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In four experiments, we investigated the impact of letter case (lower case vs. UPPER CASE) on the processing of sequences of written words. Experiment 1 used the rapid parallel visual presentation (RPVP) paradigm with postcued identification of one word in a five-word sequence. The sequence could be grammatically correct (e.g., "the boy likes his bike") or be an ungrammatical reordering of the same words (e.g., "his boy the bike likes the"). We replicated the standard sentence superiority effect (more accurate identification of target words when embedded in a grammatically correct sequence compared with ungrammatical sequences), and also found that lowercase presentation led to higher word identification accuracy, but equally so for the grammatical and ungrammatical sequences. This pattern suggests that the lowercase advantage was mostly operating at the level of individual word identification. The following three experiments used the grammatical decision task to provide an examination of letter case effects on more global sentence processing measures. All these experiments revealed a significant lowercase advantage in grammatical decisions, independently of the nature of the ungrammatical sequence (Experiments 2 and 3) and independently of whether or not the letter case manipulation was blocked (Experiment 4). The size of the effects observed in grammatical decisions again points to individual word identification as the primary locus of the lowercase advantage. We conclude that letter case mainly affects early visuo-orthographic processing and access to case-independent letter and word identities. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

International audience; Background: The exact architecture of the human auditory cortex remains a subject of debate, with discrepancies between functional and microstructural studies. In a hierarchical framework for sensory perception, simple sound perception is expected to take place in the primary auditory cortex, while the processing of complex, or more integrated perceptions is proposed to rely on associative and higherorder cortices. Objectives: We hypothesize that auditory symptoms induced by direct electrical stimulation (DES) offer a window into the architecture of the brain networks involved in auditory hallucinations and illusions. The intracranial recordings of these evoked perceptions of varying levels of integration provide the evidence to discuss the theoretical model. Methods: We analyzed SEEG recordings from 50 epileptic patients presenting auditory symptoms induced by DES. First, using the Juelich cytoarchitectonic parcellation, we quantified which regions induced auditory symptoms when stimulated (ROI approach). Then, for each evoked auditory symptom type (illusion or hallucination), we mapped the cortical networks showing concurrent high-frequency activity modulation (HFA approach). Results: Although on average, illusions were found more laterally and hallucinations more posteromedially in the temporal lobe, both perceptions were elicited in all levels of the sensory hierarchy, with mixed responses found in the overlap. The spatial range was larger for illusions, both in the ROI and HFA approaches. The limbic system was specific to the hallucinations network, and the inferior parietal lobule was specific to the illusions network. Discussion: Our results confirm a network-based organization underlying conscious sound perception, for both simple and complex components. While symptom localization is interesting from an epilepsy semiology perspective, the hallucination-specific modulation of the limbic system is particularly relevant to tinnitus and schizophrenia.

International audience; Background and purpose: Studies on long-term nonmotor outcomes of subthalamic nucleus stimulation in Parkinson disease (PD) are scarce. This study reports on very long-term non-motor and motor outcomes in one of the largest cohorts of people with advanced PD, treated for >10 years with subthalamic nucleus stimulation. The main outcome was to document the evolution of independence in activities of daily living. The secondary outcomes were to measure the change in quality of life, as well as non-motor and motor outcomes.Methods: Patients were studied preoperatively, at 1 year, and beyond 10 years after subthalamic stimulation with an established protocol including motor, non-motor, and neuropsychological assessments.Results: Eighty-five people with PD were included. Independence scores in the off-medication condition (measured with the Schwab & England Activities of Daily Living Scale) as well as quality of life (measured with the Parkinson's Disease Questionnaire [PDQ]-37) remained improved at longest follow-up compared to preoperatively (respectively, p < 0.001, p = 0.015). Cognitive scores, measured with the Mattis Dementia Rating Scale, significantly worsened compared to before and 1 year after surgery (p < 0.001), without significant change in depression, measured with the Beck Depression Inventory. Motor fluctuations, dyskinesias, and off dystonia remained improved at longest follow-up (p < 0.001), with a significant reduction in dopaminergic treatment (45%, p < 0.001).Conclusions: This study highlights the long-term improvement of subthalamic stimulation on independence and quality of life, despite the progression of disease and the occurrence of levodopa-resistant symptoms.

International audience; Conversation represents a considerable amount of the daily language usage and plays an important role in language acquisition. In conversation, listeners simultaneously process their interlocutor's turn and prepare their own next turn. As such the turn-taking dynamics heavily relies on prediction. In other words, listeners avail prior knowledge to constrain both speech perception and production. Here we explored the relation between prediction and comprehension while watching two interlocutors having a conversation. We capitalize on gaze switch as a proxy of predictive behaviour to class dialogue turns as more or less well predicted and explore how this affects dialogue comprehension. Moreover, we study the extent to which speech degradation, by increasing the global uncertainty of the context, affects the relation between predictions, brain correlates of prediction errors (N400) and 2 global comprehension. Results show that 1) listeners direct gaze to the current speaker, in particular in challenging conditions, 2) gaze behaviour possibly affects the semantic processing of the upcoming turn (N400), 3) participants with a more efficient gaze predictive behaviour better solve semantic uncertainties at the turn onset, in particular in the most challenging listening condition. Our findings contribute to a better understanding of the relation between predictions, neural predictions errors and speech comprehension under challenging conditions.

The objective of this study was twofold. We assessed whether individuals with Alzheimer's disease (AD) demonstrate higher empathy toward people with the same disorder. We also assessed whether empathy may enhance the recognition of these peoples' faces.Twenty-seven mild AD participants and 30 healthy older adults were invited to retain faces depicting either people diagnosed with AD or healthy people. Participants were also invited to rate their empathy toward all faces.Although AD participants reported higher empathy for "AD-labeled" than for "healthy" faces, recognition was similar for both categories of faces. Healthy older adults also reported higher empathy for "AD-labeled" than for "healthy" faces. However, they demonstrated higher recognition for "healthy" than for "AD-labeled" faces.Although our paper shows no effect of empathy on face recognition in AD, it provides a clinically relevant finding: individuals with mild AD can demonstrate significant empathy toward people with the same medical condition.

International audience; AbstractAimYoung children with weaker self-regulation use more digital media, but studies have been limited by parent-reported screen time measures. We examine associations between early childhood executive functioning and objective mobile device usage.MethodsThe parents of 368 American children (51.6% male) aged 3–4 years of age completed standardised measures of executive functioning, parenting stress and household chaos. They provided mobile sampling data for 1 week in 2018–2019 and reported how often the children used mobile devices to calm themselves.ResultsThe children's mean age was about 3.8 years. A third of the children who were given devices to calm them down had weaker executive functioning in the overall and multivariable models, including working memory, planning and organisation. So did 39.7% of the children who used educational apps. Streaming videos, using age-inappropriate apps and using the mobile device for more than1 h per day were not associated with executive functioning levels. Parenting stress and household chaos did not moderate the associations.ConclusionThis study confirms previous studies that suggesting that children with weaker overall executive functioning used devices more for calming purposes. It also raises questions about whether children with weaker executive functioning should use educational apps.

