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The author reflects on the link between having multiple sexual partners and the epidemic of human immunodeficiency virus (HIV). He reveals that having multiple sexual partners is the major cause of the generalized epidemic of HIV in southern and Eastern Africa. He notes that understanding why people have multiple sexual partnerships will be relevant to change behavior and sexual practices. The author argues that multilevel approaches are needed to promote behavioral change toward multiple sexual partnerships.

Examines partner reduction as a crucial factor for balanced "ABC" approach to HIV prevention. Epidemiological importance of partner reduction; "ABCs" of sexual behavior change; Role of partner reduction in HIV prevention; Implications for behavior change programs.

Two letters to the editor are presented in response to the article "A Tale of Two-Component Generalised HIV Epidemics," by James Shelton published in the March 20, 2010 issue, including a comment and the author's reply.

A letter to the editor is presented discussing several articles on the human immunodeficiency virus (HIV) and reproductive health with major flaws and respective comments.