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3 results on '"Heike Röckmann-Helmbach"'

1. Causes of perioperative hypersensitivity reactions in the Netherlands from 2002 to 2014

Author

Maurits S. van Maaren, Ron Tupker, Vera Nederhoed, Heike Röckmann-Helmbach, Joanne N G Oude Elberink, Annick A J M van de Ven, Internal Medicine, and Groningen Research Institute for Asthma and COPD (GRIAC)

Subjects
medicine.medical_specialty, drug hypersensitivity reaction, medicine.drug_class, Immunology, Antibiotics, Drug allergy, Immunoglobulin E, Drug Hypersensitivity, Internal medicine, Allergy test, medicine, Immunology and Allergy, Humans, General anaesthesia, general anaesthesia, perioperative, Perioperative Period, Netherlands, ANESTHESIA, biology, ANAPHYLAXIS, business.industry, Incidence (epidemiology), Perioperative, medicine.disease, ALLERGY, biology.protein, business, Anaphylaxis, drug allergy
Abstract

Although relatively rare, immediate perioperative hypersensitivity reactions (POH) are important complications of drug administration prior to, during and after surgical and other interventional procedures. Both the incidence of immediate POH as well as their major culprits are difficult to establish and vary considerably between reports; the incidence may be as high as 1:1250 or almost a tenfold lower.(1) Most studies have a yield of positive allergy test results of 50 to 60%, suggestive of an immunoglobulin E (IgE)-mediated reaction. Neuromuscular blocking agents (NMBA) were shown to be the most common cause of immediate POH in various countries including France and Australia,(2) while other countries (U.S.A., U.K., Spain, Denmark) identify antibiotics to be the primary culprit.(1, 3, 4).

Published
2022

2. Definition, aims, and implementation of GA

Author

Marcus, Maurer, Werner, Aberer, Rosana, Agondi, Mona, Al-Ahmad, Maryam Ali, Al-Nesf, Ignacio, Ansotegui, Rand, Arnaout, Luisa Karla, Arruda, Riccardo, Asero, Emel, Aygören-Pürsün, Aleena, Banerji, Andrea, Bauer, Moshe, Ben-Shoshan, Alejandro, Berardi, Jonathan A, Bernstein, Stephen, Betschel, Carsten, Bindslev-Jensen, Mojca, Bizjak, Isabelle, Boccon-Gibod, Konrad, Bork, Laurence, Bouillet, Henrik Balle, Boysen, Nicholas, Brodszki, Sigurd, Broesby-Olsen, Paula, Busse, Thomas, Buttgereit, Anette, Bygum, Teresa, Caballero, Régis A, Campos, Mauro, Cancian, Ivan, Cherrez-Ojeda, Danny M, Cohn, Célia, Costa, Timothy, Craig, Paulo Ricardo, Criado, Roberta F, Criado, Dorottya, Csuka, Joachim, Dissemond, Aurélie, Du-Thanh, Luis Felipe, Ensina, Ragıp, Ertaş, José E, Fabiani, Claudio, Fantini, Henriette, Farkas, Silvia Mariel, Ferrucci, Ignasi, Figueras-Nart, Natalia L, Fili, Daria, Fomina, Atsushi, Fukunaga, Asli, Gelincik, Ana, Giménez-Arnau, Kiran, Godse, Mark, Gompels, Margarida, Gonçalo, Maia, Gotua, Richard, Gower, Anete S, Grumach, Guillermo, Guidos-Fogelbach, Michihiro, Hide, Natalia, Ilina, Naoko, Inomata, Thilo, Jakob, Dario O, Josviack, Hye-Ryun, Kang, Allen, Kaplan, Alicja, Kasperska-Zając, Constance, Katelaris, Aharon, Kessel, Andreas, Kleinheinz, Emek, Kocatürk, Mitja, Košnik, Dorota, Krasowska, Kanokvalai, Kulthanan, M Sendhil, Kumaran, José Ignacio, Larco Sousa, Hilary J, Longhurst, William, Lumry, Andrew, MacGinnitie, Markus, Magerl, Michael P, Makris, Alejandro, Malbrán, Alexander, Marsland, Inmaculada, Martinez-Saguer, Iris V, Medina, Raisa, Meshkova, Martin, Metz, Iman, Nasr, Jan, Nicolay, Chikako, Nishigori, Isao, Ohsawa, Kemal, Özyurt, Nikolaos G, Papadopoulos, Claudio A S, Parisi, Jonathan Grant, Peter, Wolfgang, Pfützner, Todor, Popov, Nieves, Prior, German D, Ramon, Adam, Reich, Avner, Reshef, Marc A, Riedl, Bruce, Ritchie, Heike, Röckmann-Helmbach, Michael, Rudenko, Andaç, Salman, Mario, Sanchez-Borges, Peter, Schmid-Grendelmeier, Faradiba S, Serpa, Esther, Serra-Baldrich, Farrukh R, Sheikh, William, Smith, Angèle, Soria, Petra, Staubach, Urs C, Steiner, Marcin, Stobiecki, Gordon, Sussman, Anna, Tagka, Simon Francis, Thomsen, Regina, Treudler, Solange, Valle, Martijn, van Doorn, Lilian, Varga, Daniel O, Vázquez, Nicola, Wagner, Liangchun, Wang, Christina, Weber-Chrysochoou, Young-Min, Ye, Anna, Zalewska-Janowska, Andrea, Zanichelli, Zuotao, Zhao, Yuxiang, Zhi, Torsten, Zuberbier, Ricardo D, Zwiener, and Anthony, Castaldo

