1. Characterizing Emerging Canine H3 Influenza Viruses
- Author
-
Huihui Kong, Laura Rodriguez, Brian R. Wasik, Hanyuan Zhang, Guojun Wang, Yoshihiro Kawaoka, Kuan-Fu Chen, Pamela Freiden, Nicholas Wohlgemuth, David F. Burke, Ashley L. Fink, Sabra L. Klein, Melissa B. Uccellini, Patrick C. Wilson, Karlie Woodard, Sander Herfst, David J. Topham, Angela Danner, Zhen-Ying Liu, Daniel R. Perez, Cheryl A. Jones, John Steel, Philippe Noriel Q. Pascua, Christopher S. Anderson, Anice C. Lowen, Katherine J. Fenstermacher, Lauren Sauer, Victoria A. Meliopoulos, Jeanne Holden-Wiltse, Richard D. Cummings, Yao-Tsun Li, Gabriele Neumann, Malik Peiris, Elena A. Govorkova, Kaori Sakamoto, Michael C. W. Chan, Derek J. Smith, Benjamin L. Miller, Sanjukta Bandyopadhyay, Colin R. Parrish, Subrata Barman, John J. Treanor, Lucas M. Ferreri, Shamika Danzy, Hui Tao, Ian E. H. Voorhees, Ranawaka A.P.M. Perera, Paul G. Thomas, Scott Krauss, David A. Steinhauer, Adolfo García-Sastre, Pilar Blanco-Lobo, Gavin J. D. Smith, Stacey Schultz-Cherry, Phuong T. M. Nguyen, Luis Martinez-Sobrido, Ron A. M. Fouchier, Masato Hatta, Sean Cherry, Brandi Livingston, Marta L. DeDiego, Gongxun Zhong, Mathilde Richard, David J. Pattinson, Mitra Lewis, Bridgett Sharp, Farah El Najjar, Andrew Pekosz, Jasmina M. Luczo, Stephen M. Tompkins, Charles J. Russell, Bindumadhav M. Marathe, Richard E. Rothman, Carole Henry, Lauren Byrd-Leotis, Mark Y. Sangster, Theresa Fitzgerald, Juan Carlos Dib, Shiho Chiba, Shufang Fan, Kathryn Shaw-Saliba, Aitor Nogales, Guohua Yang, Richard J. Webby, Virology, Martinez-Sobrido, Luis [0000-0001-7084-0804], Zhang, Hanyuan [0000-0002-0736-4603], Nguyen, Phuong [0000-0002-8273-730X], Anderson, Christopher S [0000-0002-8560-3438], Holden-Wiltse, Jeanne [0000-0003-2694-7465], Nogales, Aitor [0000-0002-2424-7900], Wasik, Brian R [0000-0001-5442-3883], Miller, Benjamin L [0000-0001-9168-8047], Henry, Carole [0000-0002-5696-527X], Wilson, Patrick C [0000-0002-3537-1245], Topham, David J [0000-0002-9435-8673], Byrd-Leotis, Lauren [0000-0002-7984-0357], Cummings, Richard D [0000-0002-8918-5034], Luczo, Jasmina M [0000-0002-8036-110X], Tompkins, Stephen M [0000-0002-1523-5588], Sakamoto, Kaori [0000-0003-0592-6403], Steel, John [0000-0003-1217-0990], Klein, Sabra L [0000-0002-0730-5224], Wohlgemuth, Nicholas [0000-0002-6450-6452], Fenstermacher, Katherine J [0000-0003-1139-3711], Pekosz, Andrew [0000-0003-3248-1761], Lewis, Mitra K [0000-0002-4737-4961], Chen, Kuan-Fu [0000-0001-7287-9497], Voorhees, Ian E H [0000-0003-3189-1101], García-Sastre, Adolfo [0000-0002-6551-1827], Perez, Daniel R [0000-0002-6569-5689], Ferreri, Lucas M [0000-0002-1069-9500], Herfst, Sander [0000-0001-9866-8903], Richard, Mathilde [0000-0003-0240-9312], Burke, David [0000-0001-8830-3951], Pattinson, David [0000-0003-0001-8203], Smith, Derek J [0000-0002-2393-1890], Freiden, Pamela [0000-0001-6167-180X], Peiris, Malik [0000-0001-8217-5995], Chan, M C W [0000-0001-8174-8405], Govorkova, Elena A [0000-0001-9067-5682], Marathe, Bindumadhav M [0000-0002-9929-7566], Pascua, Philippe N Q [0000-0001-6777-2994], Smith, Gavin [0000-0001-5031-468X], Schultz-Cherry, Stacey [0000-0002-2021-727X], Apollo - University of Cambridge Repository, Voorhees, Ian EH [0000-0003-3189-1101], Chan, MCW [0000-0001-8174-8405], Pascua, Philippe NQ [0000-0001-6777-2994], Anderson, Christopher S. [0000-0002-8560-3438], Wasik, Brian R. [0000-0001-5442-3883], Miller, Benjamin L. [0000-0001-9168-8047], Wilson, Patrick C. [0000-0002-3537-1245], Topham, David J. [0000-0002-9435-8673], Cummings, Richard D. [0000-0002-8918-5034], Luczo, Jasmina M. [0000-0002-8036-110X], Tompkins, Stephen M. [0000-0002-1523-5588], Klein, Sabra L. [0000-0002-0730-5224], Fenstermacher, Katherine J. [0000-0003-1139-3711], Lewis, Mitra K. [0000-0002-4737-4961], Voorhees, Ian E. H. [0000-0003-3189-1101], Perez, Daniel R. [0000-0002-6569-5689], Ferreri, Lucas M. [0000-0002-1069-9500], Smith, Derek J. [0000-0002-2393-1890], Chan, M. C. W. [0000-0001-8174-8405], Govorkova, Elena A. [0000-0001-9067-5682], Marathe, Bindumadhav M. [0000-0002-9929-7566], and Pascua, Philippe N. Q. [0000-0001-6777-2994]
