4 results on '"Dorothy Byrne"'
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2. British Society for Rheumatology guideline on diagnosis and treatment of giant cell arteritis: executive summary
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Wolfgang A. Schmidt, Sarah L. Mackie, Marco A. Cimmino, Lorna Neill, Tanaz A. Kermani, Peter A. Merkel, Peter Lanyon, Alexandre Wagner Silva de Souza, Susan P Mollan, Dorothy Byrne, Asad Khan, Chetan Mukhtyar, Christina Duftner, Madeline Whitlock, Dario Camellino, Simone Appenzeller, Elaine Yacyshyn, Eric L. Matteson, Maria C. Cid, Alfred Mahr, Marwan Bukhari, Haner Direskeneli, Christian D Mallen, Eoin O' Sullivan, Justin C Mason, Richard A. Watts, Christian Dejaco, Maria Sandovici, Raashid Luqmani, Frank Buttgereit, Elisabeth Brouwer, Gary Reynolds, Bhaskar Dasgupta, Steven R. Ytterberg, Kate Gilbert, Solange Gonzalez-Chiappe, Mackie, Sarah L., Dejaco, Christian, Appenzeller, Simone, Camellino, Dario, Duftner, Christina, Gonzalez-Chiappe, Solange, Mahr, Alfred, Mukhtyar, Chetan, Reynolds, Gary, de Souza, Alexandre Wagner S., Brouwer, Elisabeth, Bukhari, Marwan, Buttgereit, Frank, Byrne, Dorothy, Cid, Maria C., Cimmino, Marco, Direskeneli, Haner, Gilbert, Kate, Kermani, Tanaz A., Khan, Asad, Lanyon, Peter, Luqmani, Raashid, Mallen, Christian, Mason, Justin C., Matteson, Eric L., Merkel, Peter A., Mollan, Susan, Neill, Lorna, O' Sullivan, Eoin, Sandovici, Maria, Schmidt, Wolfgang A., Watts, Richard, Whitlock, Madeline, Yacyshyn, Elaine, Ytterberg, Steven, Dasgupta, Bhaskar, Translational Immunology Groningen (TRIGR), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
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medicine.medical_specialty ,diagnosis ,POLYMYALGIA-RHEUMATICA ,large-vessel vasculitis ,RECOMMENDATIONS ,Polymyalgia rheumatica ,chemistry.chemical_compound ,DOUBLE-BLIND ,Tocilizumab ,Rheumatology ,Internal medicine ,Large vessel vasculitis ,medicine ,MANAGEMENT ,Humans ,Pharmacology (medical) ,guidelines ,BSR ,Glucocorticoids ,TOCILIZUMAB ,Ultrasonography ,Executive summary ,treatment ,business.industry ,giant cell arteritis ,BHPR GUIDELINES ,Guideline ,medicine.disease ,Dermatology ,investigations ,Giant cell arteritis ,chemistry ,temporal arteritis ,TRIAL ,COLLEGE ,Vasculitis ,business - Published
- 2020
3. British Society for Rheumatology guideline on diagnosis and treatment of giant cell arteritis
- Author
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Alfred Mahr, Eric L. Matteson, Maria Sandovici, Elisabeth Brouwer, Justin C Mason, Tanaz A. Kermani, Gary Reynolds, Madeline Whitlock, Lorna Neill, Alexandre Wagner Silva de Souza, Wolfgang A. Schmidt, Dario Camellino, Marco A. Cimmino, Chetan Mukhtyar, Susan P Mollan, Bhaskar Dasgupta, Christian D Mallen, Christian Dejaco, Steven R. Ytterberg, Raashid Luqmani, Elaine Yacyshyn, Frank Buttgereit, Richard A. Watts, Sarah L. Mackie, Eoin O' Sullivan, Marwan Bukhari, Dorothy Byrne, Haner Direskeneli, Kate Gilbert, Asad Khan, Peter A. Merkel, Peter Lanyon, Solange Gonzalez-Chiappe, Christina Duftner, Simone Appenzeller, Maria C. Cid, Mackie, Sarah L., Dejaco, Christian, Appenzeller, Simone, Camellino, Dario, Duftner, Christina, Gonzalez-Chiappe, Solange, Mahr, Alfred, Mukhtyar, Chetan, Reynolds, Gary, de Souza, Alexandre Wagner S., Brouwer, Elisabeth, Bukhari, Marwan, Buttgereit, Frank, Byrne, Dorothy, Cid, Maria C., Cimmino, Marco, Direskeneli, Haner, Gilbert, Kate, Kermani, Tanaz A., Khan, Asad, Lanyon, Peter, Luqmani, Raashid, Mallen, Christian, Mason, Justin C., Matteson, Eric L., Merkel, Peter A., Mollan, Susan, Neill, Lorna, O' Sullivan, Eoin, Sandovici, Maria, Schmidt, Wolfgang A., Watts, Richard, Whitlock, Madeline, Yacyshyn, Elaine, Ytterberg, Steven, Dasgupta, Bhaskar, Imperial College Healthcare NHS Trust- BRC Funding, Translational Immunology Groningen (TRIGR), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)
