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Two glioblastoma groups, which are distinguished from each other by expression level of 416 genes (P0.05), were determined using a mathematical model of linear Boolean programming on the basis of gene expression data, obtained by microarray analysis of the glioblastomas and available in Gene Expression Omnibus (GEO) data base. The expression level of 15 genes was more than two-fold higher in the first group of glioblastoma (80 samples) in comparison with the second group (144 samples) and 401 genes and--more than two-fold lower as compared to the second group. 10 of 15 genes, which expression level prevailed in the first group, encode the proteins involved in cell cycle regulation and cell proliferation. A significant percentage of 401 genes are the genes that encode proteins involved in the functioning of neural cells and participating in the processes such as synaptic transmission, neurogenesis, the formation of myelin sheath, axon formation. Kohonen map, built on the basis of the data of 15 genes with prevailed expression in the first group and 60 (of4 01) genes, whose expression level elevated in the second group, confirmed the existence of two glioblastoma groups with specific gene expression profiles. Distribution of the glioblastomas into two groups may reflect two pathways of astrocytic glioma development, one of which leads to the formation of tumors with higher levels of gene expression, which protein products are involved in cell cycle regulation and proliferation. On the other hand, the existence of two molecular variants may reflect different states of glioblastoma progression.

17 observations of the perforation of gastroduodenal ulcer in pulmonary tuberculosis cases are analysed. Most of the patients were males, aged over 50, with protracted chronic forms of tuberculosis. In all cases the suturing of perforation was carried out. 9 patients died. The conclusion has been drawn that a massive antibacterial therapy, which should be carried out in specialized medical institutions, is imperiable.

The authors have widened the volume of clinical, biochemical and functional examinations of patients and introduced the examination by the anesthesiologist and other specialists under ambulatory conditions. The patients having concomitant diseases were given the necessary treatment at the prehospital stage. Most of the patients were operated upon in the day of their admission. The patients who needed preoperative preparation were operated in the nearest days (after performing intensive therapy). These measures allowed to shorten the average stay of the patients at the hospital from 16.1 to 10.3 days, and annually 600 patients were admitted additionally to the hospital at the department with 75 beds without an increase of the number of places.