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To evaluate perceptions of fifth-year dental students' towards case-based orthodontic education.The sample population consisted of 108 final year dental students (39 men, 69 women) who volunteered to participate in the project during their orthodontic clinical internship. Patient files including extraoral, intraoral photographs, hand-wrist, panoramic and cephalometric radiographs were randomly distributed. Each group presented their evaluations after 1 week. At the end of case discussions, students were given a questionnaire regarding their perceptions of case-based education. Differences in mean scores between groups were compared by independent samples t‑test.The response rate was 100%. The majority of students strongly agreed that their interest and ability to interpret and diagnose the orthodontic data were increased. More than 60% strongly agreed that this education had a positive effect on their attention and effective learning. More than 45% strongly agreed that their communication with colleagues was increased, and women were significantly more inclined to group work than men (p 0.05). More than 45% declared no additional burden.Orthodontic case-based education was well received by final year dental students. The most noted improvement was observed in motivation, ability to comment on the diagnosis and treatment planning of orthodontic cases, without feeling an extra workload.ZIEL: Untersucht wurde die Einstellung von Zahnmedizinstudierenden im fünften Studienjahr zur fallbezogenen kieferorthopädischen Ausbildung.Die Stichprobenpopulation bestand aus 108 Zahnmedizinstudierenden im letzten Studienjahr (39 Männer, 69 Frauen), die während ihres kieferorthopädischen klinischen Praktikums freiwillig an dem Projekt teilnahmen. Die Patientenakten mit extra- und intraoralen Fotos, Hand-Handgelenk‑, Panorama- und Fernröntgenaufnahmen wurden nach dem Zufallsprinzip verteilt. Jede Gruppe präsentierte ihre Auswertungen nach einer Woche. Nach Abschluss der Fallbesprechungen erhielten die Studenten einen Fragebogen zu ihren Wahrnehmungen der fallbezogenen Ausbildung. Die Unterschiede in den Mittelwerten zwischen den Gruppen wurden mit dem t‑Test für unabhängige Stichproben verglichen.Die Rücklaufquote betrug 100 %. Die Mehrheit der Studierenden stimmte der Aussage, dass ihr Interesse und ihre Fähigkeit, die kieferorthopädischen Daten zu interpretieren und zu diagnostizieren, erhöht worden seien, entschieden zu. Mehr als 60% stimmten deutlich zu, dass diese Ausbildung einen positiven Effekt auf Aufmerksamkeit und effektives Lernen gehabt habe. Mehr als 45% stimmten stark zu, dass ihre Kommunikation mit Kollegen gesteigert worden sei, wobei Frauen signifikant häufiger zur Gruppenarbeit neigten als Männer (p 0,05). Mehr als 45 % gaben keine zusätzliche Belastung an.Die fallbezogene kieferorthopädische Ausbildung wurde von den Zahnmedizinstudierenden im letzten Jahr des Studiums gut angenommen. Die am meisten wahrgenommene Verbesserung wurde beobachtet bei der Motivation und der Fähigkeit, die Diagnose und Behandlungsplanung von kieferorthopädischen Fällen zu kommentieren, ohne dass eine zusätzliche Arbeitsbelastung empfunden wurde.

The aim of this study was to assess the genetic evaluation of a three-generation consanguineous family with isolated oligodontia.A 16-year-old male patient who had been referred for orthodontic treatment due to the presence of oligodontia, and his family members who presented several missing teeth had been enrolled in the study. Clinical and radiological assessments and genetic analysis including whole-exome sequencing were performed.Genetic evaluations revealed both homozygous and heterozygous mutations (c.T682A:p.F228I) in the WNT10A gene of six affected members of the family. Higher frequency of agenesis of mandibular second molar was found in homozygous relative to heterozygous WNT10A mutations.The present findings have provided evidence for a known variant in the WNT10A gene in a three-generation consanguineous family with isolated oligodontia, while the results confirmed that cases with homozygous mutation revealed clinical heterogeneity.