International audience; Temporal accounts of Developmental Dyslexia (DD) postulate that a timing impairment plays an important role in this learning disorder. However, DD has been associated to timing disorders as well as other motor and cognitive dysfunctions. It is still unclear whether non-verbal timing skills per se might be considered as independent determinants of DD. In this study, we investigated the independent contribution of predictive timing to DD beside motor and cognitive dysfunctions typically impaired in this disorder. We submitted children with DD (aged 8-12) and controls to perceptual timing, finger tapping, fine motor control, as well as attention and executive tasks. Children with DD’s performance was poorer than controls in most of these tasks. Predictors of DD, as found with logistic regression modeling, were beat perception and precision in tapping to the beat, which are both predictive timing variables, children’s tapping rate, and mental flexibility. Flexibility was also correlated to predictive timing, suggesting common mechanisms between these functions although they contributed separately to DD. These data support temporal accounts of DD in which predictive timing impairments partially explain the core phonological deficit, independently from general motor and cognitive functioning, making predictive timing a valuable tool for early diagnosis and remediation of DD.; Les théories temporelles de la dyslexie développementale (DD) postulent qu'un déficit temporel joue un rôle important dans ce trouble de l'apprentissage. Cependant, la DD a été associée à des troubles temporels ainsi qu'à d'autres dysfonctionnements moteurs et cognitifs. Le fait que les capacités non verbales de timing en soi puissent être considérées comme des déterminants indépendants de la DD n'est pas encore clarifié. Dans cette étude, nous avons examiné la contribution indépendante du timing prédictif à la DD, en plus des dysfonctionnements moteurs et cognitifs généralement altérés dans cette pathologie. Nous avons réalisé chez des enfants atteints de DD (âgés de 8 à 12 ans) et des témoins appariés des tests de perception temporelle, de tapping, de motricité fine, ainsi que des tâches d'attention et de fonctions exécutives. Les performances des enfants atteints de DD étaient inférieures à celles des enfants témoins dans la plupart de ces tâches. Les prédicteurs de la DD, tels qu'ils ont été trouvés avec la modélisation de régression logistique, étaient la perception de la pulsation et la précision du tapping, qui sont toutes deux des variables de timing prédictif, ainsi que la vitesse du tapping et la flexibilité mentale. La flexibilité mentale était également corrélée au timing prédictif, ce qui suggère des mécanismes communs entre ces fonctions, bien qu'elles contribuent séparément à la DD. Ces données soutiennent les théories temporelles de la DD dans lesquelles les déficits du timing prédictif expliquent en partie le déficit phonologique central, indépendamment du fonctionnement moteur et cognitif général, ce qui fait du timing prédictif un outil précieux pour le diagnostic précoce et la remédiation de la DD.

OBJECTIVE Prism adaptation was shown to modify auditory perception. Using a dichotic listening task, which assesses auditory divided attention, benefits of a rightward prism adaptation were demonstrated in neglect patients (i.e., a syndrome following right hemisphere brain damage) by reducing their left auditory extinction. It is currently unknown whether prism adaptation affects auditory divided attention in healthy subjects. In the present study, we investigated the aftereffects of prism adaptation on dichotic listening. METHOD A sample of 47 young adults performed a dichotic listening task, in which pairs of words were presented with two words sounded simultaneously, one in each ear. Three parameters were measured: The percentage of recalled words, the percentage of correctly recalled words, and the laterality index (LI). RESULTS Prism adaptation to a leftward optical deviation (L-PA) significantly increased the overall percentage of recalled words (p = .044) and that from the right ear (p = .002), and the overall LI (p = .049). CONCLUSIONS For the first time, these findings demonstrate that L-PA produced an orientation of the auditory divided attention in favor of the right ear in healthy participants. This asymmetrical aftereffect provides a new argument in favor of the cross-modal dimension of prism adaptation, although an acclimatization effect of the dichotic listening task is also discussed. Our study opens up a new avenue for using prism adaptation in the field of auditory rehabilitation requiring a modulation of auditory attention. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

International audience; The neural circuitry involved in moral decisions has been studied since the early days of cognitive neuroscience, mainly using moral dilemma. However, the neurocomputational mechanisms describing how the human brain makes moral decisions and learns in various moral contexts are only starting to be established. Here we review recent results from an emerging field using model-based fMRI, which describes moral choices at a mechanistic level. These findings unify the field of moral decision making, extend a conceptual framework previously developed for value-based decision making and characterize how moral processes are computed in the brain. Moral dilemma can be modeled as value-based decisions that weigh self-interests against moral costs/harm to others and different types of prediction errors can be distinguished in different aspects of moral learning. These key computational signals help to describe moral choices and moral learning at an algorithmic level and to reveal how these cognitive operations are implemented in the brain. This researches provide a foundation to account for the neurocomputational mechanisms underlying moral decision making.

International audience; Objective: Dysfunction of social cognition is well-recognized as one of amyotrophic lateral sclerosis (ALS) cognitive impairments. Previous studies have mostly associated social cognition subcomponents, including Theory of Mind (ToM), with executive dysfunction using highlydemanding tasks. In the present study, we investigate dysfunction of affective ToM in a sample of ALS patients without dementia and evaluate any possible associations both with executive and non-executive dysfunction. Methods: We included 42 ALS patients and 30 healthy controls (HC) and administered the Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen (ECAS). Affective ToM was examined based on the ECAS judgment of preference task; total score and type of errors ("favourite", "unclassified") were recorded for all participants. Results: A significant proportion of ALS patients (31%) were impaired on ToM task, scoring significantly lower compared to HC. Impairments in ToM task were more frequent (45%) in patients with cognitive impairment compared to those with intact cognition (15%). ALS patients showed significantly more errors on ToM task compared to HC. A significant association was found between ToM score and ECAS language and visuospatial abilities but not fluency, executive or memory function. Conclusion: Dysfunction of affective ToM appears prevalent in ALS patients without dementia, and associates with language and visuospatial abilities. These associations align with motor and extra-motor symptoms due to the degeneration across corresponding networks. Impaired ToM should be considered in clinical settings, since it might contribute to patients' social life, as well as the burden of their caregivers and relatives.

Contains fulltext : 285517.pdf (Publisher’s version ) (Open Access) Attention is a core cognitive function that filters and selects behaviourally relevant information in the environment. The cortical mapping of attentional systems identified two segregated networks that mediate stimulus-driven and goal-driven processes, the Ventral and the Dorsal Attention Networks (VAN, DAN). Deep brain electrophysiological recordings, behavioral data from phylogenetic distant species, and observations from human brain pathologies challenge purely corticocentric models. Here, we used advanced methods of functional alignment applied to resting-state functional connectivity analyses to map the subcortical architecture of the Ventral and Dorsal Attention Networks. Our investigations revealed the involvement of the pulvinar, the superior colliculi, the head of caudate nuclei, and a cluster of brainstem nuclei relevant to both networks. These nuclei are densely connected structural network hubs, as revealed by diffusion-weighted imaging tractography. Their projections establish interrelations with the acetylcholine nicotinic receptor as well as dopamine and serotonin transporters, as demonstrated in a spatial correlation analysis with a normative atlas of neurotransmitter systems. This convergence of functional, structural, and neurochemical evidence provides a comprehensive framework to understand the neural basis of attention across different species and brain diseases. 14 p.