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medicine.medical_specialty ,COLOR DUPLEX ULTRASONOGRAPHY ,diagnosis ,POPULATION-BASED COHORT ,MEDLINE ,Placebo-controlled study ,POLYMYALGIA-RHEUMATICA ,TEMPORAL ARTERITIS ,large-vessel vasculitis ,PLACEBO-CONTROLLED TRIAL ,AORTIC-ANEURYSM ,1117 Public Health and Health Services ,Polymyalgia rheumatica ,Aortic aneurysm ,LARGE-VESSEL INVOLVEMENT ,DOUBLE-BLIND ,Rheumatology ,Internal medicine ,Large vessel vasculitis ,medicine ,Humans ,Pharmacology (medical) ,guidelines ,Science & Technology ,treatment ,business.industry ,giant cell arteritis ,1103 Clinical Sciences ,Guideline ,PERMANENT VISUAL-LOSS ,medicine.disease ,Arthritis & Rheumatology ,investigations ,Giant cell arteritis ,1107 Immunology ,RISK-FACTORS ,Radiology ,business ,Life Sciences & Biomedicine - Published
- 2020
4. Association between BRAF V600E mutation and recurrence of papillary thyroid cancer
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Eyal Robenshtok, Tae Yong Kim, Rossella Elisei, Elizabeth H. Holt, Federica Vianello, Mark Sywak, Bela Bendlova, Ali S. Alzahrani, Garcilaso Riesco-Eizaguirre, Linwah Yip, R. Michael Tuttle, Caterina Mian, Pilar Santisteban, Barbara Jarzab, Hirotaka Nakayama, Laura Fugazzola, Mingzhao Xing, Kathryn A. Carson, Young Kee Shong, James A. Fagin, Alfred King-Yin Lam, Vlasta Sýkorová, Efisio Puxeddu, Christine J. O'Neill, Agnieszka Czarniecka, Roderick J. Clifton-Bligh, David Viola, Giovanni Tallini, Comunidad de Madrid, National Institutes of Health (US), National Science Centre (Poland), Instituto de Salud Carlos III, Jack and Dorothy Byrne Foundation, Fondazione Cassa di Risparmio di Perugia, Associazione Italiana per la Ricerca sul Cancro, Beadle Family Foundation, Ministry of Health of the Czech Republic, Ministero dell'Istruzione, dell'Università e della Ricerca, Ministero della Salute, Xing, Mingzhao, Alzahrani, Ali S., Carson, Kathryn A., Shong, Young Kee, Kim, Tae Yong, Viola, David, Elisei, Rossella, Bendlová, Bela, Yip, Linwah, Mian, Caterina, Vianello, Federica, Tuttle, R. Michael, Robenshtok, Eyal, Fagin, James A., Puxeddu, Efisio, Fugazzola, Laura, Czarniecka, Agnieszka, Jarzab, Barbara, O'Neill, Christine J., Sywak, Mark S., Lam, Alfred K., Riesco-Eizaguirre, Garcilaso, Santisteban, Pilar, Nakayama, Hirotaka, Clifton-Bligh, Roderick, Tallini, Giovanni, Holt, Elizabeth H., and Sýkorová, Vlasta
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Oncology ,Male ,Pathology ,Cancer Research ,endocrine system diseases ,Papillary ,Kaplan-Meier Estimate ,Papillary thyroid cancer ,Retrospective Studie ,Risk Factors ,Missense mutation ,Adult ,Carcinoma, Papillary ,Female ,Follow-Up Studies ,Humans ,Middle Aged ,Neoplasm Recurrence, Local ,Prognosis ,Proto-Oncogene Proteins B-raf ,Retrospective Studies ,Risk Assessment ,Thyroid Neoplasms ,Mutation, Missense ,skin and connective tissue diseases ,Thyroid Neoplasm ,Follow up studies ,Local ,Mutation (genetic algorithm) ,Human ,medicine.medical_specialty ,endocrine system ,Prognosi ,Follow-Up Studie ,Internal medicine ,Carcinoma ,medicine ,neoplasms ,business.industry ,Risk Factor ,Retrospective cohort study ,medicine.disease ,digestive system diseases ,BRAF V600E ,Neoplasm Recurrence ,Multicenter study ,Mutation ,Missense ,business - Abstract
