1. Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer
- Author
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Cemil Colak, Aysun Eraslan Fatma Eraslan, Bahaddin Yaprak, A. Altinok, N. Kucuk, Öztun Temelli, Kemal Ekici, Ozlem D. Alpak, Pelin Altinok Sut, Eda Kaya Pepele, Alpaslan Mayadagli, and ALTINOK SÜT, PELİN
- Subjects
Glottis ,medicine.medical_specialty ,Ekici K., Pepele E. K. , Yaprak B., Ternelli O., Eraslan A. F. , Kucuk N., Altinok A. Y. , Sut P. A. , ALPAK O. D. , ÇOLAK C., et al., -Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer-, Medical Dosimetry, cilt.41, ss.329-333, 2016 ,genetic structures ,medicine.medical_treatment ,Planning target volume ,Conformal Therapy ,Tomotherapy ,030218 nuclear medicine & medical imaging ,Intensity-Modulated Radiotherapy ,03 medical and health sciences ,0302 clinical medicine ,otorhinolaryngologic diseases ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Helical Tomotherapy ,Laryngeal Neoplasms ,Neoplasm Staging ,Radiological and Ultrasound Technology ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Cancer ,Radiotherapy Dosage ,Intensity-modulated radiation therapy ,medicine.disease ,Larynx Cancer ,Volumetric modulated arc therapy ,Radiation therapy ,Oncology ,Glottic cancer ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Radiotherapy, Intensity-Modulated ,Radiology ,Volumetric Arc Therapy ,Radiotherapy, Conformal ,Nuclear medicine ,business ,therapeutics - Abstract
Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT. IMRT, VMAT, and HT plans vs 3D-CRT plans consistently provided superior planning target volume (PTV) coverage. Similar target coverage was observed between the 3 IMRT modalities. Compared with 3D-CRT, IMRT, HT, and VMAT significantly reduced the mean dose to the carotid arteries. VMAT resulted in the lowest mean dose to the submandibular and thyroid glands. Compared with 3D-CRT, IMRT, HT, and VMAT significantly increased the maximum dose to the spinal cord It was observed that the 3 IMRT modalities studied showed superior target coverage with less variation between each plan in comparison with 3D-CRT. The 3D-CRT plans performed better at the Dmax of the spinal cord. Clinical investigation is warranted to determine if these treatment approaches would translate into a reduction in radiation therapy-induced toxicities. (C) 2016 American Association of Medical Dosimetrists.
- Published
- 2016