International audience; The present study investigated transposed-word effects in a post-cued word-in-sequence identification experiment. Five horizontally aligned words were simultaneously presented for a brief duration and followed by a backward mask and cue for the position of the word to be identified within the sequence. The five-word sequences could form a grammatically correct sentence (e.g., The boy can run fast), an ungrammatical transposed-word sequence (e.g., The can boy run fast) or an ungrammatical control sequence (e.g., The can get run fast), and the same target word at the same position (e.g., the word ‘run’) was tested in the three conditions. Consistent with previous studies using a grammatical decision task and a same-different matching task, a transposed-word effect was observed, with word identification being more accurate in transposed-word sequences than in control sequences. Furthermore, here we could show for the first time that word identification was more accurate in correct sentences compared with transposed-word sequences. We suggest that the word identification advantage found for transposed-word sequences compared with ungrammatical control sequences is due to facilitatory feedback to word identities from sentence-level representations, albeit with less strength compared to the feedback provided by correct sentences.

International audience; Human vision requires us to analyze the visual periphery to decide where to fixate next. In the present study, we investigated this process in people with age-related macular degeneration (AMD). In particular, we examined viewing biases and the extent to which visual salience guides fixation selection during free-viewing of naturalistic scenes. We used an approach combining generalized linear mixed modeling (GLMM) with a-priori scene parcellation. This method allows one to investigate group differences in terms of scene coverage and observers’ well-known tendency to look at the center of scene images. Moreover, it allows for testing whether image salience influences fixation probability above and beyond what can be accounted for by the central bias. Compared with age-matched normally sighted control subjects (and young subjects), AMD patients’ viewing behavior was less exploratory, with a stronger central fixation bias. All three subject groups showed a salience effect on fixation selection—higher-salience scene patches were more likely to be fixated. Importantly, the salience effect for the AMD group was of similar size as the salience effect for the control group, suggesting that guidance by visual salience was still intact. The variances for by-subject random effects in the GLMM indicated substantial individual differences. A separate model exclusively considered the AMD data and included fixation stability as a covariate, with the results suggesting that reduced fixation stability was associated with a reduced impact of visual salience on fixation selection.

International audience; Everyday movements are guided by objects’ positions relative to other items in the scene (allocentric information) as well as by objects’ positions relative to oneself (egocentric information). Allocentric information can guide movements to the remembered positions of hidden objects, but is it also used when the object remains visible? To stimulate the use of allocentric information, the position of the participant’s finger controlled the velocity of a cursor that they used to intercept moving targets, so there was no one-to-one mapping between egocentric positions of the hand and cursor. We evaluated whether participants relied on allocentric information by shifting all task-relevant items simultaneously leaving their allocentric relationships unchanged. If participants rely on allocentric information they should not respond to this perturbation. However, they did. They responded in accordance with their responses to each item shifting independently, supporting the idea that fast guidance of ongoing movements primarily relies on egocentric information.

International audience; Past research shows that when a discourse referent is mentioned repeatedly, it is usually introduced with a full noun phrase and maintained with a reduced form such as a pronoun. Is this also the case in dialogue, where the same referent may be introduced by one person and maintained by another person? An experiment was conducted in which participants either told entire stories to each other or told stories together, thus enabling us to contrast situations in which characters were introduced and maintained by the same person (control condition) and situations in which the introduction and the maintaining of each character were performed by different people (alternating condition). Story complexity was also manipulated through the introduction of one or two characters in each story. We found that participants were less likely to use reduced forms to maintain referents in the alternating condition. The use of reduced forms also depended on the context in which the referent was maintained (in particular, first or second mention of a character) and on story complexity. These results shed light on how the pressure to signal understanding to one’s conversational partner affects referential choices throughout the interaction.

Previous studies have shown that self-generated stimuli in auditory, visual, and somatosensory domains are attenuated, producing decreased behavioral and neural responses compared with the same stimuli that are externally generated. Yet, whether such attenuation also occurs for higher-level cognitive functions beyond sensorimotor processing remains unknown. In this study, we assessed whether cognitive functions such as numerosity estimations are subject to attenuation in 56 healthy participants (32 women). We designed a task allowing the controlled comparison of numerosity estimations for self-generated (active condition) and externally generated (passive condition) words. Our behavioral results showed a larger underestimation of self-generated compared with externally generated words, suggesting that numerosity estimations for self-generated words are attenuated. Moreover, the linear relationship between the reported and actual number of words was stronger for self-generated words, although the ability to track errors about numerosity estimations was similar across conditions. Neuroimaging results revealed that numerosity underestimation involved increased functional connectivity between the right intraparietal sulcus and an extended network (bilateral supplementary motor area, left inferior parietal lobule, and left superior temporal gyrus) when estimating the number of self-generated versus externally generated words. We interpret our results in light of two models of attenuation and discuss their perceptual versus cognitive origins.SIGNIFICANCE STATEMENTWe perceive sensory events as less intense when they are self-generated compared with when they are externally generated. This phenomenon, called attenuation, enables us to distinguish sensory events from self and external origins. Here, we designed a novel fMRI paradigm to assess whether cognitive processes such as numerosity estimations are also subject to attenuation. When asking participants to estimate the number of words they had generated or passively heard, we found bigger underestimation in the former case, providing behavioral evidence of attenuation. Attenuation was associated with increased functional connectivity of the intraparietal sulcus, a region involved in numerosity processing. Together, our results indicate that the attenuation of self-generated stimuli is not limited to sensory consequences but is also impact cognitive processes such as numerosity estimations.

Long-standing affective science theories conceive the perception of emotional stimuli either as discrete categories (for example, an angry voice) or continuous dimensional attributes (for example, an intense and negative vocal emotion). Which position provides a better account is still widely debated. Here we contrast the positions to account for acoustics-independent perceptual and cerebral representational geometry of perceived voice emotions. We combined multimodal imaging of the cerebral response to heard vocal stimuli (using functional magnetic resonance imaging and magneto-encephalography) with post-scanning behavioural assessment of voice emotion perception. By using representational similarity analysis, we find that categories prevail in perceptual and early (less than 200 ms) frontotemporal cerebral representational geometries and that dimensions impinge predominantly on a later limbic–temporal network (at 240 ms and after 500 ms). These results reconcile the two opposing views by reframing the perception of emotions as the interplay of cerebral networks with different representational dynamics that emphasize either categories or dimensions. Are vocal emotions perceived as categories (for example, anger) or as dimensions (for example, an intense negative emotion)? Here, using functional magnetic resonance imaging and magneto-encephalography, Giordano et al. find that categories prevail in early (less than 200 ms) neural representations, whereas dimensions emerge later (240 ms and more than 500 ms).

International audience; Caregiving and other interpersonal interactions often require accurate perception of others' pain from nonverbal cues, but perceivers may be subject to systematic biases based on gender, race, and other contextual factors. Such biases could contribute to systematic under-recognition and undertreatment of pain. In 2 experiments, we studied the impact of perceived patient sex on lay perceivers' pain estimates and treatment recommendations. In Experiment 1 (N = 50), perceivers viewed facial video clips of female and male patients in chronic shoulder pain and estimated patients' pain intensity. Multi-level linear modeling revealed that perceivers underestimated female patients' pain compared with male patients, after controlling for patients' self-reported pain and pain facial expressiveness. Experiment 2 (N = 200) replicated these findings, and additionally found that 1) perceivers' pain-related gender stereotypes, specifically beliefs about typical women's vs. men's willingness to express pain, predicted pain estimation biases; and 2) perceivers judged female patients as relatively more likely to benefit from psychotherapy, whereas male patients were judged to benefit more from pain medicine. In both experiments, the gender bias effect size was on average 2.45 points on a 0−100 pain scale. Gender biases in pain estimation may be an obstacle to effective pain care, and experimental approaches to characterizing biases, such as the one we tested here, could inform the development of interventions to reduce such biases. Perspective: This study identifies a bias towards underestimation of pain in female patients, which is related to gender stereotypes. The findings suggest caregivers' or even clinicians' pain stereotypes are a potential target for intervention.

