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2 results on '"FM Accardo"'

1. Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy.

Author

Tomasello G, Sciumé C, Rappa F, Rodolico V, Zerilli M, Martorana A, Cicero G, De Luca R, Damiani P, Accardo FM, Romeo M, Farina F, Bonaventura G, Modica G, Zummo G, Conway de Macario E, Macario AJ, and Cappello F

Subjects
Anti-Inflammatory Agents, Non-Steroidal pharmacology, Chaperonin 10 genetics, Chaperonin 10 ultrastructure, Colitis, Ulcerative physiopathology, Down-Regulation drug effects, HSP70 Heat-Shock Proteins genetics, HSP70 Heat-Shock Proteins ultrastructure, HSP90 Heat-Shock Proteins genetics, HSP90 Heat-Shock Proteins ultrastructure, Humans, Immunohistochemistry, Mesalamine pharmacology, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Chaperonin 10 metabolism, Colitis, Ulcerative drug therapy, HSP70 Heat-Shock Proteins metabolism, HSP90 Heat-Shock Proteins metabolism, Mesalamine therapeutic use
Abstract

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).

Published
2011
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2. HSP10,HSP70 AND HSP90 IMMUNOHISTOCHEMICAL LEVELS CHANGE IN ULCERATIVE COLITIS AFTER THERAPY

Author

Carmelo Sciumè, Provvidenza Damiani, Felicia Farina, Anna Martorana, Marcello Romeo, Vito Rodolico, Fm Accardo, E. Conway de Macario, Giovanni Zummo, R De Luca, Monica Zerilli, Giuseppe Cicero, Giovanni Tomasello, Francesca Rappa, A.J.L. Macario, Giuseppe Modica, Giuseppe Bonaventura, Francesco Cappello, Tomasello, G, Sciumè, C, Rappa, F, Rodolico, V, Zerilli, M, Martorana, A, Cicero, G, De Luca, R, Damiani, P, Accardo, FM, Romeo, M, Farina, F, Bonaventura, G, Modica, G, Zummo, G, Convay de Macario, E, Macario, AJL, and Cappello, F

Subjects
Histology, Biophysics, Down-Regulation, Inflammation, comorbidity, Inflammatory bowel disease, ulcerative colitis, heat shock proteins, Hsp, molecular chaperones, inflammation comorbidity, Pathogenesis, chemistry.chemical_compound, Mesalazine, ulcerative colitis, heat shock proteins, Hsp, molecular chaperones, inflammation, comorbidity, Heat shock protein, Chaperonin 10, Medicine, Hsp, Humans, HSP70 Heat-Shock Proteins, HSP90 Heat-Shock Proteins, Colitis, Mesalamine, lcsh:QH301-705.5, ulcerative colitis, business.industry, Brief Report, molecular chaperones, Anti-Inflammatory Agents, Non-Steroidal, Cell Biology, medicine.disease, Ulcerative colitis, Immunohistochemistry, digestive system diseases, chemistry, lcsh:Biology (General), inflammation, Immunology, heat shock proteins, Biomarker (medicine), Colitis, Ulcerative, medicine.symptom, business
Abstract

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).

Published
2011

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