03 medical and health sciences ,Pregnancy ,Prevalence ,medicine ,Humans ,Atrioventricular Septal Defect ,Child ,education ,Organ system ,education.field_of_study ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Population based study ,Case ascertainment ,030104 developmental biology ,Population Surveillance ,Pediatrics, Perinatology and Child Health ,Female ,Diagnosis code ,Down Syndrome ,business ,Live Birth ,Maternal Age ,Developmental Biology - Abstract
BACKGROUND: Down syndrome is the most common chromosomal disorder at birth and is often accompanied by structural birth defects. Current data on major structural defects in this population are limited. METHODS: States and territorial population-based surveillance programs submitted data on identified cases of Down syndrome and identified structural birth defects during 2013–2017. We estimated prevalence by program type and maternal and infant characteristics. Among programs with active case ascertainment, we estimated the prevalence of birth defects by organ system and for specific defects by maternal age (
- Published
- 2020