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Background: Immunization recommendations depend on epidemiological factors as well as age, sex, history of previous vaccination, current health status, occupation and lifestyle. Several vaccines are recommended for adults including, tetanus-diphtheria-acellular pertussis, tetanus-diphtheria, influenza, human papillomavirus, varicella, measles, mumps, and rubella, and pneumococcal 13-valent conjugate or pneumococcal 23-valent polysaccharide, and hepatitis. Such diseases have shown dramatic decrease in incidence and mortality after introduction of vaccines. Methodology: We conducted this review using a comprehensive search of MEDLINE, PubMed, and EMBASE, January 2001, through February 2017. The following search terms were used: adult immunization, adult vaccine, recent vaccine guidelines, preventive medicine, human papillomavirus, MMR, S. pneumoniae, PCV13, PPSV23, hepatitis A, hepatitis B Aim: In this review, we aimed at reviewing the updates in adult vaccine and their effectivity. Conclusion: Vaccination for adult population has proved to be of extreme importance and has achieved great successes. Combined efforts of patients, physicians, and policy makers are needed to achieve higher levels of success and improve vaccine coverage. [ABSTRACT FROM AUTHOR]