International audience; This article reports on vowel clarity metrics based on spectrotemporal modulations of speech signals. Motivated by previous findings on the relevance of modulation-based metrics for speech intelligibility assessment and pathology classification, the current study used factor analysis to identify regions within a bi-dimensional modulation space, the magnitude power spectrum, as in Elliott and Theunissen [(2009). PLoS Comput. Biol. 5(3), e1000302] by relating them to a set of conventional acoustic metrics of vowel space area and vowel distinctiveness. Two indices based on the energy ratio between high and low modulation rates across temporal and spectral dimensions of the modulation space emerged from the analyses. These indices served as input for measurements of central tendency and classification analyses that aimed to identify vowel-related speech impairments in French native speakers with head and neck cancer (HNC) and Parkinson dysarthria (PD). Following the analysis, vowel-related speech impairment was identified in HNC speakers, but not in PD. These results were consistent with findings based on subjective evaluations of speech intelligibility. The findings reported are consistent with previous studies indicating that impaired speech is associated with attenuation in energy in higher spectrotemporal modulation bands.

International audience; No abstract available

International audience; BACKGROUND: In pediatric intensive care units (PICUs), parents and healthcare professionals attend to children who verbally and non-verbally express their pain and suffering, fears, anxieties, desires, and wishes in complex intensive care situations. What can we learn from these experiences to improve the way we can take care of and support children? OBJECTIVES: The main objective of this clinical ethics study was to focus on the experience stories of parents during their child’s hospitalization in a PICU, to analyze their discourse, and to propose an ethical perspective. METHOD: The current research collects the experience reports of parents during their child’s hospitalization in a PICU and those of the caregivers who treated them. A total of 17 semi-directive interviews were conducted in the PICU of the Nantes University Hospital from November 2017 to June 2019. Each interview lasted around 1 h. The main results of our study are analyzed and informed by the four ethical principles of T. Beauchamp and J. Childress: autonomy, beneficence, non-maleficence, and justice. RESULTS: The interviews highlighted the difficulties encountered by parents during the hospitalization of their children, such as the distance between their home and the hospital, the technicality of PICU environment, and the difficulty in finding their place as parents. For medical and paramedical teams, their main concerns are undoubtedly to improve the coherence and continuity of their stand toward parents, to promote parental autonomy, and to remain fully aware of the profound existential changes that the child’s illness brings about for parents: It is the caregivers’ duty to take this into account and to respect the parents’ rhythm as much as possible. CONCLUSIONS: The main disagreements between healthcare teams and parents, where they exist, are communication problems that are easily controlled, for the most part, by caregivers.

International audience; Tactile perception is involved in a variety of contexts (adaptations to climatic conditions, protection of the body against external dangers…) and is as important as the other sensory modalities for the survival of an individual. This tactile modality has been particularly well studied in humans, revealing high individual variations modulated by a variety of intrinsic and extrinsic factors such as age, sex, pathological disorders, or temperament. Tactility is also involved in animals' social lives, although there are disparities between species. For example, social tactile contact among horses is limited, but this does not mean that they do not react to tactile stimuli but rather with their very thin skin they are able to detect minute stimuli (although they respond more to larger stimuli). Despite a fairly large effort to characterize it, there are controversies concerning equine tactile sensitivity. In this review, we examine studies that have used the same tool (von Frey filaments) and try to disentangle what could explain the differences observed. It appears that many aspects are poorly known or controversial and that the procedures may be so different that the results of different studies cannot be compared. We went further by testing tactile reactivity of a population of unridden horses and found that four factors influenced their tactile reactivity (type of horse, filament size, body area, time of day). These results could explain some of the discrepancies observed in the literature and suggest, in particular, that more attention should be paid to the context of the test.

International audience; Several factors influencing dream recall frequency (DRF) have been identified, but some remain poorly understood. One way to study DRF is to compare cognitive processes in low and high dream recallers (LR and HR). According to the arousal-retrieval model, long-term memory encoding of a dream requires wakefulness while its multisensory short-term memory is still alive. Previous studies showed contradictory results concerning short-term memory differences between LR and HR. It has also been found that extreme dream recall frequencies are associated with different electrophysiological traits related to attentional processes. However, to date, there is no evidence for attentional differences between LR and HR at the behavioural level. To further investigate attention and working memory in HR and LR, we used a newly-developed challenging paradigm, called MEMAT: it allows to study selective attention and working memory interaction, during memory encoding of non-verbal auditory stimuli. We manipulated the difficulties of the distractor to ignore and of the memory task. The performance of the two groups were not differentially impacted by working memory load. However, HR were slower and less accurate in presence of hard, rather than easy, toignore distractor, while LR were much less impacted by the distractor difficulty. Therefore, we show behavioural evidence towards less resistance to hard-to-ignore distractors in HR. Using a challenging task, we show for the first time attentional differences between HR and LR at the behavioural level. The impact of auditory attention and working memory on dream recall is discussed.

