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1. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Collaborators, GBD 2017 Mortality, Dicker, Daniel, Nguyen, Grant, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abdurahman, Ahmed Abdulahi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abebo, Teshome Abuka, Aboyans, Victor, Abraha, Haftom Niguse, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen ME, Accrombessi, Manfred Mario Kokou, Acharya, Pawan, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Arsène Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Aggarwal, Rakesh, Aghayan, Sargis Aghasi, Agrawal, Sutapa, Agrawal, Anurag, Ahmadi, Mehdi, Ahmadi, Alireza, Ahmadieh, Hamid, Ahmed, Mohamed Lemine Cheikh brahim, Ahmed, Sayem, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alebel, Animut, Aleman, Alicia V, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine A, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Anlay, Degefaye Zelalem, Ansari, Hossein, Ansariadi, Ansariadi, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Appiah, Seth Christopher Yaw, Aremu, Olatunde, Areri, Habtamu Abera, Ärnlöv, Johan, Arora, Megha, and Artaman, Al
Subjects: Behavioral and Social Science, Pediatric, Prevention, Basic Behavioral and Social Science, 2.4 Surveillance and distribution, Aetiology, Good Health and Well Being, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Global Burden of Disease, Global Health, Humans, Infant, Infant, Newborn, Life Expectancy, Male, Middle Aged, Mortality, Sex Distribution, Socioeconomic Factors, Young Adult, GBD 2017 Mortality Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract: BackgroundAssessments of age-specific mortality and life expectancy have been done by the UN Population Division, Department of Economics and Social Affairs (UNPOP), the United States Census Bureau, WHO, and as part of previous iterations of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD). Previous iterations of the GBD used population estimates from UNPOP, which were not derived in a way that was internally consistent with the estimates of the numbers of deaths in the GBD. The present iteration of the GBD, GBD 2017, improves on previous assessments and provides timely estimates of the mortality experience of populations globally.MethodsThe GBD uses all available data to produce estimates of mortality rates between 1950 and 2017 for 23 age groups, both sexes, and 918 locations, including 195 countries and territories and subnational locations for 16 countries. Data used include vital registration systems, sample registration systems, household surveys (complete birth histories, summary birth histories, sibling histories), censuses (summary birth histories, household deaths), and Demographic Surveillance Sites. In total, this analysis used 8259 data sources. Estimates of the probability of death between birth and the age of 5 years and between ages 15 and 60 years are generated and then input into a model life table system to produce complete life tables for all locations and years. Fatal discontinuities and mortality due to HIV/AIDS are analysed separately and then incorporated into the estimation. We analyse the relationship between age-specific mortality and development status using the Socio-demographic Index, a composite measure based on fertility under the age of 25 years, education, and income. There are four main methodological improvements in GBD 2017 compared with GBD 2016: 622 additional data sources have been incorporated; new estimates of population, generated by the GBD study, are used; statistical methods used in different components of the analysis have been further standardised and improved; and the analysis has been extended backwards in time by two decades to start in 1950.FindingsGlobally, 18·7% (95% uncertainty interval 18·4-19·0) of deaths were registered in 1950 and that proportion has been steadily increasing since, with 58·8% (58·2-59·3) of all deaths being registered in 2015. At the global level, between 1950 and 2017, life expectancy increased from 48·1 years (46·5-49·6) to 70·5 years (70·1-70·8) for men and from 52·9 years (51·7-54·0) to 75·6 years (75·3-75·9) for women. Despite this overall progress, there remains substantial variation in life expectancy at birth in 2017, which ranges from 49·1 years (46·5-51·7) for men in the Central African Republic to 87·6 years (86·9-88·1) among women in Singapore. The greatest progress across age groups was for children younger than 5 years; under-5 mortality dropped from 216·0 deaths (196·3-238·1) per 1000 livebirths in 1950 to 38·9 deaths (35·6-42·83) per 1000 livebirths in 2017, with huge reductions across countries. Nevertheless, there were still 5·4 million (5·2-5·6) deaths among children younger than 5 years in the world in 2017. Progress has been less pronounced and more variable for adults, especially for adult males, who had stagnant or increasing mortality rates in several countries. The gap between male and female life expectancy between 1950 and 2017, while relatively stable at the global level, shows distinctive patterns across super-regions and has consistently been the largest in central Europe, eastern Europe, and central Asia, and smallest in south Asia. Performance was also variable across countries and time in observed mortality rates compared with those expected on the basis of development.InterpretationThis analysis of age-sex-specific mortality shows that there are remarkably complex patterns in population mortality across countries. The findings of this study highlight global successes, such as the large decline in under-5 mortality, which reflects significant local, national, and global commitment and investment over several decades. However, they also bring attention to mortality patterns that are a cause for concern, particularly among adult men and, to a lesser extent, women, whose mortality rates have stagnated in many countries over the time period of this study, and in some cases are increasing.FundingBill & Melinda Gates Foundation.
Published: 2018

2. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Author: Kyu, Hmwe Hmwe, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M, Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Molla, Abebe, Zegeye, Abil, Olifan Zewdie, Aboyans, Victor, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen ME, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Acharya, Pawan, Ackerman, Ilana N, Adamu, Abdu A, Adebayo, Oladimeji M, Adekanmbi, Victor, Ademi, Zanfina, Adetokunboh, Olatunji O, Adib, Mina G, Adsuar, Jose C, Afanvi, Kossivi Agbelenko, Afarideh, Mohsen, Afshin, Ashkan, Agarwal, Gina, Agesa, Kareha M, Aggarwal, Rakesh, Aghayan, Sargis Aghasi, Agrawal, Anurag, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Ahmed, Sayem, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akinyemiju, Tomi, Akseer, Nadia, Al-Aly, Ziyad, Al-Eyadhy, Ayman, Al-Mekhlafi, Hesham M, Al-Raddadi, Rajaa M, Alahdab, Fares, Alam, Khurshid, Alam, Tahiya, Alashi, Alaa, Alavian, Seyed Moayed, Alene, Kefyalew Addis, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Alonso, Jordi, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Aminde, Leopold N, Amini, Erfan, Amiresmaili, Mohammadreza, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Arabloo, Jalal, Aremu, Olatunde, Ärnlöv, Johan, Arora, Amit, Arora, Megha, Artaman, Al, Aryal, Krishna K, Asayesh, Hamid, Ataro, Zerihun, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide FGA, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayer, Rakesh, Azzopardi, Peter S, Babazadeh, Arefeh, Badali, Hamid, and Balakrishnan, Kalpana
Subjects: Prevention, Aging, Good Health and Well Being, Aged, Communicable Diseases, Disabled Persons, Female, Global Burden of Disease, Health Status, Healthy Lifestyle, Humans, Life Expectancy, Male, Mortality, Mortality, Premature, Prevalence, Quality-Adjusted Life Years, Risk Factors, Socioeconomic Factors, Wounds and Injuries, GBD 2017 DALYs and HALE Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract: BackgroundHow long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted life-years (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severity of ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years.MethodsWe used data for age-specific mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Socio-demographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males.FindingsGlobally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the five leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2).InterpretationWith increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low SDI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health.FundingBill & Melinda Gates Foundation.
Published: 2018

3. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Collaborators, GBD 2016 DALYs and HALE, Hay, Simon I, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abdulkader, Rizwan Suliankatchi, Abdulle, Abdishakur M, Abebo, Teshome Abuka, Abera, Semaw Ferede, Aboyans, Victor, Abu-Raddad, Laith J, Ackerman, Ilana N, Adedeji, Isaac A, Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Sutapa, Agrawal, Anurag, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibtihel, Aiyar, Sneha, Akinyemiju, Tomi F, Akseer, Nadia, Al Lami, Faris Hasan, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alasfoor, Deena, Alene, Kefyalew Addis, Ali, Raghib, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Maskari, Fatma, AlMazroa, Mohammad AbdulAziz, Al-Raddadi, Rajaa, Alsharif, Ubai, Alsowaidi, Shirina, Althouse, Benjamin M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asgedom, Solomon W, Atey, Tesfay Mehari, Atnafu, Niguse Tadele, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Awasthi, Shally, Azarpazhooh, Mahmoud Reza, Azzopardi, Peter, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Bannick, Marlena S, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barquera, Simon, Barrero, Lope H, Basu, Sanjay, Battista, Robert, Battle, Katherine E, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, and Beyene, Addisu Shunu
Subjects: Epidemiology, Public Health, Health Sciences, Clinical Research, Behavioral and Social Science, Burden of Illness, Prevention, Social Determinants of Health, 2.4 Surveillance and distribution, Good Health and Well Being, Adult, Age Distribution, Aged, Aged, 80 and over, Cause of Death, Communicable Diseases, Disabled Persons, Female, Global Burden of Disease, Global Health, Humans, Life Expectancy, Male, Middle Aged, Noncommunicable Diseases, Quality-Adjusted Life Years, Residence Characteristics, Sex Distribution, Wounds and Injuries, GBD 2016 DALYs and HALE Collaborators, Medical and Health Sciences, General & Internal Medicine, Biomedical and clinical sciences, Health sciences
Abstract: BackgroundMeasurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI).MethodsWe used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate.FindingsThe highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally.InterpretationAt a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support.FundingBill & Melinda Gates Foundation.
Published: 2017

4. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Collaborators, GBD 2016 Causes of Death, Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert RA, Breitborde, Nicholas JK, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesus, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, and Chimed-Ochir, Odgerel
Subjects: Pediatric, Clinical Research, Infant Mortality, Infectious Diseases, 2.4 Surveillance and distribution, Aetiology, Infection, Cardiovascular, Good Health and Well Being, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Cause of Death, Child, Child, Preschool, Communicable Diseases, Disasters, Female, Global Burden of Disease, Global Health, Humans, Infant, Infant, Newborn, Male, Middle Aged, Noncommunicable Diseases, Nutrition Disorders, Pregnancy, Pregnancy Complications, Socioeconomic Factors, Wounds and Injuries, Young Adult, GBD 2016 Causes of Death Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract: BackgroundMonitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends.MethodsWe estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016.FindingsThe quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72·3% (95% uncertainty interval [UI] 71·2-73·2) of deaths in 2016 with 19·3% (18·5-20·4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8·43% (8·00-8·67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16-age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1·80 million deaths (95% UI 1·59 million to 1·89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2·89%); the median annualised rate of change for all other causes was lower (a decrease of 1·59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe.InterpretationThe past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and conflict and terrorism. Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially increasing costs to health systems.FundingBill & Melinda Gates Foundation.
Published: 2017

5. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

Author: Collaborators, GBD 2016 SDG, Fullman, Nancy, Barber, Ryan M, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abdulkader, Rizwan Suliankatchi, Abdulle, Abdishakur M, Abera, Semaw Ferede, Aboyans, Victor, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen ME, Adedeji, Isaac Akinkunmi, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Agrawal, Sutapa, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibtihel, Aiyar, Sneha, Akinyemi, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alasfoor, Deena, Alene, Kefyalew Addis, Alizadeh-Navaei, Reza, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon Weldegebreal, Assadi, Reza, Atey, Tesfay Mehari, Atre, Sachin R, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Bannick, Marlena S, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barrero, Lope H, Basu, Sanjay, Battle, Katherine E, Baune, Bernhard T, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michelle L, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Beyene, Addisu Shunu, Bhala, Neeraj, Bhansali, Anil, Bhatt, Samir, Bhutta, Zulfiqar A, Bicer, Burcu Kucuk, Bidgoli, Hassan Haghparast, Bikbov, Boris, Bilal, Arebu I, Birungi, Charles, Biryukov, Stan, Bizuayehu, Habtamu Mellie, Blosser, Christopher D, Boneya, Dube Jara, Bose, Dipan, and Bou-Orm, Ibrahim R
Subjects: Infectious Diseases, Pediatric, Prevention, Rare Diseases, Good Health and Well Being, Adolescent, Adult, Child, Child Abuse, Sexual, Child, Preschool, Conservation of Natural Resources, Female, Global Burden of Disease, Global Health, Health Status, Health Status Indicators, Humans, Infant, Infant Mortality, Infant, Newborn, Male, Middle Aged, Noncommunicable Diseases, Quality-Adjusted Life Years, Sex Offenses, Young Adult, GBD 2016 SDG Collaborators, Medical and Health Sciences, General & Internal Medicine
Abstract: BackgroundThe UN's Sustainable Development Goals (SDGs) are grounded in the global ambition of "leaving no one behind". Understanding today's gains and gaps for the health-related SDGs is essential for decision makers as they aim to improve the health of populations. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016), we measured 37 of the 50 health-related SDG indicators over the period 1990-2016 for 188 countries, and then on the basis of these past trends, we projected indicators to 2030.MethodsWe used standardised GBD 2016 methods to measure 37 health-related indicators from 1990 to 2016, an increase of four indicators since GBD 2015. We substantially revised the universal health coverage (UHC) measure, which focuses on coverage of essential health services, to also represent personal health-care access and quality for several non-communicable diseases. We transformed each indicator on a scale of 0-100, with 0 as the 2·5th percentile estimated between 1990 and 2030, and 100 as the 97·5th percentile during that time. An index representing all 37 health-related SDG indicators was constructed by taking the geometric mean of scaled indicators by target. On the basis of past trends, we produced projections of indicator values, using a weighted average of the indicator and country-specific annualised rates of change from 1990 to 2016 with weights for each annual rate of change based on out-of-sample validity. 24 of the currently measured health-related SDG indicators have defined SDG targets, against which we assessed attainment.FindingsGlobally, the median health-related SDG index was 56·7 (IQR 31·9-66·8) in 2016 and country-level performance markedly varied, with Singapore (86·8, 95% uncertainty interval 84·6-88·9), Iceland (86·0, 84·1-87·6), and Sweden (85·6, 81·8-87·8) having the highest levels in 2016 and Afghanistan (10·9, 9·6-11·9), the Central African Republic (11·0, 8·8-13·8), and Somalia (11·3, 9·5-13·1) recording the lowest. Between 2000 and 2016, notable improvements in the UHC index were achieved by several countries, including Cambodia, Rwanda, Equatorial Guinea, Laos, Turkey, and China; however, a number of countries, such as Lesotho and the Central African Republic, but also high-income countries, such as the USA, showed minimal gains. Based on projections of past trends, the median number of SDG targets attained in 2030 was five (IQR 2-8) of the 24 defined targets currently measured. Globally, projected target attainment considerably varied by SDG indicator, ranging from more than 60% of countries projected to reach targets for under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria, to less than 5% of countries projected to achieve targets linked to 11 indicator targets, including those for childhood overweight, tuberculosis, and road injury mortality. For several of the health-related SDGs, meeting defined targets hinges upon substantially faster progress than what most countries have achieved in the past.InterpretationGBD 2016 provides an updated and expanded evidence base on where the world currently stands in terms of the health-related SDGs. Our improved measure of UHC offers a basis to monitor the expansion of health services necessary to meet the SDGs. Based on past rates of progress, many places are facing challenges in meeting defined health-related SDG targets, particularly among countries that are the worst off. In view of the early stages of SDG implementation, however, opportunity remains to take actions to accelerate progress, as shown by the catalytic effects of adopting the Millennium Development Goals after 2000. With the SDGs' broader, bolder development agenda, multisectoral commitments and investments are vital to make the health-related SDGs within reach of all populations.FundingBill & Melinda Gates Foundation.
Published: 2017

6. Global, regional, and national burden of suicide mortality 1990 to 2016:Systematic analysis for the Global Burden of Disease Study 2016

Author: Orpana, Heather M., Marczak, Laurie B., Arora, Megha, Abbasi, Nooshin, Abdulkader, Rizwan Suliankatchi, Abebe, Zegeye, Abraha, Haftom Niguse, Afarideh, Mohsen, Afshari, Mahdi, Ahmadi, Alireza, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Akseer, Nadia, Al‐raddadi, Rajaa M., Alahdab, Fares, Alkerwi, Ala'a, Allebeck, Peter, Alvis‐guzman, Nelson, Anber, Nahla Hamed, Anjomshoa, Mina, Antonio, Carl Abelardo T., Arora, Amit, Aryal, Krishna K., Asgedom, Solomon Weldegebreal, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Badali, Hamid, Barker‐collo, Suzanne Lyn, Bärnighausen, Till Winfried, Bazargan‐hejazi, Shahrzad, Benjet, Corina, Bensenor, Isabela M., Berfeld, Noami, Beuran, Mircea, Bhutta, Zulfiqar A., Biadgo, Belete, Bililign, Nigus, Borges, Guilherme, Borschmann, Rohan, Brazinova, Alexandra, Breitborde, Nicholas J.K., Brugha, Traolach, Butt, Zahid A., Carrero, Juan J., Carvalho, Félix, Malta, Deborah Carvalho, Castañeda‐orjuela, Carlos A., Catalá‐lópez, Ferrán, Ciobanu, Liliana G., Dachew, Berihun Assefa, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., Daryani, Ahmad, Davitoiu, Dragos Virgil, Davletov, Kairat, Degenhardt, Louisa, Demoz, Gebre Teklemariam, Jarlais, Don C.Des, Dharmaratne, Samath Dhamminda, Djalalinia, Shirin, Doan, Linh, Doku, David Teye, Dubey, Manisha, El‐khatib, Ziad, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Faro, Andre, Farzadfar, Farshad, Fekadu, Wubalem, Fernandes, Eduarda, Ferrari, Alize J., Filip, Irina, Fischer, Florian, Foreman, Kyle J., Fukumoto, Takeshi, Gebre, Abadi Kahsu, Grosso, Giuseppe, Gupta, Rahul, Haagsma, Juanita A., Bidgoli, Hassan Haghparast, Haj‐mirzaian, Arvin, Hamidi, Samer, Hankey, Graeme J., Haro, Josep Maria, Hassen, Hamid Yimam, Hay, Simon I., Heidari, Behnam, Hendrie, Delia, Rad, Enayatollah Homaie, Hosseini, Seyed Mostafa, Hostiuc, Sorin, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Jakovljevic, Mihajlo, James, Spencer, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, Jonas, Jost B., Jozwiak, Jacek Jerzy, Kadel, Rajendra, Kahsay, Amaha, Kasaeian, Amir, Kassa, Getachew Mullu, Kawakami, Norito, Kefale, Adane Teshome, Kemp, Grant Rodgers, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Ali, Khan, Muhammad Shahzeb, Khang, Young Ho, Khubchandani, Jagdish, Kiadaliri, Aliasghar A., Kieling, Christian, Kim, Young Eun, Kisa, Adnan, Knudsen, Ann Kristin Skrindo, Kokubo, Yoshihiro, Koyanagi, Ai, Krish, Varsha Sarah, Defo, Barthelemy Kuate, Kumar, G. Anil, Kumar, Manasi, Lamichhane, Prabhat, Lang, Justin J., Latifi, Arman, Lee, Paul H., Leung, Janni, Lim, Lee Ling, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Mahesh, P. A., Majdan, Marek, Majdzadeh, Reza, Malekzadeh, Reza, Manda, Ana