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1. Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

Author

Strosberg, J, El Haddad, G, Wolin, E, Hendifar, A, Yao, J, Chasen, B, Mittra, E, Kunz, Pl, Kulke, Mh, Jacene, H, Bushnell, D, O'Dorisio, Tm, Baum, Rp, Kulkarni, Hr, Caplin, M, Lebtahi, R, Hobday, T, Delpassand, E, Van Cutsem, E, Benson, A, Srirajaskanthan, R, Pavel, M, Mora, J, Berlin, J, Grande, E, Reed, N, Seregni, E, Öberg, K, Lopera Sierra, M, Santoro, P, Thevenet, T, Erion, Jl, Ruszniewski, P, Kwekkeboom, D, Krenning, E, Ansquer, C, Baudin, E, Courbon, F, Giammarile, F, Taieb, D, Scheidhauer, K, Weber, M, Bodei, L, Brianzoni, E, DELLE FAVE, Gianfranco, Chiara Grana, M, Mariani, G, Rindi, G, Severi, S, Azevedo, I, Sundin, A, Al‐nahhas, A, Freemantle, N, Grossman, A, Manoharan, P, Anthony, L, Benson, Ab, Garbus, S, Kulke, M, Kvols, L, Metz, D, Morse, M, Schipper, M, Yao, J., and Radiology & Nuclear Medicine

Subjects
Male, medicine.medical_specialty, Octreotide, Antineoplastic Agents, Kaplan-Meier Estimate, Neuroendocrine tumors, Gastroenterology, Disease-Free Survival, Drug Administration Schedule, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Randomized controlled trial, law, Internal medicine, Organometallic Compounds, medicine, Clinical endpoint, Humans, Infusions, Intravenous, Telotristat ethyl, Aged, Gastrointestinal Neoplasms, Tumors, DOTA-TATE, Intestins, business.industry, Nausea, General Medicine, receptor radionuclide therapy, radiolabeled somatostatin analog, carcinoid-syndrome, prognostic-factors, survival, prrt, lu-177-dota-octreotate, lu-177-octreotate, scintigraphy, octreotide, Middle Aged, medicine.disease, Surgery, Intestines, Clinical trial, Neuroendocrine Tumors, chemistry, Delayed-Action Preparations, 030220 oncology & carcinogenesis, Radionuclide therapy, Female, business, medicine.drug
Abstract

Background: Patients with advanced midgut neuroendocrine tumors who have had disease progression during first-line somatostatin analogue therapy have limited therapeutic options. This randomized, controlled trial evaluated the efficacy and safety of lutetium-177 ((177)Lu)-Dotatate in patients with advanced, progressive, somatostatin-receptor-positive midgut neuroendocrine tumors. Methods: We randomly assigned 229 patients who had well-differentiated, metastatic midgut neuroendocrine tumors to receive either (177)Lu-Dotatate (116 patients) at a dose of 7.4 GBq every 8 weeks (four intravenous infusions, plus best supportive care including octreotide long-acting repeatable [LAR] administered intramuscularly at a dose of 30 mg) ((177)Lu-Dotatate group) or octreotide LAR alone (113 patients) administered intramuscularly at a dose of 60 mg every 4 weeks (control group). The primary end point was progression-free survival. Secondary end points included the objective response rate, overall survival, safety, and the side-effect profile. The final analysis of overall survival will be conducted in the future as specified in the protocol; a prespecified interim analysis of overall survival was conducted and is reported here. Results: At the data-cutoff date for the primary analysis, the estimated rate of progression-free survival at month 20 was 65.2% (95% confidence interval [CI], 50.0 to 76.8) in the (177)Lu-Dotatate group and 10.8% (95% CI, 3.5 to 23.0) in the control group. The response rate was 18% in the (177)Lu-Dotatate group versus 3% in the control group (PConclusions: Treatment with (177)Lu-Dotatate resulted in markedly longer progression-free survival and a significantly higher response rate than high-dose octreotide LAR among patients with advanced midgut neuroendocrine tumors. Preliminary evidence of an overall survival benefit was seen in an interim analysis; confirmation will be required in the planned final analysis. Clinically significant myelosuppression occurred in less than 10% of patients in the (177)Lu-Dotatate group. (Funded by Advanced Accelerator Applications; NETTER-1 ClinicalTrials.gov number, NCT01578239 ; EudraCT number 2011-005049-11 .).

Published
2017

2. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers

Author

O'Toole, D., Grossman, A., Gross, D., Fave, G. D., Barkmanova, J., O'Connor, J., Pape, U. F., Plöckinger, U., Åkerström, G., Annibale, B., Arnold, R., Bajetta, E., Chen, Y. J., Costa, F., Couvelard, A., Davar, J., Herder, W. D., Eriksson, B., Falconi, M., Ferone, D., Gustafsson, B., Hyrdel, R., Ivan, D., Kaltsas, G., Kianmanesh, R., Klöppel, G., Knigge, U. P., Komminoth, P., Kos Kudla, B., Kwekkeboom, D., Lebtahi, R., Lewington, V., Mcnicol, A. M., Mitry, E., Nilsson, O., Öberg, K., Papotti, M., Pavel, M., Perren, A., Platania, M., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scheidhauer, K., Scoazec, J. Y., Sundin, A., Szpak, W., Taal, B., Vitek, P., Vullierme, M. P., and Wiedenmann, B.

Subjects
Endocrinology, Diabetes and Metabolism, Diagnostic accuracy, insulinoma, Neuroendocrine tumors, Bioinformatics, secretin, 0302 clinical medicine, Endocrinology, immune system diseases, cancer diagnosis, conference paper, Biochemical markers, biology, Urinary 5-hydroxyindoleacetic acid, Chromogranin A, Fasting, Hydroxyindoleacetic Acid, Diabetes and Metabolism, Neuroendocrine Tumors, priority journal, 030220 oncology & carcinogenesis, diagnostic accuracy, 5 hydroxyindoleacetic acid, neuroendocrine tumor, hormones, hormone substitutes, and hormone antagonists, Neuroendocrine tumor test, musculoskeletal diseases, medicine.medical_specialty, Standard of care, MEDLINE, 610 Medicine & health, 030209 endocrinology & metabolism, 03 medical and health sciences, Cellular and Molecular Neuroscience, Patient information, Internal medicine, gastrin, medicine, Humans, biochemistry, human, Insulinoma, Gastrinoma, gastrinoma, Endocrine and Autonomic Systems, business.industry, practice guideline, biochemical marker, chromogranin A, hypoglycemia, patient information, medicine.disease, body regions, biology.protein, 570 Life sciences, Biomarkers, business
Abstract

Biomarkers have been the mainstay in the diagnosis and follow-up of patients with neuroendocrine tumors (NETs) over the last few decades. In the beginning, secretory products from a variety of subtypes of NETs were regarded as biomarkers to follow during diagnosis and treatment: serotonin for small intestinal (SI) NETs, and gastrin and insulin for pancreatic NETs. However, it became evident that a large number of NETs were so-called nonfunctioning tumors without secreting substances that caused hormone-related symptoms. Therefore, it was necessary to develop so-called “general tumor markers.” The most important ones so far have been chromogranin A and neuron-specific enolase (NSE). Chromogranin A is the most important general biomarker for most NETs with a sensitivity and specificity somewhere between 60 and 90%. NSE has been a relevant biomarker for patients with high-grade tumors, particularly lung and gastrointestinal tract tumors. Serotonin and the breakdown product urinary 5-hydroxyindoleacetic acid (U-5-HIAA) is still an important marker for diagnosing and follow-up of SI NETs. Recently, 5-HIAA in plasma has been analyzed by high-performance liquid chromatography and fluorometric detection and has shown good agreement with U-5-HIAA analysis. In the future, we will see new tests including circulating tumor cells, circulating DNA and mRNA. Recently, a NET test has been developed analyzing gene transcripts in circulating blood. Preliminary data indicate high sensitivity and specificity for NETs. However, its precise role has to be validated in prospective randomized controlled trials which are ongoing right now.