International audience; ObjectivesChildhood trauma (physical, emotional, sexual abuse and/or physical and emotional neglect) represents a specific risk for developmental perturbations and long-term negative outcomes. Adolescents and young adults with childhood trauma have rarely experienced a single type of traumatic event but rather multiple traumatic experiences. However, studies on adolescent PTSD are sparse. This study examines the possible mediating role of mentalizing, cognitive and interpersonal emotion regulation strategies between multiple types of childhood trauma exposure and PTSD in adolescents and young adults.MethodsThe sample consisted of 456 adolescents and young adults aged 15 and 25, recruited from four high schools and one university. Participants completed self-report questionnaires assessing childhood trauma, mentalizing, cognitive and interpersonal strategies of emotion regulation and PTSD.ResultsStructural Equation Modeling revealed that multiple types of childhood trauma exposure have a significant indirect effect on PTSD symptoms through its association with hypomentalizing and maladaptive cognitive strategies of emotion regulation (i.e. self-blame, rumination, catastrophizing). Results also showed a significant indirect effect between multiple types of childhood trauma exposure and PTSD symptoms through its association with hypomentalizing and maladaptive interpersonal strategies of emotion regulation (i.e. emotional reactivity and tendency to avoid emotional connection). Indirect paths were also run in reverse to control for the direction of the effect.ConclusionOur findings show that exposure to multiple types of childhood trauma contributes to severe PTSD through several complex pathways including both hypomentalizing and maladaptive emotion regulation strategies in adolescence and young adulthood.; ObjectifsLes traumatismes de l'enfance (abus physiques, émotionnels, sexuels et/ou négligence physique et émotionnelle) représentent un risque spécifique de perturbations du développement et de résultats négatifs à long terme. Les adolescents et les jeunes adultes victimes de traumatismes infantiles ont rarement vécu un seul type d'événement traumatique, mais plutôt des expériences traumatiques multiples. Cependant, les études sur le TSPT des adolescents sont rares. Cette étude examine le rôle médiateur possible des stratégies de mentalisation, de régulation cognitive et interpersonnelle des émotions entre les types multiples d'exposition aux traumatismes de l'enfance et le TSPT chez les adolescents et les jeunes adultes.MéthodesL'échantillon était composé de 456 adolescents et jeunes adultes âgés de 15 à 25 ans, recrutés dans quatre lycées et une université. Les participants ont rempli des questionnaires d'auto-évaluation portant sur les traumatismes subis durant l'enfance, les stratégies de mentalisation, cognitives et interpersonnelles de régulation des émotions et le TSPT.RésultatsLa modélisation par équations structurelles a révélé que de multiples types d'exposition aux traumatismes de l'enfance ont un effet indirect significatif sur les symptômes du TSPT par le biais de leur association avec l'hypomentalisation et les stratégies cognitives inadaptées de régulation des émotions (c'est-à-dire l'auto-culpabilisation, la rumination, la catastrophisation). Les résultats ont également montré un effet indirect significatif entre les multiples types d'exposition aux traumatismes de l'enfance et les symptômes du TSPT par le biais de son association avec les stratégies hypomentalistes et interpersonnelles inadaptées de régulation des émotions (c'est-à-dire la réactivité émotionnelle et la tendance à éviter les liens émotionnels). Les chemins indirects ont également été parcourus en sens inverse pour contrôler la direction de l’effet.ConclusionNos résultats montrent que l'exposition à de multiples types de traumatismes dans l'enfance contribue au TSPT sévère par le biais de plusieurs voies complexes comprenant à la fois l'hypomentalisation et les stratégies inadaptées de régulation des émotions à l'adolescence et au début de l'âge adulte.

International audience; Aims: To specify the determinants of low-risk alcohol drinking and relapse at different timepoints after detoxification in patients with severe Alcohol Use Disorder (AUD).Methods: Fifty-four AUD patients and 36 healthy controls (HC) were evaluated early inabstinence (T1). They underwent clinical, neuropsychological and neuroimaging (structuralMRI and 18FDG-PET) investigations.AUD patients were subsequently classified as “low-risk drinkers” (LR) or “relapsers” (R)based on their alcohol drinking at 6 months (T2) and one year (T3) after discharge, using theirmedical record or self-reported drinking estimation at follow-up.Results: Based on the alcohol status at T2 and compared to HC, only R had alexithymia,lower gray matter volume in the midbrain and hypermetabolism in the cerebellum andhippocampi. Based on the alcohol status at T3 and compared to HC, only R had more severenicotinic dependence, lower episodic and working memory performance, lower gray mattervolume in the amygdala, ventromedial prefrontal cortex and anterior cingulate gyrus, andhypermetabolism in cerebellum, hippocampi and anterior cingulate gyrus. Moreover, R hadbilateral frontal hypometabolism, whereas LR only presented right frontal hypometabolism.Conclusion: Nicotine dependence, memory impairments, and structural brain abnormalitiesin regions involved in impulsivity and decision-making might contribute to a one-yearrelapse. Treatment outcome at one year may also be associated with an imbalance between ahypermetabolism of the limbic system and a hypometabolism of the frontal executive system.Finally, cerebellar hypermetabolism and alexithymia may be determinants of relapse at both 6months and one year.

International audience; The aim of the present study was to investigate the role of mental representation processes during the planning, reaching, and use phases of actions with tools commonly used toward the body (TB, e.g., toothbrush) or away from the body (AB, e.g., pencil). In the first session, healthy participants were asked to perform TB (i.e., making circular movements with the toothbrush near the mouth) and AB (i.e., making circular movements with the pencil near the desk) actions both with (i.e., actual use) and without the tool in hand (i.e., the pantomime of tool use). In the second session, the same participants performed a series of mental rotation tasks involving body- (i.e., face and hands) and object-related (i.e., abstract lines) stimuli. The temporal and kinematic analysis of the motor actions showed that the time required to start the pantomimes (i.e., the planning phase) was shorter for the AB action than for the TB action. In contrast, the reaching phase lasted longer for the AB action than for the TB action. Furthermore, the TB pantomime was associated with the performance in the mental rotation of body-related stimuli, especially during the planning and reaching phases, whereas the AB pantomime was more related to the performance in the mental rotation of object-related stimuli, especially during the tool use phase. Thus, the results revealed that the direction of a goal-directed motor action influences the dynamics of the different phases of the motor action and can determine the type of mental images involved in the planning and execution of the action.

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International audience; Background: Childhood severe traumatic brain injury (TBI) is a leading cause of long-lasting acquired disability, but predicting long-term functional outcome remains difficult.Objectives: This study aimed to 1) describe the functional outcome at 1 and 7 years post-TBI; 2) determine the initial and concurrent factors associated with long-term outcome; and 3) evaluate the predictive value of functional status, overall disability level and intellectual ability measured at 1 year post-injury to determine 7-year clinically meaningful outcomes.Methods: Among the children (

The use of pesticides for plague control in agroecosystems generates a threat to wildlife and a major problem for human health. Pesticide compounds are also an important source of water and atmosphere contamination. Although insecticides are effective on their target organisms, they often affect organisms that are not their target The aim of the present study was to research the effects of three types of neurotoxic insecticides-a pyrethroid (cypermethrin), a neonicotinoid (imidacloprid) and an organophosphate (chlorpyrifos)-on behavioral and physiological parameters of Pardosa saltans spider (Lycosidae). This study analyzed for the first time the exploratory behavior of the spider mothers in the presence of these three insecticides on their egg-sacs and also on the ground. It was also evaluated the oxidative stress effects on the juveniles hatched in the egg-sac protected by silk in relation to variations of detoxification enzymes (catalase, glutathione of action, such as spiders, which are agrobionts of great importance in agroecosystems. reductase, superoxide dismutase, glutathione-S-transferase and glutathione peroxidase) and lipid peroxidation (reactive oxygen species or ROS). The results show that these insecticides are repellents for mothers (cypermethrin is the most repellent) and maternal behavior is modified after detection of an insecticide on their egg-sac but mothers do not abandon their egg-sac. These neurotoxic insecticides affect the juveniles inside their egg-sac. Cypermethrin and chlorpyrifos caused more oxidative stress in juveniles than did imidacloprid. The ROS generated by these insecticides seemed to be adequately eliminated by the juveniles' antioxidant systems. This article is protected by copyright. All rights reserved.

Though we know little more about deja vu today than we did back in the days of Arnaud over a century ago, we have learned a great deal about other forms of misattribution. This is hard-won knowledg...