Laura, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Maravilla, Joemer C., Martinez‐raga, Jose, Mathur, Manu Raj, Maulik, Pallab K., McGrath, John J., Mehrotra, Ravi, Mekonen, Tesfa, Mendoza, Walter, Meretoja, Tuomo J., Mestrovic, Tomislav, Miller, Ted R., Mini, G. K., Mirrakhimov, Erkin M., Mitchell, Philip B., Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadi, Moslem, Mohammed, Shafiu, Mokdad, Ali H., Monasta, Lorenzo, Moosazadeh, Mahmood, Moradi, Ghobad, Moradi‐lakeh, Maziar, Moradinazar, Mehdi, Velásquez, Ilais Moreno, Morisaki, Naho, Morrison, Shane Douglas, Moschos, Marilita M., Mousavi, Seyyed Meysam, Mustafa, Ghulam, Nagel, Gabriele, Naheed, Aliya, Naik, Gurudatta, Najafi, Farid, Negoi, Ionut, Negoi, Ruxandra Irina, Nguyen, Huong Lan Thi, Nguyen, Long Hoang, Nixon, Molly R., Ofori‐asenso, Richard, Ogbo, Felix Akpojene, Oh, In Hwan, Olagunju, Andrew T., Olagunju, Tinuke O., Øverland, Simon, Owolabi, Mayowa Ojo, Panda‐jonas, Songhomitra, Parry, Charles D.H., Pati, Sanghamitra, Patten, Scott B., Patton, George C., Petzold, Max, Phillips, Michael R., Plana‐ripoll, Oleguer, Postma, Maarten J., Pourshams, Akram, Poustchi, Hossein, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi‐movaghar, Afarin, Rahimi‐movaghar, Vafa, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rezaeian, Shahab, Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostami, Ali, Sachdev, Perminder S., Safari, Hosein, Safiri, Saeid, Salamati, Payman, Salimi, Yahya, Salomon, Joshua A., Samy, Abdallah M., Santos, Itamar S., Santric‐milicevic, Milena M., Sartorius, Benn, Sarvi, Shahabeddin, Satpathy, Maheswar, Sawhney, Monika, Schwebel, David C., Sepanlou, Sadaf G., Shaikh, Masood Ali, Sharif, Mehdi, Shibuya, Kenji, Shigematsu, Mika, Shiri, Rahman, Shiue, Ivy, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Silva, João Pedro, Singh, Jasvinder A., Filho, Adauto Martins Soares, Sobhani, Soheila, Stein, Dan J., Stein, Murray B., Sufiyan, Mu'awiyyah Babale, Sunguya, Bruno F., Tabarés‐seisdedos, Rafael, Tabb, Karen M., Tavakkoli, Mohammad, Tehrani‐banihashemi, Arash, Temsah, Mohamad Hani, Topor‐madry, Roman, Tran, Bach Xuan, Tran, Khanh Bao, Ullah, Irfan, Unutzer, Jurgen, Usman, Muhammad Shariq, Uthman, Olalekan A., Valdez, Pascual R., Yonemoto, Naohiro, Vasconcelos, Cintia, Vlassov, Vasily, Vos, Theo, Vujcic, Isidora S., Waheed, Yasir, Wang, Yuan Pang, Weiderpass, Elisabete, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A., Wyper, Grant M.A., Yaseri, Mehdi, Yimer, Ebrahim M., Yisma, Engida, Yoon, Seok Jun, Yotebieng, Marcel, Yousefifard, Mahmoud, Yu, Chuanhua, Zaidi, Zoubida, Zamani, Mohammad, Murray, Christopher J.L., Naghavi, Mohsen, Orpana, H, Marczak, L, Arora, M, Abbasi, N, Abdulkader, R, Abebe, Z, Abraha, H, Afarideh, M, Afshari, M, Ahmadi, A, Aichour, A, Aichour, I, Aichour, M, Akseer, N, Al‐raddadi, R, Alahdab, F, Alkerwi, A, Allebeck, P, Alvis‐guzman, N, Anber, N, Anjomshoa, M, Antonio, C, Arora, A, Aryal, K, Asgedom, S, Awasthi, A, Quintanilla, B, Badali, H, Barker‐collo, S, Bärnighausen, T, Bazargan‐hejazi, S, Benjet, C, Bensenor, I, Berfeld, N, Beuran, M, Bhutta, Z, Biadgo, B, Bililign, N, Borges, G, Borschmann, R, Brazinova, A, Breitborde, N, Brugha, T, Butt, Z, Carrero, J, Carvalho, F, Malta, D, Castañeda‐orjuela, C, Catalá‐lópez, F, Ciobanu, L, Dachew, B, Dandona, L, Dandona, R, Dargan, P, Daryani, A, Davitoiu, D, Davletov, K, Degenhardt, L, Demoz, G, Jarlais, D, Dharmaratne, S, Djalalinia, S, Doan, L, Doku, D, Dubey, M, El‐khatib, Z, Eskandarieh, S, Esteghamati, A, Esteghamati, S, Faro, A, Farzadfar, F, Fekadu, W, Fernandes, E, Ferrari, A, Filip, I, Fischer, F, Foreman, K, Fukumoto, T, Gebre, A, Grosso, G, Gupta, R, Haagsma, J, Bidgoli, H, Haj‐mirzaian, A, Hamidi, S, Hankey, G, Haro, J, Hassen, H, Hay, S, Heidari, B, Hendrie, D, Rad, E, Hosseini, S, Hostiuc, S, Irvani, S, Islam, S, Jakovljevic, M, James, S, Jayatilleke, A, Jha, R, Jonas, J, Jozwiak, J, Kadel, R, Kahsay, A, Kasaeian, A, Kassa, G, Kawakami, N, Kefale, A, Kemp, G, Khader, Y, Khafaie, M, Khalil, I, Khan, E, Khan, M, Khang, Y, Khubchandani, J, Kiadaliri, A, Kieling, C, Kim, Y, Kisa, A, Knudsen, A, Kokubo, Y, Koyanagi, A, Krish, V, Defo, B, Kumar, G, Kumar, M, Lamichhane, P, Lang, J, Latifi, A, Lee, P, Leung, J, Lim, L, Lopez, A, Lorkowski, S, Lotufo, P, Lozano, R, Lunevicius, R, Mahesh, P, Majdan, M, Majdzadeh, R, Malekzadeh, R, Manda, A, Mansournia, M, Mantovani, L, Maravilla, J, Martinez‐raga, J, Mathur, M, Maulik, P, Mcgrath, J, Mehrotra, R, Mekonen, T, Mendoza, W, Meretoja, T, Mestrovic, T, Miller, T, Mini, G, Mirrakhimov, E, Mitchell, P, Moazen, B, Mohammad, K, Mohammadi, M, Mohammed, S, Mokdad, A, Monasta, L, Moosazadeh, M, Moradi, G, Moradi‐lakeh, M, Moradinazar, M, Velásquez, I, Morisaki, N, Morrison, S, Moschos, M, Mousavi, S, Mustafa, G, Nagel, G, Naheed, A, Naik, G, Najafi, F, Negoi, I, Negoi, R, Nguyen, H, Nguyen, L, Nixon, M, Ofori‐asenso, R, Ogbo, F, Oh, I, Olagunju, A, Olagunju, T, Øverland, S, Owolabi, M, Panda‐jonas, S, Parry, C, Pati, S, Patten, S, Patton, G, Petzold, M, Phillips, M, Plana‐ripoll, O, Postma, M, Pourshams, A, Poustchi, H, Qorbani, M, Radfar, A, Rafay, A, Rafiei, A, Rahim, F, Rahimi‐movaghar, A, Rahimi‐movaghar, V, Rahman, M, Rai, R, Rezaeian, S, Roever, L, Ronfani, L, Roshandel, G, Rostami, A, Sachdev, P, Safari, H, Safiri, S, Salamati, P, Salimi, Y, Salomon, J, Samy, A, Santos, I, Santric‐milicevic, M, Sartorius, B, Sarvi, S, Satpathy, M, Sawhney, M, Schwebel, D, Sepanlou, S, Shaikh, M, Sharif, M, Shibuya, K, Shigematsu, M, Shiri, R, Shiue, I, Siabani, S, Siddiqi, T, Sigfusdottir, I, Silva, J, Singh, J, Filho, A, Sobhani, S, Stein, D, Stein, M, Sufiyan, M, Sunguya, B, Tabarés‐seisdedos, R, Tabb, K, Tavakkoli, M, Tehrani‐banihashemi, A, Temsah, M, Topor‐madry, R, Tran, B, Tran, K, Ullah, I, Unutzer, J, Usman, M, Uthman, O, Valdez, P, Vasankari, T, Vasconcelos, C, Vlassov, V, Vos, T, Vujcic, I, Waheed, Y, Wang, Y, Weiderpass, E, Werdecker, A, Westerman, R, Whiteford, H, Wyper, G, Yaseri, M, Yimer, E, Yisma, E, Yonemoto, N, Yoon, S, Yotebieng, M, Yousefifard, M, Yu, C, Zaidi, Z, Zamani, M, Murray, C, and Naghavi, M
Subjects: Suicide Prevention, Adult, Cross-Cultural Comparison, Male, Data Interpretation, Adolescent, Outcome Assessment, Age Distribution, Age Factors, Aged, Cause of Death, Data Interpretation, Statistical, Female, Global Health, Humans, Life Expectancy, Mortality, Outcome Assessment, Health Care, Sex Distribution, Sex Factors, Socioeconomic Factors, Global Burden of Disease, Suicide, Medicine (all), Research, Statistical, Health Care
Abstract: Objectives To use the estimates from the Global Burden of Disease Study 2016 to describe patterns of suicide mortality globally, regionally, and for 195 countries and territories by age, sex, and Socio-demographic index, and to describe temporal trends between 1990 and 2016. Design Systematic analysis. Main outcome measures Crude and age standardised rates from suicide mortality and years of life lost were compared across regions and countries, and by age, sex, and Socio-demographic index (a composite measure of fertility, income, and education). Results The total number of deaths from suicide increased by 6.7% (95% uncertainty interval 0.4% to 15.6%) globally over the 27 year study period to 817 000 (762 000 to 884 000) deaths in 2016. However, the age standardised mortality rate for suicide decreased by 32.7% (27.2% to 36.6%) worldwide between 1990 and 2016, similar to the decline in the global age standardised mortality rate of 30.6%. Suicide was the leading cause of age standardised years of life lost in the Global Burden of Disease region of high income Asia Pacific and was among the top 10 leading causes in eastern Europe, central Europe, western Europe, central Asia, Australasia, southern Latin America, and high income North America. Rates for men were higher than for women across regions, countries, and age groups, except for the 15 to 19 age group. There was variation in the female to male ratio, with higher ratios at lower levels of Socio-demographic index. Women experienced greater decreases in mortality rates (49.0%, 95% uncertainty interval 42.6% to 54.6%) than men (23.8%, 15.6% to 32.7%). Conclusions Age standardised mortality rates for suicide have greatly reduced since 1990, but suicide remains an important contributor to mortality worldwide. Suicide mortality was variable across locations, between sexes, and between age groups. Suicide prevention strategies can be targeted towards vulnerable populations if they are informed by variations in mortality rates.
Published: 2019

7. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abdulkader, Rizwan Suliankatchi, Abdulle, Abdishakur M, Abebo, Teshome Abuka, Abera, Semaw Ferede, Aboyans, Victor, Abu-Raddad, Laith J, Ackerman, Ilana N, Adedeji, Isaac A, Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Sutapa, Agrawal, Anurag, Ahmed, Muktar Beshir, Aichour, Miloud Taki Eddine, Aichour, Amani Nidhal, Aichour, Ibtihel, Aiyar, Sneha, Akinyemiju, Tomi F, Akseer, Nadia, Al Lami, Faris Hasan, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alasfoor, Deena, Alene, Kefyalew Addis, Ali, Raghib, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Maskari, Fatma, AlMazroa, Mohammad AbdulAziz, Al-Raddadi, Rajaa, Alsharif, Ubai, Alsowaidi, Shirina, Althouse, Benjamin M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asgedom, Solomon W, Atey, Tesfay Mehari, Atnafu, Niguse Tadele, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Awasthi, Shally, Azarpazhooh, Mahmoud Reza, Azzopardi, Peter, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Bannick, Marlena S, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barquera, Simon, Barrero, Lope H, Basu, Sanjay, Battista, Robert, Battle, Katherine E, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Beyene, Addisu Shunu, Bhansali, Anil, Bhatt, Samir, Bhutta, Zulfiqar A, Biadgilign, Sibhatu, Bicer, Burcu Kucuk, Bienhoff, Kelly, Bikbov, Boris, Birungi, Charles, Biryukov, Stan, Bisanzio, Donal, Bizuayehu, Habtamu Mellie, Blyth, Fiona M, Boneya, Dube Jara, Bose, Dipan, Bou-Orm, Ibrahim R, Bourne, Rupert R A, Brainin, Michael, Brayne, Carol, Brazinova, Alexandra, Breitborde, Nicholas J K, Briant, Paul S, Britton, Gabrielle, Brugha, Traolach S, Buchbinder, Rachelle, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campos-Nonato, Ismael Ricardo, Carabin, Hélène, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesus, Carter, Austin, Carvalho, Felix, Casey, Daniel, Castañeda-Orjuela, Carlos A, Castle, Chris D, Catalá-López, Ferrán, Chang, Jung-Chen, Charlson, Fiona J, Chaturvedi, Pankaj, Chen, Honglei, Chibalabala, Mirriam, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Chowdhury, Rajiv, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cirillo, Massimo, Colombara, Danny, Cooper, Leslie Trumbull, Cooper, Cyrus, Cortesi, Paolo Angelo, Cortinovis, Monica, Criqui, Michael H, Cromwell, Elizabeth A, Cross, Marita, Crump, John A, Dadi, Abel Fekadu, Dalal, Koustuv, Damasceno, Albertino, Dandona, Lalit, Dandona, Rakhi, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, De Leo, Diego, De Steur, Hans, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Dellavalle, Robert P, Deribe, Kebede, Deribew, Amare, Des Jarlais, Don C, Dey, Subhojit, Dharmaratne, Samath D, Dhillon, Preet K, Dicker, Daniel, Djalainia, Shirin, Do, Huyen Phuc, Dokova, Klara, Doku, David Teye, Dorsey, E Ray, dos Santos, Kadine Priscila Bender, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Ebel, Beth E, Echko, Michelle, El-Khatib, Ziad Ziad, Enayati, Ahmadali, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E, Eshetie, Setegn, Eshrati, Babak, Esteghamati, Alireza, Estep, Kara, Fanuel, Fanuel Belayneh Bekele, Farag, Tamer, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Fazeli, Mir Sohail, Feigin, Valery L, Feigl, Andrea B, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Foreman, Kyle J, Franklin, Richard C, Frostad, Joseph J, Fullman, Nancy, Fürst, Thomas, Furtado, Joao M, Futran, Neal D, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Geleijnse, Johanna M, Geleto, Ayele, Gemechu, Bikila Lencha, Gesesew, Hailay Abrha, Gething, Peter W, Ghajar, Alireza, Gibney, Katherine B, Gillum, Richard F, Ginawi, Ibrahim Abdelmageem Mohamed, Gishu, Melkamu Dedefo, Giussani, Giorgia, Godwin, William W, Goel, Kashish, Goenka, Shifalika, Goldberg, Ellen M, Gona, Philimon N, Goodridge, Amador, Gopalani, Sameer Vali, Gosselin, Richard A, Gotay, Carolyn C, Goto, Atsushi, Goulart, Alessandra Carvalho, Graetz, Nicholas, Gugnani, Harish Chander, Gupta, Prakash C, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Gupta, Rahul, Gutiérrez, Reyna A, Hachinski, Vladimir, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Haro, Josep Maria, Harun, Kimani M, Harvey, James, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I, Hay, Roderick J, Hedayati, Mohammad T, Hendrie, Delia, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Heydarpour, Pouria, Hoek, Hans W, Hoffman, Howard J, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Htet, Aung Soe, Hu, Guoqing, Huang, John J, Huynh, Chantal, Iburg, Kim Moesgaard, Igumbor, Ehimario Uche, Ikeda, Chad, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, James, Peter, Jassal, Simerjot K, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jensen, Paul N, Jha, Vivekanand, Jiang, Guohong, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Kar, Chittaranjan, Karam, Nadim E, Karch, André, Karema, Corine Kakizi, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassa, Getachew Mullu, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Kastor, Anshul, Katikireddi, Srinivasa Vittal, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khalil, Ibrahim A, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah T, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna A, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A, Kosen, Soewarta, Kotsakis, Georgios A, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Krohn, Kristopher J, Kumar, G Anil, Kumar, Pushpendra, Kyu, Hmwe H, Lager, Anton Carl Jonas, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Anders, Leasher, Janet L, Lee, Paul H, Leigh, James, Leshargie, Cheru Tesema, Leung, Janni, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Linn, Shai, Liu, Patrick Y, Liu, Angela, Liu, Shiwei, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Looker, Katharine J, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Lunevicius, Raimundas, Lyons, Ronan A, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Hassan Magdy Abd, Magdy Abd El Razek, Mohammed, Magis-Rodriguez, Carlos, Mahdavi, Mahdi, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Mamun, Abdullah A, Manguerra, Helena, Manhertz, Treh, Mantovani, Lorenzo G, Mapoma, Chabila C, March, Lyn M, Marczak, Laurie B, Martinez-Raga, Jose, Martins, Paulo Henrique Viegas, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, März, Winfried, Mathur, Manu Raj, Mazidi, Mohsen, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, McKee, Martin, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mengistu, Desalegn Tadese, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Mezgebe, Haftay Berhane, Micha, Renata, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mitchell, Philip B, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Muktar Sano Kedir, Mohammed, Kedir Endris, Mohammed, Shafiu, Mohan, Murali B V, Mokdad, Ali H, Mollenkopf, Sarah K, Monasta, Lorenzo, Montañez Hernandez, Julio Cesar, Montico, Marcella, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Mori, Rintaro, Morrison, Shane D, Moses, Mark, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Mueller, Ulrich O, Muller, Kate, Murdoch, Michele E, Murray, Christopher J L, Murthy, Gudlavalleti Venkata Satyanarayana, Murthy, Srinivas, Musa, Kamarul Imran, Nachega, Jean B, Nagel, Gabriele, Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S, Nangia, Vinay, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negasa, Dumessa Edessa, Negoi, Ruxandra Irina, Negoi, Ionut, Newton, Charles R, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Norheim, Ole F, Norrving, Bo, Noubiap, Jean Jacques N, Nyandwi, Alypio, Obermeyer, Carla Makhlouf, O'Donnell, Martin J, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew Toyin, Olagunju, Tinuke Oluwasefunmi, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osborne, Richard H, Osgood-Zimmerman, Aaron, Osman, Majdi, Ota, Erika, Owolabi, Mayowa O, PA, Mahesh, Pacella, Rosana E, Panda, Basant Kumar, Pandian, Jeyaraj Durai, Papachristou, Christina, Park, Eun-Kee, Parry, Charles D, Parsaeian, Mahboubeh, Patil, Snehal T, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pearce, Neil, Pereira, David M, Perez, Krystle Marie, Perico, Norberto, Pesudovs, Konrad, Peterson, Carrie Beth, Petri, William Arthur, Petzold, Max, Phillips, Michael Robert, Phipps, Geoffrey, Pigott, David M, Pillay, Julian David, Pinho, Christine, Piradov, Michael A, Plass, Dietrich, Pletcher, Martin A, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Narayan, Purcell, Carrie, Purwar, Manorama, Qorbani, Mostafa, Quintanilla, 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Mari, Sobaih, Badr H A, Sobngwi, Eugene, Soljak, Michael, Sorensen, Reed J D, Sousa, Tatiane Cristina Moraes, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Stovner, Lars Jacob, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Sylte, Dillon, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Taffere, Getachew Redae, Takala, Jukka S, Tandon, Nikhil, Tanne, David, Tarekegn, Yihunie L, Tavakkoli, Mohammad, Taveira, Nuno, Taylor, Hugh R, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Terkawi, Abdullah Sulieman, Tesfaye, Dawit Jember, Tesssema, Belay, Thakur, JS, Thamsuwan, Ornwipa, Theadom, Alice M, Theis, Andrew M, Thomas, Katie E, Thomas, Nihal, Thompson, Robert, Thrift, Amanda G, Tobe-Gai, Ruoyan, Tobollik, Myriam, Tonelli, Marcello, Topor-Madry, Roman, Tortajada, Miguel, Touvier, Mathilde, Traebert, Jefferson, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tymeson, Hayley, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Varughese, Santosh, Vasankari, Tommi, Veerman, Lennert J, Venkatesh, S, Venketasubramanian, Narayanaswamy, Vidavalur, Ramesh, Vijayakumar, Lakshmi, Violante, Francesco S, Vishnu, Abhishek, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wadilo, Fiseha, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wijeratne, Tissa, Williams, Hywel C, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Woodbrook, Rachel, Woolf, Anthony D, Workicho, Abdulhalik, Xavier, Denis, Xu, Gelin, Yadgir, Simon, Yaghoubi, Mohsen, Yakob, Bereket, Yan, Lijing L, Yano, Yuichiro, Ye, Pengpeng, Yihdego, Mahari Gidey, Yimam, Hassen Hamid, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zhang, Xueying, Zheng, Yingfeng, Zhou, Maigeng, Zipkin, Ben, Zodpey, Sanjay, Zoeckler, Leo, Zuhlke, Liesl Joanna, Viðskiptadeild (HR), School of Business (RU), Háskólinn í Reykjavík, Reykjavik University, Cell biology, Hematology, Neurology, Simon, I, Hay, Amanuel, Alemu, Abajobir, Kalkidan, Hassen, Abate, Cristiana, Abbafati, Kaja, M, Abbas, Foad, Abd Allah, Abdishakur, M, Abdulle, Teshome, Abuka, Abebo, Semaw, Ferede, Abera, Victor, Aboyan, Laith, J, Abu, Raddad, Ilana, N, Ackerman, Isaac, A, Adedeji, Olatunji, Adetokunboh, Ashkan, Afshin, Rakesh, Aggarwal, Sutapa, Agrawal, Anurag, Agrawal, Aliasghar, Ahmad, Kiadaliri, Muktar, Beshir, Ahmed, Amani, Nidhal, Aichour, Ibtihel, Aichour, Miloud, Taki, Eddine, Aichour, Sneha, Aiyar, Tomi, F, Akinyemiju, Nadia, Akseer, Faris, Hasan, Al, Lami, Fares, Alahdab, Ziyad, Al Aly, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Deena, Alasfoor, Kefyalew, Addi, Alene, Raghib, Ali, Reza, Alizadeh Navaei, Juma, M, Alkaabi, Ala’A, Alkerwi, François, Alla, Peter, Allebeck, Christine, Allen, Fatma, Al Maskari, Mohammad, Abdulaziz, Almazroa, Rajaa, Al Raddadi, Ubai, Alsharif, Shirina, Alsowaidi, Benjamin, M, Althouse, Khalid, A, Altirkawi, Nelson, Alvis Guzman, Azmeraw, T, Amare, Erfan, Amini, Walid, Ammar, Yaw, Ampem, Amoako, Mustafa, Geleto, Ansha, Carl, Abelardo, T, Antonio, Palwasha, Anwari, Johan, Ärnlöv, Megha, Arora, Al, Artaman, Krishna, Kumar, Aryal, Solomon, W, Asgedom, Tesfay, Mehari, Atey, Niguse, Tadele, Atnafu, Leticia, Avila Burgo, Euripide, Frinel, G, Arthur, Avokpaho, Ashish, Awasthi, Shally, Awasthi, Beatriz, Paulina, Ayala, 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Subjects: Male, Dánarmein, AUSTRALIA, GBD, disability-adjusted life-years (DALYs), Heilsufar, Lífslíkur, Epidemiology, Life expectancy, Diseases, Global Health, THERAPY, Global Burden of Disease, Residence Characteristics, Fullorðnir, Cause of Death, Medicine and Health Sciences, Psychology, Konur, Aged, 80 and over, Tölfræði, PLASMODIUM-FALCIPARUM, Aldraðir, Sjúkdómar, Medicine (all), Fatlaðir, Men, Þjóðir, 11 Medical And Health Sciences, ASSOCIATION, Middle Aged, Health policy, PREVALENCE, Sálfræði, disability-adjusted life-years (DALYs), Female, Lýðheilsa, Quality-Adjusted Life Years, Life Sciences & Biomedicine, Global Health Metrics, Adult, AFRICA, Quality of life, People with disabilities, GBD, WEIGHTS, Social ecology, Lífsgæði, Communicable Diseases, World health/statistics, Age Distribution, Life Expectancy, Medicine, General & Internal, SDG 3 - Good Health and Well-being, General & Internal Medicine, Heilbrigðisstefna, Humans, Adults, Disabled Persons, Women, Sex Distribution, Mortality, Noncommunicable Diseases, Aged, Science & Technology, Faraldsfræði, MORTALITY, Wounds and injuries, EPIDEMIOLOGIC TRANSITION, HIV, Áverkar, Karlar, Wounds and Injuries, Félagshagfræði, Older people
Abstract: Correction in: LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE differed from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings The highest globally observed HALE at birth for both women and men was in Singapore, at 75.2 years (95% uncertainty interval 71.9-78.6) for females and 72.0 years (68.8-75.1) for males. The lowest for females was in the Central African Republic (45.6 years [42.0-49.5]) and for males was in Lesotho (41.5 years [39.0-44.0]). From 1990 to 2016, global HALE increased by an average of 6.24 years (5.97-6.48) for both sexes combined. Global HALE increased by 6.04 years (5.74-6.27) for males and 6.49 years (6.08-6.77) for females, whereas HALE at age 65 years increased by 1.78 years (1.61-1.93) for males and 1.96 years (1.69-2.13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2.3% [-5.9 to 0.9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs offset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the five lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16.1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. Interpretation At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs offset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention efforts, and development assistance for health, including financial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support., Bill & Melinda Gates Foundation
Published: 2017

8. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

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Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A, Kosen, Soewarta, Kotsakis, Georgios A, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A, Kuipers, Ernst J, Kumar, G Anil, Kutz, Michael, Kwan, Gene F, Lal, Aparna, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lam, Jennifer O, Langan, Sinead M, Larsson, Anders, Lavados, Pablo M, Leasher, Janet L, Leigh, James, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lo, Warren D, Logroscino, Giancarlo, Looker, Katharine J, Lotufo, Paulo A, Lunevicius, Raimundas, Lyons, Ronan A, Mackay, Mark T, Magdy, Mohammed, Razek, Abd El, Mahdavi, Mahdi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David Joel, Martinez-Raga, Jose, Masiye, Felix, Massano, João, McGarvey, Stephen Theodore, McGrath, John J, McKee, Martin, McMahon, Brian J, Meaney, Peter A, Mehari, Alem, Mejia-Rodriguez, Fabiola, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J, Mhimbira, Francis Apolinary, Millear, Anoushka, Miller, Ted R, Mills, Edward J, Mirarefin, Mojde, Mitchell, Philip B, Mock, Charles N, Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Hernandez, Julio Cesar Montañez, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Morawska, Lidia, Mueller, Ulrich O, Mullany, Erin, Mumford, John Everett, Murdoch, Michele E, Nachega, Jean B, Nagel, Gabriele, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Newton, John N, Ng, Marie, Ngalesoni, Frida Namnyak, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Nolla, Joan M, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nunes, Bruno P, Ogbo, Felix Akpojene, Oh, In-Hwan, Ohkubo, Takayoshi, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valéria Maria, Caicedo, Angel J Paternina, Patten, Scott B, Patton, George C, Pereira, David M, Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B, Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A, Polinder, Suzanne, Pond, Constance D, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Qorbani, Mostafa, Rabiee, Rynaz H S, Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, 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Orjuela, Ca, Rivas, Jc, Catalá López, F, Chang, Jc, Chiang, Pp, Chibueze, Ce, Chisumpa, Vh, Choi, Jj, Chowdhury, R, Christensen, H, Christopher, Dj, Ciobanu, Lg, Cirillo, Massimo, Coates, Mm, Colquhoun, Sm, Cooper, C, Cortinovis, M, Crump, Ja, Gastroenterology & Hepatology, Health Services Management & Organisation (HSMO), Public Health, Psychiatry, Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M, Bhutta, Zulfiqar A, Brown, Alexandria, Carter, Austin, Casey, Daniel C, Charlson, Fiona J, Chen, Alan Z, Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J, Dilegge, Tina, Erskine, Holly E, Ferrari, Alize J, Fitzmaurice, Christina, Fleming, Tom, Forouzanfar, Mohammad H, Fullman, Nancy, Gething, Peter W, Goldberg, Ellen M, Graetz, Nichola, Haagsma, Juanita A, Johnson, Catherine O, Kassebaum, Nicholas J, Kawashima, Toana, Kemmer, Laura, Khalil, Ibrahim A, Kinfu, Yohanne, Kyu, Hmwe H, Leung, Janni, Liang, Xiaofeng, Lim, Stephen S, Lopez, Alan D, Lozano, Rafael, 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Samia, Ali, Raghib, Alkerwi, Ala'A, Alla, Françoi, Allebeck, Peter, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H, Anderson, Gregory M, Anderson, Benjamin O, Antonio, Carl Abelardo T, Aregay, Atsede Fantahun, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Assadi, Reza, Atique, Suleman, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barker-Collo, Suzanne L, Bärnighausen, Till, Barregard, Lar, Barrero, Lope H, Basu, Arindam, Bazargan-Hejazi, Shahrzad, Bell, Brent, Bell, Michelle L, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Bori, Biryukov, Stan, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Borschmann, Rohan, Boufous, Soufiane, Brainin, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Brown, Jonathan, Buchbinder, Rachelle, Buckle, Geoffrey Colin, Butt, Zahid A, Calabria, Bianca, Campos-Nonato, Ismael Ricardo, Campuzano, Julio Cesar, Carabin, Hélène, Cárdenas, Rosario, Carpenter, David O, Carrero, Juan Jesu, Castañeda-Orjuela, Carlos A, Rivas, Jacqueline Castillo, Catalá-López, Ferrán, Chang, Jung-Chen, Chiang, Peggy Pei-Chia, Chibueze, Chioma Ezinne, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam Jesuda, Ciobanu, Liliana G, Coates, Matthew M, Colquhoun, Samantha M, Cooper, Cyru, Cortinovis, Monica, Crump, John A, Damtew, Solomon Abrha, Dandona, Rakhi, Daoud, Farah, Dargan, Paul I, das Neves, José, Davey, Gail, Davis, Adrian C, Leo, Diego De, Degenhardt, Louisa, Gobbo, Liana C Del, Dellavalle, Robert P, Deribe, Kebede, Deribew, Amare, Derrett, 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Ha, Jeemon, Panniyammakal, Jensen, Paul N, Jiang, Ying, Jibat, Tariku, Jimenez-Corona, Aida, Jin, Ye, Jonas, Jost B, Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Karch, André, Karema, Corine Kakizi, Karimkhani, Chante, Kasaeian, Amir, Kaul, Anil, Kawakami, Norito, Keiyoro, Peter Njenga, Kemp, Andrew Haddon, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khang, Young-Ho, Khera, Sahil, Khoja, Tawfik Ahmed Muthafer, Khubchandani, Jagdish, Kieling, Christian, Kim, Pauline, Kim, Cho-il, Kim, Daniel, Kim, Yun Jin, Kissoon, Niranjan, Knibbs, Luke D, Knudsen, Ann Kristin, Kokubo, Yoshihiro, Kolte, Dhaval, Kopec, Jacek A, Kosen, Soewarta, Kotsakis, Georgios A, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kudom, Andreas A, Kuipers, Ernst J, Kumar, G Anil, Kutz, Michael, Kwan, Gene F, Lal, Aparna, Lalloo, Ratilal, Lallukka, Tea, Lam, Hilton, Lam, Jennifer O, Langan, Sinead M, Larsson, Ander, Lavados, Pablo M, Leasher, Janet L, Leigh, Jame, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Liang, Juan, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lo, Warren D, Logroscino, Giancarlo, Looker, Katharine J, Lotufo, Paulo A, Lunevicius, Raimunda, Lyons, Ronan A, Mackay, Mark T, Magdy, Mohammed, Razek, Abd El, Mahdavi, Mahdi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Marcenes, Wagner, Margolis, David Joel, Martinez-Raga, Jose, Masiye, Felix, Massano, João, Mcgarvey, Stephen Theodore, Mcgrath, John J, Mckee, Martin, Mcmahon, Brian J, Meaney, Peter A, Mehari, Alem, Mejia-Rodriguez, Fabiola, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Meretoja, Atte, Meretoja, Tuomo J, Mhimbira, Francis Apolinary, Miller, Ted R, Mills, Edward J, Mirarefin, Mojde, Mitchell, Philip B, Mock, Charles N, Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, Hernandez, Julio Cesar Montañez, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Morawska, Lidia, Mueller, Ulrich O, Mullany, Erin, Mumford, John Everett, Murdoch, Michele E, Nachega, Jean B, Nagel, Gabriele, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Newton, John N, Ng, Marie, Ngalesoni, Frida Namnyak, Nguyen, Quyen Le, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Nolla, Joan M, Norheim, Ole F, Norman, Rosana E, Norrving, Bo, Nunes, Bruno P, Ogbo, Felix Akpojene, Oh, In-Hwan, Ohkubo, Takayoshi, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Pa, Mahesh, Park, Eun-Kee, Parsaeian, Mahboubeh, de Azeredo Passos, Valéria Maria, Caicedo, Angel J Paternina, Patten, Scott B, Patton, George C, Pereira, David M, Perez-Padilla, Rogelio, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B, Pillay, Julian David, Pishgar, Farhad, Plass, Dietrich, Platts-Mills, James A, Polinder, Suzanne, Pond, Constance D, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Noela M, Qorbani, Mostafa, Rabiee, Rynaz H S, Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Rao, Puja, Refaat, Amany H, Reitsma, Marissa B, Remuzzi, Giuseppe, Resnikoff, Serge, Reynolds, Alex, Ribeiro, Antonio L, Blancas, Maria Jesus Rio, Roba, Hirbo Shore, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Roy, Ambuj, Sagar, Rajesh, Sahathevan, Ramesh, Sanabria, Juan R, Sanchez-Niño, Maria Dolore, Santos, Itamar S, Santos, João Vasco, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Schaub, Michael P, Schmidt, Maria Inê, Schneider, Ione J C, Schöttker, Ben, Schwebel, David C, Scott, James G, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya A, Shaheen, Amira, Shaikh, Masood Ali, Sharma, Rajesh, Sharma, Upasana, Shen, Jiabin, Shepard, Donald S, Sheth, Kevin N, Shibuya, Kenji, Shin, Min-Jeong, Shiri, Rahman, Shiue, Ivy, Shrime, Mark G, Sigfusdottir, Inga Dora, Silva, Diego Augusto Santo, Silveira, Dayane Gabriele Alve, Singh, Abhishek, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Sivonda, Anna, Skirbekk, Vegard, Skogen, Jens Christoffer, Sligar, Amber, Sliwa, Karen, Soljak, Michael, Søreide, Kjetil, Soriano, Joan B, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stathopoulou, Vasiliki, Steel, Nichola, Stein, Dan J, Steiner, Timothy J, Steinke, Sabine, Stovner, Lar, Stroumpoulis, Konstantino, Sunguya, Bruno F, Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Takala, Jukka S, Tandon, Nikhil, Tanne, David, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R, Ao, Braden J Te, Tedla, Bemnet Amare, Terkawi, Abdullah Sulieman, Thomson, Alan J, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Foti, Tran, Bach Xuan, Dimbuene, Zacharie Tsala, Tsilimbaris, Miltiadi, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefano, Ukwaja, Kingsley N, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Uthman, Olalekan A, van Gool, Coen H, Varakin, Yuri Y, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Wagner, Gregory R, Waller, Stephen G, Wang, Linhong, Watkins, David A, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Werdecker, Andrea, Westerman, Ronny, White, Richard A, Williams, Hywel C, Wiysonge, Charles Shey, Wolfe, Charles D A, Won, Sungho, Woodbrook, Rachel, Wubshet, Mamo, Xavier, Deni, Xu, Gelin, Yadav, Ajit Kumar, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yebyo, Henock Gebremedhin, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, and Murray, Christopher J L
Subjects: Medicine(all), VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, Incidence, Medicine (all), Public Health, Global Health, Social Medicine and Epidemiology, Bayes Theorem, 11 Medical And Health Sciences, Articles, Department of Error, Global Health, Cost of Illne, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Cost of Illness, disability, General & Internal Medicine, Quality-Adjusted Life Year, Prevalence, Humans, Disabled Person, Disabled Persons, Quality-Adjusted Life Years, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, Human
Abstract: Background Non-fatal outcomes of disease and injury increasingly detract from the ability of the world's population to live in full health, a trend largely attributable to an epidemiological transition in many countries from causes affecting children, to non-communicable diseases (NCDs) more common in adults. For the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015), we estimated the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015. Methods We estimated incidence and prevalence by age, sex, cause, year, and geography with a wide range of updated and standardised analytical procedures. Improvements from GBD 2013 included the addition of new data sources, updates to literature reviews for 85 causes, and the identification and inclusion of additional studies published up to November, 2015, to expand the database used for estimation of non-fatal outcomes to 60 900 unique data sources. Prevalence and incidence by cause and sequelae were determined with DisMod-MR 2.1, an improved version of the DisMod-MR Bayesian meta-regression tool first developed for GBD 2010 and GBD 2013. For some causes, we used alternative modelling strategies where the complexity of the disease was not suited to DisMod-MR 2.1 or where incidence and prevalence needed to be determined from other data. For GBD 2015 we created a summary indicator that combines measures of income per capita, educational attainment, and fertility (the Socio-demographic Index [SDI]) and used it to compare observed patterns of health loss to the expected pattern for countries or locations with similar SDI scores. Findings We generated 9·3 billion estimates from the various combinations of prevalence, incidence, and YLDs for causes, sequelae, and impairments by age, sex, geography, and year. In 2015, two causes had acute incidences in excess of 1 billion: upper respiratory infections (17·2 billion, 95% uncertainty interval [UI] 15·4–19·2 billion) and diarrhoeal diseases (2·39 billion, 2·30–2·50 billion). Eight causes of chronic disease and injury each affected more than 10% of the world's population in 2015: permanent caries, tension-type headache, iron-deficiency anaemia, age-related and other hearing loss, migraine, genital herpes, refraction and accommodation disorders, and ascariasis. The impairment that affected the greatest number of people in 2015 was anaemia, with 2·36 billion (2·35–2·37 billion) individuals affected. The second and third leading impairments by number of individuals affected were hearing loss and vision loss, respectively. Between 2005 and 2015, there was little change in the leading causes of years lived with disability (YLDs) on a global basis. NCDs accounted for 18 of the leading 20 causes of age-standardised YLDs on a global scale. Where rates were decreasing, the rate of decrease for YLDs was slower than that of years of life lost (YLLs) for nearly every cause included in our analysis. For low SDI geographies, Group 1 causes typically accounted for 20–30% of total disability, largely attributable to nutritional deficiencies, malaria, neglected tropical diseases, HIV/AIDS, and tuberculosis. Lower back and neck pain was the leading global cause of disability in 2015 in most countries. The leading cause was sense organ disorders in 22 countries in Asia and Africa and one in central Latin America; diabetes in four countries in Oceania; HIV/AIDS in three southern sub-Saharan African countries; collective violence and legal intervention in two north African and Middle Eastern countries; iron-deficiency anaemia in Somalia and Venezuela; depression in Uganda; onchoceriasis in Liberia; and other neglected tropical diseases in the Democratic Republic of the Congo. Interpretation Ageing of the world's population is increasing the number of people living with sequelae of diseases and injuries. Shifts in the epidemiological profile driven by socioeconomic change also contribute to the continued increase in years lived with disability (YLDs) as well as the rate of increase in YLDs. Despite limitations imposed by gaps in data availability and the variable quality of the data available, the standardised and comprehensive approach of the GBD study provides opportunities to examine broad trends, compare those trends between countries or subnational geographies, benchmark against locations at similar stages of development, and gauge the strength or weakness of the estimates available. Funding Bill & Melinda Gates Foundation. Open Access funded by Bill & Melinda Gates FoundationUnder a Creative Commons license Attribution 4.0 International (CC BY 4.0)
Published: 2016

9. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

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Valentine, Whiteford, Harvey A, Zhou, Maigeng, Zoeckler, Leo, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Achoki, Tom, Ackerman, Ilana N, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Adsuar, José C, Afanvi, Kossivi Agbelenko, Afshin, Ashkan, Agardh, Emilie Elisabet, Agarwal, Arnav, Agarwal, Sanjay Kumar, Ahmed, Muktar Beshir, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore K M, Aldhahri, Saleh Fahed, Alegretti, Miguel Angel, Aleman, Alicia V, Alemu, Zewdie Aderaw, Alexander, Lily T, Ali, Raghib, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Alsharif, Ubai, Altirkawi, Khalid A, Martin, Elena Alvarez, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Anderson, Gregory M, Anderson, 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Woldeyohannes, Solomon Meseret, Wolfe, Charles D A, Won, Sungho, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zeeb, Hajo, Zodpey, Sanjay, Zonies, David, Zuhlke, Liesl Joanna, Vos, Theo, Lopez, Alan D, Murray, Christopher J L, Public Health, Gastroenterology & Hepatology, Health Services Management & Organisation (HSMO), RS: MHeNs - R2 - Mental Health, MUMC+: MA Psychiatrie (3), MUMC+: Hersen en Zenuw Centrum (3), Psychiatrie & Neuropsychologie, and Kardiyoloji
Subjects: Medicine(all), Medical And Health Sciences, Medicine (all), Public Health, Global Health, Social Medicine and Epidemiology, Articles, Global Health, Article, Cost of Illne, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Life Expectancy, Cost of Illness, SDG 3 - Good Health and Well-being, General & Internal Medicine, Quality-Adjusted Life Year, Humans, Disabled Persons, Disabled Person, Quality-Adjusted Life Years, Morbidity, Human
Abstract: Background Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development. Methods We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015. We calculated DALYs by summing years of life lost (YLLs) and years of life lived with disability (YLDs) for each geography, age group, sex, and year. We estimated HALE using the Sullivan method, which draws from age-specific death rates and YLDs per capita. We then assessed how observed levels of DALYs and HALE differed from expected trends calculated with the Socio-demographic Index (SDI), a composite indicator constructed from measures of income per capita, average years of schooling, and total fertility rate. Findings Total global DALYs remained largely unchanged from 1990 to 2015, with decreases in communicable, neonatal, maternal, and nutritional (Group 1) disease DALYs off set by increased DALYs due to non-communicable diseases (NCDs). Much of this epidemiological transition was caused by changes in population growth and ageing, but it was accelerated by widespread improvements in SDI that also correlated strongly with the increasing importance of NCDs. Both total DALYs and age-standardised DALY rates due to most Group 1 causes significantly decreased by 2015, and although total burden climbed for the majority of NCDs, age-standardised DALY rates due to NCDs declined. Nonetheless, age-standardised DALY rates due to several high-burden NCDs (including osteoarthritis, drug use disorders, depression, diabetes, congenital birth defects, and skin, oral, and sense organ diseases) either increased or remained unchanged, leading to increases in their relative ranking in many geographies. From 2005 to 2015, HALE at birth increased by an average of 2.9 years (95% uncertainty interval 2.9-3.0) for men and 3.5 years (3.4-3.7) for women, while HALE at age 65 years improved by 0.85 years (0.78-0.92) and 1.2 years (1.1-1.3), respectively. Rising SDI was associated with consistently higher HALE and a somewhat smaller proportion of life spent with functional health loss; however, rising SDI was related to increases in total disability. Many countries and territories in central America and eastern sub-Saharan Africa had increasingly lower rates of disease burden than expected given their SDI. At the same time, a subset of geographies recorded a growing gap between observed and expected levels of DALYs, a trend driven mainly by rising burden due to war, interpersonal violence, and various NCDs. Interpretation Health is improving globally, but this means more populations are spending more time with functional health loss, an absolute expansion of morbidity. The proportion of life spent in ill health decreases somewhat with increasing SDI, a relative compression of morbidity, which supports continued efforts to elevate personal income, improve education, and limit fertility. Our analysis of DALYs and HALE and their relationship to SDI represents a robust framework on which to benchmark geography-specific health performance and SDG progress. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform financial and research investments, prevention efforts, health policies, and health system improvement initiatives for all countries along the development continuum. Copyright (C) The Author(s). Published by Elsevier Ltd.
Published: 2016

10. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author: Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Arnlov, Johan, Afshin, Ashkan, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Aiyar, Sneha, Al-Eyadhy, Ayman, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M., Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A., Alvis-Guzman, Nelson, Amare, Azmeraw T., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H., Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T., Anwari, Palwasha, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W., Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G. Arthur, Awasthi, Ashish, Paulina, Beatriz, Quintanilla, Ayala, Bejot, Yannick, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A., Barker-Collo, Suzanne L., Barquera, Simon, Barregard, Lars, Barrero, Lope H., Baune, Bernhard T., Bedi, Neeraj, Beghi, Ettore, Bekele, Bayu Begashaw, Bell, Michelle L., Bennett, James R., Bensenor, Isabela M., Berhane, Adugnaw, Bernabe, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert R. A., Breitborde, Nicholas J. K., Negesa, Lemma, Bulto, Bulto, Bumgarner, Blair R., Butt, Zahid A., Cardenas, Rosario, Cahuana-Hurtado, Lucero, Cameron, Ewan, Cesar Campuzano, Julio, Car, Josip, Jesus Carrero, Juan, Carter, Austin, Casey, Daniel C., Castaneda-Orjuela, Carlos A., Catala-Lopez, Ferran, Charlson, Fiona J., Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A., Christopher, Devasahayam Jesudas, Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Colombara, Danny, Cooper, Cyrus, Cowie, Benjamin C., Criqui, Michael H., Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I., das Neves, Jose, Davitoiu, Dragos V., Davletov, Kairat, de Courten, Barbora, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L., Djalalinia, Shirin, Huyen Phuc Do, Huyen Phuc Do, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R., Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E., Eskandarieh, Sharareh, Esteghamati, Alireza, Ermakov, Sergey P., Estep, Kara, E Sa Farinha, Carla Sofia, Faro, Andre, Farzadfar, Farshad, Feigin, Valery L., Fereshtehnejad, Seyed-Mohammad, Fernandes, Joao C., Ferrari, Alize J., Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D., Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Furst, Thomas, Furtado, Joao M., Gakidou, Emmanuela, Garcia-Basteiro, Alberto L., Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M., Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W., Gillum, Richard F., Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Giussani, Giorgia, Godwin, William W., Gold, Audra L., Goldberg, Ellen M., Gona, Philimon N., Gopalani, Sameer Vali, Gouda, Hebe N., Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Prakash C., Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J., Hankey, Graeme J., Hao, Yuantao, Harb, Hilda L., Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I., He, Fei, Hedayati, Mohammad T., Henry, Nathaniel J., Beatriz Heredia-Pi, Ileana, Herteliu, Claudiu, Hoek, Hans W., Horino, Masako, Horita, Nobuyuki, Hosgood, H. Dean, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Jurisson, Mikk, Jacobsen, Kathryn H., Jahanmehr, Nader, Jakovljevic, Mihajlo B., Javanbakht, Mehdi, Jayaraman, Sudha P., Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O., Johnson, Sarah Charlotte, Jonas, Jost B., Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, Andre, Karimi, Seyed M., Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kieling, Christian, Kievlan, Daniel, Kim, Daniel, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A., Kosen, Soewarta, Koul, Parvaiz A., Koyanagi, Ai, Defo, Barthelemy Kuate, Kulikoff, Xie Rachel, Kumar, G. Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H., Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lambert, Nkurunziza, Lan, Qing, Lansingh, Van C., Larsson, Anders, Lee, Paul H., Leigh, James, Leung, Janni, Levi, Miriam, Li, Yongmei, Kappe, Darya Li, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S., Liu, Angela, Liu, Patrick Y., Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lucas, Timothy C. D., Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R., Abd el Razek, Mohammed Magdy, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C., Marczak, Laurie B., Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J., Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A., Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A., Meretoja, Atte, Meretoja, Tuomo J., Millear, Anoushka, Miller, Ted R., Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M., Misganaw, Awoke, Mishra, Shiva Raj, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H., Mola, Glen Liddell D., Mollenkopf, Sarah K., Molokhia, Mariam, Monasta, Lorenzo, Montanez Hernandez, Julio C., Montico, Marcella, Mooney, Meghan D., Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morrison, Shane D., Morozoff, Chloe, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B., Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramos, Nasher, Jamal T., Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Cuong Tat Nguyen, Cuong Tat Nguyen, Grant Nguyen, Grant Nguyen, Minh Nguyen, Minh Nguyen, Quyen Le Nguyen, Quyen Le Nguyen, Trang Huyen Nguyen, Trang Huyen Nguyen, Nichols, Emma, Ningrum, Dina Nur Anggraini, Vuong Minh Nong, Vuong Minh Nong, Noubiap, Jean Jacques N., Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, Pa, Mahesh, Pacella, Rosana E., Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B., Patton, George C., Paudel, Deepak, Paulson, Katherine, Pereira, David M., Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M., Pinho, Christine, Plass, Dietrich, Pletcher, Martin A., Polinder, Suzanne, Postma, Maarten J., Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C., Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E., Rehm, Jurgen, Reiner, Robert C., Reitsma, Marissa B., Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Ruhago, George Mugambage, Saadat, Rizwan S. A. Soheil, Sachdev, Perminder S., Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A., Samy, Abdallah M., Sanabria, Juan Ramon, Dolores Sanchez-Nino, Maria, Santomauro, Damian, Santos, Itamar S., Milicevic, Milena M. Santric, Sartorius, Benn, Satpathy, Maheswar, Shahraz, Saeid, Schmidt, Maria Ines, Schneider, Ione J. C., Schulhofer-Wohl, Sam, Schutte, Aletta E., Schwebel, David C., Schwendicke, Falk, Sepanlou, Sadaf G., Servan-Mori, Edson E., Shackelford, Katya Anne, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Islam, Sheikh Mohammed Shariful, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shi, Peilin, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G., Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, Joao Pedro, Singh, Abhishek, Singh, Jasvinder A., Skiadaresi, Eirini, Sligar, Amber, Smith, Alison, Smith, David L., Smith, Mari, Sobaih, Badr H. A., Soneji, Samir, Sorensen, Reed J. D., Soriano, Joan B., Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stanaway, Jeffrey D., Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J., Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F., Sur, Patrick J., Swaminathan, Soumya, Sykes, Bryan L., Tabares-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S., Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J. S., Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E., Thompson, Alex H., Thomson, Alan J., Thrift, Amanda G., Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Bach Xuan Tran, Bach Xuan Tran, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Undurraga, Eduardo A., Updike, Rachel, Uthman, Olalekan A., Uzochukwu, Benjamin S. Chudi, van Boven, Job F. M., Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T., Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G., Weiss, Daniel J., Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A., Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D. A., Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Denis, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Lopez, Alan D., Murray, Christopher J. L., Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fare, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addi, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, Françoi, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lar, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Bori, Bisanzio, Donal, Bourne, Rupert R A, Breitborde, Nicholas J K, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesu, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Christopher, Devasahayam Jesuda, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colombara, Danny, Cooper, Cyru, Cowie, Benjamin C, Criqui, Michael H, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Erskine, Holly E, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Fürst, Thoma, Furtado, Joao M, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gillum, Richard F, Giroud, Maurice, Giussani, Giorgia, Godwin, William W, Gold, Audra L, Goldberg, Ellen M, Gona, Philimon N, Gopalani, Sameer Vali, Gouda, Hebe N, Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmu, Hay, Simon I, He, Fei, Hedayati, Mohammad T, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, André, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kievlan, Daniel, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohanne, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Tea Lallukka Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Ander, Lee, Paul H, Leigh, Jame, Leung, Janni, Levi, Miriam, Li, Yongmei, Li Kappe, Darya, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Liu, Patrick Y, Liu, Angela, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lopez, Alan D, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Mohammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohamed, Ibrahim Abdelmageem, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Liddell D, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio C, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morozoff, Chloe, Morrison, Shane D, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murray, Christopher J L, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Naghavi, Mohsen, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramo, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pereira, David M, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M, Pinho, Christine, Plass, Dietrich, Pletcher, Martin A, Polinder, Suzanne, Postma, Maarten J, Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Radfar, Amir, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C, Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E, Rehm, Jürgen, Reiner, Robert C, Reitsma, Marissa B, Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Ruhago, George Mugambage, SA, Rizwan, Saadat, Soheil, Sachdev, Perminder S, Sadat, Nafi, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolore, Santomauro, Damian, Santos, Itamar S, Santric Milicevic, Milena M, Sartorius, Benn, Satpathy, Maheswar, Schmidt, Maria Inê, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G, Sigfusdottir, Inga Dora, Silpakit, Nari, Silva, João Pedro, Singh, Jasvinder A, Singh, Abhishek, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Smith, Alison, Smith, Mari, Sobaih, Badr H A, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nichola, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S, Talongwa, Roberto Tchio, 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Ibtihel, Aichour, Miloud, Taki, Eddine, Aichour, Sneha, Aiyar, Ayman, Al Eyadhy, Fares, Alahdab, Ziyad, Al Aly, Khurshid, Alam, Noore, Alam, Tahiya, Alam, Kefyalew, Addi, Alene, Syed, Danish, Ali, Reza, Alizadeh Navaei, Juma, M, Alkaabi, Ala’A, Alkerwi, François, Alla, Peter, Allebeck, Christine, Allen, Rajaa, Al Raddadi, Ubai, Alsharif, Khalid, A, Altirkawi, Nelson, Alvis Guzman, Azmeraw, T, Amare, Erfan, Amini, Walid, Ammar, Yaw, Ampem, Amoako, Nahla, Anber, Hjalte, H, Andersen, Catalina, Liliana, Andrei, Sofia, Androudi, Hossein, Ansari, Carl, Abelardo, T, Antonio, Palwasha, Anwari, Megha, Arora, Al, Artaman, Krishna, Kumar, Aryal, Hamid, Asayesh, Solomon, W, Asgedom, Tesfay, Mehari, Atey, Leticia, Avila Burgo, Euripide, Frinel, G, Arthur, Avokpaho, Ashish, Awasthi, Beatriz, Paulina, Ayala, Quintanilla, Yannick, Béjot, Tesleem, Kayode, Babalola, Umar, Bacha, Kalpana, Balakrishnan, Aleksandra, Barac, Miguel, A, Barboza, Suzanne, L, Barker, Collo, Simon, Barquera, Lars, Barregard, Lope, H, Barrero, Bernhard, T, Baune, Neeraj, Bedi, Ettore, Beghi, Bayu, Begashaw, Bekele, Michelle, L, Bell, James, R, Bennett, Isabela, M, Bensenor, Adugnaw, Berhane, Eduardo, Bernabé, Balem, Demtsu, Betsu, Mircea, Beuran, Samir, Bhatt, Sibhatu, Biadgilign, Kelly, Bienhoff, Boris, Bikbov, Donal, Bisanzio, Rupert, R, A, Bourne, Nicholas, J, K, Breitborde, Lemma, Negesa, Bulto, Bulto, Blair, R, Bumgarner, Zahid, A, Butt, Rosario, Cárdena, Lucero, Cahuana Hurtado, Ewan, Cameron, Julio, Cesar, Campuzano, Josip, Car, Juan, Jesu, Carrero, Austin, Carter, Daniel, C, Casey, Carlo, A, Castañeda, Orjuela, Ferrán, Catalá López, Fiona, J, Charlson, Chioma, Ezinne, Chibueze, Odgerel, Chimed Ochir, Vesper, Hichilombwe, Chisumpa, Abdulaal, A, Chitheer, Devasahayam, Jesuda, Christopher, Liliana, G, Ciobanu, Aaron, J, and Cohen
Subjects: Dánarmein, Male, Heilsufar, Dánartíðni, Newborn infants, Lífslíkur, Life expectancy, Communicable diseases, Global Health, Global Burden of Disease, Disasters, Pregnancy, Cause of Death, Psychology, Child, Konur, Aged, 80 and over, Ungbörn, CLIMATE-CHANGE, PLASMODIUM-FALCIPARUM, Kransæðasjúkdómar, Global burden of disease/statistics and numerical data, Medicine (all), Men, Þjóðir, Öndunarfærasjúkdómar, 11 Medical And Health Sciences, Middle Aged, Nutrition Disorders, PREVALENCE, Coronary heart disease, Smitsjúkdómar, Death, Suicide, Cardiovascular diseases, Sálfræði, World health, Child, Preschool, Nýburar, Female, GBD, mortality, Infants, Life Sciences & Biomedicine, Age distribution, Global Health Metrics, Adult, Diarrhea, AFRICA, HUMAN HEALTH, Adolescent, GBD, UNITED-STATES, Socioeconomic factors, Communicable Diseases, Young Adult, Age Distribution, Heilbrigðisvísindi, Medicine, General & Internal, General & Internal Medicine, Humans, QUALITY, Women, Nutrition disorders, INCOME COUNTRIES, Mortality, Noncommunicable Diseases, Aged, Science & Technology, Infant, Newborn, Infant, Respiratory infections, Næringarskortur, ALCOHOL POLICY, mortality, Malaria, Pregnancy Complications, Socioeconomic Factors, Áverkar, Karlar, Wounds and Injuries, Félagshagfræði, Accidental Falls, Cause of death/trends, RESISTANCE
Abstract: Correction: Group Author(s): GBD 2016 Causes Death LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017 Group Author(s): GBD 2016 Dis Injury Incidence LANCET Volume: 390 Issue: 10106 Pages: E38-E38 Published: OCT 28 2017, Background Monitoring levels and trends in premature mortality is crucial to understanding how societies can address prominent sources of early death. The Global Burden of Disease 2016 Study (GBD 2016) provides a comprehensive assessment of cause-specific mortality for 264 causes in 195 locations from 1980 to 2016. This assessment includes evaluation of the expected epidemiological transition with changes in development and where local patterns deviate from these trends. Methods We estimated cause-specific deaths and years of life lost (YLLs) by age, sex, geography, and year. YLLs were calculated from the sum of each death multiplied by the standard life expectancy at each age. We used the GBD cause of death database composed of: vital registration (VR) data corrected for under-registration and garbage coding; national and subnational verbal autopsy (VA) studies corrected for garbage coding; and other sources including surveys and surveillance systems for specific causes such as maternal mortality. To facilitate assessment of quality, we reported on the fraction of deaths assigned to GBD Level 1 or Level 2 causes that cannot be underlying causes of death (major garbage codes) by location and year. Based on completeness, garbage coding, cause list detail, and time periods covered, we provided an overall data quality rating for each location with scores ranging from 0 stars (worst) to 5 stars (best). We used robust statistical methods including the Cause of Death Ensemble model (CODEm) to generate estimates for each location, year, age, and sex. We assessed observed and expected levels and trends of cause-specific deaths in relation to the Socio-demographic Index (SDI), a summary indicator derived from measures of average income per capita, educational attainment, and total fertility, with locations grouped into quintiles by SDI. Relative to GBD 2015, we expanded the GBD cause hierarchy by 18 causes of death for GBD 2016. Findings The quality of available data varied by location. Data quality in 25 countries rated in the highest category (5 stars), while 48, 30, 21, and 44 countries were rated at each of the succeeding data quality levels. Vital registration or verbal autopsy data were not available in 27 countries, resulting in the assignment of a zero value for data quality. Deaths from non-communicable diseases (NCDs) represented 72.3% (95% uncertainty interval [UI] 71.2-73.2) of deaths in 2016 with 19.3% (18.5-20.4) of deaths in that year occurring from communicable, maternal, neonatal, and nutritional (CMNN) diseases and a further 8.43% (8.00-8.67) from injuries. Although age-standardised rates of death from NCDs decreased globally between 2006 and 2016, total numbers of these deaths increased; both numbers and age-standardised rates of death from CMNN causes decreased in the decade 2006-16-age-standardised rates of deaths from injuries decreased but total numbers varied little. In 2016, the three leading global causes of death in children under-5 were lower respiratory infections, neonatal preterm birth complications, and neonatal encephalopathy due to birth asphyxia and trauma, combined resulting in 1.80 million deaths (95% UI 1.59 million to 1.89 million). Between 1990 and 2016, a profound shift toward deaths at older ages occurred with a 178% (95% UI 176-181) increase in deaths in ages 90-94 years and a 210% (208-212) increase in deaths older than age 95 years. The ten leading causes by rates of age-standardised YLL significantly decreased from 2006 to 2016 (median annualised rate of change was a decrease of 2.89%); the median annualised rate of change for all other causes was lower (a decrease of 1.59%) during the same interval. Globally, the five leading causes of total YLLs in 2016 were cardiovascular diseases; diarrhoea, lower respiratory infections, and other common infectious diseases; neoplasms; neonatal disorders; and HIV/AIDS and tuberculosis. At a finer level of disaggregation within cause groupings, the ten leading causes of total YLLs in 2016 were ischaemic heart disease, cerebrovascular disease, lower respiratory infections, diarrhoeal diseases, road injuries, malaria, neonatal preterm birth complications, HIV/AIDS, chronic obstructive pulmonary disease, and neonatal encephalopathy due to birth asphyxia and trauma. Ischaemic heart disease was the leading cause of total YLLs in 113 countries for men and 97 countries for women. Comparisons of observed levels of YLLs by countries, relative to the level of YLLs expected on the basis of SDI alone, highlighted distinct regional patterns including the greater than expected level of YLLs from malaria and from HIV/AIDS across sub-Saharan Africa; diabetes mellitus, especially in Oceania; interpersonal violence, notably within Latin America and the Caribbean; and cardiomyopathy and myocarditis, particularly in eastern and central Europe. The level of YLLs from ischaemic heart disease was less than expected in 117 of 195 locations. Other leading causes of YLLs for which YLLs were notably lower than expected included neonatal preterm birth complications in many locations in both south Asia and southeast Asia, and cerebrovascular disease in western Europe. Interpretation The past 37 years have featured declining rates of communicable, maternal, neonatal, and nutritional diseases across all quintiles of SDI, with faster than expected gains for many locations relative to their SDI. A global shift towards deaths at older ages suggests success in reducing many causes of early death. YLLs have increased globally for causes such as diabetes mellitus or some neoplasms, and in some locations for causes such as drug use disorders, and conflict and terrorism. Increasing levels of YLLs might reflect outcomes from conditions that required high levels of care but for which effective treatments remain elusive, potentially increasing costs to health systems., Bill & Melinda Gates Foundation.
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11. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

