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Your search keyword '"Ter Telgte, Annemieke"' showing total 3 results
Start Over Author "Ter Telgte, Annemieke" Topic hippocampus
3 results on '"Ter Telgte, Annemieke"'

1. Hippocampal disconnection in early Alzheimer's disease: a 7 tesla MRI study.

Author

Wisse LE, Reijmer YD, ter Telgte A, Kuijf HJ, Leemans A, Luijten PR, Koek HL, Geerlings MI, and Biessels GJ

Subjects
Aged, Anisotropy, Atrophy, Diffusion Magnetic Resonance Imaging instrumentation, Female, Humans, Image Processing, Computer-Assisted, Linear Models, Male, Organ Size, Alzheimer Disease pathology, Cognitive Dysfunction pathology, Hippocampus pathology
Abstract

Background: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts., Objective: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD., Methods: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial volume., Results: Fornix FA was significantly lower and subiculum, cornu ammonis (CA) 1, and dentate gyrus &CA4 volume were significantly smaller in patients with MCI or AD as compared to controls. In patients with MCI or AD, fornix FA was positively associated with subiculum volume (β = 0.53, 95% CI 0.10; 0.96), but not with ERC/other subfield volumes. PHC FA was not associated with ERC/subfield volumes., Conclusion: These findings indicate that in early AD subiculum atrophy is associated with lower FA of the fornix, which primarily consists of axons originating in the subiculum. This suggests that degeneration of subicular cell bodies and their axons are related processes in early AD.

Published
2015
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2. Hippocampal Disconnection in Early Alzheimer's Disease : A 7 Tesla MRI Study

Author

Wisse, Laura E. M., Reijmer, Yael D., ter Telgte, Annemieke, Kuijf, Hugo J., Leemans, Alexander, Luijten, Peter R., Koek, Huiberdina L., Geerlings, Mirjam I., Biessels, Geert Jan, and Utrecht Vasc Cognitive Impairment

Subjects
NATIONAL INSTITUTE, MILD COGNITIVE IMPAIRMENT, RHESUS-MONKEY, hippocampus, fornix, Alzheimer's disease, TENSOR IMAGING TRACTOGRAPHY, subiculum, VOLUME, DIAGNOSTIC GUIDELINES, ASSOCIATION WORKGROUPS, CINGULUM BUNDLE, DIFFUSION MRI, MATTER, diffusion magnetic resonance imaging
Abstract

Background: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts. Objective: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD. Methods: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial volume. Results: Fornix FA was significantly lower and subiculum, cornu ammonis (CA) 1, and dentate gyrus & CA4 volume were significantly smaller in patients with MCI or AD as compared to controls. In patients with MCI or AD, fornix FA was positively associated with subiculum volume (beta = 0.53, 95% CI 0.10; 0.96), but not with ERC/other subfield volumes. PHC FA was not associated with ERC/subfield volumes. Conclusion: These findings indicate that in early AD subiculum atrophy is associated with lower FA of the fornix, which primarily consists of axons originating in the subiculum. This suggests that degeneration of subicular cell bodies and their axons are related processes in early AD.

Published
2015

3. Hippocampal disconnection in early Alzheimer's disease: a 7 tesla MRI study

Author

Wisse, Laura E.M., Reijmer, Yael D., Ter Telgte, Annemieke, Kuijf, Hugo J., Leemans, Alexander, Luijten, Peter R., Koek, Huiberdina L., Geerlings, Mirjam I., Biessels, Geert Jan, Van Den Berg, E., Brundel, M., Bouvy, W. H., Heringa, S. M., Kappelle, L. J., De Bresser, J., Mali, W. P.Th M., Viergever, M. A., Vincken, K. L., Zwanenburg, J. J.M., De Wit, J. E., Hamaker, M., Faaij, R., Pleizier, M., Vriens, E., Algra, A., Van Der Graaf, Y., Rutten, G. E.H.M., Neurology, Pediatrics, Erasmus School of Economics, Erasmus MC other, Epidemiology, and Public Health

Subjects
Male, NATIONAL INSTITUTE, Pathology, medicine.medical_specialty, MILD COGNITIVE IMPAIRMENT, hippocampus, fornix, Hippocampal formation, White matter, Atrophy, TENSOR IMAGING TRACTOGRAPHY, SDG 3 - Good Health and Well-being, Alzheimer Disease, Fractional anisotropy, Image Processing, Computer-Assisted, medicine, Humans, Cingulum (brain), Cognitive Dysfunction, CINGULUM BUNDLE, Aged, diffusion magnetic resonance imaging, RHESUS-MONKEY, General Neuroscience, Fornix, Subiculum, Organ Size, General Medicine, Alzheimer's disease, Entorhinal cortex, medicine.disease, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Psychiatry and Mental health, Clinical Psychology, medicine.anatomical_structure, nervous system, subiculum, VOLUME, Linear Models, Anisotropy, Female, DIAGNOSTIC GUIDELINES, Geriatrics and Gerontology, Psychology, ASSOCIATION WORKGROUPS, DIFFUSION MRI, MATTER
Abstract

Item does not contain fulltext BACKGROUND: In patients with Alzheimer's disease (AD), atrophy of the entorhinal cortex (ERC) and hippocampal formation may induce degeneration of connecting white matter tracts. OBJECTIVE: We examined the association of hippocampal subfield and ERC atrophy at 7 tesla MRI with fornix and parahippocampal cingulum (PHC) microstructure in patients with early AD. METHODS: Twenty-five patients with amnestic mild cognitive impairment (aMCI) (n = 15) or early AD (n = 10) and 17 controls underwent 3 tesla diffusion MRI to obtain fractional anisotropy (FA) of the fornix and PHC and 7 tesla MRI to obtain ERC and hippocampal subfield volumes. Linear regression analyses were performed, adjusted for age, gender, and intracranial volume. RESULTS: Fornix FA was significantly lower and subiculum, cornu ammonis (CA) 1, and dentate gyrus &CA4 volume were significantly smaller in patients with MCI or AD as compared to controls. In patients with MCI or AD, fornix FA was positively associated with subiculum volume (beta = 0.53, 95% CI 0.10; 0.96), but not with ERC/other subfield volumes. PHC FA was not associated with ERC/subfield volumes. CONCLUSION: These findings indicate that in early AD subiculum atrophy is associated with lower FA of the fornix, which primarily consists of axons originating in the subiculum. This suggests that degeneration of subicular cell bodies and their axons are related processes in early AD.

Published
2015

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