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1. Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4 + T cells to reduce the latent HIV + cell reservoir.

Author

Patasic L, Seifried J, Bezler V, Kaljanac M, Schneider IC, Schmitz H, Tondera C, Hartmann J, Hombach A, Buchholz CJ, Abken H, König R, and Cichutek K

Subjects
CD4-Positive T-Lymphocytes drug effects, CD4-Positive T-Lymphocytes immunology, Dose-Response Relationship, Immunologic, Drug Evaluation, Preclinical, Gammaretrovirus genetics, Genetic Vectors genetics, HEK293 Cells, HIV Infections virology, Humans, Lymphocyte Activation, Peptides chemistry, Single-Chain Antibodies immunology, Transduction, Genetic, Ankyrin Repeat, CD4-Positive T-Lymphocytes virology, HIV isolation & purification, HIV Infections immunology, Immunotherapy, Adoptive, Lymphocyte Depletion methods, Peptides pharmacology
Abstract

Chimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4 + target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.

Published
2020
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