1. PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
- Author
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Maikel Luis Colli, Decio L. Eizirik, Fabrice Moore, Marco Bugliani, Piero Marchetti, Miriam Cnop, Daniel Andrade Da Cunha, Mariana Igoillo Esteve, and Alessandra K Cardozo
- Subjects
Male ,Small interfering RNA ,Nitric Oxide -- metabolism ,Endocrinology, Diabetes and Metabolism ,Interleukin-1beta ,Apoptosis ,Recombinant Proteins -- pharmacology ,Diabetes Mellitus, Type 1 -- genetics ,0302 clinical medicine ,Interferon ,Insulin-Secreting Cells ,Interferon gamma ,STAT1 ,RNA, Small Interfering ,0303 health sciences ,Gene knockdown ,Protein Tyrosine Phosphatase, Non-Receptor Type 2 ,Cell Death ,Insulin-Secreting Cells -- cytology -- drug effects -- physiology ,Chromosome Mapping ,Sciences bio-médicales et agricoles ,Interferon-gamma -- adverse effects ,Middle Aged ,Cell Survival -- drug effects ,Recombinant Proteins ,Tissue Donors ,3. Good health ,Original Article ,Signal transduction ,medicine.drug ,Signal Transduction ,RNA, Small Interfering -- genetics ,medicine.medical_specialty ,Programmed cell death ,Cell Survival ,Interleukin-1beta -- pharmacology ,Protein Tyrosine Phosphatase, Non-Receptor Type 2 -- genetics ,030209 endocrinology & metabolism ,Biology ,Nitric Oxide ,Cell Line ,03 medical and health sciences ,Interferon-gamma ,Internal medicine ,Internal Medicine ,medicine ,Animals ,Humans ,Genetic Predisposition to Disease ,RNA, Messenger ,Rats, Wistar ,030304 developmental biology ,Aged ,Rats ,Endocrinology ,Diabetes Mellitus, Type 1 ,biology.protein ,Cancer research ,RNA, Messenger -- genetics - Abstract
The pathogenesis of type 1 diabetes has a strong genetic component. Genome-wide association scans recently identified novel susceptibility genes including the phosphatases PTPN22 and PTPN2. We hypothesized that PTPN2 plays a direct role in beta-cell demise and assessed PTPN2 expression in human islets and rat primary and clonal beta-cells, besides evaluating its role in cytokine-induced signaling and beta-cell apoptosis., info:eu-repo/semantics/published
- Published
- 2009