Subjects
Urticaria, Humans, Angioedema
Published
2020

3. Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk

Author

Heike Röckmann-Helmbach, Anurag Relan, Mignon T. van den Elzen, Helma van Doorn, Ans F.M. Lebens, C. Erik Hack, Carla A.F.M. Bruijnzeel-Koomen, Els van Hoffen, Leonard Kaufman, André C. Knulst, Rob J.B. Klemans, and Harmieke van Os-Medendorp

Subjects
Male, Allergy, Immunoglobulin E, Gastroenterology, Severity of Illness Index, law.invention, 030207 dermatology & venereal diseases, 0302 clinical medicine, law, Immunology and Allergy, Young adult, skin and connective tissue diseases, subcutaneous administration, Hereditary angioedema, biology, food and beverages, Middle Aged, cow's milk allergy, Recombinant Proteins, Milk, Phenotype, allergenicity, Recombinant DNA, Female, Rabbits, Complement C1 Inhibitor Protein, intracutaneous test, Adult, medicine.medical_specialty, Immunology, 03 medical and health sciences, Young Adult, Internal medicine, parasitic diseases, Severity of illness, Journal Article, medicine, Animals, Humans, In patient, recombinant human C1 esterase inhibitor, Adverse effect, Skin Tests, subcutaneous challenge, business.industry, Angioedemas, Hereditary, medicine.disease, intradermal testing, skin prick test, 030228 respiratory system, biology.protein, Cattle, rabbit allergy, Milk Hypersensitivity, business
Abstract

Recombinant human C1 inhibitor (rhC1INH) for on-demand treatment of hereditary angioedema is purified from milk of transgenic rabbits. It contains low amounts (0.002%) of host-related impurities, which could trigger hypersensitivity reactions in patients with rabbit allergy (RA) and/or cow's milk allergy (CMA).This study is an assessment of allergenicity and safety of rhC1INH in patients with RA and/or CMA.Patients with CMA and/or RA underwent skin prick test (SPT), intracutaneous test (ICT), and, when results for both were negative, subcutaneous (SC) challenge with up to 2100U (14 mL) rhC1INH. The negative predictive value of the skin test protocol was calculated, defined as the ratio of patients without systemic symptoms of hypersensitivity following SC challenge, over the number of patients having tested negative for both the SPT and the ICT. Adverse events after exposure to rhC1INH were recorded.Twenty-six patients with RA and/or CMA were enrolled. Twenty-four had negative SPT and ICT results for rhC1INH, whereas 2 had negative SPT result but positive ICT result to rhC1INH (only the highest concentration). Twenty-two patients with negative SPT and ICT results underwent SC challenge. None developed allergic symptoms. Local treatment-emergent adverse events occurred in 7 patients (32%) after SC challenge. In 5 these were considered drug related. All were mild.None of the patients with negative SPT and ICT results for rhC1INH had allergic symptoms during rhC1INH challenge. The negative predictive value of the combination of SPT and ICT for the outcome of the SC challenge was 100% (95% CI, 84.6%-100%). SC administration of rhC1INH was well tolerated.

Published
2016

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