1. Diagnosis and management of central nervous system histoplasmosis.
- Author
-
Wheat LJ, Musial CE, and Jenny-Avital E
- Subjects
- Acquired Immunodeficiency Syndrome complications, Adult, Aged, Amphotericin B therapeutic use, Antifungal Agents therapeutic use, Female, Fluconazole therapeutic use, Humans, Immunocompromised Host, Male, Meningitis, Fungal drug therapy, Mycological Typing Techniques methods, Sensitivity and Specificity, Histoplasmosis diagnosis, Histoplasmosis drug therapy, Meningitis, Fungal diagnosis, Meningitis, Fungal microbiology
- Abstract
Two cases of Histoplasma meningitis are presented, illustrating the difficulty in diagnosis and treatment. The first case occurred in a patient with acquired immunodeficiency syndrome as a relapse of disseminated histoplasmosis and resolved after prolonged treatment and ongoing antiretroviral therapy. The second case occurred in a cardiac allograft recipient as meningitis and focal brain lesions that responded to liposomal amphotericin B, but the patient died shortly after therapy was completed. Unfortunately, there are no prospective studies addressing the diagnosis and management of patients with histoplasmosis of the central nervous system from which to provide evidence-based guidelines for care. In the absence of such data, an approach will be presented on the basis of our experience and opinions.
- Published
- 2005
- Full Text
- View/download PDF