- Subjects
RNA viruses ,Viral Diseases ,Influenza Viruses ,Pulmonology ,Physiology ,Pathology and Laboratory Medicine ,Communicable Diseases, Emerging ,Biochemistry ,Fluorescence Microscopy ,Basic research ,Zoonoses ,Immune Physiology ,Research article ,Dog Diseases ,Biology (General) ,Enzyme-Linked Immunoassays ,Mammals ,Mice, Inbred BALB C ,Microscopy ,0303 health sciences ,Immune System Proteins ,Viral Vaccine ,030302 biochemistry & molecular biology ,Eukaryota ,Light Microscopy ,Influenza research ,Infectious Diseases ,Influenza A virus ,Mice, Inbred DBA ,Medical Microbiology ,Viral Pathogens ,Viruses ,Vertebrates ,Pathogens ,Research Article ,medicine.medical_specialty ,QH301-705.5 ,Guinea Pigs ,Immunology ,Microbiology ,Antibodies ,Influenza A Virus, H3N8 Subtype ,03 medical and health sciences ,Dogs ,Virology ,Influenza, Human ,Genetics ,medicine ,Animals ,Humans ,Immunoassays ,Microbial Pathogens ,Molecular Biology ,030304 developmental biology ,Medicine and health sciences ,Biology and life sciences ,business.industry ,Influenza A Virus, H3N2 Subtype ,Public health ,Ferrets ,Organisms ,Proteins ,Influenza a ,RC581-607 ,United States ,Influenza ,Viral Replication ,Mice, Inbred C57BL ,Research and analysis methods ,Viral replication ,Respiratory Infections ,Amniotes ,Immunologic Techniques ,Parasitology ,Immunologic diseases. Allergy ,business ,Orthomyxoviruses - Abstract
The continual emergence of novel influenza A strains from non-human hosts requires constant vigilance and the need for ongoing research to identify strains that may pose a human public health risk. Since 1999, canine H3 influenza A viruses (CIVs) have caused many thousands or millions of respiratory infections in dogs in the United States. While no human infections with CIVs have been reported to date, these viruses could pose a zoonotic risk. In these studies, the National Institutes of Allergy and Infectious Diseases (NIAID) Centers of Excellence for Influenza Research and Surveillance (CEIRS) network collaboratively demonstrated that CIVs replicated in some primary human cells and transmitted effectively in mammalian models. While people born after 1970 had little or no pre-existing humoral immunity against CIVs, the viruses were sensitive to existing antivirals and we identified a panel of H3 cross-reactive human monoclonal antibodies (hmAbs) that could have prophylactic and/or therapeutic value. Our data predict these CIVs posed a low risk to humans. Importantly, we showed that the CEIRS network could work together to provide basic research information important for characterizing emerging influenza viruses, although there were valuable lessons learned., Author summary The 2009 influenza pandemic was a stark reminder that ongoing vigilance is critical to protect the public from an influenza pandemic. The continual evolution of influenza viruses and emergence from animal reservoirs, leads to the need to quickly identify strains that pose a public health risk. In these studies, members of the National Institutes of Allergy and Infectious Diseases (NIAID) Centers for Excellence in Influenza Research and Surveillance (CEIRS) network worked together to demonstrate that the emerging canine H3 influenza viruses posed a low risk to public health and identified several therapeutic options in the event of an emergence. In addition to providing important new basic research, many lessons were learned that may be important in dealing with any emerging disease outbreak.
- Published
- 2020