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Ampem, Yaw Amoako, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Arnlov, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asgedom, Solomon W, Atey, Tesfay Mehari, Atnafu, Niguse Tadele, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Awasthi, Shally, Quintanilla, Beatriz Paulina Ayala, Azarpazhooh, Mahmoud Reza, Azzopardi, Peter, Babalola, Tesleem Kayode, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Bannick, Marlena S, Barac, Aleksandra, Barker-Collo, Suzanne L, Barnighausen, Till, Barquera, Simon, Barrero, Lope H, Basu, Sanjay, Battista, Robert, Battle, Katherine E, Baune, Bernhard T, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Bejot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, Derrick A, Bennett, James R, Bensenor, Isabela M, Benson, Jennifer, Berhane, Adugnaw, Berhe, Derbew Fikadu, Bernabe, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Beyene, Addisu Shunu, Bhansali, Anil, Bhatt, Samir, 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Rajesh, Malta, Deborah Carvalho, Mamun, Abdullah A, Manguerra, Helena, Manhertz, Treh, Mantovani, Lorenzo G, Mapoma, Chabila C, March, Lyn M, Marczak, Laurie B, Martinez-Raga, Jose, Henrique, Paulo, Martins, Viegas, Martins-Melo, Francisco Rogerlndio, Martopullo, Ira, Marz, Winfried, Mathur, Manu Raj, Mazidi, Mohsen, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mckee, Martin, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mengesha, Melkamu Merid, Mengistie, Mubarek Abera, Mengistu, Desalegn Tadese, Mensah, George A, Meretoja, Atte, Meretoja, Tuomo J, Mezgebe, Haftay Berhane, Micha, Renata, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mitchell, Philip B, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mohammed, Kedir Endris, Mohammed, Muktar Sano Kedir, Mohan, Murali BV, Mokdad, Ali H, Mollenkopf, Sarah K, Monasta, Lorenzo, Montanez Hernandez, Julio Cesar, Montico, Marcella, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Mori, Rintaro, Morrison, Shane D, Moses, Mark, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Mueller, Ulrich O, Muller, Kate, Mudoch, Michele E, Murthy, Srinivas, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Nagel, Gabriele, Naghavi, Mohsen, Naheed, Aliya, Naidoo, Kovin S, Nangia, Vinay, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negasa, Dumessa Edessa, Negoi, Ionut, Negoi, Ruxandra Irina, Newton, Charles R, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Grant, Nguyen, Trang Huyen, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Norheim, Ole F, Norrving, Bo, Noubiap, Jean Jacques N, Nyandwi, Alypio, Obermeyer, Carla Makhlouf, O'Donnell, Martin J, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Oladimeji, Olanrewaju, Olagunju, Andrew Toyin, Olagunju, Tinuke Oluwasefunmi, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osborne, Richard H, Osgood-Zimmerman, Aaron, Osman, Majdi, Ota, Erika, Owolabi, Mayowa O, Pa, Mahesh, Pacella, Rosana E, Panda, Basant Kumar, Pandian, Jeyaraj D, Papachristou, Christina, Park, Eun-Kee, Parry, Charles D, Parsaeian, Mahboubeh, Patil, Snehal T, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pearce, Neil, Pereira, David M, Perez, Krystle Marie, Perico, Norberto, Pesudovs, Konrad, Peterson, Carrie Beth, Petri, William Arthur, Petzold, Max, Phillips, Michael Robert, Phipps, Geoffrey, Pigott, David M, Pillay, Julian David, Pinho, Christine, Piradov, Michael A, Plass, Dietrich, Pletcher, Martin A, Popova, Svetlana, Poulton, Richie G, Pourmalek, Farshad, Prabhakaran, Dorairaj, Prasad, Narayan, Purcell, Carrie, Purwar, Manorama, Qorbani, Mostafa, Rabiee, Rynaz HS, Radfar, Amir, Rafay, Anwar, Rahimi, Kazem, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Muhammad Aziz, Rahman, Mohammad Hifz Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Ranabhat, Chhabi Lal, Rangaswamy, Thara, Rankin, Zane, Rao, Paturi Vishnupriya, Rao, Puja C, Rawaf, Salman, Ray, Sarah E, Reiner, Robert C, Reinig, Nikolas, Reitsma, Marissa, Remuzzi, Giuseppe, Renzaho, Andre MN, Resnikoff, Serge, Rezaei, Satar, Ribeiro, Antonio L, Roba, Hirbo Shore, Robinson, Stephen R, Rojas-Rueda, David, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Roy, Ambuj, Rubagotti, Enrico, Ruhago, George Mugambage, Saadat, Soheil, Safdarian, Mahdi, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Sahraian, Mohammad Ali, Salama, Joseph, Saleh, Muhammad Muhammad, Salomon, Joshua A, Salvi, Sundeep Santosh, Samy, Abdallah M, Sanabria, Juan Ramon, Dolores Sanchez-Nino, Maria, Santomauro, Damian, Santos, Joao Vasco, Santos, Itamar S, Milicevic, Milena M Santric, Sartorius, Benn, Satpathy, Maheswar, Sawhney, Monika, Saxena, Sonia, Schelonka, Kathryn, Schmidt, Maria Ines, Schneider, Ione JC, Schottker, Ben, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shaheen, Amira, Shaikh, Masood Ali, Shamsipour, Mansour, Islam, Sheikh Mohammed Shariful, Sharma, Rajesh, Sharma, Jayendra, She, Jun, Shi, Peilin, Shibuya, Kenji, Shields, Chloe, Shiferaw, Mekonnen Sisay, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shirude, Shreya, Shishani, Kawkab, Shoman, Haitham, Siabani, Soraya, Sibai, Abla Mehio, Sigfusdottir, Inga Dora, Silberberg, Donald H, Silva, Joao Pedro, Santos Silva, Diego Augusto, Alves Silveira, Dayane Gabriele, Singh, Jasvinder A, Singh, Virendra, Singh, Om Prakash, Singh, Narinder Pal, Sinha, Dhirendra Narain, Skiadaresi, Eirini, Skirbekk, Vegard, Slepak, Erica Leigh, Smith, David L, Smith, Mari, Sobaih, Badr HA, Sobngwi, Eugene, Soljak, Michael, Sorensen, Reed JD, Moraes Sousa, Tatiane Cristina, Sposato, Luciano A, Sufiyan, Muawiyyah Babale, Abdulkader, Rizwan Suliankatchi, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Sylte, Dillon, Szoeke, Cassandra EI, Tabares-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Taffere, Getachew Redae, Takala, Jukka S, Tandon, Nikhil, Tanne, David, Tarekegn, Yihunie L, Tavakkoli, Mohammad, Taveira, Nuno, Taylor, Hugh R, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Tekelab, Tesfalidet, Shifa, Girma Temam, Terkawi, Abdullah Sulieman, Tesfaye, Dawit Jember, Tesssema, Belay, Thakur, JS, Thamsuwan, Ornwipa, Theadom, Alice M, Theis, Andrew M, Thomas, Katie E, Thomas, Nihal, Thompson, Robert, Thrift, Amanda G, Tobe-Gai, Ruoyan, Tobollik, Myriam, Tonelli, Marcello, Topor-Madry, Roman, Tortajada, Miguel, Touvier, Mathilde, Traebert, Jefferson, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tymeson, Hayley, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, Van Boven, Job FM, Varughese, Santosh, Vasankari, Tommi, Veerman, Lennert J, Venkatesh, S, Venketasubramanian, Narayanaswamy, Vidavalur, Ramesh, Vijayakumar, Lakshmi, Violante, Francesco S, Vishnu, Abhishek, Vladimirov, Sergey K, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wadilo, Fiseha, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wijeratne, Tissa, Williams, Hywel C, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles DA, Woodbrook, Rachel, Woolf, Anthony D, Workicho, Abdulhalik, Xavier, Denis, Xu, Gelin, Yadgir, Simon, Yaghoubi, Mohsen, Yakob, Bereket, Yan, Lijing L, Yano, Yuichiro, Ye, Pengpeng, Yihdego, Mahari Gidey, Yimam, Hassen Hamid, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zhang, Xueying, Zheng, Yingfeng, Zhou, Maigeng, Zipkin, Ben, Zodpey, Sanjay, Zoeckler, Leo, Zuhlke, Liesl Joanna, Murray, Christopher JL, and Collaborators, GBD DALYs HALE
Subjects: Adult, Aged, 80 and over, Male, 1. No poverty, Middle Aged, Global Health, Communicable Diseases, 3. Good health, Global Burden of Disease, Age Distribution, Life Expectancy, Residence Characteristics, Cause of Death, Humans, Wounds and Injuries, Disabled Persons, Female, sense organs, Quality-Adjusted Life Years, Sex Distribution, Noncommunicable Diseases, Aged
Abstract: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI).

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11 results on '"Arora, Megha"'

1. Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017

2. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

3. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

4. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

5. Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016

6. Global, regional, and national burden of suicide mortality 1990 to 2016:Systematic analysis for the Global Burden of Disease Study 2016

7. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

8. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

9. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

10. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

11. Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

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11 results on '"Arora, Megha"'

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