The aim of the present study was to evaluate 3D frontal sinus morphology in consideration with different vertical facial developments. The study was conducted with the pre-treatment CBCT images of 87 patients, who were divided into 3 groups according to the sum of the posterior angle. The frontal sinus measurements were performed on the axial, sagittal, and coronal sections of the CBCT images. Craniofacial measurements were performed on the lateral cephalograms, obtained from the CBCT scans. Normal distribution of the data was confirmed by the Kolmogorov-Smirnov test. ANOVA, followed by post hoc Duncan tests, was used to compare the differences among the three groups. The relationships between sinus dimensions and craniofacial parameters were assessed by the Pearson's correlation coefficient (P < 0.05). The maximum anterior-posterior dimension of the frontal sinuses (0.017), the width of the right (0.020) and left (0.041) frontal sinuses, and the anterior-posterior dimension of the left (0.038) frontal sinus were significantly smaller in the hyperdivergent group compared to hypodivergent group. There was no significant difference between groups in terms of the height of the frontal sinuses. Significant correlation was noted between the maximum anterior-posterior dimension of the frontal sinus and SN-PP, N-Me, N-ANS, SN-GoGn, Post. sum, and Jarabak's ratio. No significant correlation between the height of the frontal sinuses and the craniofacial measurements was found. Individuals with vertical growth pattern presented decreased anterior-posterior dimension of the frontal sinuses, revealing significant correlations with vertical craniofacial parameters.

Background Anterior open bite is one of the most difficult malocclusions to treat and maintain in orthodontics. An effective treatment approach to correct anterior open bite is the intrusion of maxillary posterior teeth. The aim of this study was to evaluate the effects of corticotomy-assisted posterior maxillary intrusion with zygomatic anchorage by using finite element stress analysis. Methods An acrylic bite block on the posterior teeth including two transpalatal arches were modeled and 1.96 N intrusive force was loaded. Three scenarios were set, first with no subapical corticotomy, second with buccal, and third with both buccal and palatal corticotomies. The stress distributions along the cortical, cancellous bone surfaces, and dental structures were assessed by finite element stress analysis. Results Stress distributions over cortical and cancellous bones were commonly located at the inferior curvature of the zygomatic buttress area and posterior teeth for all scenarios. Stress values above the apices of anchor teeth were decreased for both corticotomy scenarios. Increased stress distributions were observed in cancellous bone around corticotomy regions. Despite the acrylic appliance and transpalatal arches, the stresses along the posterior teeth were not uniform. The apical third of the first molar mesiobuccal apex showed the highest stress values in all scenarios. Conclusions Corticotomy-assistance effected biomechanical responses of dentoalveolar structures during maxillary posterior intrusion. There was no apparent difference for the stress levels of the root apices between corticotomy scenarios, pointing out that only buccal corticotomy may be a better option in corticotomy-assisted maxillary intrusion.

Aim To assess the sagittal soft tissue morphology of patients with acromegaly in comparison with a healthy control group. Methods Twenty-seven patients with acromegaly (11 male, 16 female; mean age 47.3 ± 11.5 years) and 30 healthy subjects (15 male, 15 female; mean age 42.2 ± 17.4 years) were included in the study. Linear and angular measurements were made on lateral cephalograms to evaluate soft tissue and skeletal characteristics. The intergroup comparisons were analysed with the Student’s t-test. Results Facial convexity (p < 0.01) and the nasolabial angle (p < 0.001) were reduced in patients with acromegaly, whereas nose prominence (p < 0.01), upper lip sulcus depth (p < 0.01), upper lip thickness (p < 0.01), basic upper lip thickness (p < 0.01), lower lip protrusion (p < 0.05), mentolabial sulcus depth (p < 0.05) and soft tissue chin thickness (p < 0.001) were increased. Anterior cranial base length (p < 0.05), the supraorbital ridge (p < 0.01), the length of the maxilla and mandible (p < 0.001, p < 0.01, respectively) were significantly increased, and mandibular prognathism was an acromegalic feature (p < 0.05). Conclusion Acromegalic coarsening and thickening of the craniofacial soft tissues was identified from lateral cephalograms, which may therefore contribute to early diagnosis when evaluated together with other changes caused by the disease.

Objective: To monitor the effects of rapid maxillary expansion (RME) on bone metabolic activities during and after 3 months of retention. Study Design: Fifteen patients with a mean age of 12.9 +/- 0.6 years were treated with a bonded expansion device, activated 2 turns per day. The retention period was 3 months. Clinical periodontal parameters were recorded at baseline and after retention. Gingival crevicular fluid (GCF) samples were collected from maxillary first molars from the compression sides at baseline, then at 1 and 10 days and after retention. Tension side samples were obtained at baseline and after retention. Interleukin-1beta (IL-1 beta), transforming growth factor betal (TGF-beta 1), prostaglandin E-2 (PGE(2)) and nitric oxide (NO) levels were specifically measured. Results: Periodontal parameters increased significantly after retention relative to baseline values. Levels of IL-1 beta, TGF-beta 1 and PGE(2) increased on day 10, and decreased after retention on the compression side. NO levels were elevated on day 10, and remained higher after retention on the compression side. Tension side cytokine levels remained higher relative to baseline values after retention. Conclusions: The results of this study indicate the importance of ongoing adaptive bone activities after 3 months of retention with RME, which should be considered questionable as an effective retention period.