et al., [Purpose]: To investigate the prognostic value of BRAF V600E mutation for the recurrence of papillary thyroid cancer (PTC). [Patients and Methods]: This was a retrospective multicenter study of the relationship between BRAF V600E mutation and recurrence of PTC in 2,099 patients (1,615 women and 484 men), with a median age of 45 years (interquartile range [IQR], 34 to 58 years) and a median follow-up time of 36 months (IQR, 14 to 75 months). [Results]: The overall BRAF V600E mutation prevalence was 48.5% (1,017 of 2,099). PTC recurrence occurred in 20.9% (213 of 1,017) of BRAF V600E mutation–positive and 11.6% (125 of 1,082) of BRAF V600E mutation–negative patients. Recurrence rates were 47.71 (95% CI, 41.72 to 54.57) versus 26.03 (95% CI, 21.85 to 31.02) per 1,000 person-years in BRAF mutation–positive versus –negative patients (P < .001), with a hazard ratio (HR) of 1.82 (95% CI, 1.46 to 2.28), which remained significant in a multivariable model adjusting for patient sex and age at diagnosis, medical center, and various conventional pathologic factors. Significant association between BRAF mutation and PTC recurrence was also found in patients with conventionally low-risk disease stage I or II and micro-PTC and within various subtypes of PTC. For example, in BRAF mutation–positive versus –negative follicular-variant PTC, recurrence occurred in 21.3% (19 of 89) and 7.0% (24 of 342) of patients, respectively, with recurrence rates of 53.84 (95% CI, 34.34 to 84.40) versus 19.47 (95% CI, 13.05 to 29.04) per 1,000 person-years (P < .001) and an HR of 3.20 (95% CI, 1.46 to 7.02) after adjustment for clinicopathologic factors. BRAF mutation was associated with poorer recurrence-free probability in Kaplan-Meier survival analyses in various clinicopathologic categories. [Conclusion]: This large multicenter study demonstrates an independent prognostic value of BRAF V600E mutation for PTC recurrence in various clinicopathologic categories., Supported by National Institutes of Health (NIH) Grants No. R01CA134225 and RO1CA113507 (M.X.); by Grant No. UL1 RR 025005 from the National Center for Advancing Translational Sciences of NIH and NIH Roadmap for Medical Research (K.A.C.); and by the following funding to individual study centers: National Science Centre Poland Grants No. N N403 194340 (A.C.) and N N401 612440 (B.J.); grants from Griffith Health Institute (Australia; A.K.L.); Grants No. BFU2010-16025, RD06/0020/0060-RD12/0036/0030 FIS, ISCIII, and S2011/BMD-2328 TIRONET (Spain; P.S.); NIH Grant No. RO1-CA50706 and the Byrne Foundation (J.A.F.); Grant No. IG 9338 from the Fondazione Cassa di Risparmio di Perugia and Associazione Italiana per la Ricerca sul Cancro (Italy) and the Beadle Family Foundation (San Antonio, TX; E.P.); Grant No. IGA MH CR NT 13901- 4 (Czech Republic; B.B., V.S.); grants from the New South Wales Cancer Institute (C.J.O.) and Cancer Council of New South Wales (Australia; R.C.- B.); Grant No. MIUR 20074zw8la from the Ministero della Istruzione Universitaria e Ricerca Scientifica and the Associazione Italiana per la Ricerca sul Cancro (Italy; G.T.); NIH/National Institute on Aging Grant No. 5R03AG042334-02 (L.Y.); grants from the Ministero della Istruzione Universitaria e Ricerca Scientifica, the Associazione Italiana per la Ricerca sul Cancro, the Istituto Toscano Tumori, and the Ministero della Salute (Italy; D.V., R.E.); and Grant No. CB-2011-03-02 from the Korean Foundation for Cancer Research (South Korea; Y.K.S., T.Y.K.).
- Published
- 2015
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