1. Novel Requirement for Staphylococcal Cell Wall-Anchored Protein SasD in Pulmonary Infection
- Author
-
Jennifer A. Grousd, Brooke P. Dresden, Abigail M. Riesmeyer, Vaughn S. Cooper, Jennifer M. Bomberger, Anthony R. Richardson, and John F. Alcorn
- Subjects
Mice, Knockout ,Microbiology (medical) ,Staphylococcus aureus ,General Immunology and Microbiology ,Ecology ,Virulence Factors ,Physiology ,Interleukin-1beta ,Membrane Proteins ,Cell Biology ,Staphylococcal Infections ,Mice ,Infectious Diseases ,Cell Wall ,Superinfection ,Influenza, Human ,Pneumonia, Staphylococcal ,Pneumonia, Bacterial ,Genetics ,Animals ,Humans ,Lung - Abstract
Staphylococcus aureus can complicate preceding viral infections, including influenza virus. A bacterial infection combined with a preceding viral infection, known as superinfection, leads to worse outcomes than a single infection. Most of the pulmonary infection literature focuses on the changes in immune responses to bacteria between homeostatic and virally infected lungs. However, it is unclear how much of an influence bacterial virulence factors have in single or superinfection. Staphylococcal species express a broad range of cell wall-anchored proteins (CWAs) that have roles in host adhesion, nutrient acquisition, and immune evasion. We screened the importance of these CWAs using mutants lacking individual CWAs
- Published
- 2022