1. Features of Mild-to-Moderate COVID-19 Patients With Dysphonia
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Maria Rosaria Barillari, Lionel Jouffe, Mihaela Horoi, Sébastien Vergez, Carlos M. Chiesa-Estomba, Fabrice Journe, Giovanna Cantarella, Serge-Daniel Le Bon, Justin Michel, Delphine Martiny, Kathy Huet, Marta P. Circiu, Géraldine Descamps, Didier Dequanter, Pierre Cabaraux, Christian Calvo-Henriquez, Lea Distinguin, Julien Hsieh, Tareck Ayad, Mohamad Khalife, Bernard Harmegnies, Jerome R. Lechien, Irene Lopez Delgado, Younes Chekkoury-Idrissi, Alexandra Rodriguez, Pierre Leich, Baptiste Hochet, Manuel Tucciarone, Nicolas Fakhry, Philippe Lavigne, Gabriele Molteni, Giuditta Mannelli, Thomas Radulesco, Christel Souchay, Giovanni Cammaroto, Eleonora M C Trecca, Stéphane Hans, Quentin Mat, Sven Saussez, Lise Crevier-Buchman, Fahd El Afia, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Laboratoire Parole et Langage (LPL), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Lechien, Jerome R., Chiesa-Estomba, Carlos M., Cabaraux, Pierre, Mat, Quentin, Huet, Kathy, Harmegnies, Bernard, Horoi, Mihaela, Bon, Serge D. Le, Rodriguez, Alexandra, Dequanter, Didier, Hans, Stéphane, Crevier-Buchman, Lise, Hochet, Baptiste, Distinguin, Lea, Chekkoury-Idrissi, Youne, Circiu, Marta, Afia, Fahd El, Barillari, Maria Rosaria, Cammaroto, Giovanni, Fakhry, Nicola, Michel, Justin, Radulesco, Thoma, Martiny, Delphine, Lavigne, Philippe, Jouffe, Lionel, Descamps, Géraldine, Journe, Fabrice, Trecca, Eleonora M. C., Hsieh, Julien, Delgado, Irene Lopez, Calvo-Henriquez, Christian, Vergez, Sebastien, Khalife, Mohamad, Molteni, Gabriele, Mannelli, Giuditta, Cantarella, Giovanna, Tucciarone, Manuel, Souchay, Christel, Leich, Pierre, Ayad, Tareck, and Saussez, Sven
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Male ,medicine.medical_specialty ,Nausea ,[SDV]Life Sciences [q-bio] ,ENT ,Dysphonia, Covid-19, Coronavirus, Voice, Symptoms, Clinical, Findings, ENT ,Chest pain ,Article ,030507 speech-language pathology & audiology ,03 medical and health sciences ,Speech and Hearing ,Clinical ,0302 clinical medicine ,Throat ,Internal medicine ,Epidemiology ,medicine ,Prevalence ,otorhinolaryngologic diseases ,Humans ,Dysphonia−Covid-19−Coronavirus−Voice−Symptoms−Clinical−Findings−ENT ,030223 otorhinolaryngology ,Hoarseness ,business.industry ,COVID-19 ,Bayes Theorem ,Findings ,LPN and LVN ,Dysphonia ,Dysphagia ,3. Good health ,Coronavirus ,Diarrhea ,medicine.anatomical_structure ,Otorhinolaryngology ,Symptoms ,Vomiting ,Voice ,Sputum ,Female ,medicine.symptom ,0305 other medical science ,business ,Covid-19 - Abstract
International audience; Introduction: To explore the prevalence of dysphonia in European patients with mild-to-moderate COVID-19 and the clinical features of dysphonic patients.Methods: The clinical and epidemiological data of 702 patients with mild-to-moderate COVID-19 were collected from 19 European Hospitals. The following data were extracted: age, sex, ethnicity, tobacco consumption, comorbidities, general, and otolaryngological symptoms. Dysphonia and otolaryngological symptoms were self-assessed through a 4-point scale. The prevalence of dysphonia, as part of the COVID-19 symptoms, was assessed. The outcomes were compared between dysphonic and nondysphonic patients. The association between dysphonia severity and outcomes was studied through Bayesian analysis.Results: A total of 188 patients were dysphonic, accounting for 26.8% of cases. Females developed more frequently dysphonia than males (P = 0.022). The proportion of smokers was significantly higher in the dysphonic group (P = 0.042). The prevalence of the following symptoms was higher in dysphonic patients compared with nondysphonic patients: cough, chest pain, sticky sputum, arthralgia, diarrhea, headache, fatigue, nausea, and vomiting. The severity of dyspnea, dysphagia, ear pain, face pain, throat pain, and nasal obstruction was higher in dysphonic group compared with nondysphonic group. There were significant associations between the severity of dysphonia, dysphagia, and cough.Conclusion: Dysphonia may be encountered in a quarter of patients with mild-to-moderate COVID-19 and should be considered as a symptom list of the infection. Dysphonic COVID-19 patients are more symptomatic than nondysphonic individuals. Future studies are needed to investigate the relevance of dysphonia in the COVID-19 clinical presentation.
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- 2022
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