1. Early Stage Longitudinal Subcortical Volumetric Changes following Mild Traumatic Brain Injury.
- Author
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Jiachen Zhuo, Li Jiang, Rhodes, Chandler Sours, Roys, Steven, Shanmuganathan, Karthikamanthan, Hegang Chen, Prince, Jerry L., Badjatia, Neeraj, and Gullapalli, Rao P.
- Subjects
GRAY matter (Nerve tissue) ,BRAIN ,HIPPOCAMPUS (Brain) ,TIME ,FUNCTIONAL status ,MAGNETIC resonance imaging ,COGNITION ,PATIENT satisfaction ,SATISFACTION ,TREATMENT effectiveness ,THALAMUS ,BRAIN concussion ,BRAIN injuries ,SYMPTOMS - Abstract
Objective: To investigate early brain volumetric changes from acute to 6 months following mild traumatic brain injury (mTBI) in deep gray matter regions and their association with patient 6-month outcome. Methods: Fifty-six patients with mTBI underwent MRI and behavioral evaluation at acute (<10 days) and approximately 1 and 6 months post injury. Regional volume changes were investigated in key gray matter regions: thalamus, hippocampus, putamen, caudate, pallidum, and amygdala, and compared with volumes from 34 healthy control subjects. In patients with mTBI, we further assessed associations between longitudinal regional volume changes with patient outcome measures at 6 months including postconcussive symptoms, cognitive performance, and overall satisfaction with life. Results: Reduction in thalamic and hippocampal volumes was observed at 1 month among patients with mTBI. Such volume reduction persisted in the thalamus until 6 months. Changes in thalamic volumes also correlated with multiple symptom and functional outcome measures in patients at 6 months. Conclusion: Our results indicate that the thalamus may be differentially affected among patients with mTBI, resulting in both structural and functional deficits with subsequent post-concussive sequelae and may serve as a biomarker for the assessment of efficacy of novel therapeutic interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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