Published
2017

3. ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

Author

Pape, U-F, Niederle, B, Costa, F, Gross, D, Kelestimur, F, Kianmanesh, R, Knigge, U, Öberg, K, Pavel, M, Perren, A, Toumpanakis, C, O'Connor, J, Krenning, E, Reed, N, O'Toole, D, Ferone, D, and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Endocrinology, Diabetes and Metabolism, MEDLINE, 610 Medicine & health, Neuroendocrine tumors, appendix, digestive system, 03 medical and health sciences, Cellular and Molecular Neuroscience, Appendiceal Neoplasms, Europe, Humans, Neuroendocrine Tumors, 0302 clinical medicine, Endocrinology, Internal medicine, Medicine, guidelines, Goblet cell, Settore MED/08 - ANATOMIA PATOLOGICA, Endocrine and Autonomic Systems, business.industry, respiratory system, medicine.disease, digestive system diseases, Appendix, Appendiceal neoplasms, stomatognathic diseases, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 570 Life sciences, biology, 030211 gastroenterology & hepatology, business
Abstract

ENETS Consensus Guidelines for Neuroendocrine Neoplasms of the Appendix (Excluding Goblet Cell Carcinomas)

Published
2016

4. ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

Author

M. Pavel, E. Baudin, A. Couvelard, E. Krenning, K. Öberg, T. Steinmüller, M. Anlauf, B. Wiedenmann, R. Salazar, B. C. Conference Anlauf M, Arnold R, Bartsch D, Baudin E, Baum R, Brandi ML, Cadiot G, Costa F, Caplin M, Couvelard A, de Herder W, Delle Fave G, Denecke T, Eriksson B, Gress T, Gross D, Grossman A, Jensen R, Kaltsas G, Kelestimur F, Kianmanesh R, Klöppel G, Klose KJ, Knigge U, Komminoth P, Kos Kudla B, Krenning E, Kwekkeboom D, Lopes JM, Niederle B, Nilsson O, Öberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pascher A, Pavel M, Perren A, Plöckinger U, Rindi G, Ruszniewski P, Salazar R, Sasano H, Sauvanet A, Scoazec JY, Steinmüller T, Sundin A, Taal B, Tomassetti P, Van Cutsem E, Vullierme MP, Wiedenmann B., FALCONI , MASSIMO, M., Pavel, E., Baudin, A., Couvelard, E., Krenning, K., Öberg, T., Steinmüller, M., Anlauf, B., Wiedenmann, R., Salazar, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, Wiedenmann, B., and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, animal structures, Endocrinology, Diabetes and Metabolism, Intestinal Neoplasm, Neuroendocrine tumors, Biology, digestive system, Cellular and Molecular Neuroscience, Endocrinology, stomatognathic system, Internal medicine, Intestinal Neoplasms, medicine, Humans, Endocrine and Autonomic Systems, Liver Neoplasms, fungi, Midgut, Hindgut, Foregut, medicine.disease, Neuroendocrine Tumors, embryonic structures, Unknown primary, Neoplasms, Unknown Primary
Abstract

ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary

Published
2012

5. ENETS Consensus Guidelines for the Management of Patients with Neuroendocrine Neoplasms from the Jejuno-Ileum and the Appendix Including Goblet Cell Carcinomas

Author

U. Pape, A. Perren, B. Niederle, D. Gross, T. Gress, F. Costa, R. Arnold, T. Denecke, U. Plöckinger, R. Salazar, A. Grossman, B. C. Conference Anlauf M, Arnold R, Bartsch D, Baudin E, Baum R, Brandi ML, Cadiot G, Costa F, Caplin M, Couvelard A, de Herder W, Delle Fave G, Denecke T, Eriksson B, Gress T, Gross D, Grossman A, Jensen R, Kaltsas G, Kelestimur F, Kianmanesh R, Klöppel G, Klose KJ, Knigge U, Komminoth P, Kos Kudla B, Krenning E, Kwekkeboom D, Lopes JM, Niederle B, Nilsson O, Öberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pascher A, Pavel M, Perren A, Plöckinger U, Rindi G, Ruszniewski P, Salazar R, Sasano H, Sauvanet A, Scoazec JY, Steinmüller T, Sundin A, Taal B, Tomassetti P, Van Cutsem E, Vullierme MP, Wiedenmann B., FALCONI , MASSIMO, Erasmus MC other, U., Pape, A., Perren, B., Niederle, D., Gro, T., Gre, F., Costa, R., Arnold, T., Denecke, U., Plöckinger, R., Salazar, A., Grossman, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, and Wiedenmann, B.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, General surgery, University hospital, Appendix, Appendiceal neoplasms, Neuroendocrine Tumors, Cellular and Molecular Neuroscience, Jejunum, Endocrinology, medicine.anatomical_structure, Appendiceal Neoplasms, Ileum, Internal medicine, Intestinal Neoplasms, neuroendocrine neoplasms from the jejuno-ileum and the appendix including goblet cell carcinomas, medicine, Humans, business
Abstract

a Division of Hepatology and Gastroenterology, Department of Internal Medicine, Campus Virchow-Klinikum, Charite-Universitatsmedizin Berlin, Berlin , Germany; b Department of Pathology, Universitatsspital, Zurich , Switzerland; c Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; d Department of Endocrinology and Metabolism, Hadassah University Hospital, Jerusalem , Israel; e Department of Internal Medicine, Philipps University, Marburg , Germany; f Hopital Sirio Libanes, Centro de Oncologia, Sao Paulo , Brazil; g Department of Radiology, Campus Virchow-Klinikum, Charite, University Medicine Berlin, Berlin , Germany; h Department of Oncology, Institut Catala d’Oncologia (IDIBELL), Barcelona , Spain; i Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Oxford , UK

Published
2012

6. Recommendations for management of patients with neuroendocrine liver metastases

Author

Andrea, Frilling, Modlin, Irvin M., Mark, Kidd, Christopher, Russell, Stefan, Breitenstein, Riad, Salem, Dik, Kwekkeboom, Wan yee Lau, Catherine, Klersy, Valerie, Vilgrain, Brian, Davidson, Mark, Siegler, Martyn, Caplin, Enrico, Solcia, Richard, Schilsky, Adam, R, Akerstrom, G, Belghiti, J, Breitenstein, S, Clavien, Pa, Frilling, A, Gustafsson, B, Krenning, E, Modlin, Im, Norton, J, Öberg, K, Poston, G, Ruszniewski, P, Tait, P, Toogood, G, Russell, C, Bouvier, C, Jarecki, A, Klersy, C, Lau, Wj, Siegler, M, Rindi, G, Kidd, M, Vilgrain, V, Baum, Rp, Heaton, N, Garden, J, Fan, St, Van Gulik, T, Sipperstein, A, Kwekkeboom, D, Caplin, M, Lawrence, B, de Herder, W, Ito, T, Perren, A, Davidson, B, Klimstra, Ds, Kloppel, G, Scarpa, A, Meyer, T, Knuth, A, Chen, H, Van Cutsem, E, Pavel, Me, Kos Kudla, B, Conlon, K, Imamura, M, Kaltsas, G, Broering, D, Wiedenmann, B, Al Nahhas, A, Lodge, P, Cosimelli, M, Grazi, G, Tang, Lh, Salazar, R, Grossman, Ab, Dejong, C, Gores, G, Nagorney, Dm, Mazzaferro, V, Jensen, R, Lesurtel, M, Falconi, M, Hellmann, P, O'Toole, D, Olauson, M, Le Treut, Y, Burroughs, Ak, Valle, J, Kianmanesch, R, Sowa Staszczak, A, Milicevic, M, Lencioni, RICCARDO ANTONIO, Ramage, J, Sangro, B, Kennedy, A, Bester, L, Salem, R, Sharma, R, Parks, R, Bodei, L, Muller Brand, J, Kvols, L, Manas, D, Ramos, J, Wasan, H., Frilling, Andrea, Modlin Irvin, M., Kidd, Mark, Russell, Christopher, Breitenstein, Stefan, Salem, Riad, Kwekkeboom, Dik, Lau Wan, Yee, Klersy, Catherine, Vilgrain, Valerie, Davidson, Brian, Siegler, Mark, Caplin, Martyn, Solcia, Enrico, Schilsky, Richard, Falconi, Massimo, Andrea, Frilling, Modlin, Irvin M., Mark, Kidd, Christopher, Russell, Stefan, Breitenstein, Riad, Salem, Dik, Kwekkeboom, Wan-yee, Lau, Catherine, Klersy, Valerie, Vilgrain, Brian, Davidson, Mark, Siegler, Martyn, Caplin, Enrico, Solcia, Richard, Schilsky, for the Working Group on Neuroendocrine Liver Metastases,, Grazi, G., Radiology & Nuclear Medicine, and Internal Medicine

