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52 results on '"Colin A. McKenzie"'

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1. Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

2. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

3. A cross-sectional clinic-based study exploring whether variants within the glutathione S-transferase, haptoglobin and uridine 5′-diphospho-glucuronosyltransferase 1A1 genes are associated with interindividual phenotypic variation in sickle cell anaemia in

4. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci

5. A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure

6. Edematous severe acute malnutrition is characterized by hypomethylation of DNA

7. Exploring putative genetic determinants of inter-individual phenotypic heterogeneity in sickle cell disease: A cross-sectional Jamaican cohort-based study

8. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure

9. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

10. Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

11. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

12. Common variants associated with plasma triglycerides and risk for coronary artery disease

13. Discovery and refinement of loci associated with lipid levels

14. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

15. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

16. Patterns of sodium and potassium excretion and blood pressure in the African Diaspora

17. Genome-wide association of anthropometric traits in African- and African-derived populations

18. Ethnic differences in F cell levels in Jamaica: a potential tool for identifying new genetic loci controlling fetal haemoglobin

19. Childhood malnutrition is associated with a reduction in the total melanin content of scalp hair

20. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

21. Epithelial Sodium Channel Allele T594M Is Not Associated With Blood Pressure or Blood Pressure Response to Amiloride

22. Angiotensin-Converting EnzymeGene Polymorphisms and Obesity: An Examination of Three Black Populations

23. Lipid-related genes and myocardial infarction in 4685 cases and 3460 controls: discrepancies between genotype, blood lipid concentrations, and coronary disease risk

24. Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans

25. Evolution of In Vitro Fertilization at the University of the West Indies, Jamaica

26. Localization of a Small Genomic Region Associated with Elevated ACE

27. Total laparoscopic hysterectomy versus vaginal hysterectomy at the University Hospital of the West Indies: a 5-year retrospective study

28. Quantitative variation in plasma angiotensin-I converting enzyme activity shows allelic heterogeneity in the ABO blood group locus

29. Evaluation of pediatric lower extremity fractures managed with external fixation: outcomes in a deployed environment

30. The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA

31. A preliminary examination of the effects of genetic variants of redox enzymes on susceptibility to oedematous malnutrition and on percentage cytotoxicity in response to oxidative stress in vitro

32. Association of common DNA sequence variants at 33 genetic loci with blood lipids in individuals of African ancestry from Jamaica

33. Fine mapping of the association with obesity at the FTO locus in African-derived populations

34. Rate of change of sickle allele frequency may be influenced by total fertility rate: a sesquicentenary reflection on human micro-evolution

35. Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients

36. Prospective evaluation and characteristics of patients with suspected primary hyperaldosteronism

37. Family medicine training by distance education

38. Gender differences in coping with infertility among couples undergoing counselling for in vitro fertilization treatment

39. Predicted declines in sickle allele frequency in Jamaica using empirical data

40. Polymorphisms in genes involved in folate metabolism as risk factors for oedematous severe childhood malnutrition: a hypothesis-generating study

41. The frequency of the sickle allele in Jamaica has not declined over the last 22 years

42. UGT1A1 variation and gallstone formation in sickle cell disease

43. Trans-ethnic fine mapping of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE)

44. Screening for the GRA mutation in Jamaica

45. The value of cervical screening in women over 50 years of age--time for a multicentre audit

46. Phenotypic Expression of Melanocortin-1 Receptor Mutations in Black Jamaicans

47. Genome-Wide Association Study of Coronary Heart Disease and Its Risk Factors in 8,090 African Americans: The NHLBI CARe Project

48. Rapid Assessment of Genetic Ancestry in Populations of Unknown Origin by Genome-Wide Genotyping of Pooled Samples

49. Fine-mapping of an ancestral recombination breakpoint in DCP1

50. Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians

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