The objective of this study was to investigate the effects of fixed functional therapy on oropharyngeal airway dimensions and hyoid bone positions in Class II patients and make comparison with an untreated Class II group. Eighteen patients (8 girls, 10 boys; mean age 13.62 ± 1.92 years) who were treated with Forsus Fatique Resistant Device (FFRD) and 19 patients (11 girls, 8 boys; mean age 12.74 ± 0.91 years) who served as control were enrolled. Cephalograms were used to assess linear, angular, and area measurements. Intragroup comparisons were made by paired t and Wilcoxon tests and intergroup comparisons were performed by independent t test. With respect to controls, FFRD group showed increased airway dimensions at soft palate (P

The purpose of this case report was to describe combined endodontic and orthodontic treatment of a patient who had permanent maxillary central incisors fused with supernumerary teeth. A severe esthetic problem and crowding in the maxillary arch were present clinically. Radiographic examination demonstrated two separate crowns, roots and pulpal canals on each side. The therapy was initiated with endodontic treatment. Six months after the completion of endodontic therapy, mesio-distal trimming was performed and the defects were restored with anterior resin composites in order to re-establish the esthetics. Orthodontic treatment was performed for the alignment of the upper arch. Follow-up at 4 years demonstrated that the teeth were asymptomatic and neither root nor alveolar bone resorption was found. In conclusion, instead of extracting the supernumerary teeth, the anomaly was treated successfully in a conservative way.

Objective. The aim of this study was to assess differences in craniofacial characteristics, upper spine and pharyngeal airway morphology in patients with acromegaly compared with healthy individuals. Materials and methods. Twenty-one patients with acromegaly were compared with 22 controls by linear and angular measurements on cephalograms. The differences between the mean values of cephalometric parameters were analyzed with Mann-Whitney U-test. Results. With respect to controls, anterior (p < 0.05), middle (p < 0.01) and posterior (p < 0.05) cranial base lengths were increased, sella turcica was enlarged (p < 0.001) and upper spine morphology demonstrated differences in the height of atlas (p < 0.01) and axis (p < 0.05) in patients with acromegaly. Craniofacial changes were predominantly found in the frontal bone (p < 0.01) and the mandible (p < 0.05). As for the airway, patients with acromegaly exhibited diminished dimensions at nasal (p < 0.001), uvular (p < 0.01), mandibular (p < 0.01) pharyngeal levels and at the narrowest point of the pharyngeal airway space (p < 0.001) compared to healthy controls. Soft palate width was significantly higher (p < 0.001) and the hyoid bone was more vertically positioned (p < 0.01) in patients with acromegaly. Conclusions. Current results point to the importance of the reduced airway dimensions and that dentists and/or orthodontists should be aware of the cranial or dental abnormalities in patients with acromegaly.

The aim of this study was to investigate the effects of reverse headgear (RH) on pharyngeal airway morphology in two groups of Class III patients with different vertical craniofacial features in comparison with an untreated Class III group. Seventeen subjects (9 males, 8 females; mean age 11.3 +/- 0.98 years) with optimum vertical growth and 17 subjects (10 males, 7 females, mean age 11.5 +/- 1.1 years) with a vertical growth pattern treated with a removable intra-oral appliance and a Delaire type facemask were included. An untreated Class III control group of 11 subjects (8 males, 3 females, mean age 9.1 +/- 1.1 years) was included to compare the treated groups. The paired t-test for intragroup and one-way ANOVA for intergroup comparisons were performed. The relationships between changes in the craniofacial morphology and airway were assessed by Spearman correlation analysis. The airway dimensions at the adenoid side and soft palate were increased in the treatment groups compared to the control group (p < 0.05). The nasopharyngeal area demonstrated a significant difference in normodivergent and control subjects (p < 0.05). No significant difference was found in the airway morphology due to different vertical features. The effect of RH treatment on the sagittal airway dimensions revealed no significant difference between different vertical craniofacial features in the short term.