Subjects
medicine.medical_specialty, Biopsy, MEDLINE, clinical practice guidelines, hepatic metastases, prognostic factors, surgical management, Neuroendocrine tumors, surgical management, Systemic therapy, NO, medicine, Hepatectomy, Humans, hepatic metastases, Intensive care medicine, medicine.diagnostic_test, business.industry, Liver Neoplasms, prognostic factors, Interventional radiology, medicine.disease, Neoplastic Cells, Circulating, Neoadjuvant Therapy, Surgery, Clinical Practice, Neuroendocrine Tumors, Oncology, Genomic information, business, Working group, clinical practice guidelines
Abstract

Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or targeted agents. A paucity of biological, molecular, and genomic information and an absence of data from rigorous trials limit the validity of many publications detailing management. This Review represents the views from an international conference, for which 15 expert working groups prepared evidence-based assessments addressing specific questions, and from which an independent jury derived final recommendations. The aim of the conference was to review the existing approaches to neuroendocrine liver metastases, assess the evidence on which management decisions were based, develop internationally acceptable recommendations for clinical practice (when evidence was available), and make recommendations for clinical and research endeavours. This report represents the final clinical statements and proposals for future research. © 2014 Elsevier Ltd.

Published
2014

7. Rare functioning pancreatic endocrine tumors

Author

O'Toole D, Salazar R, Kaltsas G, Couvelard A, De Herder WW, Hyrdel R, Nikou G, Krenning E, Vullierme MP, Caplin M, Jensen R, Eriksson B, Ahlman H, Arnold R, Bechstein WO, Cadiot G, Christ E, Chung D, Delle Fave G, Falchetti A, Ferone D, Goretzki P, Gross D, Hochhauser D, Keleştimur F, Kianmanesh R, Knapp W, Knigge UP, Komminoth P, Körner M, Kos Kudła B, Kvols L, Kwekkeboom DJ, Lewington V, Lopes JM, Manfredi R, McNicol AM, Mitry E, Niederle B, Nilsson O, Öberg K, O'Connor J, Pauwels S, Pape UF, Pavel M, Perren A, Plöckinger U, Ramage J, Ricke J, Rindi G, Ruszniewski P, Sauvanet A, Scarpa A, Scoazec JY, Sevilla Garcia MI, Steinmüller T, Sundin A, Taal B, Van Cutsem E, Wiedenmann B, Wildi S, Yao JC, Zgliczynski S., FALCONI , MASSIMO, Internal Medicine, Radiology & Nuclear Medicine, O'Toole, D, Salazar, R, Falconi, Massimo, Kaltsas, G, Couvelard, A, De Herder, Ww, Hyrdel, R, Nikou, G, Krenning, E, Vullierme, Mp, Caplin, M, Jensen, R, Eriksson, B, Ahlman, H, Arnold, R, Bechstein, Wo, Cadiot, G, Christ, E, Chung, D, Delle Fave, G, Falchetti, A, Ferone, D, Goretzki, P, Gross, D, Hochhauser, D, Keleştimur, F, Kianmanesh, R, Knapp, W, Knigge, Up, Komminoth, P, Körner, M, Kos Kudła, B, Kvols, L, Kwekkeboom, Dj, Lewington, V, Lopes, Jm, Manfredi, R, Mcnicol, Am, Mitry, E, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, Pauwels, S, Pape, Uf, Pavel, M, Perren, A, Plöckinger, U, Ramage, J, Ricke, J, Rindi, G, Ruszniewski, P, Sauvanet, A, Scarpa, A, Scoazec, Jy, Sevilla Garcia, Mi, Steinmüller, T, Sundin, A, Taal, B, Van Cutsem, E, Wiedenmann, B, Wildi, S, Yao, Jc, and Zgliczynski, S.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Humans, Neuroendocrine Tumors, Pancreatic Neoplasms, Biology, University hospital, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine
Abstract

a Department of Gastroenterology, Beaujon Hospital, Clichy , France; b Department of Oncology, Institut Catala d’Oncologia, Barcelona , Spain; c Department of Surgery, Verona University, Verona , Italy; d Department of Endocrinology and Metabolism, Genimatas Hospital, Athens , Greece; e Department of Gastroenterology, Beaujon Hospital, Clichy , France; f Department of Endocrinology, Erasmus MC University, Rotterdam , The Netherlands; g Department of Internal Medicine, Martin University, Martin , Slovakia; h Department of Propaedeutic Internal Medicine, Laiko Hospital, Athens , Greece; i Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; j Department of Gastroenterology, Beaujon Hospital, Clichy , France; k Department of Gastroenterology, Royal Free Hospital, London , UK; l Department of Cell Biology, National Institute of Health, Bethesda, Md. , USA; m Department of Endocrinology, University Hospital, Uppsala , Sweden

Published
2006

8. ENETS Consensus Guidelines Update for Neuroendocrine Neoplasms of the Jejunum and Ileum

Author

Niederle, B, Pape, U-F, Costa, F, Gross, D, Kelestimur, F, Knigge, U, Öberg, K, Pavel, M, Perren, A, Toumpanakis, C, O'Connor, J, O'Toole, D, Krenning, E, Reed, N, Kianmanesh, R, Ferone, D, Cardiology, and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Consensus, Endocrinology, Diabetes and Metabolism, MEDLINE, 610 Medicine & health, 030209 endocrinology & metabolism, Ileum, Neuroendocrine tumors, Ileal Neoplasm, Jejunum, Jejunal Neoplasm, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Humans, Europe, Ileal Neoplasms, Jejunal Neoplasms, Neuroendocrine Tumors, Endocrine and Autonomic Systems, business.industry, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, 570 Life sciences, biology, business
Published
2016
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9. ENETS Consensus Guidelines Update for the Management of Distant Metastatic Disease of Intestinal, Pancreatic, Bronchial Neuroendocrine Neoplasms (NEN) and NEN of Unknown Primary Site

Author

Pavel, M, O'Toole, D, Costa, F, Capdevila, J, Gross, D, Kianmanesh, R, Krenning, E, Knigge, U, Salazar, R, Pape, U-F, Öberg, K, Ferone, D, and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Intestinal Neoplasm, MEDLINE, 030209 endocrinology & metabolism, Disease, Neuroendocrine tumors, Gastroenterology, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Endocrinology, Internal medicine, Intestinal Neoplasms, Bronchial neoplasm, medicine, Humans, Neuroendocrine neoplasia, Endocrine and Autonomic Systems, business.industry, Bronchial Neoplasms, medicine.disease, Europe, Pancreatic Neoplasms, Neuroendocrine Tumors, 030220 oncology & carcinogenesis, Unknown primary, business
Abstract

The goal of this paper is to update a more extensive review and guidelines paper published in 2012 [1] . Gen-erally, any pertinent update pertaining to the diagnosis and staging of individual prima ...

