1. Characteristics of Vogt-Koyanagi-Harada disease in a French cohort: ethnicity, systemic manifestations, and HLA genotype data.
- Author
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Abad S, Monnet D, Caillat-Zucman S, Mrejen S, Blanche P, Chalumeau M, Mouthon L, Dhote R, and Brézin AP
- Subjects
- Adult, Alleles, Cohort Studies, Cross-Sectional Studies, Europe ethnology, Female, Genotype, HLA-DRB1 Chains, Humans, Male, Mediterranean Region, Middle Aged, Nervous System Diseases etiology, Retrospective Studies, Skin Diseases etiology, Uveomeningoencephalitic Syndrome ethnology, Uveomeningoencephalitic Syndrome genetics, HLA-DR Antigens genetics, Hispanic or Latino, Uveomeningoencephalitic Syndrome complications, Uveomeningoencephalitic Syndrome physiopathology, White People
- Abstract
Purpose: To assess in patients followed in a French referral center the clinical spectrum of Vogt-Koyanagi-Harada (VKH) disease and the HLA-DRB1*04 genotype., Methods: Patients previously diagnosed as having VKH disease were re-evaluated in a cross-sectional study using the VKH Committee's revised criteria. High-resolution HLA-DRB1 genotyping was performed., Results: Eleven white patients satisfied ophthalmologic diagnostic criteria. All originated from Mediterranean countries. Nine and 3 patients had neurologic and/or cutaneous abnormalities, respectively. Among DRB1*04-positive patients, the HLA-DRB1*0405 subtype was 71%., Conclusion: These VKH patients predominantly had an incomplete form. The HLA-DRB1*0405 subtype allele was enriched in a group of Mediterranean stock.
- Published
- 2008
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