Aim. The aim of this study was to evaluate the long-term effects of Class 2 functional treatment on airway dimensions and positional changes in hyoid bone and compare it with that of an untreated Class 2 control group. Methods. Lateral cephalograms of 16 patients (eight girls, eight boys, mean chronological age = 11.36 +/- 0.77 years) who were treated with activator and 19 patients (11 girls, eight boys, mean chronological age = 12.14 +/- 0.65 years) who served as control were used for linear, angular and area measurements regarding airway track and hyoid bone. Statistics. Intra-group comparisons were performed by paired t-test and Wilcoxon test, whereas independent t-test and Mann Whitney-U were used for inter-group comparisons. Results. During treatment (T2-T1), nasopharyngeal height and nasopharyngeal area increased (p < 0.05) and hyoid bone moved downward (H-SN; p < 0.001) and forward (H-C3; p < 0.01). During retention period (T3-T2); nasopharyngeal (p < 0.01) and oropharyngeal area increased (p < 0.05). H-SN (p < 0.01) and C3-H distances (p < 0.05) increased. Hyoid bone position exhibited significant changes (H-SN, p < 0.001; C3-H, p < 0.01). The increases in C3-H in long-term was more in the activator group than control (p < 0.05). Conclusions. In growing Class 2 patients with mandibular deficiency and airway track without obstructions, functional appliance treatment provided favorable effects on nasopharyngeal and oropharyngeal area throughout the retention period.

Introduction: The aim of this study was to analyze the effect of an enamel-protective resin on the shear bond strength (SBS) of orthodontic brackets bonded with self-etching primer. Methods: Eighty extracted premolars were randomly divided into 4 groups of 20, and metal brackets were bonded. Group 1 specimens were bonded with Transbond Plus self-etching primer (3M Unitek, Monrovia, Calif) and no fluoride resin; in group 2, a fluoride-releasing resin (Ortho-Coat, Pulpdent, Watertown, Mass) was used with the Transbond Plus self-etching primer; group 3 teeth were bonded with a new antimicrobial self-etching primer (Clearfil Protect Bond, Kuraray Medical, Osaka, Japan) with no fluoride resin; and the same protocol was used in group 4 with an application of Ortho-Coat. A universal testing machine was used to determine the SBS, and the adhesive remaining after debonding was assessed. Results: There was no difference in SBS whether fluoride-releasing resin was used. Groups 3 and 4 had higher SBS values than the other groups (P < 0.001). The Kruskal-Wallis test showed no significant differences in the adhesive remnant index (chi-square = 0.019, P = 0.990). Conclusions: The application of enamel-protective resin did not affect the bond strength of orthodontic brackets to enamel with self-etching primer systems. (Am J Orthod Dentofacial Orthop 2009; 135:14.e1-14.e6)

Objective: To evaluate the long-term outcome of treatment with reverse headgear in patients with skeletal Class III malocclusion diagnosed as maxillary deficient. Materials and Methods: Twenty-five patients (11 girls, 14 boys; mean age, 11.32 years) treated with a reverse headgear appliance were included in this study. Pretreatment, posttreatment, and 4-year follow-up cephalometric radiographs were obtained; linear, angular, and area measurements were performed. Comparison of treatment and observation changes was performed using a paired t-test. Results: A significant increase was found in the forward movement of the maxilla, which was maintained 4 years after reverse headgear treatment. Treatment changes revealed significant increases in the sagittal dimensions and area of nasopharyngeal airway and remained significant at the end of the 4-year follow-up period. The oropharyngeal airway area increased nonsignificantly after the treatment, but significant increases occurred during the follow-up period. Conclusions: In young individuals diagnosed with maxillary deficiency treated with reverse headgear, the nasopharyngeal airway dimensions were improved after the treatment, and favorable effects of the treatment remained over the posttreatment period of 4 years.

A host-derived neutrophil-activating cytokine interleukin-8 (IL-8) is secreted mainly by monocytes and is considered to be important in regulating alveolar bone resorption during tooth movement. The aim of this study was to evaluate the levels of IL-8 during mechanical forces on periodontal tissues at different stages of orthodontic therapy. Ten canine teeth of patients having different Angle classifications were selected for the study. After the premolars were extracted, the maxillary/mandibular canines were tipped distally. Gingival crevicular fluid was sampled from mesial and distal gingival crevices of each canine separately at baseline and one hour, 24 hours, six days, 10 days, and 30 days after the application of the force. An enzyme-linked immunosorbent assay for quantitative detection of IL-8 was used. Although there was an increase in the concentration of IL-8 at tension (mesial) sites after one hour, 24 hours, six days, and 10 days, a decrease was observed at 30 days. Pressure (distal) sites did not demonstrate such an increase at any period except at 10 days. However, the concentration of IL-8 at both sites showed a similar decrease and approached each other at day 30. We concluded that local host response toward the orthodontic forces might lead an increase in IL-8 and neutrophil accumulation, and this may be one of the triggers for bone remodeling processes.