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2 results on '"Ayaka Shimo"'

1. [Clinical Significance of the Curative Effect after Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer-Correlation to Prognosis]

Author

Ei, Haku, Yasuyuki, Kojima, Kaori, Sakamaki, Mina, Kitajima, Mariko, Takishita, Nao, Sakamoto, Mizuho, Tazou, Mari, Nakano, Takako, Kuroda, Reiko, Yoshie, Tomoko, Tsuruga, Ayaka, Shimo, Arata, Shimo, Ai, Motoyoshi, Hisanori, Kawamoto, Mamoru, Fukuda, and Koichiro, Tsugawa

Subjects
Antineoplastic Combined Chemotherapy Protocols, Humans, Breast Neoplasms, Triple Negative Breast Neoplasms, Neoplasm Recurrence, Local, Prognosis, Disease-Free Survival, Neoadjuvant Therapy
Abstract

We investigated factors related to the recurrence and prognosis of patients with triple-negative breast cancer (TNBC)after neoadjuvant chemotherapy(NAC). Of the 545 patients who underwent surgery after NAC between January 2013 and December 2016, 131 patients had TNBC. An analysis of each TNBC case indicated that the presence or absence of clinical lymph node metastasis(cN)before treatment might be a predictive factor of prognosis. There were 57(43.5%)pathological complete response(pCR)(ypT0 or ypTis/N0)cases after NAC. Overall survival(OS)and disease free survival(DFS) were significantly better in pCR cases than in non-pCR cases. However, recurrence was observed in 8 of 57(14%)pCR cases and 29 of 74(39%)non-pCR cases. The factors defining DFS from the univariate analysis of the non-pCR group were cN, ypT, ypN, and vascular invasion. The multivariate analysis of these factors suggested that residual cN and vascular invasion might be independent factors predicting DFS. Residual vascular invasion was found to predict OS, and was considered to be a poor prognostic factor.

Published
2020

2. Oncologic outcomes and technical considerations of nipple-sparing mastectomies in breast cancer: experience of 425 cases from a single institution

Author

Koichiro Tsugawa, Ryosuke Hayami, Tomoko Uejima, Yoshihide Kanemaki, Reiko Yoshie, Mamoru Fukuda, Seiko Tsuchiya, Yasuyuki Kojima, Yukari Yabuki, Toru Nishikawa, Ichiro Maeda, Arata Shimo, Ayaka Shimo, Hisanori Kawamoto, Akihiko Sudo, and Kyoko Tsuchiya

Subjects
Adult, medicine.medical_specialty, Mammaplasty, Mastectomy, Subcutaneous, medicine.medical_treatment, Breast Neoplasms, 030230 surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Breast cancer, Risk Factors, Surgical oncology, medicine, Humans, Pharmacology (medical), Radiology, Nuclear Medicine and imaging, Single institution, Total Mastectomy, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Retrospective cohort study, General Medicine, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Oncology, Nipples, 030220 oncology & carcinogenesis, Female, Neoplasm Recurrence, Local, Breast reconstruction, business, Mastectomy
Abstract

Nipple-sparing mastectomy (NSM) is an advantageous treatment option, providing a complete cure and good cosmetic results. We tested whether NSM is a surgically and oncologically safe technique. We evaluated the oncological outcome of 425 breasts in 413 patients who underwent NSM between January 2000 and March 2013. We retrospectively reviewed patient data and analyzed all patient characteristics as potential risk factors of recurrence at the nipple–areola complex (NAC). To confirm the oncological safety of NSM, we compared outcomes of NSM and conventional total mastectomy. The median follow-up time after surgery was 46.8 months (range 6–158 months). Nipple necrosis was observed in 6 cases (1.4 %). The cumulative local recurrence rate after NSM was 5.8 % (25/425 cases), similar to that of conventional total mastectomy in the same period (5.6 %, 49/878 cases). Furthermore, the cumulative local recurrence rate at the NAC was 2.3 % (10 cases). HER2-enriched tumors and young age (

Published
2015
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