1. An immunogenetic basis for lung cancer risk.
- Author
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Krishna, Chirag, Tervi, Anniina, Saffern, Miriam, Wilson, Eric A., Seong-Keun Yoo, Mars, Nina, Roudko, Vladimir, Cho, Byuri Angela, Jones, Samuel Edward, Vaninov, Natalie, Selvan, Myvizhi Esai, Gümüs, Zeynep H., FinnGen, Lenz, Tobias L., Merad, Miriam, Boffetta, Paolo, Martínez-Jiménez, Francisco, Ollila, Hanna M., Samstein, Robert M., and Chowell, Diego
- Subjects
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LUNG cancer , *DISEASE risk factors , *GENETIC risk score , *HUMAN genetic variation , *T cell receptors , *HOMOZYGOSITY - Abstract
The article offers information on the role of the human leukocyte antigen (HLA) locus in influencing lung cancer risk, particularly in relation to the immune system's role in preventing lung cancer. Topics include the cancer immunosurveillance theory; the HLA heterozygote advantage theory; and the association of HLA-II heterozygosity with reduced risk of lung cancer, especially among smokers.
- Published
- 2024
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