1. Establishment of a prediction algorithm for the Honghe minority group based on warfarin maintenance dose
- Author
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Mengjiao Qian, Huan Zhao, Yunli Lou, Jing Wang, Sibo Wang, Zhongyin Wang, Haibo Ou, Jun Li, Fajian Yang, Lingying Bai, Hong Lv, Xuguan Peng, Xiao Chen, and Xiubing Yang
- Subjects
Pharmacology ,Male ,Genotype ,Anticoagulants ,Vitamin K Epoxide Reductases ,Genetics ,Molecular Medicine ,Humans ,Aryl Hydrocarbon Hydroxylases ,International Normalized Ratio ,Warfarin ,Algorithms ,Minority Groups ,Cytochrome P-450 CYP2C9 - Abstract
Background: CYP2C9 and VKORC1 are important factors in warfarin metabolism. The authors explored the effects of these genetic polymorphisms and clinical factors on a warfarin maintenance dose and then established the prediction algorithm for Honghe minorities in China. Materials & methods: Quantitative fluorescence PCR determined the mutation frequency of CYP2C9 and VKORC1-1639 G>A alleles. The authors collected the relevant clinical factors, including age, gender, body surface area (BSA), international normalized ratio value, daily warfarin dose, comorbidity and concomitant prescriptions. Results: The mean values of BSA and international normalized ratio in Honghe minorities were lower than in Han Chinese (p = 0.00). The genotype of CYP2C9*1/*1 and VKORC1- 1639 AA was the main allele, the mutationfrequency of VKORC1-1639 AA and the number of male of Honghe minorities were lower than that of Han Chinese (p = 0.013 and p = 0.04). The significances of the effect on actual warfarin dose value were gender, VKORC1 AA mutant, CYP2C9*1/*1, age, hypertension and BSA sequentially. Conclusion: By multiple linear regression analysis with genetic and clinical factors, the authors determined a prediction algorithm for adjusting individual dosing of warfarin in this population. Clinical trial registration number: ChiCTR2100051778.
- Published
- 2022