1. The applicability of Magseed® for targeted axillary dissection in breast cancer patients treated with neoadjuvant chemotherapy
- Author
-
Florentia Peintinger, Andreas Sir, E. Forsthuber, and Roland Reitsamer
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Sentinel lymph node ,Lymph node biopsy ,chemistry.chemical_element ,Breast Neoplasms ,Technetium ,Magnetic marker ,03 medical and health sciences ,Neoplasm Seeding ,0302 clinical medicine ,Breast cancer ,Targeted lymph node biopsy ,Antineoplastic Combined Chemotherapy Protocols ,Biopsy ,medicine ,Humans ,030212 general & internal medicine ,Radionuclide Imaging ,Targeted axillary dissection ,Lymph node ,RC254-282 ,Chemotherapy ,medicine.diagnostic_test ,Sentinel Lymph Node Biopsy ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,General Medicine ,Sentinel node ,medicine.disease ,Neoadjuvant Therapy ,Treatment Outcome ,medicine.anatomical_structure ,chemistry ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Axilla ,Lymph Node Excision ,Original Article ,Female ,Surgery ,Lymph Nodes ,Radiology ,Radiopharmaceuticals ,Sentinel Lymph Node ,business - Abstract
Background Targeted axillary dissection (TAD), the combination of sentinel lymph node biopsy (SLNB) and targeted lymph node biopsy (TLNB), can reduce the false negative rates of sentinel node biopsy alone dramatically in breast cancer patients, who received neoadjuvant chemotherapy (NAC). However methods for TAD are still under investigation. Methods Magseed®, a non-radioactive magnetic marker was used to mark the biopsied positive TLN after NAC. The SLNB with the standard technetium-based method and the selective TLNB with Magseed® localization were performed in 40 patients. The TLNs were identified with the Sentimag® probe and excised in all patients. Specimen x-ray was performed to confirm the Magseed® within the prior to NAC biopsied and clipped lymph node. Results The TLN identification rate was 100% (40/40), the SLN identification rate was 82.5% (33/40), the concordance rate between the TLN and the SLN was 65% (26/40). Complications according Magseed® deployment or identification could not be observed. Conclusion Magseed® is a reliable and feasible marker for the identification of TLNs after NAC., Highlights • TLNB is an accurate method for the identification of marked lymph nodes after NAC. • Selective excision of TLNs is feasible. • Magseed® allows a non-radioactive, wireless marking of TLNs.
- Published
- 2021
- Full Text
- View/download PDF