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Conventional chemical synthesis methods for nanomaterials fabrication do not always provide precise reproducible synthesis with controllable physicochemical parameters. A better control over the resultant properties of nanomaterials can be achieved by scaling down the synthesis approach to the microlevel. This can be realized by means of microfluidics. In this work, a microfluidic approach is applied for the controllable synthesis of perovskite particles with defined cubic morphology. The structural characterization of perovskite particles is performed using scanning electron microscopy and X-ray diffraction. All the synthesized particles demonstrate photoluminescence.

We developed a technique for fabrication microfluidic silicon-glass chips with a system of nanochannels connecting two microchannel using traditional optical lithography and a focused ion beam. To investigate the transport phenomena in the nanochannels we experimentally studied their ion conductivity and using optical microscopy confirmed the existence of the diffusion flow through them. The developed method allows us to create systems of nanochannels with on-purpose geometry and controlled sizes. Devices with such nanochannels can be applied in the creation of biosensor devices and for genetic studies.

Organic-inorganic lead halide perovskites are the class of materials with unique physical properties that have attracted an interest in scientific and industrial communities. With microfluidic devices it is possible to obtain high-quality nanoparticles (NPs) based on perovskites of different physico-chemical properties such as size, shape, chemical composition. The aim of this work is to achieve the stable and reproducible synthesis of perovskite NPs on the microfluidic device. To obtain perovskite NPs two microfluidic chips (MFCs) of different topologies are investigated, where a porous membrane is introduced into MFCs using different methods: first method includes direct incorporation of commercial membrane into straight channel of MFC resulting in a "sandwich" structure, the second method implied membrane preparation as a part of a chip fabrication process. The results revealed that microfluidic devices allow synthesis of monodisperse perovskite NPs.

Here we discuss the concepts of “biological quantity” and “nominal property” within the framework of the problem of biological measurements based on new specific results of biological analysis using a microfluidic platform and chips developed by our team earlier. It was shown that based on different microfluidic platforms it is possible to develop chips with a polyenzymatic bioluminescent system NAD(P)H:FMN-oxidoreductase-luciferase (Red + Luc), which can be used in various areas of biological analysis. Thus, disposable microfluidic chips with Red + Luc system suitable for field and indoor use were developed using continuous flow microfluidic platform. The use of droplet-based microfluidic platform allowed to develop microfluidic chips with Red + Luc system for long-term continuous measurements of water samples, for example, in places of waste disposal by industrial enterprises. The reference for comparing different biological quantities with each other in the proposed system was a photodetector, which converted non-numeric values and nominal properties recorded by a biological module Red + Luc into numerical variables. Such a reference was implemented as a portable luminometer based on silicon photomultiplier. The results allow to perform other biological measurements and to start the discussion of modern biological concepts in the language of biological measures.

Heart problems tend to occupy a leading position among elderly diseases. Organ-on-a-chip is suitable technology for researches of human body mechanisms without animal models. One of the widely spread diseases is valve calcification. To study growth of hydroxyapatite crystals a microfluidic device was created. For simulating the heart valve on microfluidic device COMSOL Multiphysics® was used. The device was fabricated from polydimethylsiloxan using spin-coating method for membrane which acts as a valve and soft lithography for the other parts.