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Abnormal protein concentration levels in human body fluids, such as urine, serum etc., are considered to associate with disease states, providing essential information for the pre-clinical diagnosis. This paper presents a wireless immunoglobulin-coated magnetoelastic (ME) biosensor for fast, cost-effective detections of human serum albumin (HSA) with small sample volumes at a microliter scale. This is the first portable resonant sensor based on magnetostrictive effect that can monitor different molecular states of HSA. Anti-HSA Immunoglobulin G (IgG) was immobilized on the surface of the ME sensor to selectively capture HSA. The rapid conjugation between the antibody and antigen changed the sensor surface states and thus induced resonance frequency shifts (RFS), which were monitored in real time for the qualitative and quantitative analysis of HSA. This paper brings forward a System on Chip (SoC)-based system architecture to realize the function of RFS sampling. The performance of the portable device was validated to be comparable to that of the Vector Network Analyzer (VNA) AV3620 using different concentrations of HSA solution. The RFS were linearly proportional to the HSA concentrations in the range from 0.1 to 100 μg/mL with a linearity up to 0.998, a sensitivity of 8.70 Hz/μg.mL-1 and a detection limit of 0.039 μg/mL, indicating good feasibility of this method. Meanwhile, the response of this portable ME biosensor was quick and specific to HSA targets. This ME biosensor shows high potential to be used in diagnosing abnormal HSA. • This paper proposed a new portable resonant sensor with high-specificity based on magnetostrictive effect. • We presented a magnetoelastic (ME) biosensor for fast, cost-effective and tiny detections of human serum albumin (HSA). • In this paper, HSA can be detected with a sensitivity of 8.70 Hz/μg.mL-1 and detection limit of 0.039 μg/ml. [ABSTRACT FROM AUTHOR]

Flexible electronics devices with tactile perception can sense the mechanical property data of the environment and the human body, and they present a huge potential in the human health system. In particular, the introduction of ultra-flexible and self-powered characteristics to tactile sensors can effectively reduce the problems caused by rigid batteries. Herein, we report a triboelectric nanogenerator (TENG), mainly consisting of an ultra-flexible polydimethylsiloxane (PDMS) film with micro-pyramid-structure and sputtered aluminum electrodes, which achieves highly conformal contact with skin and the self-powered detection of human body motions. The flexible polyethylene terephthalate (PET) film was selected as spacer layer, which made the sensor work in the contact-separation mode and endowed the perfect coupling of triboelectrification and electrostatic induction. Moreover, the controllable and uniform micro-structure PDMS film was fabricated by using the micro-electro-mechanical system (MEMS) manufacturing process, bringing a good sensitivity and high output performance to the device. The developed TENG can directly convert mechanical energy into electric energy and light up 110 green Light-Emitting Diodes (LEDs). Furthermore, the TENG-based sensor displays good sensitivity (2.54 V/kPa), excellent linearity (R2 = 0.99522) and good stability (over 30,000 cycles). By virtue of the compact size, great electrical properties, and great mechanical properties, the developed sensor can be conformally attached to human skin to monitor joint movements, presenting a promising application in wearable tactile devices. We believe that the ultra-flexible and self-powered tactile TENG-based sensor could have tremendous application in wearable electrons. [ABSTRACT FROM AUTHOR]