Published
2016

10. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors:Echocardiography

Author

Plöckinger, U., Gustafsson, B., Ivan, D., Szpak, W., Davar, J., Åkerstrom, G., Annibale, B., Arnold, R., Bajetta, E., Barkmanova, J., Chen, Y. J., Costa, F., Couvelard, A., Herder, W. D., Fave, G. D., Eriksson, B., Falconi, M., Ferone, D., Gross, D., Grossman, A., Hyrdel, R., Kaltsas, G., Kianmanesh, R., Klöppel, G., Knigge, U. P., Komminoth, P., Kos Kudla, B., Kwekkeboom, D., Lebtahi, R., Lewington, V., Mcnicol, A. M., Mitry, E., Nilsson, O., Öberg, K., O'Connor, J., O'Toole, D., Pape, U. F., Papotti, M., Pavel, M., Perren, A., Platania, M., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scheidhauer, K., Scoazec, J. Y., Sundin, A., Taal, B., Vitek, P., Vullierme, M. P., and Wiedenmann, B.

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Carcinoid tumors, MEDLINE, Carcinoid Heart Disease, carcinoid syndrome, Diagnostic accuracy, Disease, Neuroendocrine tumors, Cellular and Molecular Neuroscience, Endocrinology, cancer diagnosis, Internal medicine, Humans, echocardiography, Medicine, human, medical society, conference paper, medical documentation, Endocrine and Autonomic Systems, business.industry, practice guideline, Medical practice, diagnostic accuracy, medical practice, neuroendocrine tumor, patient information, priority journal, medicine.disease, Medical documents, Neuroendocrine Tumors, business, Carcinoid syndrome
Abstract

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : echocardiography.

Published
2009

11. Consensus guidelines for the management of patients with liver metastases from digestive (neuro) endocrine tumors: Foregut, midgut, hindgut, and unknown primary

Author

Steinmüller, T., Kianmanesh, R., Falconi, Massimo, Scarpa, Aldo, Taal, B., Kwekkeboom, D., Lopes, J., Perren, A., Nikou, G., Yao, J., Fave, G. D., O'Toole, D., Ahlman, H., Arnold, R., Auernhammer, C., Caplin, M., Christ, E., Couvelard, A., Herder, W. D., Eriksson, B., Ferone, D., Goretzki, P., Gross, D., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Klöppel, G., Knapp, W., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Krenning, E., Kulke, M., Kvols, L., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Öberg, K., O'Connor, J., Pape, U., Pavel, M., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scoazec, J., Garcia, M. S., Sundin, A., Vullierme, M., Wiedenmann, B., Wildi, S., Thomas, Steinmüller, Reza, Kianmanesh, Falconi, Massimo, Aldo, Scarpa, Babs, Taal, Dik J., Kwekkeboom, José M., Lope, Aurel, Perren, George, Nikou, James, Yao, Gian Franco, Delle, Dermot, O'Toole, Frascati Consensus, Conference, Radiology & Nuclear Medicine, and Cardiology

Subjects
medicine.medical_specialty, Consensus, ACTING SOMATOSTATIN ANALOG, Endocrinology, Diabetes and Metabolism, Guidelines as Topic, Biology, HEPATIC ARTERIAL CHEMOEMBOLIZATION, Metastasis, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Endocrine Gland Neoplasms, medicine, Digestive System, Humans, Liver Neoplasms, Endocrine system, Endocrine gland neoplasm, Endocrine and Autonomic Systems, General surgery, Cancer, Hindgut, Midgut, Foregut, LASER-INDUCED THERMOTHERAPY, medicine.disease, HEPATIC ARTERIAL CHEMOEMBOLIZATION, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS, LASER-INDUCED THERMOTHERAPY, ACTING SOMATOSTATIN ANALOG, PORTAL-VEIN EMBOLIZATION, ISLET-CELL CARCINOMA, ISLET-CELL CARCINOMA, PORTAL-VEIN EMBOLIZATION, Unknown primary, GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS
Abstract

a DRK Kliniken Westend, Berlin , Germany; b UFR Bichat-Beaujon-Louis Mourier, Service de Chirurgie Digestive, Hopital Louis Mourier, Colombes , France; c Medicine and Surgery, General Surgery Section, MED/18 – General Surgery and d Department of Pathology, University of Verona, Verona , Italy; e Netherlands Cancer Centre, Amsterdam , and f Department of Nuclear Medicine, Erasmus University Medical Center, Rotterdam , The Netherlands

Published
2008

12. Consensus guidelines for the management of patients with digestive neuroendocrine tumors - Well-differentiated jejunal-ileal tumor/carcinoma

Author

Eriksson, B., Klöppel, G., Krenning, E., Ahlman, H., Plöckinger, U., Wiedenmann, B., Arnold, R., Auernhammer, C., Körner, M., Rindi, G., Wildi, S., Caplin, M., Fave, G. D., Ferone, D., Goretzki, P., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Komminoth, P., Kos Kudła, B., Kvols, L., Kwekkeboom, D., Lopes, J., Manfredi, Riccardo, Mcnicol, A., Niederle, B., Nilsson, O., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pavel, M., Perren, A., Ramage, J., Ricke, J., Ruszniewski, P., Scarpa, Aldo, Scoazec, J., Garcia, M. S., Steinmüller, T., Taal, B., Vullierme, M., Yao, J., and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Consensus, MIDGUT CARCINOID-TUMORS, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, RECEPTOR-MEDIATED RADIOTHERAPY, RADIOLABELED SOMATOSTATIN ANALOG, RECOMBINANT INTERFERON-ALPHA, RADIONUCLIDE THERAPY, MIDGUT CARCINOID-TUMORS, Endocrinology, Diabetes and Metabolism, RADIONUCLIDE THERAPY, Neuroendocrine tumors, digestive system, RECOMBINANT INTERFERON-ALPHA, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, Carcinoma, Humans, Medicine, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, Gastrointestinal Neuroendocrine Tumor, RADIOLABELED SOMATOSTATIN ANALOG, Jejunal Neoplasms, Endocrine and Autonomic Systems, business.industry, digestive, oral, and skin physiology, Metastatic carcinoid tumor, Cancer, medicine.disease, Carcinoma, Neuroendocrine, Well differentiated, Ileal Neoplasms, Practice Guidelines as Topic, Radionuclide therapy, Neuroendocrine therapy, business, RECEPTOR-MEDIATED RADIOTHERAPY
Abstract

Consensus guidelines for the management of patients with digestive neuroendocrine tumors : well-differentiated jejunal-ileal tumor/carcinoma

