1. Cervical carcinoma in the Grampian region (1980-1991): a population-based study of survival and cervical cytology history
- Author
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E. Mann, N. Gordon, A. Macleod, Henry C Kitchener, David E. Parkin, Marion K Campbell, T. K. Sarkar, and I.D. Miller
- Subjects
Adult ,medicine.medical_specialty ,Uterine Cervical Neoplasms ,Age Distribution ,Cytology ,Internal medicine ,Cervical carcinoma ,Carcinoma ,medicine ,Humans ,Sampling (medicine) ,Pathological ,Aged ,Neoplasm Staging ,Randomized Controlled Trials as Topic ,Retrospective Studies ,Aged, 80 and over ,Gynecology ,Epithelioma ,business.industry ,Incidence ,Obstetrics and Gynecology ,Retrospective cohort study ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Population based study ,Scotland ,Multivariate Analysis ,Regression Analysis ,Female ,business ,Follow-Up Studies - Abstract
To study survival in women treated for cervical carcinoma in Grampian region, to identify clinical and pathological prognostic factors, and to correlate survival with cytology history.A retrospective study of all cases of cervical carcinoma using a prospectively gathered database. Data validated by 1 in 10 randomised retrospective case note sampling.Aberdeen Royal Infirmary.Three hundred and sixty-three women resident within Grampian diagnosed as having cervical carcinoma between 1980 and 1991, with five-year survival data on the 206 diagnosed by the end of 1986.Five-year survival rates.The mean annual incidence of cervical carcinoma in our population was 11.2 per 100,000 women, with an overall five-year survival of 67% in those under 40 years of age and 60% in those aged 40 years and over. On univariate analysis, survival was significantly adversely affected by tumour stage, grade and absence of previous smears. On multivariate analysis, the effect of previous smear history was lost, but stage and grade remained strong independent risk factors for survival. There was no significant difference in five-year survival by age or tumour type.The prognosis of cervical carcinoma in Grampian region was independently affected only by stage of disease and tumour grading and cervical smear history.
- Published
- 1994
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