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The Asian monsoon (AM) is an important atmosphere circulation system of the global climate system, acting as a bridge across high-northern latitude and tropic climates. However, dynamical origins of AM variations during the Holocene remain unclear. Here we present stable isotope records (δ 18 O and δ 13 C) of a Holocene stalagmite from Niu Cave, central China, to address the nature and causes of East Asian summer monsoon (EASM) changes. Our δ 18 O record shows a gradual weakening of the EASM intensity from the middle to the late Holocene, corresponding with a decrease in Northern Hemisphere summer insolation and an enhancement of ENSO activity. The δ 13 C profile exhibits similar variability to δ 18 O record, suggesting that regional hydrological changes were primarily controlled by the large-scale summer monsoon circulation. Power spectrum analyses of δ 18 O and δ 13 C records show that the EASM intensity varies at a dominant periodicity of ~ 830 yr, probably correlated to an ENSO-like cycle. Furthermore, millennial-scale shifts in our records exhibit a strong correlation with that in ENSO proxies over the past 3000 years. The EASM-ENSO relationship may be related to the shifts in the mean position of Walker circulation and western North Pacific subtropical high. Our finding suggests that millennial-scale monsoon changes in the late Holocene are primarily modulated by changes in tropical ocean–atmosphere circulation, rather than variations in the North Atlantic thermohaline circulation. [ABSTRACT FROM AUTHOR]