Published
2008

13. Poorly differentiated carcinomas of the foregut (gastric, duodenal and pancreatic)

Author

Nilsson, O., Cutsem, E. V., Fave, G. D., Yao, J., Pavel, M., Mcnicol, A., Garcia, M. S., Knapp, W., Keleştimur, F., Sauvanet, A., Pauwels, S., Kwekkeboom, D., Caplin, M., Ahlman, H., Arnold, R., Bechstein, W., Cadiot, G., Christ, E., Chung, D., Couvelard, A., Herder, W. D., Eriksson, B., Falchetti, A., Falconi, Massimo, Ferone, D., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Jensen, R., Kaltsas, G., Kianmanesh, R., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Lopes, J., Manfredi, Riccardo, Mitry, E., Niederle, B., Nikou, G., Öberg, K., O'Connor, J., O'Toole, D., Pape, U., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Rindi, G., Ruszniewski, P., Salazar, R., Scarpa, Aldo, Scoazec, J., Steinmüller, T., Sundin, A., Taal, B., Vullierme, M., Wiedenmann, B., Wildi, S., Zgliczynski, S., Radiology & Nuclear Medicine, O., Nilsson, E. V., Cutsem, G. D., Fave, J., Yao, M., Pavel, A., Mcnicol, M. S., Garcia, W., Knapp, F., Keleştimur, A., Sauvanet, S., Pauwel, D., Kwekkeboom, M., Caplin, and Falconi, M

Subjects
SMALL-CELL-CARCINOMA, NEUROENDOCRINE CARCINOMAS, TUMORS, CHEMOTHERAPY, STOMACH, MANAGEMENT, CISPLATIN, ETOPOSIDE, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Biology, Cellular and Molecular Neuroscience, CISPLATIN, Endocrinology, Duodenal Neoplasms, Stomach Neoplasms, Internal medicine, STOMACH, SMALL-CELL-CARCINOMA, medicine, MANAGEMENT, Humans, ddc:610, Royal infirmary, Endocrine and Autonomic Systems, Poorly differentiated, General surgery, GASTRIC/DUODENAL, Carcinoma, CHEMOTHERAPY, TUMORS, Neuroendocrine Carcinomas, Pancreatic Neoplasms, ETOPOSIDE, NEUROENDOCRINE CARCINOMAS
Abstract

a Department of Pathology, Gothenburg University, Gothenburg , Sweden; b Department of Gastroenterology, Gasthuisberg University, Leuven , Belgium; c Department of Gastroenterology, Ospedale S. Andrea, Rome , Italy; d Department of Oncology, University of Texas, Houston, Tex. , USA; e Department of Endocrinology, Erlangen University, Erlangen , Germany; f Department of Oncology and Pathology, Royal Infirmary Hospital, Glasgow , UK; g Department of Oncology, Virgen de la Victoria Hospital, Malaga , Spain; h Department of Nuclear Medicine, Medizinische Hochschule Hannover, Hannover , Germany; i Department of Endocrinology, Erciyes University, Kayseri , Turkey; j Department of Surgery, Beaujon Hospital, Clichy , France; k Department of Nuclear Medicine, Catholique de Louvain University, Brussels , Belgium; l Department of Nuclear Medicine, Erasmus MC University, Rotterdam , The Netherlands; m Department of Gastroenterology, Royal Free Hospital, London , UK

Published
2006

14. ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes

Author

Jensen, R. T., Cadiot, G., Brandi, M. L., W. W., De, Kaltsas, G., Komminoth, P., Scoazec, J., Salazar, R., Sauvanet, A., Kianmanesh, R., Conference Anlauf M, B. C., Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, Wiedenmann, B., R. T., Jensen, G., Cadiot, M. L., Brandi, W. W., De, G., Kaltsa, P., Komminoth, J., Scoazec, R., Salazar, A., Sauvanet, R., Kianmanesh, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, Wiedenmann, B., and Internal Medicine

Subjects
ENETS Consensus Guidelines, medicine.medical_specialty, Pathology, Endocrinology, Diabetes and Metabolism, ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: functional pancreatic endocrine tumor syndromes, Hypoglycemia, Neuroendocrine tumors, Cellular and Molecular Neuroscience, Endocrinology, Internal medicine, medicine, Humans, Pancreatic polypeptide, MEN1, Multiple endocrine neoplasia, biology, Endocrine and Autonomic Systems, business.industry, Chromogranin A, medicine.disease, Pancreatic Neoplasms, Neuroendocrine Tumors, medicine.anatomical_structure, biology.protein, Pancreas, business, Carcinoid syndrome
Abstract

Pancreatic endocrine tumors (p-NETs) include both pancreatic neuroendocrine tumors (p-NETs) associated with a functional syndrome (functional p-NETs) or those associated with no distinct clinical syndrome (non-functional p-NETs) [1,2,3,4]. Non-functional p-NETs frequently secrete pancreatic polypeptide, chromogranin A, neuron-specific enolase, human chorionic gonadotrophin subunits, calcitonin, neurotensin or other peptides, but they do not usually produce specific symptoms and thus are considered clinically to be non-functional tumors [2,3,5,6,7]. Only the functional p-NETs will be considered in this section. The two most common functional p-NETs (gastrinomas, insulinomas) are considered separately, whereas the other well-described and possible rare functional p-NETs are considered together as a group called rare functional p-NETs (RFTs) (table ​(table1)1) [1,2,3,4]. Table 1 Functional pancreatic endocrine tumor (PET) syndromes Gastrinomas are neuroendocrine neoplasms, usually located in the duodenum or pancreas, that secrete gastrin and cause a clinical syndrome known as Zollinger-Ellison syndrome (ZES). ZES is characterized by gastric acid hypersecretion resulting in severe peptic disease (peptic ulcer disease (PUD), gastroesophageal reflux disease (GERD)) [8,9,10]. In this section, ZES due to both duodenal and pancreatic gastrinomas will be covered together because clinically they are similar [8,10]. Specific points related to gastrinomas associated with the genetic syndrome of Multiple Endocrine Neoplasia type 1 (MEN1) (25% of cases) will also be mentioned [11,12]. Insulinomas are neuroendocrine neoplasms located in the pancreas that secrete insulin, which causes a distinct syndrome characterized by symptoms due to hypoglycemia [2,13,14,15]. The symptoms are typically associated with fasting and the majority of patients have symptoms secondary to hypoglycemic central nervous system (CNS) effects (headaches, confusion, visual disturbances, etc.) or due to catecholamine excess secondary to hypoglycemia (sweating, tremor, palpitations, etc.) [2,3,13,14,15]. RFTs can occur in the pancreas or in other locations (VIPomas, somatostatinomas, GRHomas, ACTHomas, p-NETs causing carcinoid syndrome or hypercalcemia (PTHrp-omas)) (table ​(table1)1) [1,2,3,4,5,7]. Each of the established RFT syndromes is associated with a distinct clinical syndrome reflecting the actions of the ectopically secreted hormone. Other RFTs are listed as causing a possible specific syndrome either because there are too few cases or there is disagreement about whether the described features are actually a distinct syndrome (table ​(table1)1) [1,2,3,4,5,7].

Published
2012

15. ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Colorectal Neuroendocrine Neoplasms

Author

M. Caplin, A. Sundin, O. Nillson, R. P. Baum, K. J. Klose, F. Kelestimur, U. Plöckinger, M. Papotti, R. Salazar, A. Pascher, B. C. Conference Anlauf M, Arnold R, Bartsch D, Baudin E, Baum R, Brandi ML, Cadiot G, Costa F, Caplin M, Couvelard A, de Herder W, Delle Fave G, Denecke T, Eriksson B, Gress T, Gross D, Grossman A, Jensen R, Kaltsas G, Kelestimur F, Kianmanesh R, Klöppel G, Klose KJ, Knigge U, Komminoth P, Kos Kudla B, Krenning E, Kwekkeboom D, Lopes JM, Niederle B, Nilsson O, Öberg K, O'Connor J, O'Toole D, Pape UF, Papotti M, Pascher A, Pavel M, Perren A, Plöckinger U, Rindi G, Ruszniewski P, Salazar R, Sasano H, Sauvanet A, Scoazec JY, Steinmüller T, Sundin A, Taal B, Tomassetti P, Van Cutsem E, Vullierme MP, Wiedenmann B., FALCONI , MASSIMO, M., Caplin, A., Sundin, O., Nillson, R. P., Baum, K. J., Klose, F., Kelestimur, U., Plöckinger, M., Papotti, R., Salazar, A., Pascher, B. C., Conference Anlauf M, Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, and Wiedenmann, B.

