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Your search keyword '"E, Dainko"' showing total 3 results
Start Over Author "E, Dainko" Topic histocompatibility testing
3 results on '"E, Dainko"'

1. The significance of a positive flow cytometry crossmatch test in primary kidney transplantation.

Author

Ogura K, Terasaki PI, Johnson C, Mendez R, Rosenthal JT, Ettenger R, Martin DC, Dainko E, Cohen L, and Mackett T

Subjects
Antibodies immunology, B-Lymphocytes immunology, Female, Graft Rejection immunology, Humans, Male, Predictive Value of Tests, Retrospective Studies, T-Lymphocytes immunology, Flow Cytometry, Histocompatibility Testing methods, Kidney Transplantation immunology, Tissue Donors
Abstract

This study was conducted to determine the efficacy of the T cell flow cytometry crossmatch (T-FCXM) test in 841 first cadaver donor transplants. Results showed one-year graft survival rates were 82% for T-FCXM-negative patients, compared with 75% for T-FCXM-positive patients (P = 0.01). Early one-month graft failure was 13 percentage points higher in those with a positive T-FCXM than those with a negative T-FCXM. The positive crossmatch patients also had more frequent immunological failures. A positive T-FCXM was found in 39% of the sensitized patients (PRA > 10%) and 8% of those who had not been sensitized. Patients with a positive T-FCXM in either category had a 74% graft survival rate. Thus, most of the T-FCXM-positive results occurred in patients with complement-fixing antibodies. It is suggested that flow cytometry crossmatching (FCXM) be used prospectively, despite the fact that many patients with a positive crossmatch did have successful transplants (TXs). In the current climate of a cadaver kidney scarcity and large recipient waiting pools, utilization of kidneys for patients with the highest probability of success seems a most prudent policy.

Published
1993
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2. The significance of a positive flow cytometry crossmatch test in primary kidney transplantation

Author

K. OCURA, P. I. TERASAKI, C. JOHNSON, R. MENDEZ, J. T. ROSENTHAL, R. ETTENGER, D. C. MARTIN, E. DAINKO, L. COHEN, T. MACKETT, T. BERNE, L. BARBA, and E. LIEBERMAN

Subjects
Graft Rejection, Male, medicine.medical_specialty, T-Lymphocytes, Urology, Cadaver kidney, Antibodies, Flow cytometry, Predictive Value of Tests, medicine, Humans, Kidney transplantation, Retrospective Studies, Transplantation, Kidney, B-Lymphocytes, biology, medicine.diagnostic_test, business.industry, Histocompatibility Testing, Retrospective cohort study, medicine.disease, Flow Cytometry, Kidney Transplantation, Tissue Donors, Surgery, medicine.anatomical_structure, Predictive value of tests, biology.protein, Female, Antibody, business
Abstract

This study was conducted to determine the efficacy of the T cell flow cytometry crossmatch (T-FCXM) test in 841 first cadaver donor transplants. Results showed one-year graft survival rates were 82% for T-FCXM-negative patients, compared with 75% for T-FCXM-positive patients (P = 0.01). Early one-month graft failure was 13 percentage points higher in those with a positive T-FCXM than those with a negative T-FCXM. The positive crossmatch patients also had more frequent immunological failures. A positive T-FCXM was found in 39% of the sensitized patients (PRA > 10%) and 8% of those who had not been sensitized. Patients with a positive T-FCXM in either category had a 74% graft survival rate. Thus, most of the T-FCXM-positive results occurred in patients with complement-fixing antibodies. It is suggested that flow cytometry crossmatching (FCXM) be used prospectively, despite the fact that many patients with a positive crossmatch did have successful transplants (TXs). In the current climate of a cadaver kidney scarcity and large recipient waiting pools, utilization of kidneys for patients with the highest probability of success seems a most prudent policy.

Published
1993

3. The Los Angeles Transplant Society

Author

P I, Terasaki, J M, Cecka, T, Berne, P, Brennan, J L, Cohen, E, Dainko, G, Danovitch, R, Ettenger, R, Glassock, and T, Mackett

Subjects
Adult, Adolescent, Histocompatibility Testing, Graft Survival, Humans, Organ Transplantation, Middle Aged, Child, Los Angeles, Societies, Medical, Aged
Abstract

For some 20 years a coordinated arrangement for sharing cadaver organs has been in place in Southern California. It's 11 transplant centers have performed 4,947 kidney transplants from 7,480 referred donors. There were 430 transplants done in 1985. The policy has been to keep one kidney and share the other within the pool. This has resulted in a better than average level of matching for HLA, and an overall better than average graft survival. The graft survival rates at the centers have been increasing yearly. Much of the improvement in graft survival resulted from the introduction of cyclosporine, but a summation of many factors contributed to a steady yearly increase. There are some 600 patients waiting for transplantation. With greater efforts in procurement of cadaver kidneys, especially from minorities, and continued collaboration between the transplant centers, it should become possible to transplant all those who are in need of a kidney.

Published
1986

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