International audience; Background: Verticality perception is frequently altered in Parkinson’s disease (PD) with Pisa syndrome (PS). Is it the cause or the consequence of the PS? Objective: We tested the hypothesis that both scenarios coexist. Methods: We performed a double-blind within-person randomized trial (NCT02704910) in 18 individuals (median age 63.5 years) with PD evolving for a median of 17.5 years and PS for 2.5 years and treated with bilateral stimulation of the subthalamus nuclei (STN-DBS) for 6.5 years. We analyzed whether head and trunk orientations were congruent with the visual (VV) and postural (PV) vertical, and whether switching on one or both sides of the STN-DBS could modulate trunk orientation via verticality representation. Results: The tilted verticality perception could explain the PS in 6/18 (33%) patients, overall in three right-handers (17%) who showed net and congruent leftward trunk and PV tilts. Two of the 18 (11%) had an outstanding clinical picture associating leftward: predominant parkinsonian symptoms, whole-body tilt (head –11°, trunk –8°) and transmodal tilt in verticality perception (PV –10°, VV –8.9°). Trunk orientation or VV were not modulated by STN-DBS, whereas PV tilts were attenuated by unilateral or bilateral stimulations if it was applied on the opposite STN. Conclusion: In most cases of PS, verticality perception is altered by the body deformity. In some cases, PS seems secondary to a biased internal model of verticality, and DBS on the side of the most denervated STN attenuated PV tilts with a quasi-immediate effect. This is an interesting track for further clinical studies.

Perceiving art is known to elicit motor cortex activation in an observer's brain. This motor activation has often been attributed to a covert approach response associated with the emotional valence of an art piece (emotional reaction hypothesis). However, recent accounts have proposed that aesthetic experiences could be grounded in the motor simulation of actions required to produce an art piece and of the sensorimotor states embedded in its subject (embodied aesthetic hypothesis). Here, we aimed to test these two hypotheses by assessing whether motor facilitation during artwork perception mirrors emotional or motor simulation processes. To this aim, we capitalized on single pulse transcranial magnetic stimulation revealing a two-stage motor coding of emotional body postures: an early, non-specific activation related to emotion processing and a later action-specific activation reflecting motor simulation. We asked art-naive individuals to rate how much they liked a series of pointillist and brushstroke canvases; photographs of artistic gardens served as control natural stimuli. After an early (150 ms) or a later (300 ms) post-stimulus delay, motor evoked potentials were recorded from wrist-extensor and finger muscles that were more involved in brushstroke- and pointillist-like painting, respectively. Results showed that observing the two canvas styles did not elicit differential motor activation in the early time window for either muscle, not supporting the emotional reaction hypothesis. However, in support of the embodied aesthetic hypothesis, we found in the later time window greater motor activation responses to brushstroke than pointillist canvases for the wrist-extensor, but not for the finger muscle. Furthermore, this muscle-selective facilitation was associated with lower liking ratings of brushstroke canvases and with greater empathy dispositions. These findings support the claim that simulation of the painter's movements is crucial for aesthetic experience, by documenting a link between motor simulation, dispositional empathy, and subjective appreciation in artwork perception.

In the present research, we provide empirical evidence for the process of symbolic integration of number associations, focusing on the development of simple addition (e.g., 5 + 3 = 8), subtraction (e.g., 5 - 3 = 2), and multiplication (e.g., 5 × 3 = 15). Canadian children were assessed twice, in Grade 2 and Grade 3 (N = 244; 55% girls). All families were English-speaking, and parent education levels ranged from high school to postgraduate, with a median of community college. In Grade 2, children completed general cognitive tasks (i.e., receptive vocabulary, working memory, nonverbal reasoning, and inhibitory control). In both grades, children completed single-digit addition and complementary subtraction problems. In Grade 3, they completed single-digit multiplication problems and measures of applied mathematics, specifically, word-problem solving, algebra, and measurement. We found that addition and subtraction were reciprocally related (controlling for cognitive skills). Subtraction fluency predicted multiplication in Grade 3, whereas addition fluency did not. In Grade 3, both subtraction and multiplication fluency were predictors of applied mathematics, with multiplication partially mediating the relation between subtraction and applied mathematics performance. These findings support the view that learning arithmetic associations is a hierarchical process. As students practice each new skill, individual differences reflect the integration of the novel component into the developing associative network. (PsycInfo Database Record (c) 2021 APA, all rights reserved).

International audience; Abstract Working animals spend hours each day in close contact with humans and require training to understand commands and fulfil specific tasks. However, factors driving cooperation between humans and animals are still unclear, and novel situations may present challenges that have been little-studied to-date. We investigated factors driving cooperation between humans and animals in a working context through behavioural experiments with 52 working semi-captive Asian elephants. Human-managed Asian elephants constitute approximately a third of the remaining Asian elephants in the world, the majority of which live in their range countries working alongside traditional handlers. We investigated how the familiarity and experience of the handler as well as the elephant’s age and sex affected their responses when asked to perform a basic task and to cross a novel surface. The results highlighted that when novelty is involved in a working context, an elephant’s relationship length with their handler can affect their cooperation: elephants who had worked with their handler for over a year were more willing to cross the novel surface than those who had a shorter relationship with their handler. Older animals also tended to refuse to walk on the novel surface more but the sex did not affect their responses. Our study contributes much needed knowledge on human-working animal relationships which should be considered when adjusting training methods and working habits.

International audience; Subjective experiences often feel rich, yet are most often quantified with simple metrics, such as a few levels on a predefined scale. What are the dimensions and topological organization of subjective experience? How do they relate to behavioral output, how do they map onto the classical cognitive domains?

International audience; ObjectivesAnosognosic patients show a lack of awareness for their hemiplegia coupled with a distorted sense of agency for the actions performed by the plegic limbs. Since anosognosia is often associated with right brain damage, this hemisphere seems to play a dominant role in monitoring awareness for motor actions. Therefore, we would expect that anosognosic patients show distorted awareness and sense of agency also for actions performed with the unimpaired limb.MethodTo test this hypothesis, we induced illusory actions that could be congruent or incongruent with a preceding verbal command. A group of 16 right brain-damaged patients performed this task and then rated i) their ability to anticipate the actions, ii) their sense of agency and iii) their sense of ownership for each limb. Measures of awareness, neglect and motor impairment were also considered for the patient group.ResultsFollowing incongruent actions with the unimpaired limb, less aware patients showed a relatively mild distortion in all three aspects. In addition, we also found a crucial relationship between motor impairment (for the plegic limb) and sense of agency for both plegic and healthy limbs.ConclusionAlthough the distortion linked to both limbs supports the initial hypothesis that the right hemisphere is responsible for monitoring awareness for action for the whole body, our data also suggest that the observed distortion may be linked to a motor compensatory phenomenon, not necessarily related to awareness processes.

International audience; We studied the fundamental issue of whether children evaluate the reliability of their language interpretation, that is, their confidence in understanding words. In two experiments, 2-year-olds (Experiment 1: N = 50; Experiment 2: N = 60) saw two objects and heard one of them being named; both objects were then hidden behind screens and children were asked to look toward the named object, which was eventually revealed. When children knew the label used, they showed increased postdecision persistence after a correct compared with an incorrect anticipatory look, a marker of confidence in word comprehension (Experiment 1). When interacting with an unreliable speaker, children showed accurate word comprehension but reduced confidence in the accuracy of their own choice, indicating that children’s confidence estimates are influenced by social information (Experiment 2). Thus, by the age of 2 years, children can estimate their confidence during language comprehension, long before they can talk about their linguistic skills.