Subjects
medicine.medical_specialty, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms, stomatognathic diseases, Cellular and Molecular Neuroscience, Neuroendocrine Tumors, Endocrinology, Internal medicine, medicine, Humans, business, Colorectal Neoplasms
Abstract

ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms : colorectal neuroendocrine neoplasms

Published
2012

16. Neuroendocrine gastro-entero-pancreatic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Öberg, K, Knigge, U, Kwekkeboom, D, Perren, A, ESMO Guidelines, Working Group, and Radiology & Nuclear Medicine

Subjects
medicine.medical_specialty, Pathology, Neoplasms, Hormone-Dependent, Antineoplastic Agents, Hormonal, Treatment outcome, MEDLINE, Gastro entero pancreatic, Risk Assessment, Stomach Neoplasms, Intestinal Neoplasms, Medicine, Combined Modality Therapy, Humans, Neoplasm Staging, Randomized Controlled Trials as Topic, business.industry, General surgery, digestive, oral, and skin physiology, Hematology, digestive system diseases, Clinical Practice, Pancreatic Neoplasms, Neuroendocrine Tumors, medicine.anatomical_structure, Treatment Outcome, Oncology, Diagnosis treatment, Neoplasm staging, business, Pancreas
Abstract

Neuroendocrine gastro-entero-pancreatic tumors : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Published
2012

17. ENETS Consensus Guidelines for the management of patients with gastroduodenal neoplasms

Author

Fave, G. D., Kwekkeboom, D. J., Cutsem, E. V., Rindi, G., Kos Kudla, B., Knigge, U., Sasano, H., Tomassetti, P., Salazar, R., Ruszniewski, P., Conference Anlauf M, B. C., Arnold, R, Bartsch, D, Baudin, E, Baum, R, Brandi, Ml, Cadiot, G, Costa, F, Caplin, M, Couvelard, A, de Herder, W, Delle Fave, G, Denecke, T, Eriksson, B, Falconi, Massimo, Gress, T, Gross, D, Grossman, A, Jensen, R, Kaltsas, G, Kelestimur, F, Kianmanesh, R, Klöppel, G, Klose, Kj, Knigge, U, Komminoth, P, Kos Kudla, B, Krenning, E, Kwekkeboom, D, Lopes, Jm, Niederle, B, Nilsson, O, Öberg, K, O'Connor, J, O'Toole, D, Pape, Uf, Papotti, M, Pascher, A, Pavel, M, Perren, A, Plöckinger, U, Rindi, G, Ruszniewski, P, Salazar, R, Sasano, H, Sauvanet, A, Scoazec, Jy, Steinmüller, T, Sundin, A, Taal, B, Tomassetti, P, Van Cutsem, E, Vullierme, Mp, Wiedenmann, B., Fave, G. D., Kwekkeboom, D. J., Cutsem, E. V., Rindi, G., Kos Kudla, B., Knigge, U., Sasano, H., Tomassetti, P., Salazar, R., Ruszniewski, P., Radiology & Nuclear Medicine, Delle Fave G., Kwekkeboom DJ., Van Cutsem E., Rindi G., Kos-Kudla B., Knigge U., Sasano H., Tomassetti P., Salazar R., and Ruszniewski P.

Subjects
medicine.medical_specialty, Settore MED/06 - ONCOLOGIA MEDICA, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, MEDLINE, diagnosis/epidemiology/therapy, GUIDELINES, University hospital, ENETS Consensus Guidelines for the management of patients with gastroduodenal neoplasms, Cellular and Molecular Neuroscience, Neuroendocrine Tumors, Endocrinology, Duodenal Neoplasms, diagnosis/epidemiology/therapy, Humans, Neuroendocrine Tumors, diagnosis/epidemiology/therapy, Stomach Neoplasms, Stomach Neoplasms, Internal medicine, medicine, Humans, business
Abstract

a Department of Digestive and Liver Disease, Ospedale Sant’Andrea, Rome , Italy; b Department of Oncology, Royal Free University UFR Bichat-Beaujon-Louis Mourier, Colombes , France; c Digestive Oncology, University Hospital Gasthuisberg/Leuven, Leuven , Belgium; d Institute of Pathology, Catholic University – Policlinic A. Gemelli, Rome , Italy; e Department of Endocrinology, Medical University of Silesia, Katowice , Poland; f Department of Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen , Denmark; g Department of Pathology, Tohoku University Graduate School of Medicine, Sendai , Japan; h Department of Internal Medicine and Gastroenterology, St. Orsola Hospital, University of Bologna, Bologna , Italy; i Institut Catala d’Oncologia (IDIBELL), Barcelona , Spain; j Department of Gastroenterology, Beaujon Hospital, Clichy , France

Published
2012

18. Neuroendocrine bronchial and thymic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Öberg, K, Hellman, P, Ferolla, P, Papotti, Mauro Giulio, ESMO Guidelines Working Group, and Radiology & Nuclear Medicine

Subjects
Male, Oncology, Pathology, Gastroenterology, Antineoplastic Combined Chemotherapy Protocols, Molecular Targeted Therapy, Neoplasm Metastasis, medicine.diagnostic_test, biology, Cytotoxins, Incidence, Incidence (epidemiology), Bronchial Neoplasms, Biopsy, Needle, Chromogranin A, Hematology, respiratory system, Embolization, Therapeutic, Europe, Clinical Practice, Neuroendocrine Tumors, Treatment Outcome, medicine.anatomical_structure, Diagnosis treatment, Drug Therapy, Combination, Female, Somatostatin, medicine.medical_specialty, Thymoma, MEDLINE, Thymic Tumors, Risk Assessment, Internal medicine, Biopsy, medicine, Humans, Survival rate, Survival analysis, Neoplasm Staging, Cancer staging, Lung, Thymus Neoplasm, business.industry, Interferon-alpha, Thymus Neoplasms, medicine.disease, Survival Analysis, respiratory tract diseases, biology.protein, Neoplasm staging, business, Follow-Up Studies
Abstract

The annual incidence of lung neuroendocrine tumour has been reported to be 1.35/100 000/year and the overall age adjusted incidence for thymic carcinoid 0.02/100 000/year. Of all neuroendocrine tumours, ∼25% are located in the respiratory tract. Both bronchial and thymic carcinoids may be part of multiple endocrine neoplasia type 1 syndrome (MEN-I) (5%–15%). The median age at diagnosis for lung neuroendocrine tumours is 64 years and for thymic tumours 59 years.

