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This study was carried out for improvement of extracorporeal detoxication results. Distribution of middle-mass molecules (MM) in various media and vascular beds in patients with acute general peritonitis (AGP) and correlation between central hemodynamics (CH) and level of MM-intoxication were studied. Results of treatment were analyzed in 72 patients with AGP. Ultraviolet irradiation of autoblood (UVIA) had negative influence on circulation in patients with AGP in terminal stage who had more severe primary disorders of CH. Therefore, UVIA without hemosorption (HS) in these patients is potentially dangerous because of undesirable hemodynamic effects due to increase of MM-concentration in blood plasma. HS was performed 1.5-2 hours after UVIA and resulted in decrease of MM-concentration in caval system blood by 28.1% with subsequent slow increase, MM-level restored 24 hours after HS. If HS and UVIA were carried out simultaneously, MM-concentration in caval system blood decreased by 13.9% only, an in 3 of 7 cases MM-concentration didn't change. Combination of UVIA and HS with 1.5-2 h interval is most effective.

Peptide fractions, affecting the state of the hemostasis system, were isolated from blood plasma of patients with abnormal development of pregnancy. The functional activity of homogeneous peptide preparation was expressed as induction of ADP-dependent thrombocytes aggregation.

Medium molecular mass peptides have been identified, using gel chromatography, in the blood of 58 patients with peritonitis of various etiology and 20 donors. Peptides with a relative molecular mass about 1300, corresponding to fraction VI and playing a key role in endogenous intoxication in the postoperative period have been detected in patients with peritonitis. A direct dependence of postoperative endogenous intoxication on the duration, dissemination and phase of peritonitis. A direct dependence of postoperative endogenous intoxication on the duration, dissemination and phase of peritonitis has been shown, with it being most expressed in patients with appendicitis-induced peritonitis. Changes in postoperative endotoxemia were demonstrated to depend on the type of detoxication therapy performed. High detoxicating effect of peritoneal intestinal lavage and hemosorption has been confirmed.

The effect of acute preoperative hemodilution on circulation, oxygen budget and blood coagulation has been studied in 54 patients with lung pathology and major vessel disease. With exfusion up to 20% circulating blood volume (CBV), circulatory changes were manifested in decreased vascular tone. With exfusion up to 25% CBV, an increase in cardiac output and a decrease in mean blood pressure were observed. O2 transport, consumption and utilization remained unchanged, with normalization of a so far enhanced blood coagulation.

The alkaline shift of blood Ph together with marked metabolic acidosis in the liquor were found postoperativery in 42 patients operated upon the colon and small intestine at the height of postoperative psychosis. The patients developed tachipnoe up to 32-36 per minute, followed with a great energy expenditure. As a consequence, artificial pulmonary ventilation (APV) at the hyperventilation regime was administered to a part of the patients to correct acidosis of the liquor. Postoperative psychotic patients need an early administration of the APV at the hyperventilation regime, which is one of effective methods of correcting liquor acidosis in the complex therapy of psychoses.