International audience; Olfactory communication plays an important role in the regulation of socio-sexual interactions in mammals. There is growing evidence that both human and nonhuman primates rely on odors to inform their mating decisions. Nevertheless, studies of primate chemical ecology remain scarce due to the difficulty of obtaining and analyzing samples. We analyzed 67 urine samples from five captive female Japanese macaques (Macaca fuscata) and 30 vaginal swabs from three of these females using gas chromatography-mass spectrometry and examined the relationship between odor (compounds identified, richness, intensity, and diversity) and female identity as well as cycle phase. We found a total of 36 urine compounds of which we identified 31, and 68 vaginal compounds of which we identified 37. Our results suggest that urine and vaginal odor varied more between individuals than within cycle phases. However, we found that within a female cycle, urine samples from similar phases may cluster more than samples from different phases. Our results suggest that female odor may encode information about identity (vaginal and urine odor) and reproductive status (urine odor). The question of how conspecifics use female urine and vaginal odor remains open and could be tested using bioassays. Our results and their interpretation are constrained by our limited sample size and our study design. Nonetheless, our study provides insight into the potential signaling role of female odor in sexual communication in Japanese macaques and contributes to our understanding of how odors may influence mating strategies in primates.

Background Frequent car use contributes to health and environmental issues such as air pollution, climate change and obesity. Active and sustainable mobility (bike, walk, public transport, car sharing) may address these issues. Different strategies have been implemented in past research, involving hard levers, aimed at modifying the economical or geographical context (e.g., free public transport), and soft levers, aimed at modifying psychological processes (e.g., personalised transport advice). However, few studies have combined both hard and soft levers. In addition, few have used robust methodologies (e.g., randomised controlled trials), followed behavioural changes in the long-term, and been anchored in behaviour change theories. InterMob aims to address these limits by implementing a 24-month randomised controlled trial including hard and soft levers. The objectives of InterMob are to a) evaluate the effectiveness of an experimental arm versus an active controlled arm, and b) identify the processes of mobility change. Methods Regular car users living in Grenoble (N = 300) will be recruited and randomised to one of the two arms. The experimental arm consists in a six-month intervention combining hard levers (free access to transport/bikes), and soft levers (e.g., personalised transport advice). The control arm consists in a six-month intervention aimed at raising awareness on air pollution and its health effects. Both arms will include eight evaluation weeks (spread out over 24 months) based on a GPS, an accelerometer, and a pollution sensor. Moreover, participants will complete mobility logbooks and surveys measuring psychological constructs, socio-economical, and socio-spatial characteristics. Discussion InterMob will assess the effectiveness of two interventions aimed at reducing car use within regular car users in the short-, mid- and long-term. Moreover, InterMob will allow to better understand the psychological processes of behaviour change, and the socio-economical and geographical conditions under which the intervention is efficient in reducing car use. Finally, the benefits of mobility change in terms of physical activity, quality of life, and exposure to pollution will be quantified. Trial registration ClinicalTrials.gov: NCT05096000 on 27/10/2021 (retrospectively registered).

International audience; Distinguishing among similar events is indeed crucial to memory. In a dangerous context, this ability may be less essential, whereas in a secure context it may provide an adaptative advantage notably in social situations. Vagal activity as a marker of the individual's adaptation in social engagement contexts might predict the ability to discriminate highly similar memories in an unthreatening context. The present study aims to test the relation between vagal activity and memory discrimination by manipulating the visual distinctiveness of stimuli (high vs. low) in an ecological memory discrimination task with humanoid characters. It was expected that vagal activity support adaptive self-regulatory processes which may be needed only when the memory discrimination is challenging (low distinctiveness between true memory and lure). In a study phase, multiple realistic fictional humanoid characters performed the same action on different objects. The characters could be very similar or very distinct one to each other. Then, during a test phase, the participants had to discriminate whether a displayed character on the screen was exactly matched the one performing the given action on a specific object in the study phase (target). Vagal activity was assessed in undergraduate students (n = 40) before the study phase. Higher vagal activity predicted better memory discrimination performance specifically when the distinctiveness between the lure and target was low. These data extend previous work on vagal activity and memory suggesting that heart-brain interactions represent an adaptive psychophysiological mechanism underlying memory discrimination specifically when it is challenging in an unthreatening context.

International audience; Background Apathy is a common behavioral syndrome that occurs across neurological and psychiatric disorders. An influential theoretical framework defined apathy as the quantitative reduction of self-generated voluntary and purposeful behaviors. There is evidence in the literature of the multidimensional nature of apathy with cognitive, behavioral, and emotional dimensions. To date, apathy has been assessed using various scales and questionnaires. Alternative objective and ecological measurements of apathy are needed. New method We used the ECOCAPTURE protocol and an ethological approach to investigate behavior in bvFTD patients under ecological conditions (a waiting room) while they freely explored a novel environment. Data were collected by behavioral coding from 7-minute video using an ethogram and transformed into behavior time series data. We present an approach considering behavioral kinetics to assess behavior. We aimed to construct a new behavior analysis method, called ECOCAPTURE kinetics, using temporal classification for behavior time series data analysis. To develop our classifier, we retained a nonelastic Euclidian metric, combined with a convolutional approach. Results We applied the ECOCAPTURE kinetics method to a cohort of 20 bvFTD patients and 18 healthy controls. We showed that bvFTD patients can be classified according to their behavioral kinetics into three groups. Each subgroup was characterized by specific behavior disorders and neuropsychological profile. Comparison with Existing Method(s) The ECOCAPTURE kinetics method is different from those of the classical approach of measuring behavior, producing time budgets, frequency of behavior occurrences, or kinematic diagrams. Conclusions This approach can be extended to any behavioral study encoding time.

International audience; Recent evidence suggests that both personality traits (PT) and emotion regulation (ER) strategies play an important role in the way people cope with the COVID-19 pandemic. The aim of this study was two folded. First, to longitudinally investigate the psychological distress (depression, anxiety, and stress levels) taking in consideration PT and ER strategies in 3 different moments: during the first lockdown period (April/20), at the first deconfinement (May/20) and 1-month after the first deconfinement (Jun/20)-Experiment I. Second, to cross-sectionally evaluate the impact of the pandemic in psychological distress and the correlates with PT and ER 6-months after the first deconfinement November/20 to February/21 -Experiment II. A total of 722 volunteers (Experiment I = 180; Experiment II = 542) aged 18 years or older participated in this online survey. The findings from Experiment I show that psychological distress decreased after the lockdown period, however, neuroticism traits predicted higher levels of depression, anxiety and stress symptoms, while difficulties in ER strategies were identified as a risk factor for depression and stress. For experiment II, neuroticism traits and being infected with COVID-19 were associated to higher levels of symptomatology, while unemployment and the use of emotional suppression strategies to cope with emotional situations were associated to depressive and anxiety symptoms. Although the psychological impact of the COVID-19 outbreak decreased over time in our sample, the current findings suggest that difficulties in emotional regulation and high levels of neuroticism traits might be potential risk factors for psychiatric symptomatology during the COVID-19 pandemic. Thus, people with difficulties in ER and neuroticism traits would benefit from psychological interventions that provide personality-appropriate support and promote emotion regulation skills during stressful events, such as the case of the global pandemic.

