1. CXCL10
- Author
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Hen, Prizant, Nilesh, Patil, Seble, Negatu, Noor, Bala, Alexander, McGurk, Scott A, Leddon, Angela, Hughson, Tristan D, McRae, Yu-Rong, Gao, Alexandra M, Livingstone, Joanna R, Groom, Andrew D, Luster, and Deborah J, Fowell
- Subjects
Inflammation ,Receptors, CXCR3 ,Histocompatibility Antigens Class II ,Antigen-Presenting Cells ,Ear ,Mice, Transgenic ,Th1 Cells ,Lymphocyte Activation ,Chemokine CXCL10 ,Interferon-gamma ,Mice ,Antigens, CD ,Animals ,Humans ,Antigens ,Cell Aggregation ,Skin - Abstract
Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation. We reveal that tissue entry and initial peripheral activation of Th1 effector T cells are tightly linked to perivascular positioning of chemokine-expressing APCs. Dermal inflammation induces tissue-wide de novo generation of discrete perivascular CXCL10
- Published
- 2020