1. Impact of detectable human cytomegalovirus DNAemia on viro-immunological effectiveness of HAART in HIV-infected patients naive to antiretroviral therapy.
- Author
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Focà E, Motta D, Pollara C, Brianese N, Gotti D, Albini L, Quiros-Roldan E, Torti C, and Manca N
- Subjects
- AIDS-Related Opportunistic Infections virology, Adult, Anti-HIV Agents therapeutic use, CD4 Lymphocyte Count, Cytomegalovirus genetics, Cytomegalovirus Infections virology, Female, HIV Infections immunology, HIV Infections virology, Humans, Male, Middle Aged, AIDS-Related Opportunistic Infections immunology, Antiretroviral Therapy, Highly Active, Cytomegalovirus isolation & purification, Cytomegalovirus Infections immunology, DNA, Viral blood, HIV Infections complications, HIV Infections drug therapy
- Abstract
Our objective was to explore whether positive human cytomegalovirus (HCMV) DNAemia at baseline impaired CD4+ T-cell increase after 1 year of HAART. A sub-study of a randomized clinical trial in selected patients with <200 cell/mm CD4+ at baseline was conducted. Six out of 30 patients had detectable HCMV DNAemia at baseline, all reaching HCMV suppression at week 52 after HAART (only 1 of them was treated with valgancyclovir). No significant differences were found between patients with detectable or undetectable HCMV DNAemia in terms of CD4+ T-cell increase and HIV RNA response to HAART. Although some data may favor HCVM pre-emptive therapy to decrease immune activation, our results do not indicate that this practice may increase CD4+ T-cell count after HAART. At the same time, HAART proved effective in reducing HCMV DNAemia without the need for a specific therapy.
- Published
- 2012