1. Practical Immunohistochemistry in Neoplastic Pathology of the Gastrointestinal Tract, Liver, Biliary Tract, and Pancreas
- Author
-
Wang, Hanlin L, Kim, Christopher J, Koo, Jamie, Zhou, Wendi, Choi, Eunice K, Arcega, Ramir, Chen, Zongming Eric, Wang, Huamin, Zhang, Lanjing, and Lin, Fan
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Digestive Diseases ,Clinical Research ,Liver Disease ,Rare Diseases ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Oral and gastrointestinal ,Good Health and Well Being ,Biliary Tract Neoplasms ,Biomarkers ,Tumor ,Digestive System Neoplasms ,Gastrointestinal Neoplasms ,Humans ,Immunohistochemistry ,Liver Neoplasms ,Pancreatic Neoplasms ,Pathology ,Surgical ,Surgical Oncology ,Pathology ,Clinical sciences - Abstract
Context- Immunomarkers with diagnostic, therapeutic, or prognostic values have been increasingly used to maximize the benefits of clinical management of patients with neoplastic diseases of the gastrointestinal tract, liver, biliary tract, and pancreas.Objectives- To review the characteristics of immunomarkers that are commonly used in surgical pathology practice for neoplasms of the gastrointestinal tract, liver, biliary tract, and pancreas, and to summarize the clinical usefulness of immunomarkers that have been discovered in recent years in these fields.Data sources- Data sources include literature review, authors' research data, and personal practice experience.Conclusions- Immunohistochemistry is an indispensable tool for the accurate diagnosis of neoplastic diseases of the gastrointestinal tract, liver, biliary tract, and pancreas. Useful immunomarkers are available to help distinguish malignant neoplasms from benign conditions, determine organ origins, and subclassify neoplasms that are morphologically and biologically heterogeneous. Specific immunomarkers are also available to help guide patient treatment and assess disease aggressiveness, which are keys to the success of personalized medicine. Pathologists will continue to play a critical role in the discovery, validation, and application of new biomarkers, which will ultimately improve patient care.
- Published
- 2017