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During the initial phase of the 2014–2016 Ebola virus disease (EBV) outbreak in Monrovia, Liberia, all hospitals' isolation capacities were overwhelmed by the sheer caseload. As a stop-gap measure to halt transmission, Medecins sans Frontieres (MSF) distributed household disinfection kits to those who were at high risk of EBV contamination. The kit contained chlorine and personal protective materials to be used for the care of a sick person or the handling of a dead body. This intervention was novel and controversial for MSF. This paper shed the light on this experience of distribution in Monrovia and assess if kits were properly used by recipients. Targeted distribution was conducted to those at high risk of EVD (relatives of confirmed EVD cases) and health staff. Mass distributions were also conducted to households in the most EBV affected urban districts. A health promotion strategy focused on the purpose and use of the kit was integrated into the distribution. Follow-up phone calls to recipients were conducted to enquire about the use of the kit. Overall, 65,609 kits were distributed between September and November 2014. A total of 1,386 recipients were reached by phone. A total of 60 cases of sickness and/or death occurred in households who received a kit. The majority of these (46, 10%) were in households of relatives of confirmed EBV cases. Overall, usage of the kits was documented in 56 out of 60 affected households. Out of the 1322 households that did not experience sickness and/or death after the distribution, 583 (44%) made use of elements of the kit, mainly (94%) chlorine for hand-washing. At the peak of an EBV outbreak, the distribution of household disinfection kits was feasible and kits were appropriately used by the majority of recipients. In similar circumstances in the future, the intervention should be considered. Author summary: Liberia was one of the worst countries hit by the 2014–2016 Ebola Virus outbreak (EBV). All hospitals' isolation capacity in Monrovia was stretched by the spiralling number of EBV cases. As a stop-gap measure, Medecins Sans Frontieres (MSF) distributed household disinfection kit to those who were considered at high risk of EBV transmission, including relatives of confirmed EVD cases, health staff and households in the most affected districts across Monrovia. The purpose of the kit was to care for sick person while waiting for an ambulance or handling dead body while waiting for burial team. The kit contained chlorine and personal protective materials. Health promotion strategy on the purpose and use of the kit was integrated into the distribution. Follow up with the kit recipients was done by phone to better understand the use of the kit. Overall, 65,609 kits were distributed between September and November 2014. Among 1,386 recipients reached by phone, 60 cases of sickness and/or death events occurred in households which received a kit. The majority of these were among the relatives of confirmed EBV cases. Kits' use was documented in 56 out of 60 affected households. The distribution of household disinfection kits was feasible and kits were appropriately used by the majority of the recipients. In similar circumstances in future, the intervention should be considered. [ABSTRACT FROM AUTHOR]