Published
2012

19. ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: pre- and perioperative therapy in patients with neuroendocrine tumors

Author

Akerström, G., Falconi, M., Kianmanesh, R., Ruszniewski, P., Plöckinger, U., Annibale, B., Arnold, R., Bajetta, E., Barkmanova, J., Chen, Y. J., Costa, F., Couvelard, A., Davar, J., Herder, W. D., Fave, G. D., Eriksson, B., Ferone, D., Gross, D., Grossman, A., Gustafsson, B., Hyrdel, R., Ivan, D., Kaltsas, G., Klöppel, G., Knigge, U. P., Komminoth, P., Kos Kudla, B., Kwekkeboom, D., Lebtahi, R., Lewington, V., Mcnicol, A. M., Mitry, E., Nilsson, O., Öberg, K., O'Connor, J., O'Toole, D., Pape, U. F., Papotti, M., Pavel, M., Perren, A., Platania, M., Rindi, G., Salazar, R., Scarpa, Aldo, Scheidhauer, K., Scoazec, J. Y., Sundin, A., Szpak, W., Taal, B., Vitek, P., Vullierme, M. P., Wiedenmann, B., G., Akerström, Falconi, Massimo, R., Kianmanesh, P., Ruszniewski, U., Plöckinger, and Mallorca Consensus Conference, Participants

Subjects
glucagonoma, Endocrinology, Diabetes and Metabolism, perioperative period, carcinoid syndrome, Haemophilus infection, somatostatin derivative, anesthesia, insulinoma, Small, Cellular and Molecular Neuroscience, Endocrinology, Stomach Neoplasms, cancer diagnosis, Intestinal Neoplasms, Intestine, Small, Preoperative Care, Humans, electrolyte disturbance, Intestine, Neuroendocrine Tumors, Pancreas, Pancreatic Neoplasms, Postoperative Care, Stomach, human, conference paper, vipoma, gastrinoma, Endocrine and Autonomic Systems, practice guideline, diazoxide, Pneumococcus vaccine, preoperative evaluation, hypoglycemia, priority journal, octreotide, neuroendocrine tumor, preoperative care
Published
2009

20. Well-differentiated pancreatic tumor/carcinoma: Insulinoma

Author

Herder, W. D., Niederle, B., Scoazec, J., Pauwels, S., Klöppel, G., Falconi, Massimo, Kwekkeboom, D., Öberg, K., Eriksson, B., Wiedenmann, B., Rindi, G., O'Toole, D., Ferone, D., Ahlman, H., Arnold, R., Bechstein, W., Cadiot, G., Caplin, M., Christ, E., Chung, D., Couvelard, A., Fave, G. D., Falchetti, A., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Jensen, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Knapp, W., Knigge, U., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Lopes, J., Manfredi, Riccardo, Mcnicol, A., Mitry, E., Nikou, G., Nilsson, O., O'Connor, J., Pape, U., Pavel, M., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Ruszniewski, P., Salazar, R., Sauvanet, A., Scarpa, Aldo, Garcia, M. S., Steinmüller, T., Sundin, A., Taal, B., Cutsem, E. V., Vullierme, M., Wildi, S., Yao, J., Zgliczyñski, S., W. W., de Herder, B., Niederle, J., Scoazec, S., Pauwel, G., Kloppel, Falconi, Massimo, D. J., Kwekkeboom, K., Oberg, B., Eriksson, B., Wiedenmann, G., Rindi, D., O'Toole, D., Ferone, F. C., Conference, E. N., Tumor Society, Internal Medicine, and Gastroenterology & Hepatology

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Intraoperative ultrasound, Carcinoma pancreas, Cellular and Molecular Neuroscience, Endocrinology, OCTREOTIDE, Internal medicine, medicine, ENDOSCOPIC ULTRASOUND, Humans, Carcinoma, Insulinoma, Pancreatic Neoplasms, Pancreas Carcinoma, Somatostatin receptor scintigraphy, SLET-CELL TUMORS, Endocrine and Autonomic Systems, business.industry, General surgery, HYPERINSULINEMIC HYPOGLYCEMIA, LOCALIZATION, University hospital, Well differentiated, SLET-CELL TUMORS, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, NEUROENDOCRINE TUMORS, HYPERINSULINEMIC HYPOGLYCEMIA, INTRAOPERATIVE ULTRASOUND, ENDOSCOPIC ULTRASOUND, ENDOCRINE TUMORS, LOCALIZATION, OCTREOTIDE, MRI, ENDOCRINE TUMORS, INTRAOPERATIVE ULTRASOUND, business, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, NEUROENDOCRINE TUMORS, MRI
Abstract

a Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands; b Division of General Surgery, Department of Surgery, Medical University of Vienna, Vienna , Austria; c Hospices Civils de Lyon, Hopital Edouard-Herriot Service Central d‘Anatomie et Cytologie Pathologiques, Lyon , France; d Centre de Medecine Nucleaire, Universite Catholique de Louvain, Brussels , Belgium; e Department of Pathology, University of Kiel, Kiel , Germany; f B Unit of Surgery, Department of Surgery, University of Verona, Verona , Italy; g Department of Nuclear Medicine, Erasmus MC, Rotterdam , The Netherlands; h Department of Endocrine Oncology, University Hospital, Uppsala , Sweden; i Department of Internal Medicine, Division of Hepatology and Gastroenterology, Interdisciplinary Center of Metabolism and Endocrinology, Charite, Campus Virchow Hospital, University for Medicine Berlin, Berlin , Germany; j Service de Gastroenterologie-Pancreatologie, Pole des Maladies de l‘Appareil Digestif, Hopital Beaujon, Clichy , France; k Department of Pathology and Laboratory Medicine, Universita degli Studi, Parma, Italy; l Department of Endocrinology, Genoa University, Genoa , Italy

Published
2006

21. Well-differenitated duodenal tumor/carcinoma(excluding gastrinomas)

Author

Jensen, R., Rindi, G., Arnold, R., Lopes, J., Brandi, M., Bechstein, W., Christ, E., Taal, B., Knigge, U., Ahlman, H., Kwekkeboom, D., O'Toole, D., Cadiot, G., Caplin, M., Chung, D., Couvelard, A., Herder, W. D., Fave, G. D., Eriksson, B., Falchetti, A., Falconi, Massimo, Ferone, D., Goretzki, P., Gross, D., Hochhauser, D., Hyrdel, R., Kaltsas, G., Keleştimur, F., Kianmanesh, R., Knapp, W., Komminoth, P., Körner, M., Kos Kudła, B., Kvols, L., Lewington, V., Manfredi, Riccardo, Mcnicol, A., Mitry, E., Niederle, B., Nikou, G., Nilsson, O., Öberg, K., O'Connor, J., Pauwels, S., Pape, U., Pavel, M., Perren, A., Plöckinger, U., Ramage, J., Ricke, J., Ruszniewski, P., Salazar, R., Sauvanet, A., Scarpa, Aldo, Scoazec, J., Garcia, M. S., Steinmüller, T., Sundin, A., Cutsem, E. V., Vullierme, M., Wiedenmann, B., Wildi, S., Yao, J., Zgliczynski, S., Radiology & Nuclear Medicine, R., Jensen, G., Rindi, R., Arnold, J., Lope, M., Brandi, W., Bechstein, E., Christ, B., Taal, U., Knigge, H., Ahlman, D., Kwekkeboom, D., O'Toole, G., Cadiot, M., Caplin, D., Chung, A., Couvelard, W. D., Herder, G. D., Fave, B., Eriksson, A., Falchetti, Falconi, Massimo, D., Ferone, P., Goretzki, D., Gro, D., Hochhauser, R., Hyrdel, G., Kaltsa, F., Keleştimur, R., Kianmanesh, W., Knapp, P., Komminoth, M., Körner, B., Kos Kudła, L., Kvol, V., Lewington, R., Manfredi, A., Mcnicol, E., Mitry, B., Niederle, G., Nikou, O., Nilsson, K., Öberg, J., O'Connor, S., Pauwel, U., Pape, M., Pavel, A., Perren, U., Plöckinger, J., Ramage, J., Ricke, P., Ruszniewski, R., Salazar, A., Sauvanet, A., Scarpa, J., Scoazec, M. S., Garcia, T., Steinmüller, A., Sundin, E. V., Cutsem, M., Vullierme, B., Wiedenmann, S., Wildi, J., Yao, and S., Zgliczynski

