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Background. Distal sensory polyneuropathy (DSP) is a common complication of HIV disease. Its effects on quality of life (QOL) and function have not been well described. Objective. The study objectives were: (1) to compare QOL and lower extremity function in people with HIV-related DSP and people with HIV disease who do not have DSP, (2) to determine the extent to which function predicts QOL, (3) to evaluate the agreement of 2 function scales, and (4) to describe the use of pain management resources. Design. This was a cross-sectional survey study with predictive modeling and measurement tool concordant validation. Methods. A demographic questionnaire, the Medical Outcomes Study HIV Health Survey, the Lower Extremity Functional Scale (LEFS), the Lower Limb Functional Index (LLFI), and a review of medical records were used. General linear modeling was used to assess group differences in QOL and the relationship between function and QOL. Bland-Altman procedures were used to assess the agreement of the LEFS and the LLFI. Results. Usable data for analyses were available for 82 of the 94 participants enrolled. The 67% of participants who reported DSP symptoms tended to be older, had HIV disease longer, and were more likely to receive disability benefits. Participants without DSP had better LLFI, LEFS, and physical health summary scores. In multivariate models, lower limb function predicted physical and mental health summary scores. The LLFI identified participants with a lower level of function more often than the LEFS. Participants with DSP were more likely to use medical treatment, physical therapy, and complementary or alternative treatments. Limitations. A sample of convenience was used; the sample size resulted in a low power for the mental health summary score of the Medical Outcomes Study HIV Health Survey. Conclusions. Quality of life and function were more impaired in participants with HIV disease and DSP. The LLFI was more likely to capture limitations in function than the LEFS. Participants with DSP reported more frequent use of pain management resources. [ABSTRACT FROM AUTHOR]

A letter to the editor is presented in response to the article "Quality of Life and Self-Reported Lower Extremity Function," by M. L. Galantino and colleagues which appeared in the previous issue.

The article describes the case of a 45-year old man with human immunodeficiency virus (HIV) and underwent highly active anti-retroviral therapy (HAART) and highlights the results of a review of clinical trials on the effects of progressive resistive exercise (PRE) on body weight, composition and strength. The application of the results of the Cochrane systemic review to the patient is discussed. It analyzes whether the outcomes of the intervention matched those suggested by the review.