1. Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: The Train the Brain study
- Author
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Chiara Braschi, I. Falorni, Gennaro D'Angelo, Margherita Maffei, Antonella Mercuri, Marco Mainardi, Maria Chiara Scali, L. Gargani, Eugenio Picano, Francesco Stea, Nicoletta Berardi, G. Cartoni, Alessandro Tonacci, Roberto Ceravolo, Matteo Caleo, Claudia Kusmic, Silvestro Micera, M. Di Galante, Tommaso Pizzorusso, Michelangelo Maestri, Loredana Fortunato, Lamberto Maffei, Pietro Pietrini, Luca Cecchetti, L. Mammana, C. Carlesi, Maria Grazia Andreassi, Andrea Borghini, Silverio Sbrana, T. Navarra, Tatjana Begenisic, F. Limongi, Veronica Mariotti, Leda Volpi, F. S. Giorgi, Laura Biagi, Maria Cristina Cenni, Danilo Scelfo, Martina Coscia, Andrea Angelucci, Enrica Bonanni, Rosa Sicari, Ugo Faraguna, S. Del Turco, Lorenza Pratali, Roberta Franco, Marianna Noale, Joyce Bonaccorsi, Alessandro Sale, Sara Palumbo, Sabrina Molinaro, Gloria Tognoni, Rosa Maria Bruno, Rosa Pasquariello, Mario Costa, Laura Baroncelli, Cristina Pagni, S. Turchi, Erika Melissari, Filippo Baldacci, Roberta Narducci, M. Broccardi, M. De Nes, A. Marabotti, Giovanni Cioni, Stefano Taddei, E Di Coscio, Michela Tosetti, R. Iannarella, Simona Cintoli, R. Gargiulo, Francesco Faita, Gabriele Siciliano, Paola D'Ascanio, Giuseppina Rota, Silvia Pellegrini, P. F. Bellinvia, Ubaldo Bonuccelli, L. Carnicelli, A. Fenu, Andrea Poli, Emiliano Ricciardi, Caterina Iofrida, Stefania Maggi, Alessandra Retico, Gaia Scabia, Lorenzo Ghiadoni, N. Di Lascio, Lucia Chico, Maffei, L., Picano, E., Andreassi, M. G., Angelucci, A., Baldacci, Fabio, Baroncelli, L., Begenisic, Tatjana, Bellinvia, P. F., Berardi, N., Biagi, L., Bonaccorsi, Joyce, Bonanni, E., Bonuccelli, U., Borghini, Andrea, Braschi, Chiara, Broccardi, M., Bruno, R. M., Caleo, M., Carlesi, C., Carnicelli, L., Cartoni, G., Cecchetti, L., Cenni, MARIA CRISTINA, Ceravolo, R., Chico, L., Cintoli, S., Cioni, Giovanni, Coscia, M., Costa, M., D'Angelo, Giulia, D’Ascanio, P., Nes, M. De, Turco, S. Del, Coscio, E. Di, Galante, M. Di, Lascio, N. di, Faita, F., Falorni, I., Faraguna, U., Fenu, A., Fortunato, L., Franco, R., Gargani, L., Gargiulo, R., Ghiadoni, L., Giorgi, F. S., Iannarella, R., Iofrida, C., Kusmic, C., Limongi, F., Maestri, M., Maffei, M., Maggi, Stefania, Mainardi, M., Mammana, L., Marabotti, A., Mariotti, V., Melissari, E., Mercuri, A., Micera, Silvestro, Molinaro, S., Narducci, R., Navarra, T., Noale, M., Pagni, C., Palumbo, S., Pasquariello, R., Pellegrini, Silvia, Pietrini, Pietro, Pizzorusso, T., Poli, Andrea, Pratali, L., Retico, A., Ricciardi, E., Rota, G., Sale, A., Sbrana, S., Scabia, G., Scali, M., Scelfo, D., Sicari, R., Siciliano, G., Stea, F., Taddei, S., Tognoni, G., Tonacci, A., Tosetti, M., Turchi, S., and Volpi, LAURA MARINA
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Male ,0301 basic medicine ,medicine.medical_specialty ,Settore BIO/09 - FISIOLOGIA ,education ,ALzheimer's disease ,Neuropsychological Tests ,Settore BIO/09 - Fisiologia ,behavioral disciplines and activities ,Article ,law.invention ,03 medical and health sciences ,mild cognitive impairment ,0302 clinical medicine ,Randomized controlled trial ,law ,mental disorders ,neural plasticity, Alzheimer's disease, physical exercise ,Humans ,Medicine ,Cognitive Dysfunction ,physical exercise cognitive training social settind MCI RM fMRI ,Psychiatry ,Physical Therapy Modalities ,Aged ,Aged, 80 and over ,Brain Mapping ,Multidisciplinary ,Cognitive Behavioral Therapy ,business.industry ,Brain ,cognitive reserve ,Magnetic Resonance Imaging ,Cognitive training ,Treatment Outcome ,030104 developmental biology ,Physical therapy ,environmental enrichment ,Female ,brain aging ,business ,030217 neurology & neurosurgery - Abstract
Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.
- Published
- 2017