The neurocognitive basis of elementary academic skills varies with parental socioeconomic status (SES). Little is known, however, about SES‐related differences underlying higher‐order cognitive skills that are critical for school success, such as reasoning. Here we used fMRI to examine how the neurocognitive basis of deductive reasoning varies as a function of parental education in school‐aged children. Higher parental education was associated with greater reliance on the left inferior frontal gyrus when solving set‐inclusion problems, consistent with other work suggesting that these problems might more heavily rely on verbal systems in the brain. In addition, children who are at the lower end of the parental education continuum, but have higher nonverbal skills relied on right parietal areas to a greater degree than their peers for solving set‐inclusion problems. Finally, lower parental education children with higher verbal or nonverbal skill engaged dorsolateral prefrontal regions to a greater degree for set‐inclusion and linear‐order relations than their peers. These findings suggest that children with lower parental education rely on spatial and cognitive control mechanisms to achieve parity with their peers with parents who have more education. Better understanding variability in the neurocognitive networks that children recruit as a function of their parental factors might benefit future individualized interventions that best match children's characteristics., Higher parental education was associated with greater reliance on the left inferior frontal gyrus when solving set‐inclusion reasoning problems, consistent with other work suggesting that these problems might more heavily rely on verbal systems in the brain. Children who are at the lower end of the parental education continuum, but have higher nonverbal skills relied on right parietal areas to a greater degree than their peers for solving set‐inclusion problems. Finally, lower parental education children with higher verbal or nonverbal skill engaged dorsolateral prefrontal regions to a greater degree for set‐inclusion and linear‐order relations than their peers.

Background Sensorimotor control of axial segments, which develops during childhood and is not mature until adolescence, is essential for the development of balance control during motor activities. Children with cerebral palsy (CP) have deficits in postural control when standing or walking, including less stabilization of the head and trunk which could affect postural control. Research question Is dynamic stabilization of axial segments during an unstable sitting task deficient in children with CP compared to typically developing children? Is this deficit correlated with the deficit of postural control during standing? Method Seventeen children with CP (GMFCS I-II) and 17 typically-developing children from 6 to 12 years old were rated on the Trunk Control Measurement Scale (TCMS). In addition, posturography was evaluated in participants while they maintained their balance in stable sitting, unstable sitting, and quiet standing, under “eyes open” and “eyes closed” conditions. In sitting tasks, the participants had to remain stable while being prevented from using the lower and upper limbs (i.e. to ensure the involvement of axial segments alone). Results Children with CP compared to TD children had significantly larger surface area, mean velocity and RMS values of CoP displacements measured during the unstable sitting task and the standing task, under both “eyes open” and “eyes closed” conditions. No significant group effects were observed during the stable sitting task. The TCMS total score was significantly lower, indicating trunk postural deficit, in the CP group than in the TD group and was significantly correlated with postural variables in the sitting and standing tasks. Significance Children with CP indeed have a specific impairment in the postural control of axial segments. Since the postural control of axial segments is important for standing and walking, its impairment should be taken into account in rehabilitation programs for children with CP.

Making accurate decisions in uncertain environments requires identifying the generative cause of sensory cues, but also the expected outcomes of possible actions. Although both cognitive processes can be formalized as Bayesian inference, they are commonly studied using different experimental frameworks, making their formal comparison difficult. Here, by framing a reversal learning task either as cue-based or outcome-based inference, we found that humans perceive the same volatile environment as more stable when inferring its hidden state by interaction with uncertain outcomes than by observation of equally uncertain cues. Multivariate patterns of magnetoencephalographic (MEG) activity reflected this behavioral difference in the neural interaction between inferred beliefs and incoming evidence, an effect originating from associative regions in the temporal lobe. Together, these findings indicate that the degree of control over the sampling of volatile environments shapes human learning and decision-making under uncertainty., Here, the authors show that humans perceive uncertain environments as more stable when actively interacting with them than when observing them. Magnetoencephalographic signals in the temporal lobe were associated with the increased stability of beliefs during active sampling.

International audience; The aim of this experiment was to investigate the postural response to specific types of long-term memory (episodic vs. semantic) in young adults performing an unperturbed upright stance. Although a similar level of steadiness (mean distance) was observed, dual tasking induced a higher velocity, more energy in the higher frequency range (power spectral density), and less regularity (sample entropy) compared with a simple postural task. Moreover, mean velocity was always greater in the semantic than in the episodic task. The differences in postural control during dual tasking may result from the types of processes involved in the memory task. Findings suggest a spatial process sharing between posture and episodic memory.

Recent research has focused on assessing either event- or time-based prospective memory (PM) using laboratory tasks. Yet, the findings pertaining to PM performance on laboratory tasks are often inconsistent with the findings on corresponding naturalistic experiments. Ecologically valid neuropsychological tasks resemble the complexity and cognitive demands of everyday tasks, offer an adequate level of experimental control, and allow a generalisation of the findings to everyday performance. The Virtual Reality Everyday Assessment Lab (VR-EAL), an immersive virtual reality neuropsychological battery with enhanced ecological validity, was implemented to comprehensively assess everyday PM (i.e., focal and non-focal event-based, and time-based). The effects of the length of delay between encoding and initiating the PM intention and the type of PM task on everyday PM performance were examined. The results revealed that everyday PM performance was affected by the length of delay rather than the type of PM task. The effect of the length of delay differentially affected performance on the focal, non-focal, and time-based tasks and was proportional to the PM cue focality (i.e., semantic relationship with the intended action). This study also highlighted methodological considerations such as the differentiation between functioning and ability, distinction of cue attributes, and the necessity of ecological validity., Comment: 9 Figures, 4 Tables

International audience; The menopause transition arises mainly from a decline in ovarian function characterized by a decrease in levels of ovarian estrogens (estradiol) and progesterone in women. Menopausal hormone therapy (MHT) has been used to counteract menopause-associated symptoms in postmenopausal women. With the development of advanced brain imaging methods, understanding MHT-related effects on brain structures and functions could help advance our understanding of the biological consequence of MHT-related effects on behavior, thereby contributing to developing new strategies for optimizing brain health during the menopause transition. This review focuses on the human research related to the impact of MHT on structural and functional organization of the prefrontal cortex in postmenopausal women. Although such MHT-related effects on brain structures and functions have only begun to be understood, it may be useful to examine present findings to identify areas for future research.

This study examined the possibility that moderators of false memories in the Deese-Roediger-McDermott (DRM) paradigm affect the occurrence of false memories in the misinformation paradigm. More precisely, the purpose was to determine to what extent an imaging instruction modulates false memories in the DRM and misinformation paradigms. A sample of young adults was assigned to the DRM or the misinformation tasks, either in control conditions or in conditions including an imaging instruction. Findings revealed that an imaging instruction decreases false memories in DRM whereas there is no evidence about imaging effects in the misinformation task. These observations tally with previous studies, reporting a weak or no correlation between false memories in these paradigms, and are discussed in the light of current theories.

International audience; Background: A large number of studies have shown time perception impairment and reaction time (RT) variability in children with attention deficit hyperactivity disorder (ADHD), and have discussed the causes of such difficulties. However, very few studies have investigated time knowledge (i.e., the correct representation and use of time units) in children with ADHD.Methods: We evaluated time knowledge in 33 children with ADHD, aged 8-12 years, who had consulted a reference center for learning disabilities in Paris, matched for age and gender with 33 typically developing (TD) children. We used a simple questionnaire-based survey and neuropsychological tests for cognitive and attentional skills.Results: The acquisition of time knowledge was delayed in children with ADHD compared with TD children (P