Subjects
ENDOCRINE GASTROENTEROPANCREATIC TUMORS, medicine.medical_specialty, Somatostatin receptor scintigraphy, Endocrine and Autonomic Systems, business.industry, Endocrinology, Diabetes and Metabolism, General surgery, Carcinoma, ZOLLINGER-ELLISON-SYNDROME, Well differentiated, Cellular and Molecular Neuroscience, Endocrinology, Duodenal Neoplasms, Internal medicine, Duodenal Tumor, Cancer centre, medicine, AMPULLARY CARCINOID-TUMORS, Humans, ZOLLINGER-ELLISON-SYNDROME, SOMATOSTATIN RECEPTOR SCINTIGRAPHY, ENDOCRINE GASTROENTEROPANCREATIC TUMORS, AMPULLARY CARCINOID-TUMORS, business, SOMATOSTATIN RECEPTOR SCINTIGRAPHY
Abstract

a Digestive Diseases Branch, NIDDK, NIH, Bethesda, Md. , USA; b Dipartimento di Patologia e Medicina di Laboratorio, Universita di Parma, Parma , Italy; c Division of Gastroenterology and Endocrinology, Department of Internal Medicine, Philipps University, Marburg , Germany; d Department of Pathology, IPATIMUP Hospital, Porto , Portugal; e Dipartimento di Fisiopatologia Clinica, Universita di Firenze, Firenze , Italy; f Department of Surgery, Johann-Wolfgang-Goethe-Universitat, Frankfurt , Germany; g E. Christ, Department of Endocrinology, Inselspital, Bern , Switzerland; h Department of Oncology, Netherlands Cancer Centre, Amsterdam , The Netherlands; i Department of Surgery, Rigshospitalet Blegdamsvej Hospital, Copenhagen , Denmark; j Department of Surgery, Gothenburg University, Gothenburg , Sweden; k Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam , The Netherlands; l Service de Gastroenterologie-Pancreatologie, Pole des Maladies de l’Appareil Digestif, Hopital Beaujon, Clichy , France

Published
2006

22. ESMO/ASCO recommendations for a Global Curriculum (GC) in medical oncology-edition 2016

Author

C. Dittrich, M. Kosty, S. Jezdic, D. Pyle, R. Berardi, J. Bergh, N. El Saghir, J.-P. Lotz, P. Österlund, N. Pavlidis, G. Purkalne, Hetty Carraway, Julia Lee Close, Jill Gilbert, Carsten Bokemeyer, Andrés Cervantes, Yuichiro Ohe, Miklos Pless, Keith McGregor, Katharine Fumassoli, Roberta Candiani, Gracemarie Bricalli, Tanya Kenny, Nicola Latino, Marina Cogo, Vanessa Pavinato, Vanessa Marchesi, Ahmad Awada, Susana Banerjee, Smita Bhatia, Jan Bogaerts, Jan Buckner, Fatima Cardoso, Paolo Casali, Edward Chu, Bertrand Coiffier, Roisin Connolly, Sarah Coupland, Luigi De Petris, Maria De Santis, Elisabeth G.E. de Vries, Don S. Dizon, Jennifer Duff, Linda R. Duska, Alexandru Eniu, Marc Ernstoff, Enriqueta Felip, Martin F. Fey, Nicolas Girard, Andor W.J.M. Glaudemans, Priya K. Gopalan, Axel Grothey, Stephen M. Hahn, Diana Hanna, Christian Herold, Jørn Herrstedt, Krisztian Homicsko, Dennie V. Jones, Lorenz Jost, Ulrich Keilholz, Saad Khan, Alexander Kiss, Claus-Henning Köhne, Rainer Kunstfeld, Heinz-Josef Lenz, Stuart Lichtman, Lisa Licitra, Thomas Lion, Saskia Litière, Lifang Liu, Patrick J. Loehrer, Merry Jennifer Markham, Ben Markman, Marius Mayerhoefer, Johannes G. Meran, Olivier Michielin, Elizabeth Charlotte Moser, Giannis Mountzios, Timothy Moynihan, Torsten Nielsen, Kjell Öberg, Antonio Palumbo, Fedro Alessandro Peccatori, Michael Pfeilstöcker, Chandrajit Raut, Scot C. Remick, Mark Robson, Piotr Rutkowski, Roberto Salgado, Lidia Schapira, Eva Schernhammer, Martin Schlumberger, Hans-Joachim Schmoll, Lowell Schnipper, Cristiana Sessa, Charles L. Shapiro, Julie Steele, Cora N. Sternberg, Friedrich Stiefel, Florian Strasser, Roger Stupp, Richard Sullivan, Josep Tabernero, Luzia Travado, Marcel Verheij, Emile Voest, Everett Vokes, Jamie Von Roenn, Jeffrey S. Weber, Hans Wildiers, Yosef Yarden, Pavlidis, Nicholas [0000-0002-2195-9961], Berardi, Rossana [0000-0002-9529-2960], Bergh, Jonas [0000-0001-5526-1847], Saghir, Nagi El [0000-0001-9612-4224], Österlund, Pia [0000-0002-7124-3515], Clinicum, Department of Oncology, ESMO/ASCO Global Curriculum Working Group, Carraway, H., Lee Close, J., Gilbert, J., Bokemeyer, C., Cervantes, A., Ohe, Y., Pless, M., McGregor, K., Fumassoli, K., Candiani, R., Bricalli, G., Kenny, T., Latino, N., Cogo, M., Pavinato, V., Marchesi, V., Awada, A., Banerjee, S., Bhatia, S., Bogaerts, J., Buckner, J., Cardoso, F., Casali, P., Chu, E., Coiffier, B., Connolly, R., Coupland, S., De Petris, L., De Santis, M., de Vries, E.G., Dizon, D.S., Duff, J., Duska, L.R., Eniu, A., Ernstoff, M., Felip, E., Fey, M.F., Girard, N., Glaudemans, A.W., Gopalan, P.K., Grothey, A., Hahn, S.M., Hanna, D., Herold, C., Herrstedt, J., Homicsko, K., Jones, D.V., Jost, L., Keilholz, U., Khan, S., Kiss, A., Köhne, C.H., Kunstfeld, R., Lenz, H.J., Lichtman, S., Licitra, L., Lion, T., Litière, S., Liu, L., Loehrer, P.J., Jennifer Markham, M., Markman, B., Mayerhoefer, M., Meran, J.G., Michielin, O., Charlotte Moser, E., Mountzios, G., Moynihan, T., Nielsen, T., Öberg, K., Palumbo, A., Alessandro Peccatori, F., Pfeilstöcker, M., Raut, C., Remick, S.C., Robson, M., Rutkowski, P., Salgado, R., Schapira, L., Schernhammer, E., Schlumberger, M., Schmoll, H.J., Schnipper, L., Sessa, C., Shapiro, C.L., Steele, J., Sternberg, C.N., Stiefel, F., Strasser, F., Stupp, R., Sullivan, R., Tabernero, J., Travado, L., Verheij, M., Voest, E., Vokes, E., Von Roenn, J., Weber, J.S., Wildiers, H., Yarden, Y., University of Zurich, Dittrich, C, and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
0301 basic medicine, Medical education, Professional competence, 2720 Hematology, education, 3122 Cancers, Health care system, Molecular imaging, 610 Medicine & health, Patient care, Clinical practice, Global Health, Medical Oncology, 03 medical and health sciences, 0302 clinical medicine, Terminal care, Humans, Curriculum/standards, Europe, Global Health/education, Global Health/standards, Medical Oncology/education, Medical Oncology/standards, Societies, Medical/standards, United States, Medical specialist, Curriculum development, Societies, Medical, Priority journal, Editorials, Hematology, Awareness, Medical society, 030104 developmental biology, Editorial, Oncology, Health education, 030220 oncology & carcinogenesis, 10032 Clinic for Oncology and Hematology, 2730 Oncology, Curriculum, Internalization
Abstract

Non

Published
2016

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