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Your search keyword '"A. N. Zotova"' showing total 12 results
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12 results on '"A. N. Zotova"'

1. Possible Role of Polymorphisms in TNFA, NFKB1, and CASP8 Gene Promoter Areas in the Development of Chronic Lymphocytic Leukemia

Author

V. A. Ovsepyan, A. A. Shubenkina, and E. N. Zotova

Subjects
0301 basic medicine, Male, Chronic lymphocytic leukemia, Biology, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Pathogenesis, 03 medical and health sciences, Gene Frequency, Genotype, medicine, Humans, Genetic Predisposition to Disease, Allele, Promoter Regions, Genetic, Gene, Transcription factor, Genetic Association Studies, Caspase 8, Tumor Necrosis Factor-alpha, NF-kappa B p50 Subunit, Promoter, General Medicine, Middle Aged, Protective Factors, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, 030104 developmental biology, Case-Control Studies, Immunology, Tumor necrosis factor alpha, Female
Abstract

We studied the relationship between polymorphisms rs1800629 (-308G>A), rs28362491 (-94ins>del), and rs3834129 (-652ins>del) in the promoter regions of TNFA, NFKB1, and CASP8 genes, respectively, encoding TNF-α, nuclear transcription factor κB1 (NF-κB1), and caspase 8 (CASP8), and the risk and stages of chronic lymphocytic leukemia in ethnic Russians, residents of the Vyatka region of Russia. Allele -308A, genotype -308AA, and -308A genotypes (-308AA/-308AG) were associated with the risk of this pathology (OR=1.64, 95%CI 1.14-2.37, p=0.007; OR=4.48, 95%CI 1.20-16.80, p=0.02, and OR=1.57, 95%CI 1.05-2.36, p=0.03). In addition, NFKB1 allele -94del and genotype -94del/del were associated with advanced stages of the disease at the time of diagnosis (OR=0.66, 95%CI 0.46-0.97, p=0.03 and OR=0.43, 95%CI 0.20-0.92, p=0.03). These data suggest that -308G>A and -94ins>del polymorphisms of genes TNFA and NFKB1, respectively, can be involved in the pathogenesis of chronic lymphocytic leukemia.

Published
2015

4. [Improved specific and prophylactic treatment methods for pregnant women and the children delivered by mothers infected with syphilis]

Author

K K, Borisenko, V N, Bednova, I N, Zotova, G A, Kekilova, and A Iu, Nazarova

Subjects
Time Factors, Pregnancy, Syphilis, Congenital, Infant, Newborn, Drug Evaluation, Humans, Infant, Female, Penicillin G Procaine, Syphilis, Pregnancy Complications, Infectious, Follow-Up Studies, Syphilis Serodiagnosis
Abstract

Uninterrupted methods of specific and prophylactic treatment of pregnant women and children, born from syphilitic mothers, were offered. A new preparation--novocainic salt of benzyl penicillin was used in specific and prophylactic treatment of pregnant women.

Published
1989

10. [Pathogenesis and methods of therapy of psoriasis in children]

Author

A A, Studnitsin, E Kh, Ganiushina, L S, Reznikova, G M, Tsvetkova, P E, Maslov, M N, Nikitina, V S, Angelova, O L, Pozdniakov, A G, Beliakova, A A, Androsova, G B, Genkina, P I, Zaturenskaia, and I N, Zotova

Subjects
Ointments, Adolescent, Child, Preschool, Humans, Infant, Prednisone, Psoriasis, Ultraviolet Therapy, Child, Triamcinolone, Antiviral Agents
Published
1969

12. [Problem of prevention of syphilis in children]

Author

A A, Studnitsin, T V, Vasil'ev, M N, Nikitina, I N, Zotova, and G B, Genkina

Subjects
Adult, Male, Time Factors, Adolescent, Child, Preschool, Humans, Infant, Mass Screening, Female, Syphilis, Child, Syphilis Serodiagnosis
Published
1972

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